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The map label for this gene is hom2 [H]

Identifier: 126699183

GI number: 126699183

Start: 1831561

End: 1832778

Strand: Direct

Name: hom2 [H]

Synonym: CD1580

Alternate gene names: 126699183

Gene position: 1831561-1832778 (Clockwise)

Preceding gene: 126699182

Following gene: 126699184

Centisome position: 42.69

GC content: 26.19

Gene sequence:

>1218_bases
ATGGAGAATAAAGTGAAAATTGGAGTACTAGGATATGGAGTTGTAGGAAGTGGACTTATAGATATAATAGATAATAATAA
AGAAAAAAGAAATATAGAAATAGTTGGAATTTTAGTTAATAATTTGGAAAAACATAAGGACAAAAAATATTCTAATATAA
TAACTAATAATATAGATGATATATTTAATAAAGATATAGATATACTTGTTGAAGTCATGGGTGGTTTAGAACCATCATTA
TCTTATATAAAAAAAGCATTAAACAATAAAATTCATGTTGTTACAGCAAATAAAGATTTGTTAGCTGAATGTGGAGATGA
GCTTGCAAAATTAGCAAGTGAAAATAAAGTAAGTATTAAATTTGAAGCTTCAGTTGCAGGAGGTATACCAGTATTAAAAC
CAATAATAGAATCACTAGAAGGAAATAATATAGATAGTATAAATGCAATTTTAAATGGAACTACTAATTTTATATTATCT
AAAATGTATGATGAGAATCTATCTTATGATATGGCATTAAGACAAGCACAAGAATTAGGTTTTGCTGAAGCAAATCCAGA
GTCAGATGTATTAGGGTATGATGCTGCTAGAAAACTATCAATATTATCAACTCTAGCTTATGACAATAGAGTATATTGGA
AAGATGTGTATTTAGAAGGAATTACAGATATAGATGAAAAAGATATTGAATATGCAAAAAAATTAAATTGTAAAATAAAA
TTGATTGGTCAAAGTAAGTATGAAAATGATAAAGTAAGTGCTTTTGTTAGACCTGTTTTAGTAGAAAAAGATAATATCCT
TGCTAGAATAGACAATGAGTTCAATGCTGTCATAGTGAATGGAGATTCAGTAGGAGAAGTTTCTTTTGTAGGTAAAGGAG
CTGGAAGTTTAGCAACAGGAAGTGCGGTTTATTCAGATGTTATAGATATAATAGATAATAGAGTTTCAAGTATAGATTCT
TTTACTAAAGATAAAATACAAGTTAATAAAATAGTTAGAGAAAAGTGTGGAGCACTTCTTAGATTTAAAAAATGTAATAA
AGATGAAATTCTAAATATAGTTGAGAATTGTTTAGTAAAATTCGATATTTTAAATGATGATGATGAACTTGCTATTATGG
TTTATGCTGATTCTGAATATGAAATAAACAACAGTTTATGTCTAATAAAAGATAAAGGATACTGCGAAAAAATGAATAAA
ATGTTGAAAATAAGTTAA

Upstream 100 bases:

>100_bases
TGGACTCGTCCCTTTATATAGGGATGAGTCTATTTTTATTGCAATAAAAGATTGAAAATAAAAAAAAATCGGAAAATTAT
AAATTTAGGAGGAAAATAAA

Downstream 100 bases:

>100_bases
AAAAGAAAAAATATAAGTTTATATGTAACATATTTTGACGATTTTAATACTATATAGTATGAGATGAAACAAAACATCTC
ATAAAAAAATTAAAATTAAA

Product: homoserine dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 405; Mature: 405

Protein sequence:

>405_residues
MENKVKIGVLGYGVVGSGLIDIIDNNKEKRNIEIVGILVNNLEKHKDKKYSNIITNNIDDIFNKDIDILVEVMGGLEPSL
SYIKKALNNKIHVVTANKDLLAECGDELAKLASENKVSIKFEASVAGGIPVLKPIIESLEGNNIDSINAILNGTTNFILS
KMYDENLSYDMALRQAQELGFAEANPESDVLGYDAARKLSILSTLAYDNRVYWKDVYLEGITDIDEKDIEYAKKLNCKIK
LIGQSKYENDKVSAFVRPVLVEKDNILARIDNEFNAVIVNGDSVGEVSFVGKGAGSLATGSAVYSDVIDIIDNRVSSIDS
FTKDKIQVNKIVREKCGALLRFKKCNKDEILNIVENCLVKFDILNDDDELAIMVYADSEYEINNSLCLIKDKGYCEKMNK
MLKIS

Sequences:

>Translated_405_residues
MENKVKIGVLGYGVVGSGLIDIIDNNKEKRNIEIVGILVNNLEKHKDKKYSNIITNNIDDIFNKDIDILVEVMGGLEPSL
SYIKKALNNKIHVVTANKDLLAECGDELAKLASENKVSIKFEASVAGGIPVLKPIIESLEGNNIDSINAILNGTTNFILS
KMYDENLSYDMALRQAQELGFAEANPESDVLGYDAARKLSILSTLAYDNRVYWKDVYLEGITDIDEKDIEYAKKLNCKIK
LIGQSKYENDKVSAFVRPVLVEKDNILARIDNEFNAVIVNGDSVGEVSFVGKGAGSLATGSAVYSDVIDIIDNRVSSIDS
FTKDKIQVNKIVREKCGALLRFKKCNKDEILNIVENCLVKFDILNDDDELAIMVYADSEYEINNSLCLIKDKGYCEKMNK
MLKIS
>Mature_405_residues
MENKVKIGVLGYGVVGSGLIDIIDNNKEKRNIEIVGILVNNLEKHKDKKYSNIITNNIDDIFNKDIDILVEVMGGLEPSL
SYIKKALNNKIHVVTANKDLLAECGDELAKLASENKVSIKFEASVAGGIPVLKPIIESLEGNNIDSINAILNGTTNFILS
KMYDENLSYDMALRQAQELGFAEANPESDVLGYDAARKLSILSTLAYDNRVYWKDVYLEGITDIDEKDIEYAKKLNCKIK
LIGQSKYENDKVSAFVRPVLVEKDNILARIDNEFNAVIVNGDSVGEVSFVGKGAGSLATGSAVYSDVIDIIDNRVSSIDS
FTKDKIQVNKIVREKCGALLRFKKCNKDEILNIVENCLVKFDILNDDDELAIMVYADSEYEINNSLCLIKDKGYCEKMNK
MLKIS

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0460

COG function: function code E; Homoserine dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Escherichia coli, GI1786183, Length=125, Percent_Identity=32.8, Blast_Score=62, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR005106
- InterPro:   IPR016204
- InterPro:   IPR001342
- InterPro:   IPR019811
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01842 ACT; PF00742 Homoserine_dh; PF03447 NAD_binding_3 [H]

EC number: =1.1.1.3 [H]

Molecular weight: Translated: 44976; Mature: 44976

Theoretical pI: Translated: 4.65; Mature: 4.65

Prosite motif: PS01042 HOMOSER_DHGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MENKVKIGVLGYGVVGSGLIDIIDNNKEKRNIEIVGILVNNLEKHKDKKYSNIITNNIDD
CCCCEEEEEEEECCCCCCEEEEECCCCCCCCEEEEEEEEHHHHHHHHHHHHHHHHCCHHH
IFNKDIDILVEVMGGLEPSLSYIKKALNNKIHVVTANKDLLAECGDELAKLASENKVSIK
HHCCCHHHHHHHHCCCCHHHHHHHHHHCCEEEEEECCHHHHHHHHHHHHHHHCCCCEEEE
FEASVAGGIPVLKPIIESLEGNNIDSINAILNGTTNFILSKMYDENLSYDMALRQAQELG
EEEECCCCCHHHHHHHHHHCCCCCCHHHHHHCCHHHHHHHHHHHCCCCHHHHHHHHHHCC
FAEANPESDVLGYDAARKLSILSTLAYDNRVYWKDVYLEGITDIDEKDIEYAKKLNCKIK
CCCCCCCCCCCCCCHHHHHHHHHHHHHCCEEEEEEEEECCCCCCCHHHHHHHHHCCCEEE
LIGQSKYENDKVSAFVRPVLVEKDNILARIDNEFNAVIVNGDSVGEVSFVGKGAGSLATG
EEECCCCCCCHHHHHHHHHEECCCCEEEEECCCCCEEEECCCCCCEEEEEECCCCCCCCC
SAVYSDVIDIIDNRVSSIDSFTKDKIQVNKIVREKCGALLRFKKCNKDEILNIVENCLVK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHEE
FDILNDDDELAIMVYADSEYEINNSLCLIKDKGYCEKMNKMLKIS
EEEECCCCCEEEEEEECCCEEECCCEEEEECCCHHHHHHHHEECC
>Mature Secondary Structure
MENKVKIGVLGYGVVGSGLIDIIDNNKEKRNIEIVGILVNNLEKHKDKKYSNIITNNIDD
CCCCEEEEEEEECCCCCCEEEEECCCCCCCCEEEEEEEEHHHHHHHHHHHHHHHHCCHHH
IFNKDIDILVEVMGGLEPSLSYIKKALNNKIHVVTANKDLLAECGDELAKLASENKVSIK
HHCCCHHHHHHHHCCCCHHHHHHHHHHCCEEEEEECCHHHHHHHHHHHHHHHCCCCEEEE
FEASVAGGIPVLKPIIESLEGNNIDSINAILNGTTNFILSKMYDENLSYDMALRQAQELG
EEEECCCCCHHHHHHHHHHCCCCCCHHHHHHCCHHHHHHHHHHHCCCCHHHHHHHHHHCC
FAEANPESDVLGYDAARKLSILSTLAYDNRVYWKDVYLEGITDIDEKDIEYAKKLNCKIK
CCCCCCCCCCCCCCHHHHHHHHHHHHHCCEEEEEEEEECCCCCCCHHHHHHHHHCCCEEE
LIGQSKYENDKVSAFVRPVLVEKDNILARIDNEFNAVIVNGDSVGEVSFVGKGAGSLATG
EEECCCCCCCHHHHHHHHHEECCCCEEEEECCCCCEEEECCCCCCEEEEEECCCCCCCCC
SAVYSDVIDIIDNRVSSIDSFTKDKIQVNKIVREKCGALLRFKKCNKDEILNIVENCLVK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHEE
FDILNDDDELAIMVYADSEYEINNSLCLIKDKGYCEKMNKMLKIS
EEEECCCCCEEEEEEECCCEEECCCEEEEECCCHHHHHHHHEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]