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The map label for this gene is ilvB [H]

Identifier: 126699169

GI number: 126699169

Start: 1812516

End: 1814210

Strand: Direct

Name: ilvB [H]

Synonym: CD1566

Alternate gene names: 126699169

Gene position: 1812516-1814210 (Clockwise)

Preceding gene: 126699168

Following gene: 126699170

Centisome position: 42.25

GC content: 31.74

Gene sequence:

>1695_bases
GTGCGTATGAATGGAGCAAAGGTAATTTTAGAATGTTTAAAGAAAGAGGGAATTGACACAATATTTGGATATCCTGGTGG
AGCCGTGATACCTCTTTATGATGCTCTATACGATTATTCAGATGATTTTAAACATATAAGGACATCCCATGAACAAGGTT
TAGTTCATGCTGCAGATGGGTACGCAAGAAGTACTAATACAGTAGGAGTTTGTTTTACAACATCTGGTCCAGGAGCAACA
AATGCCATAACTGGAATAGCAACAGCTTTTATGGATTCTTCACCTATGGTTGTAATTTCAGGGCAGGTGCCAACTAGTTT
ATTAGGAAAAGATTCTTTTCAAGAAATTGACATAACTGGAGCAACATTATCTATGACAAAACATAATTATTTAGTTAGAA
ACACTAAAGAATTAGTTCCTACAATAAAAGAAGCTTTTAGAGTTGCAAATTCAGGTAGAAAAGGACCTGTACTTGTAGAT
GTTCCAAAAGATTTATTTTTAGCAGAAATGGATTTTAGTGGTGAGGACTATGATTTATGTCAAATAGATGATTATATGGA
TTATAAGAGTGATTTTGATCTAGATGATGAAACTAATATTAAGCTTTTAAATGAAGCAATAGATATCATAAAAGAATCTA
AAAAGCCTGTAATATATGCAGGTGGAGGTGTTAAATCTTCAGACAGTGAGGAAATTCTTGAAAAATTTGCAACTAAGATA
GATACACCTGTACTAAATACACTTATGGGGCTTGGAAATATAGATAGAAAGAATGAACTATCTCTTGGAATGGTTGGAAT
GCATGGAAGTAGAGAAAGTAATTTAGCACTTTCTAATTCAGATTTAGTGATAGCGATAGGTGCGAGATTTAGTGATAGAG
TGATAAGTAAAAGTTCTGAATTTGCTAAAAATGCAAAAATAATACACATAGACATAGACCCATCTGAAATAAGTAAAAAT
ATAGAATCTAATGTATCTTTGGTTGGAGATGTAAAGCTAGTCCTTAGTTTATTAATTGAAAGGGTTGAAAGTAAGAATAA
TAGCAATTGGAAAGAAGAGATAAAGAGATTTAGAAAGAGTGAGGGTGTACAAACATATGAATTTCATCCACAAAATATAC
TTAAAAAAATAAATGAAAAATATGAAACATTAAAGAAACCCACTGTGGTAGTAACTGATGTCGGTCAACATCAAATGTGG
GCTGCTAAGTACTGGAATTTTAAAGGTAATAAAAGTTTTATAACATCAGCAGGGTTAGGAACTATGGGATTTGGTTTAGG
TGCAGCTATTGGAACTAAAGTTGGTAATGTAGATAAAAATGTAGTTTTAGTCACTGGTGATGGAAGTTTTAGAATGAACT
GTAATGAACTAGCTACAGTTGCAAATTATAATGTACCTATGCTTATTTTACTACTCAATAATAGAACATTAGGAATGGTA
AGGCAATGGCAAAAGTTATTTTCCAATCAAAGATACTCTCAAACTGACATTAATGAAAATGTGGATTATGTTAAACTCGT
AAATGCATATAATATTGATGGATATAAGGTATCCAGTATGGAAGAATTAGGAAAGGCGCTAGATATGATAGATTTTAATA
AACCTGTATTTTTGCAATGTGATATAGATAAGGATTATGATGTTTATCCTATTGTAGCACCTAATGATGCATTGGAAAAT
TTGATATGTAACTAA

Upstream 100 bases:

>100_bases
GAAATTGCTGAAGTTGGTAGAAATCTAAGAAGTATGATGTCATTCTTAAAATAAATATATATTAAATGGATTAGTTTGAG
GGAAAGAGTGGTGTATAGTA

Downstream 100 bases:

>100_bases
AACTTATACTGAATATTGATAAAATTTTTTATTAAATTTTTATTGGTATTCAGTTTTTGTTGTTTAGAGATAGATTGGCA
TTTTTTATTTTTTCAAATAA

Product: acetolactate synthase large subunit

Products: NA

Alternate protein names: AHAS; Acetohydroxy-acid synthase large subunit; ALS; Vegetative protein 105; VEG105 [H]

Number of amino acids: Translated: 564; Mature: 564

Protein sequence:

>564_residues
MRMNGAKVILECLKKEGIDTIFGYPGGAVIPLYDALYDYSDDFKHIRTSHEQGLVHAADGYARSTNTVGVCFTTSGPGAT
NAITGIATAFMDSSPMVVISGQVPTSLLGKDSFQEIDITGATLSMTKHNYLVRNTKELVPTIKEAFRVANSGRKGPVLVD
VPKDLFLAEMDFSGEDYDLCQIDDYMDYKSDFDLDDETNIKLLNEAIDIIKESKKPVIYAGGGVKSSDSEEILEKFATKI
DTPVLNTLMGLGNIDRKNELSLGMVGMHGSRESNLALSNSDLVIAIGARFSDRVISKSSEFAKNAKIIHIDIDPSEISKN
IESNVSLVGDVKLVLSLLIERVESKNNSNWKEEIKRFRKSEGVQTYEFHPQNILKKINEKYETLKKPTVVVTDVGQHQMW
AAKYWNFKGNKSFITSAGLGTMGFGLGAAIGTKVGNVDKNVVLVTGDGSFRMNCNELATVANYNVPMLILLLNNRTLGMV
RQWQKLFSNQRYSQTDINENVDYVKLVNAYNIDGYKVSSMEELGKALDMIDFNKPVFLQCDIDKDYDVYPIVAPNDALEN
LICN

Sequences:

>Translated_564_residues
MRMNGAKVILECLKKEGIDTIFGYPGGAVIPLYDALYDYSDDFKHIRTSHEQGLVHAADGYARSTNTVGVCFTTSGPGAT
NAITGIATAFMDSSPMVVISGQVPTSLLGKDSFQEIDITGATLSMTKHNYLVRNTKELVPTIKEAFRVANSGRKGPVLVD
VPKDLFLAEMDFSGEDYDLCQIDDYMDYKSDFDLDDETNIKLLNEAIDIIKESKKPVIYAGGGVKSSDSEEILEKFATKI
DTPVLNTLMGLGNIDRKNELSLGMVGMHGSRESNLALSNSDLVIAIGARFSDRVISKSSEFAKNAKIIHIDIDPSEISKN
IESNVSLVGDVKLVLSLLIERVESKNNSNWKEEIKRFRKSEGVQTYEFHPQNILKKINEKYETLKKPTVVVTDVGQHQMW
AAKYWNFKGNKSFITSAGLGTMGFGLGAAIGTKVGNVDKNVVLVTGDGSFRMNCNELATVANYNVPMLILLLNNRTLGMV
RQWQKLFSNQRYSQTDINENVDYVKLVNAYNIDGYKVSSMEELGKALDMIDFNKPVFLQCDIDKDYDVYPIVAPNDALEN
LICN
>Mature_564_residues
MRMNGAKVILECLKKEGIDTIFGYPGGAVIPLYDALYDYSDDFKHIRTSHEQGLVHAADGYARSTNTVGVCFTTSGPGAT
NAITGIATAFMDSSPMVVISGQVPTSLLGKDSFQEIDITGATLSMTKHNYLVRNTKELVPTIKEAFRVANSGRKGPVLVD
VPKDLFLAEMDFSGEDYDLCQIDDYMDYKSDFDLDDETNIKLLNEAIDIIKESKKPVIYAGGGVKSSDSEEILEKFATKI
DTPVLNTLMGLGNIDRKNELSLGMVGMHGSRESNLALSNSDLVIAIGARFSDRVISKSSEFAKNAKIIHIDIDPSEISKN
IESNVSLVGDVKLVLSLLIERVESKNNSNWKEEIKRFRKSEGVQTYEFHPQNILKKINEKYETLKKPTVVVTDVGQHQMW
AAKYWNFKGNKSFITSAGLGTMGFGLGAAIGTKVGNVDKNVVLVTGDGSFRMNCNELATVANYNVPMLILLLNNRTLGMV
RQWQKLFSNQRYSQTDINENVDYVKLVNAYNIDGYKVSSMEELGKALDMIDFNKPVFLQCDIDKDYDVYPIVAPNDALEN
LICN

Specific function: Valine and isoleucine biosynthesis; first step. [C]

COG id: COG0028

COG function: function code EH; Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TPP enzyme family [H]

Homologues:

Organism=Homo sapiens, GI93004078, Length=576, Percent_Identity=25.3472222222222, Blast_Score=165, Evalue=1e-40,
Organism=Homo sapiens, GI21361361, Length=509, Percent_Identity=24.3614931237721, Blast_Score=147, Evalue=4e-35,
Organism=Escherichia coli, GI87081685, Length=562, Percent_Identity=39.8576512455516, Blast_Score=438, Evalue=1e-124,
Organism=Escherichia coli, GI1790104, Length=558, Percent_Identity=37.2759856630824, Blast_Score=400, Evalue=1e-112,
Organism=Escherichia coli, GI1786717, Length=570, Percent_Identity=30.7017543859649, Blast_Score=300, Evalue=2e-82,
Organism=Escherichia coli, GI1788716, Length=555, Percent_Identity=26.4864864864865, Blast_Score=165, Evalue=6e-42,
Organism=Escherichia coli, GI1787096, Length=559, Percent_Identity=23.9713774597496, Blast_Score=155, Evalue=7e-39,
Organism=Caenorhabditis elegans, GI17542570, Length=518, Percent_Identity=26.8339768339768, Blast_Score=153, Evalue=3e-37,
Organism=Caenorhabditis elegans, GI17531299, Length=574, Percent_Identity=26.1324041811847, Blast_Score=151, Evalue=7e-37,
Organism=Caenorhabditis elegans, GI17531301, Length=574, Percent_Identity=26.1324041811847, Blast_Score=151, Evalue=1e-36,
Organism=Saccharomyces cerevisiae, GI6323755, Length=578, Percent_Identity=39.7923875432526, Blast_Score=438, Evalue=1e-124,
Organism=Saccharomyces cerevisiae, GI6320816, Length=499, Percent_Identity=24.0480961923848, Blast_Score=114, Evalue=4e-26,
Organism=Saccharomyces cerevisiae, GI6323073, Length=535, Percent_Identity=22.9906542056075, Blast_Score=98, Evalue=3e-21,
Organism=Saccharomyces cerevisiae, GI6323163, Length=552, Percent_Identity=23.5507246376812, Blast_Score=96, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6321524, Length=530, Percent_Identity=22.4528301886792, Blast_Score=89, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6320588, Length=560, Percent_Identity=23.0357142857143, Blast_Score=88, Evalue=4e-18,
Organism=Drosophila melanogaster, GI19922626, Length=577, Percent_Identity=24.7833622183709, Blast_Score=157, Evalue=2e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012846
- InterPro:   IPR012000
- InterPro:   IPR012001
- InterPro:   IPR011766 [H]

Pfam domain/function: PF02775 TPP_enzyme_C; PF00205 TPP_enzyme_M; PF02776 TPP_enzyme_N [H]

EC number: =2.2.1.6 [H]

Molecular weight: Translated: 62424; Mature: 62424

Theoretical pI: Translated: 5.04; Mature: 5.04

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRMNGAKVILECLKKEGIDTIFGYPGGAVIPLYDALYDYSDDFKHIRTSHEQGLVHAADG
CCCCHHHHHHHHHHHCCCCEEECCCCCCEEHHHHHHHCCCHHHHHHHHHHHCCCEECCCC
YARSTNTVGVCFTTSGPGATNAITGIATAFMDSSPMVVISGQVPTSLLGKDSFQEIDITG
CCCCCCEEEEEEECCCCCCCHHHHHHHHHHCCCCCEEEEECCCCHHHHCCCCCCEEEECC
ATLSMTKHNYLVRNTKELVPTIKEAFRVANSGRKGPVLVDVPKDLFLAEMDFSGEDYDLC
CEEEEECCCEEECCHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCEEEEECCCCCCCCEE
QIDDYMDYKSDFDLDDETNIKLLNEAIDIIKESKKPVIYAGGGVKSSDSEEILEKFATKI
ECCCHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEECCCCCCCCHHHHHHHHHHHC
DTPVLNTLMGLGNIDRKNELSLGMVGMHGSRESNLALSNSDLVIAIGARFSDRVISKSSE
CCHHHHHHHHCCCCCCCCCCCEEEEECCCCCCCCEEECCCCEEEEECCCCCHHHHHCCHH
FAKNAKIIHIDIDPSEISKNIESNVSLVGDVKLVLSLLIERVESKNNSNWKEEIKRFRKS
HHHCCEEEEEECCHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
EGVQTYEFHPQNILKKINEKYETLKKPTVVVTDVGQHQMWAAKYWNFKGNKSFITSAGLG
CCCEEEEECHHHHHHHHHHHHHHHCCCEEEEEECCCCCEEHHHHCCCCCCCCEEEECCCC
TMGFGLGAAIGTKVGNVDKNVVLVTGDGSFRMNCNELATVANYNVPMLILLLNNRTLGMV
HHHHHHHHHHHCCCCCCCCCEEEEECCCCEEECHHHHHHHHCCCCCEEEEEECCCCHHHH
RQWQKLFSNQRYSQTDINENVDYVKLVNAYNIDGYKVSSMEELGKALDMIDFNKPVFLQC
HHHHHHHCCCCCCCCCCCCCCCEEEEEEEECCCCEEECCHHHHHHHHHHHCCCCCEEEEE
DIDKDYDVYPIVAPNDALENLICN
ECCCCCCEEEEECCCHHHHHHHCC
>Mature Secondary Structure
MRMNGAKVILECLKKEGIDTIFGYPGGAVIPLYDALYDYSDDFKHIRTSHEQGLVHAADG
CCCCHHHHHHHHHHHCCCCEEECCCCCCEEHHHHHHHCCCHHHHHHHHHHHCCCEECCCC
YARSTNTVGVCFTTSGPGATNAITGIATAFMDSSPMVVISGQVPTSLLGKDSFQEIDITG
CCCCCCEEEEEEECCCCCCCHHHHHHHHHHCCCCCEEEEECCCCHHHHCCCCCCEEEECC
ATLSMTKHNYLVRNTKELVPTIKEAFRVANSGRKGPVLVDVPKDLFLAEMDFSGEDYDLC
CEEEEECCCEEECCHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCEEEEECCCCCCCCEE
QIDDYMDYKSDFDLDDETNIKLLNEAIDIIKESKKPVIYAGGGVKSSDSEEILEKFATKI
ECCCHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEECCCCCCCCHHHHHHHHHHHC
DTPVLNTLMGLGNIDRKNELSLGMVGMHGSRESNLALSNSDLVIAIGARFSDRVISKSSE
CCHHHHHHHHCCCCCCCCCCCEEEEECCCCCCCCEEECCCCEEEEECCCCCHHHHHCCHH
FAKNAKIIHIDIDPSEISKNIESNVSLVGDVKLVLSLLIERVESKNNSNWKEEIKRFRKS
HHHCCEEEEEECCHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
EGVQTYEFHPQNILKKINEKYETLKKPTVVVTDVGQHQMWAAKYWNFKGNKSFITSAGLG
CCCEEEEECHHHHHHHHHHHHHHHCCCEEEEEECCCCCEEHHHHCCCCCCCCEEEECCCC
TMGFGLGAAIGTKVGNVDKNVVLVTGDGSFRMNCNELATVANYNVPMLILLLNNRTLGMV
HHHHHHHHHHHCCCCCCCCCEEEEECCCCEEECHHHHHHHHCCCCCEEEEEECCCCHHHH
RQWQKLFSNQRYSQTDINENVDYVKLVNAYNIDGYKVSSMEELGKALDMIDFNKPVFLQC
HHHHHHHCCCCCCCCCCCCCCCEEEEEEEECCCCEEECCHHHHHHHHHHHCCCCCEEEEE
DIDKDYDVYPIVAPNDALENLICN
ECCCCCCEEEEECCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969504; 9384377; 1577690; 9298659 [H]