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The map label for this gene is prsA [H]

Identifier: 126699161

GI number: 126699161

Start: 1805602

End: 1806558

Strand: Direct

Name: prsA [H]

Synonym: CD1557

Alternate gene names: 126699161

Gene position: 1805602-1806558 (Clockwise)

Preceding gene: 126699160

Following gene: 126699162

Centisome position: 42.09

GC content: 26.85

Gene sequence:

>957_bases
TTGAATAAAAAACTTTATATAGGAATGGTCGGAATATTGTCTTTGATGATGGTTGGTTGTAATAAAAGTTTAGCAAAAGT
AAATGATGTGGAAATCACAAAAGAACAGTACAAAAAAACAAAAGCAGTTTTATCTGCTACTAATAATTATATAAATGGGC
AGTCTTTAGATGAATTAGAAAAAACTTTGGATAAAAAAGGTAGAAATAAATTAGAAAATGTTATAATATCGTTTATGGTG
GATAATGAACTTTTATATCAAGAGGCTAAGGATAAAGGACTAACTCCAAGTAAAAGTGAAGTAGACTCAAAATATCAAGA
ACTAGAAGATAAGATGAATTTGAATACAAGCTATAAGGAAAAAATGGACAAAGCAGGTGTTGATAAAGATTATTTAAAAC
AAGAAATATCTAGAGATTTAGCAATAGATAAAAATAAAAAGGCCTTTGAAGATAGAATAAACATAAGTGATAATGATATG
GAAGCCTACTATACAAGTCATAAAAAAGATTTTAATGTAGAAGAAGTAAGTGCTTCTCAGATACTTATATCGACTTTAGA
TAAAAATAAAAAAGAAGTAAGCAAAGATAAAAAAGAAGCTTTGAAGAAGAAGGCAGATAATATATTGACTAAAATCAAAA
ATGGAGAAAGTTTTGAAAGTTTGGCTAAAAAATATTCGGATGATAAAGCAACTGGAAAAAATGGAGGACAGCTAGGATAT
TTTACAAAGGATGATAAAAATGCTGAGTTTACAAAGGAAGTGTTCAAATTAAAGAAAAATGAAGTTTCAAATGTGTTTGA
AACTAGTTATGGATATCATATAGTCAAAGTTACTGATAAAAGAGAAAGACAAAAAAGTTTTAATGAGTGTCAGAGTTTAA
TAAGAGAATCTATTTTAAATGAAAAGTATATTGAGCATATAAAAAAACTGAATGAAGATGCTAAAATAGACAGATAG

Upstream 100 bases:

>100_bases
CAAAAAATTATTGGTTACGTAATTTAGAGTAGTTAAAATATAAGAATATTGATTGATATTTTTAGAAATTGAGAATAAAA
ATGAGTGAGGTGTAGGTATA

Downstream 100 bases:

>100_bases
AATTTCTAACAGCTCAATCCTAGCCTGTAATCGGAGGGAGATTTTACAGGAATGTTTAAGAGTTTAAAGAGAACGAAAGT
TGAGAAATACATTATCGATA

Product: peptidyl-prolyl isomerase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 318; Mature: 318

Protein sequence:

>318_residues
MNKKLYIGMVGILSLMMVGCNKSLAKVNDVEITKEQYKKTKAVLSATNNYINGQSLDELEKTLDKKGRNKLENVIISFMV
DNELLYQEAKDKGLTPSKSEVDSKYQELEDKMNLNTSYKEKMDKAGVDKDYLKQEISRDLAIDKNKKAFEDRINISDNDM
EAYYTSHKKDFNVEEVSASQILISTLDKNKKEVSKDKKEALKKKADNILTKIKNGESFESLAKKYSDDKATGKNGGQLGY
FTKDDKNAEFTKEVFKLKKNEVSNVFETSYGYHIVKVTDKRERQKSFNECQSLIRESILNEKYIEHIKKLNEDAKIDR

Sequences:

>Translated_318_residues
MNKKLYIGMVGILSLMMVGCNKSLAKVNDVEITKEQYKKTKAVLSATNNYINGQSLDELEKTLDKKGRNKLENVIISFMV
DNELLYQEAKDKGLTPSKSEVDSKYQELEDKMNLNTSYKEKMDKAGVDKDYLKQEISRDLAIDKNKKAFEDRINISDNDM
EAYYTSHKKDFNVEEVSASQILISTLDKNKKEVSKDKKEALKKKADNILTKIKNGESFESLAKKYSDDKATGKNGGQLGY
FTKDDKNAEFTKEVFKLKKNEVSNVFETSYGYHIVKVTDKRERQKSFNECQSLIRESILNEKYIEHIKKLNEDAKIDR
>Mature_318_residues
MNKKLYIGMVGILSLMMVGCNKSLAKVNDVEITKEQYKKTKAVLSATNNYINGQSLDELEKTLDKKGRNKLENVIISFMV
DNELLYQEAKDKGLTPSKSEVDSKYQELEDKMNLNTSYKEKMDKAGVDKDYLKQEISRDLAIDKNKKAFEDRINISDNDM
EAYYTSHKKDFNVEEVSASQILISTLDKNKKEVSKDKKEALKKKADNILTKIKNGESFESLAKKYSDDKATGKNGGQLGY
FTKDDKNAEFTKEVFKLKKNEVSNVFETSYGYHIVKVTDKRERQKSFNECQSLIRESILNEKYIEHIKKLNEDAKIDR

Specific function: Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins [H]

COG id: COG0760

COG function: function code O; Parvulin-like peptidyl-prolyl isomerase

Gene ontology:

Cell location: Cell membrane; Lipid-anchor (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PpiC domain [H]

Homologues:

None

Paralogues:

None

Copy number: 400 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 160 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023059
- InterPro:   IPR000297
- InterPro:   IPR023058
- InterPro:   IPR015391
- InterPro:   IPR008880 [H]

Pfam domain/function: PF00639 Rotamase; PF09312 SurA_N [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 36610; Mature: 36610

Theoretical pI: Translated: 9.28; Mature: 9.28

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS01096 PPIC_PPIASE_1 ; PS50198 PPIC_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKKLYIGMVGILSLMMVGCNKSLAKVNDVEITKEQYKKTKAVLSATNNYINGQSLDELE
CCCEEEEHHHHHHHHHHHHCCCHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHH
KTLDKKGRNKLENVIISFMVDNELLYQEAKDKGLTPSKSEVDSKYQELEDKMNLNTSYKE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCHHHH
KMDKAGVDKDYLKQEISRDLAIDKNKKAFEDRINISDNDMEAYYTSHKKDFNVEEVSASQ
HHHHCCCCHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCHHHHHHHCCCCCCCHHHHHHHH
ILISTLDKNKKEVSKDKKEALKKKADNILTKIKNGESFESLAKKYSDDKATGKNGGQLGY
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCEECC
FTKDDKNAEFTKEVFKLKKNEVSNVFETSYGYHIVKVTDKRERQKSFNECQSLIRESILN
CCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHH
EKYIEHIKKLNEDAKIDR
HHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MNKKLYIGMVGILSLMMVGCNKSLAKVNDVEITKEQYKKTKAVLSATNNYINGQSLDELE
CCCEEEEHHHHHHHHHHHHCCCHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHH
KTLDKKGRNKLENVIISFMVDNELLYQEAKDKGLTPSKSEVDSKYQELEDKMNLNTSYKE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCHHHH
KMDKAGVDKDYLKQEISRDLAIDKNKKAFEDRINISDNDMEAYYTSHKKDFNVEEVSASQ
HHHHCCCCHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCHHHHHHHCCCCCCCHHHHHHHH
ILISTLDKNKKEVSKDKKEALKKKADNILTKIKNGESFESLAKKYSDDKATGKNGGQLGY
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCEECC
FTKDDKNAEFTKEVFKLKKNEVSNVFETSYGYHIVKVTDKRERQKSFNECQSLIRESILN
CCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHH
EKYIEHIKKLNEDAKIDR
HHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11997336 [H]