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The map label for this gene is hisI [H]

Identifier: 126699158

GI number: 126699158

Start: 1801149

End: 1801817

Strand: Direct

Name: hisI [H]

Synonym: CD1554

Alternate gene names: 126699158

Gene position: 1801149-1801817 (Clockwise)

Preceding gene: 126699157

Following gene: 126699159

Centisome position: 41.98

GC content: 27.65

Gene sequence:

>669_bases
ATGGATAATAAGTGTAACAATGTATACAGTGATGAAGTAGAGAAATTTATAAGAAGTATAAAGTTTGATGATAAAGGGTT
AGTCCCTGTTGTTGTTCAAGAGGTAGTTAGCAAAGATGTACTGATGTTAGCATATATGAATAAAGATGCTATAAAGAAAA
CCTTAAAAGATAAAATAGCTTGCTATTTTAGTAGAAGTAGACAAGAACTTTGGGTTAAAGGTGAGACATCTGGTAATACT
CAAAAAGTAGTTAAGATGTCTTATGATTGTGATGTAGATACTATACTACTTTTTGTTGAACAAACTGGTGTAGCTTGTCA
TACAGGCAATTATTCTTGTTTTTACAGAGACTTGTTTGATGATAGTTCAAAAATGGAGCTTGAAGTACAAACAAATATAT
TGAAAGAATTATATGATTTAATCAATGAAAGAAAAAATAATCCAGTTGAAGGTTCTTATACTAATTATCTTTTTGAAAAA
GGAATAGATAAGATTCTTAAAAAAGTAGGTGAAGAGAGTAGTGAGGTAATTATAGCATCAAAAAATACCGATAAAAGTGA
ACTTATTTACGAAATTAGCGATTTAGTATATCATACATTGGTTTTAATGATAGAAAAAGGTGTTGAAATTGATGAAATAA
AAAAAGAATTACTTAAAAGAAGAAAATAG

Upstream 100 bases:

>100_bases
TCATTTTGGCGAGATAAAAATAAACGATTTAAAGAAATATTTAAAAGACATGGGTGTAGAAGTAAGATTATAAGTTAAAT
ACTAAAAGGAGATTAGAAAT

Downstream 100 bases:

>100_bases
AATAAGATAGATTAATGGGTAATAAGAAAATATACCGCTTTTAATAAAAAGTGGTATATTTTTTATTTTATATTTTAATT
TATAGAATAATATTTAAATT

Product: histidine biosynthesis bifunctional protein

Products: NA

Alternate protein names: Phosphoribosyl-AMP cyclohydrolase; PRA-CH; Phosphoribosyl-ATP pyrophosphatase; PRA-PH [H]

Number of amino acids: Translated: 222; Mature: 222

Protein sequence:

>222_residues
MDNKCNNVYSDEVEKFIRSIKFDDKGLVPVVVQEVVSKDVLMLAYMNKDAIKKTLKDKIACYFSRSRQELWVKGETSGNT
QKVVKMSYDCDVDTILLFVEQTGVACHTGNYSCFYRDLFDDSSKMELEVQTNILKELYDLINERKNNPVEGSYTNYLFEK
GIDKILKKVGEESSEVIIASKNTDKSELIYEISDLVYHTLVLMIEKGVEIDEIKKELLKRRK

Sequences:

>Translated_222_residues
MDNKCNNVYSDEVEKFIRSIKFDDKGLVPVVVQEVVSKDVLMLAYMNKDAIKKTLKDKIACYFSRSRQELWVKGETSGNT
QKVVKMSYDCDVDTILLFVEQTGVACHTGNYSCFYRDLFDDSSKMELEVQTNILKELYDLINERKNNPVEGSYTNYLFEK
GIDKILKKVGEESSEVIIASKNTDKSELIYEISDLVYHTLVLMIEKGVEIDEIKKELLKRRK
>Mature_222_residues
MDNKCNNVYSDEVEKFIRSIKFDDKGLVPVVVQEVVSKDVLMLAYMNKDAIKKTLKDKIACYFSRSRQELWVKGETSGNT
QKVVKMSYDCDVDTILLFVEQTGVACHTGNYSCFYRDLFDDSSKMELEVQTNILKELYDLINERKNNPVEGSYTNYLFEK
GIDKILKKVGEESSEVIIASKNTDKSELIYEISDLVYHTLVLMIEKGVEIDEIKKELLKRRK

Specific function: Histidine biosynthesis; second step. Histidine biosynthesis; third step. [C]

COG id: COG0139

COG function: function code E; Phosphoribosyl-AMP cyclohydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PRA-PH family [H]

Homologues:

Organism=Escherichia coli, GI2367128, Length=197, Percent_Identity=43.1472081218274, Blast_Score=163, Evalue=8e-42,
Organism=Saccharomyces cerevisiae, GI6319819, Length=180, Percent_Identity=34.4444444444444, Blast_Score=92, Evalue=9e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023019
- InterPro:   IPR008179
- InterPro:   IPR021130
- InterPro:   IPR002496
- ProDom:   PD002610 [H]

Pfam domain/function: PF01502 PRA-CH; PF01503 PRA-PH [H]

EC number: =3.5.4.19; =3.6.1.31 [H]

Molecular weight: Translated: 25676; Mature: 25676

Theoretical pI: Translated: 5.09; Mature: 5.09

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDNKCNNVYSDEVEKFIRSIKFDDKGLVPVVVQEVVSKDVLMLAYMNKDAIKKTLKDKIA
CCCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCHHHHHHHHCHHHHHHHHHHHHH
CYFSRSRQELWVKGETSGNTQKVVKMSYDCDVDTILLFVEQTGVACHTGNYSCFYRDLFD
HHHHCCCCEEEEECCCCCCCEEEEEEECCCCHHHHEEEEECCCCEEECCCCCEEEHHHHC
DSSKMELEVQTNILKELYDLINERKNNPVEGSYTNYLFEKGIDKILKKVGEESSEVIIAS
CCCCEEEHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEE
KNTDKSELIYEISDLVYHTLVLMIEKGVEIDEIKKELLKRRK
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCC
>Mature Secondary Structure
MDNKCNNVYSDEVEKFIRSIKFDDKGLVPVVVQEVVSKDVLMLAYMNKDAIKKTLKDKIA
CCCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCHHHHHHHHCHHHHHHHHHHHHH
CYFSRSRQELWVKGETSGNTQKVVKMSYDCDVDTILLFVEQTGVACHTGNYSCFYRDLFD
HHHHCCCCEEEEECCCCCCCEEEEEEECCCCHHHHEEEEECCCCEEECCCCCEEEHHHHC
DSSKMELEVQTNILKELYDLINERKNNPVEGSYTNYLFEKGIDKILKKVGEESSEVIIAS
CCCCEEEHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEE
KNTDKSELIYEISDLVYHTLVLMIEKGVEIDEIKKELLKRRK
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11997336 [H]