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The map label for this gene is ywrD [H]

Identifier: 126699138

GI number: 126699138

Start: 1778465

End: 1780078

Strand: Direct

Name: ywrD [H]

Synonym: CD1534

Alternate gene names: 126699138

Gene position: 1778465-1780078 (Clockwise)

Preceding gene: 126699137

Following gene: 126699140

Centisome position: 41.45

GC content: 33.52

Gene sequence:

>1614_bases
ATGAAGTTTAATGCCTACCAACATAAATACTCATCAATAAGAAATGTCGTGTATGCTAAAAATGGAGCAGTTGCAACATC
AACACCACTAGCATCTCAAGCTGGACTTGAAATACTAAAAAAGGGTGGAAATGCTGTTGATGCAGCAGTTGCAACAGCCG
CCACATTAGCAGTAGTAGAACCTACAAGCAATGGGATTGGAGGAGATGCATATGCCCTTGTTTGGATAGAGGAAGAAAAA
CGATTGTATGGTTTAAATTCTAGTGGCTTTGCTCCAGAAAATATGGAATTAAAAAATTATAATAATATGAAAGAAATGCC
AAAATATGGGTTTGGAGCAGTAACTGTACCTGGAATACCAGCAGCTTGGTCAGAATTAAATAAAAAATATGGTAAACTTA
GCTTAATGGAATGCTTATCTCCAGCGATAAACTATGCAAGAGAGGGATACGTAGTATCTCCTAATGTAGCTAAGGTATGG
AAAAAATCATATGAACTCTATGAAAAAGAACTTATTGGAGAAGAGTTCAAACCATGGTTTGATACATTTTCTAAAGATGG
TAAAGCTCCAGAGGCTGGAGATATATTTATATGTGAAGAACAGGCAAGTACATTAGAAGAGATAGCAAATACTCAGGCTG
AAAGCTTTTATAGAGGAAGACTTGCTGATAAAATAGATGAATATTCTAAAAAATTTAATGGGGCTATAAGAAAGAGTGAC
TTAGAGTGTTTTTATCCAACATGGGTAGAACCTATAAGTACAGAATATAAGGGATATAAAATATTTGAAATCCCACCAAA
TGGTCATGGAATAACAGTTTTAATGGCACTTAACATATTAAAAGAACTGGAATTAGAAGGAAATATAGAAAATGTAGAAG
ACATACATAAAATTATAGAGAGTTTAAAATTAGCTTTTGCAGATTCTAAAACATATGTAACTGATATAGAGCATATGAAG
GTAAAGATTCAGGAATTACTAAGCCAAGAGTATGCCAAAAAAAGAAGTTTATTGATTGACAATAAAGAGGCTTTGTATCC
AACTGCAGGAGAGCCATATTGTGGTGGTACAGTATACCTTTGTACTGCAGATAAGGATGGAAATATGGTTTCATATATAC
AGAGCAATTACATAAATTTTGGTTCAGGAATTGTGATACCAAGAACTGGGATTGCTTTACATAGTAGAGGAAATAATTTT
AATTTAGACCCTAAACACCACAATGTAGTAAAACCATTTAAAAAACCTTATCATACTATAATACCTGGATTTTTAGGTAA
AGAAGATAAAGCAATAGGTCCATTTGGTGTAATGGGAGCTTTTATGCAACCACAAGGACATATTCAAGTGTTAACAAATA
TGATTGATTTTGGATTAAATCCACAAGAGGCGCTAGATGCTCCAAGATGGCAGTGGATAAAAGGAAAAGAAATAGAAGTT
GAACCAGAGATGCCAAAGCATATAATAGATTCATTAATTGAAAAGGGTCATGAAATAAAAGTAATTCATGATACTGTTGA
CATGGGACGAGGTCAAATAATATTTAAAACAGAACAGGAAAGTTATATTTGTGGGACGGAATCAAGATGTGATGGTCATA
TTGCAGTTTATTAA

Upstream 100 bases:

>100_bases
AGTCTATATTTTATATCATTTTGTATCAGTTACATTACTTGATGTTATATAATAAATCTAAGCAGAATATCAAATAAAAA
ATGACGAGGAGCTGAAATTT

Downstream 100 bases:

>100_bases
TATTATCAACTAAAATATATATAATAAATTTAAAGAGTATATGAAATAATAAGTAAAGGCGAAAGTCTACAATGACTGAC
GCCTTTACAAAACTTAAGCT

Product: gamma-glutamyltranspeptidase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 537; Mature: 537

Protein sequence:

>537_residues
MKFNAYQHKYSSIRNVVYAKNGAVATSTPLASQAGLEILKKGGNAVDAAVATAATLAVVEPTSNGIGGDAYALVWIEEEK
RLYGLNSSGFAPENMELKNYNNMKEMPKYGFGAVTVPGIPAAWSELNKKYGKLSLMECLSPAINYAREGYVVSPNVAKVW
KKSYELYEKELIGEEFKPWFDTFSKDGKAPEAGDIFICEEQASTLEEIANTQAESFYRGRLADKIDEYSKKFNGAIRKSD
LECFYPTWVEPISTEYKGYKIFEIPPNGHGITVLMALNILKELELEGNIENVEDIHKIIESLKLAFADSKTYVTDIEHMK
VKIQELLSQEYAKKRSLLIDNKEALYPTAGEPYCGGTVYLCTADKDGNMVSYIQSNYINFGSGIVIPRTGIALHSRGNNF
NLDPKHHNVVKPFKKPYHTIIPGFLGKEDKAIGPFGVMGAFMQPQGHIQVLTNMIDFGLNPQEALDAPRWQWIKGKEIEV
EPEMPKHIIDSLIEKGHEIKVIHDTVDMGRGQIIFKTEQESYICGTESRCDGHIAVY

Sequences:

>Translated_537_residues
MKFNAYQHKYSSIRNVVYAKNGAVATSTPLASQAGLEILKKGGNAVDAAVATAATLAVVEPTSNGIGGDAYALVWIEEEK
RLYGLNSSGFAPENMELKNYNNMKEMPKYGFGAVTVPGIPAAWSELNKKYGKLSLMECLSPAINYAREGYVVSPNVAKVW
KKSYELYEKELIGEEFKPWFDTFSKDGKAPEAGDIFICEEQASTLEEIANTQAESFYRGRLADKIDEYSKKFNGAIRKSD
LECFYPTWVEPISTEYKGYKIFEIPPNGHGITVLMALNILKELELEGNIENVEDIHKIIESLKLAFADSKTYVTDIEHMK
VKIQELLSQEYAKKRSLLIDNKEALYPTAGEPYCGGTVYLCTADKDGNMVSYIQSNYINFGSGIVIPRTGIALHSRGNNF
NLDPKHHNVVKPFKKPYHTIIPGFLGKEDKAIGPFGVMGAFMQPQGHIQVLTNMIDFGLNPQEALDAPRWQWIKGKEIEV
EPEMPKHIIDSLIEKGHEIKVIHDTVDMGRGQIIFKTEQESYICGTESRCDGHIAVY
>Mature_537_residues
MKFNAYQHKYSSIRNVVYAKNGAVATSTPLASQAGLEILKKGGNAVDAAVATAATLAVVEPTSNGIGGDAYALVWIEEEK
RLYGLNSSGFAPENMELKNYNNMKEMPKYGFGAVTVPGIPAAWSELNKKYGKLSLMECLSPAINYAREGYVVSPNVAKVW
KKSYELYEKELIGEEFKPWFDTFSKDGKAPEAGDIFICEEQASTLEEIANTQAESFYRGRLADKIDEYSKKFNGAIRKSD
LECFYPTWVEPISTEYKGYKIFEIPPNGHGITVLMALNILKELELEGNIENVEDIHKIIESLKLAFADSKTYVTDIEHMK
VKIQELLSQEYAKKRSLLIDNKEALYPTAGEPYCGGTVYLCTADKDGNMVSYIQSNYINFGSGIVIPRTGIALHSRGNNF
NLDPKHHNVVKPFKKPYHTIIPGFLGKEDKAIGPFGVMGAFMQPQGHIQVLTNMIDFGLNPQEALDAPRWQWIKGKEIEV
EPEMPKHIIDSLIEKGHEIKVIHDTVDMGRGQIIFKTEQESYICGTESRCDGHIAVY

Specific function: GGT PLAYS A KEY ROLE IN THE GAMMA-GLUTAMYL CYCLE, A PATHWAY FOR THE SYNTHESIS AND DEGRADATION OF GLUTATHIONE. [C]

COG id: COG0405

COG function: function code E; Gamma-glutamyltransferase

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI73915092, Length=550, Percent_Identity=23.4545454545455, Blast_Score=127, Evalue=3e-29,
Organism=Homo sapiens, GI73915090, Length=550, Percent_Identity=23.4545454545455, Blast_Score=127, Evalue=3e-29,
Organism=Homo sapiens, GI73915096, Length=550, Percent_Identity=23.4545454545455, Blast_Score=127, Evalue=3e-29,
Organism=Homo sapiens, GI73915094, Length=550, Percent_Identity=23.4545454545455, Blast_Score=127, Evalue=3e-29,
Organism=Homo sapiens, GI113429324, Length=481, Percent_Identity=24.948024948025, Blast_Score=120, Evalue=4e-27,
Organism=Homo sapiens, GI113429326, Length=481, Percent_Identity=24.948024948025, Blast_Score=119, Evalue=6e-27,
Organism=Homo sapiens, GI109148539, Length=505, Percent_Identity=24.950495049505, Blast_Score=116, Evalue=7e-26,
Organism=Homo sapiens, GI153266885, Length=392, Percent_Identity=25, Blast_Score=102, Evalue=1e-21,
Organism=Homo sapiens, GI153266901, Length=392, Percent_Identity=25, Blast_Score=102, Evalue=1e-21,
Organism=Homo sapiens, GI153266907, Length=390, Percent_Identity=24.1025641025641, Blast_Score=89, Evalue=8e-18,
Organism=Escherichia coli, GI1789856, Length=516, Percent_Identity=31.0077519379845, Blast_Score=202, Evalue=4e-53,
Organism=Caenorhabditis elegans, GI72000294, Length=432, Percent_Identity=26.6203703703704, Blast_Score=125, Evalue=5e-29,
Organism=Caenorhabditis elegans, GI212646519, Length=432, Percent_Identity=26.6203703703704, Blast_Score=125, Evalue=7e-29,
Organism=Caenorhabditis elegans, GI193208245, Length=514, Percent_Identity=24.9027237354086, Blast_Score=119, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI193208247, Length=514, Percent_Identity=24.9027237354086, Blast_Score=119, Evalue=4e-27,
Organism=Caenorhabditis elegans, GI17506189, Length=528, Percent_Identity=25.7575757575758, Blast_Score=114, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI17542894, Length=509, Percent_Identity=24.3614931237721, Blast_Score=109, Evalue=3e-24,
Organism=Saccharomyces cerevisiae, GI6323330, Length=532, Percent_Identity=24.0601503759398, Blast_Score=74, Evalue=4e-14,
Organism=Drosophila melanogaster, GI161077878, Length=533, Percent_Identity=24.953095684803, Blast_Score=123, Evalue=4e-28,
Organism=Drosophila melanogaster, GI24642670, Length=529, Percent_Identity=25.3308128544423, Blast_Score=122, Evalue=4e-28,
Organism=Drosophila melanogaster, GI24642666, Length=529, Percent_Identity=25.3308128544423, Blast_Score=122, Evalue=4e-28,
Organism=Drosophila melanogaster, GI45551474, Length=533, Percent_Identity=24.953095684803, Blast_Score=122, Evalue=4e-28,
Organism=Drosophila melanogaster, GI161077880, Length=533, Percent_Identity=24.953095684803, Blast_Score=122, Evalue=4e-28,
Organism=Drosophila melanogaster, GI161077496, Length=520, Percent_Identity=24.6153846153846, Blast_Score=107, Evalue=2e-23,
Organism=Drosophila melanogaster, GI18859741, Length=533, Percent_Identity=22.3264540337711, Blast_Score=105, Evalue=8e-23,
Organism=Drosophila melanogaster, GI18859893, Length=441, Percent_Identity=25.6235827664399, Blast_Score=97, Evalue=3e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000101 [H]

Pfam domain/function: PF01019 G_glu_transpept [H]

EC number: =2.3.2.2 [H]

Molecular weight: Translated: 59963; Mature: 59963

Theoretical pI: Translated: 5.81; Mature: 5.81

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKFNAYQHKYSSIRNVVYAKNGAVATSTPLASQAGLEILKKGGNAVDAAVATAATLAVVE
CCCCHHHHHHHHHHHEEEECCCCEECCCCCCHHHHHHHHHCCCCHHHHHHHHHEEEEEEC
PTSNGIGGDAYALVWIEEEKRLYGLNSSGFAPENMELKNYNNMKEMPKYGFGAVTVPGIP
CCCCCCCCCEEEEEEEECCCEEECCCCCCCCCCCCCCCCCCCHHHCCCCCCCEEECCCCC
AAWSELNKKYGKLSLMECLSPAINYAREGYVVSPNVAKVWKKSYELYEKELIGEEFKPWF
HHHHHHHHHHCCHHHHHHHHHHHHHHHCCEEECCCHHHHHHHHHHHHHHHHHCHHCCHHH
DTFSKDGKAPEAGDIFICEEQASTLEEIANTQAESFYRGRLADKIDEYSKKFNGAIRKSD
HHHCCCCCCCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
LECFYPTWVEPISTEYKGYKIFEIPPNGHGITVLMALNILKELELEGNIENVEDIHKIIE
CCEECCCCCCCCCCCCCCEEEEEECCCCCCEEHHHHHHHHHHHCCCCCCCCHHHHHHHHH
SLKLAFADSKTYVTDIEHMKVKIQELLSQEYAKKRSLLIDNKEALYPTAGEPYCGGTVYL
HHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHHHHHCEEECCCCCCCCCCCCCCCCCEEEE
CTADKDGNMVSYIQSNYINFGSGIVIPRTGIALHSRGNNFNLDPKHHNVVKPFKKPYHTI
EEECCCCCEEHHHHHCCEECCCCEEEECCCEEEEECCCCCCCCCCCCCCCCHHHCCHHHH
IPGFLGKEDKAIGPFGVMGAFMQPQGHIQVLTNMIDFGLNPQEALDAPRWQWIKGKEIEV
CCCCCCCCCCCCCCHHHHHHHCCCCCHHHHHHHHHHCCCCHHHHHCCCCEEEECCCEEEE
EPEMPKHIIDSLIEKGHEIKVIHDTVDMGRGQIIFKTEQESYICGTESRCDGHIAVY
CCCCHHHHHHHHHHCCCEEEEEEEHHCCCCCEEEEEECCCCEEECCCCCCCCCEEEC
>Mature Secondary Structure
MKFNAYQHKYSSIRNVVYAKNGAVATSTPLASQAGLEILKKGGNAVDAAVATAATLAVVE
CCCCHHHHHHHHHHHEEEECCCCEECCCCCCHHHHHHHHHCCCCHHHHHHHHHEEEEEEC
PTSNGIGGDAYALVWIEEEKRLYGLNSSGFAPENMELKNYNNMKEMPKYGFGAVTVPGIP
CCCCCCCCCEEEEEEEECCCEEECCCCCCCCCCCCCCCCCCCHHHCCCCCCCEEECCCCC
AAWSELNKKYGKLSLMECLSPAINYAREGYVVSPNVAKVWKKSYELYEKELIGEEFKPWF
HHHHHHHHHHCCHHHHHHHHHHHHHHHCCEEECCCHHHHHHHHHHHHHHHHHCHHCCHHH
DTFSKDGKAPEAGDIFICEEQASTLEEIANTQAESFYRGRLADKIDEYSKKFNGAIRKSD
HHHCCCCCCCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
LECFYPTWVEPISTEYKGYKIFEIPPNGHGITVLMALNILKELELEGNIENVEDIHKIIE
CCEECCCCCCCCCCCCCCEEEEEECCCCCCEEHHHHHHHHHHHCCCCCCCCHHHHHHHHH
SLKLAFADSKTYVTDIEHMKVKIQELLSQEYAKKRSLLIDNKEALYPTAGEPYCGGTVYL
HHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHHHHHCEEECCCCCCCCCCCCCCCCCEEEE
CTADKDGNMVSYIQSNYINFGSGIVIPRTGIALHSRGNNFNLDPKHHNVVKPFKKPYHTI
EEECCCCCEEHHHHHCCEECCCCEEEECCCEEEEECCCCCCCCCCCCCCCCHHHCCHHHH
IPGFLGKEDKAIGPFGVMGAFMQPQGHIQVLTNMIDFGLNPQEALDAPRWQWIKGKEIEV
CCCCCCCCCCCCCCHHHHHHHCCCCCHHHHHHHHHHCCCCHHHHHCCCCEEEECCCEEEE
EPEMPKHIIDSLIEKGHEIKVIHDTVDMGRGQIIFKTEQESYICGTESRCDGHIAVY
CCCCHHHHHHHHHHCCCEEEEEEEHHCCCCCEEEEEECCCCEEECCCCCCCCCEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]