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The map label for this gene is ilvC

Identifier: 126699168

GI number: 126699168

Start: 1811480

End: 1812469

Strand: Direct

Name: ilvC

Synonym: CD1565

Alternate gene names: 126699168

Gene position: 1811480-1812469 (Clockwise)

Preceding gene: 126699167

Following gene: 126699169

Centisome position: 42.22

GC content: 32.42

Gene sequence:

>990_bases
ATGGCAAGAATGTATTATGAAAAAGATGTGGATTTAGAGGTTTTAAAAAATAAAAAGGTTGCAGTTTTAGGTTATGGAAG
TCAAGGACATGCACATGCACAAAATCTTAGAGATAACGGTGTACATGTAATGATAGGTCTTTATGACGGAAGTAAATCAG
CACAAAAAGCAAAAGAAGATGGATTTGAAGTTAAGAGTGTAGCAGAAGCTACAAAAGAAAGTGATTTGACAATGATGTTA
ATGCCTGATGAAAAACAAAAGAAAGTTTATGAAGAGAGTGTAAAGGATAACTTAAAAGAAGGTCAGACATTAGCTTTTGC
TCATGGATTCAATATACATTATAATCAAGTACAACCACCAGAATTTGTTGATGTTGTAATGGTAGCTCCTAAAGGACCTG
GTCACTTAGTTAGAAATGTATTTACAAAGGGAAGTGGAGTTCCTGCACTATTTGCAGTATATCAAGACCACACTAAAAAA
GCTACAGAGACAGTTTTAGCATATGCAAAAGGGATAGGAGCAACAAGAGCAGGTGTTTTAGAAACTACTTTTAAAGAAGA
AACAGAAACAGATTTATTTGGAGAACAATCAGTACTTTGTGGTGGAATAAGTGAACTTATAAAATTGGGATATAAAACGC
TTGTAGATGCAGGTTATCAAAAAGAAGTAGCATATTTTGAATGTTTACATGAAATGAAACTAATAGTCGACCTTATATAT
GAAGGTGGATTTGAAAGAATGAGATATAGTATAAGTGACACAGCAGAATATGGAGATTATGTATCTGGTAAAAGAGTAAT
AACTGATGCTGCAAAACAAGGTATGCAAAATGTTTTAGAGGATATACAAAATGGAAAATTTGCAAAAGCGTGGATTAAAG
AAAATGAAGAAGGACGTGAAAACTTCCTAAAAACTAGAGAAGAAGAATATAATACAGAAATTGCTGAAGTTGGTAGAAAT
CTAAGAAGTATGATGTCATTCTTAAAATAA

Upstream 100 bases:

>100_bases
TTAAATCTGTTGAATAATATTAAAACAATGATAATGAGTATGAATTTCTAATAAAAATAAATATCATAAAAATAAGAAAA
AGTATTGGGAGGAAATGAAA

Downstream 100 bases:

>100_bases
ATATATATTAAATGGATTAGTTTGAGGGAAAGAGTGGTGTATAGTAGTGCGTATGAATGGAGCAAAGGTAATTTTAGAAT
GTTTAAAGAAAGAGGGAATT

Product: ketol-acid reductoisomerase

Products: NA

Alternate protein names: Acetohydroxy-acid isomeroreductase; Alpha-keto-beta-hydroxylacil reductoisomerase

Number of amino acids: Translated: 329; Mature: 328

Protein sequence:

>329_residues
MARMYYEKDVDLEVLKNKKVAVLGYGSQGHAHAQNLRDNGVHVMIGLYDGSKSAQKAKEDGFEVKSVAEATKESDLTMML
MPDEKQKKVYEESVKDNLKEGQTLAFAHGFNIHYNQVQPPEFVDVVMVAPKGPGHLVRNVFTKGSGVPALFAVYQDHTKK
ATETVLAYAKGIGATRAGVLETTFKEETETDLFGEQSVLCGGISELIKLGYKTLVDAGYQKEVAYFECLHEMKLIVDLIY
EGGFERMRYSISDTAEYGDYVSGKRVITDAAKQGMQNVLEDIQNGKFAKAWIKENEEGRENFLKTREEEYNTEIAEVGRN
LRSMMSFLK

Sequences:

>Translated_329_residues
MARMYYEKDVDLEVLKNKKVAVLGYGSQGHAHAQNLRDNGVHVMIGLYDGSKSAQKAKEDGFEVKSVAEATKESDLTMML
MPDEKQKKVYEESVKDNLKEGQTLAFAHGFNIHYNQVQPPEFVDVVMVAPKGPGHLVRNVFTKGSGVPALFAVYQDHTKK
ATETVLAYAKGIGATRAGVLETTFKEETETDLFGEQSVLCGGISELIKLGYKTLVDAGYQKEVAYFECLHEMKLIVDLIY
EGGFERMRYSISDTAEYGDYVSGKRVITDAAKQGMQNVLEDIQNGKFAKAWIKENEEGRENFLKTREEEYNTEIAEVGRN
LRSMMSFLK
>Mature_328_residues
ARMYYEKDVDLEVLKNKKVAVLGYGSQGHAHAQNLRDNGVHVMIGLYDGSKSAQKAKEDGFEVKSVAEATKESDLTMMLM
PDEKQKKVYEESVKDNLKEGQTLAFAHGFNIHYNQVQPPEFVDVVMVAPKGPGHLVRNVFTKGSGVPALFAVYQDHTKKA
TETVLAYAKGIGATRAGVLETTFKEETETDLFGEQSVLCGGISELIKLGYKTLVDAGYQKEVAYFECLHEMKLIVDLIYE
GGFERMRYSISDTAEYGDYVSGKRVITDAAKQGMQNVLEDIQNGKFAKAWIKENEEGRENFLKTREEEYNTEIAEVGRNL
RSMMSFLK

Specific function: Valine and isoleucine biosynthesis; second step. [C]

COG id: COG0059

COG function: function code EH; Ketol-acid reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketol-acid reductoisomerase family

Homologues:

Organism=Escherichia coli, GI1790210, Length=307, Percent_Identity=32.5732899022801, Blast_Score=140, Evalue=1e-34,
Organism=Saccharomyces cerevisiae, GI6323387, Length=332, Percent_Identity=33.7349397590361, Blast_Score=150, Evalue=3e-37,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1420 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): ILVC_CLOD6 (Q18C83)

Other databases:

- EMBL:   AM180355
- RefSeq:   YP_001088065.1
- ProteinModelPortal:   Q18C83
- SMR:   Q18C83
- STRING:   Q18C83
- GeneID:   4913060
- GenomeReviews:   AM180355_GR
- KEGG:   cdf:CD1565
- NMPDR:   fig|1496.1.peg.3354
- eggNOG:   COG0059
- HOGENOM:   HBG286525
- OMA:   MAYAKGI
- ProtClustDB:   CLSK2534938
- HAMAP:   MF_00435
- InterPro:   IPR008927
- InterPro:   IPR013023
- InterPro:   IPR000506
- InterPro:   IPR013328
- InterPro:   IPR013116
- Gene3D:   G3DSA:1.10.1040.10
- PANTHER:   PTHR21371
- TIGRFAMs:   TIGR00465

Pfam domain/function: PF01450 IlvC; PF07991 IlvN; SSF48179 6DGDH_C_like

EC number: =1.1.1.86

Molecular weight: Translated: 36878; Mature: 36747

Theoretical pI: Translated: 5.50; Mature: 5.50

Prosite motif: NA

Important sites: ACT_SITE 108-108

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARMYYEKDVDLEVLKNKKVAVLGYGSQGHAHAQNLRDNGVHVMIGLYDGSKSAQKAKED
CCCCCCCCCCCHHHHCCCCEEEEECCCCCCHHHHHHCCCCCEEEEEEECCCCHHHHHHHC
GFEVKSVAEATKESDLTMMLMPDEKQKKVYEESVKDNLKEGQTLAFAHGFNIHYNQVQPP
CCHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHHHCCCEEEEEECCCEEECCCCCC
EFVDVVMVAPKGPGHLVRNVFTKGSGVPALFAVYQDHTKKATETVLAYAKGIGATRAGVL
CCEEEEEECCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHH
ETTFKEETETDLFGEQSVLCGGISELIKLGYKTLVDAGYQKEVAYFECLHEMKLIVDLIY
HHHHHHHHHHHHCCCCHHHHHCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
EGGFERMRYSISDTAEYGDYVSGKRVITDAAKQGMQNVLEDIQNGKFAKAWIKENEEGRE
HCCHHHHHCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEHHHHCCCHHHH
NFLKTREEEYNTEIAEVGRNLRSMMSFLK
HHHHHHHHHHCCHHHHHHHHHHHHHHHHC
>Mature Secondary Structure 
ARMYYEKDVDLEVLKNKKVAVLGYGSQGHAHAQNLRDNGVHVMIGLYDGSKSAQKAKED
CCCCCCCCCCHHHHCCCCEEEEECCCCCCHHHHHHCCCCCEEEEEEECCCCHHHHHHHC
GFEVKSVAEATKESDLTMMLMPDEKQKKVYEESVKDNLKEGQTLAFAHGFNIHYNQVQPP
CCHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHHHCCCEEEEEECCCEEECCCCCC
EFVDVVMVAPKGPGHLVRNVFTKGSGVPALFAVYQDHTKKATETVLAYAKGIGATRAGVL
CCEEEEEECCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHH
ETTFKEETETDLFGEQSVLCGGISELIKLGYKTLVDAGYQKEVAYFECLHEMKLIVDLIY
HHHHHHHHHHHHCCCCHHHHHCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
EGGFERMRYSISDTAEYGDYVSGKRVITDAAKQGMQNVLEDIQNGKFAKAWIKENEEGRE
HCCHHHHHCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEHHHHCCCHHHH
NFLKTREEEYNTEIAEVGRNLRSMMSFLK
HHHHHHHHHHCCHHHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA