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The map label for this gene is proC1 [H]

Identifier: 126699099

GI number: 126699099

Start: 1731904

End: 1732707

Strand: Direct

Name: proC1 [H]

Synonym: CD1495

Alternate gene names: 126699099

Gene position: 1731904-1732707 (Clockwise)

Preceding gene: 126699098

Following gene: 126699101

Centisome position: 40.37

GC content: 32.59

Gene sequence:

>804_bases
GTGAAAAAAATTGGATTCATAGGTGCAGGAAATATGGCAAGCGCTATGATAGGGGGAATAGTAAATTCAAAATTAGTTGA
ACCTAATATGGTTATAGCATCAGCATATAGTCAAGGAACTCTCGATAGAATAGATGCAAATTTTGGAATAAATACTACAA
AAGACTCGAAGGAAGTAACTAGAACCTCTGATATAGTAATTGTAGCTGTTAAACCAGATATATATGATGATATTTTGGAA
GAGATAAAAGACTTTATAGATGACAATAAAATTATAGTTACAATAGCAGCAGGAAAATCTATAAAAGATATAGAGTCTAT
TATAGGAGAAGATAAAAAAATAGTTAGAACTATGCCAAATACTCCAGCTCTTGTAAATGAAGCCATGTCTTCTCTTTCTA
TAAATAAAAATATAAACAAAGAAGACTTAGAAGCAGTTACAGAAGTATTTAATTCTTTTGGAAATACTGAGGTAGTACCA
GAGTATCTTATAGAAGCTGTAATTGGTGCAAGTGGTTCTGCACCAGCATATGTATTTTTATTTATAGAAGCTATAGCAGA
TGCAGCAGTAATTGCAGGAATGCCAAGACCACAAGCATATAAGTTTGCATCACAGGCTGTTATGGGTTCTGCAAAAATGG
TACTTGAGACAGGAAAACATCCTGGTGAATTAAAAGATATGGTATGTTCACCTGGTGGAACTACTATAGAAGCAGTTAAA
GTACTTGAAGAAGAAGGTTTTAGAGCTTCTGTGATAAAAGCAATATGTGCATGTATAGAAAAATCTAAAAAAATGAGTGA
GTAA

Upstream 100 bases:

>100_bases
AATTTTGGTAGTAAGTATACCAAATCCATTTGAAAAGTCTGATGCAGTTAAAGAAGCTTAAATTTTAACGATTACTATTA
GTCAATAAGGAGGTACTAAA

Downstream 100 bases:

>100_bases
TAAAAATTTATTGTAAATAAAGAGAATTGCCTTTTATAGAAAATTTCCATTTTAGGCAATTCTTTTTATTTGTTTAATTT
CTAAAATAAGCCTGAAAGCC

Product: pyrroline-5-carboxylate reductase

Products: NA

Alternate protein names: P5C reductase; P5CR [H]

Number of amino acids: Translated: 267; Mature: 267

Protein sequence:

>267_residues
MKKIGFIGAGNMASAMIGGIVNSKLVEPNMVIASAYSQGTLDRIDANFGINTTKDSKEVTRTSDIVIVAVKPDIYDDILE
EIKDFIDDNKIIVTIAAGKSIKDIESIIGEDKKIVRTMPNTPALVNEAMSSLSINKNINKEDLEAVTEVFNSFGNTEVVP
EYLIEAVIGASGSAPAYVFLFIEAIADAAVIAGMPRPQAYKFASQAVMGSAKMVLETGKHPGELKDMVCSPGGTTIEAVK
VLEEEGFRASVIKAICACIEKSKKMSE

Sequences:

>Translated_267_residues
MKKIGFIGAGNMASAMIGGIVNSKLVEPNMVIASAYSQGTLDRIDANFGINTTKDSKEVTRTSDIVIVAVKPDIYDDILE
EIKDFIDDNKIIVTIAAGKSIKDIESIIGEDKKIVRTMPNTPALVNEAMSSLSINKNINKEDLEAVTEVFNSFGNTEVVP
EYLIEAVIGASGSAPAYVFLFIEAIADAAVIAGMPRPQAYKFASQAVMGSAKMVLETGKHPGELKDMVCSPGGTTIEAVK
VLEEEGFRASVIKAICACIEKSKKMSE
>Mature_267_residues
MKKIGFIGAGNMASAMIGGIVNSKLVEPNMVIASAYSQGTLDRIDANFGINTTKDSKEVTRTSDIVIVAVKPDIYDDILE
EIKDFIDDNKIIVTIAAGKSIKDIESIIGEDKKIVRTMPNTPALVNEAMSSLSINKNINKEDLEAVTEVFNSFGNTEVVP
EYLIEAVIGASGSAPAYVFLFIEAIADAAVIAGMPRPQAYKFASQAVMGSAKMVLETGKHPGELKDMVCSPGGTTIEAVK
VLEEEGFRASVIKAICACIEKSKKMSE

Specific function: Proline biosynthesis; third (last) step. [C]

COG id: COG0345

COG function: function code E; Pyrroline-5-carboxylate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyrroline-5-carboxylate reductase family [H]

Homologues:

Organism=Homo sapiens, GI198041662, Length=266, Percent_Identity=33.8345864661654, Blast_Score=191, Evalue=7e-49,
Organism=Homo sapiens, GI21361454, Length=267, Percent_Identity=37.4531835205993, Blast_Score=182, Evalue=2e-46,
Organism=Homo sapiens, GI24797095, Length=267, Percent_Identity=38.2022471910112, Blast_Score=181, Evalue=6e-46,
Organism=Homo sapiens, GI24797097, Length=267, Percent_Identity=38.2022471910112, Blast_Score=181, Evalue=6e-46,
Organism=Escherichia coli, GI1786585, Length=266, Percent_Identity=54.1353383458647, Blast_Score=302, Evalue=2e-83,
Organism=Caenorhabditis elegans, GI17569021, Length=263, Percent_Identity=39.5437262357414, Blast_Score=193, Evalue=7e-50,
Organism=Caenorhabditis elegans, GI17540664, Length=278, Percent_Identity=31.294964028777, Blast_Score=149, Evalue=1e-36,
Organism=Saccharomyces cerevisiae, GI6320861, Length=213, Percent_Identity=28.169014084507, Blast_Score=114, Evalue=2e-26,
Organism=Drosophila melanogaster, GI21358587, Length=265, Percent_Identity=38.4905660377359, Blast_Score=192, Evalue=2e-49,
Organism=Drosophila melanogaster, GI24648116, Length=274, Percent_Identity=39.4160583941606, Blast_Score=187, Evalue=8e-48,
Organism=Drosophila melanogaster, GI24647700, Length=169, Percent_Identity=40.8284023668639, Blast_Score=135, Evalue=2e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR004455
- InterPro:   IPR000304 [H]

Pfam domain/function: PF03807 F420_oxidored [H]

EC number: =1.5.1.2 [H]

Molecular weight: Translated: 28530; Mature: 28530

Theoretical pI: Translated: 4.59; Mature: 4.59

Prosite motif: PS00521 P5CR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKIGFIGAGNMASAMIGGIVNSKLVEPNMVIASAYSQGTLDRIDANFGINTTKDSKEVT
CCCEEEEECCHHHHHHHHHHHHCCCCCCCEEEEECCCCCCHHHHCCCCCCCCCCCCHHHH
RTSDIVIVAVKPDIYDDILEEIKDFIDDNKIIVTIAAGKSIKDIESIIGEDKKIVRTMPN
CCCCEEEEEECCCHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHCCCHHHHHCCCC
TPALVNEAMSSLSINKNINKEDLEAVTEVFNSFGNTEVVPEYLIEAVIGASGSAPAYVFL
CHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCHHHHH
FIEAIADAAVIAGMPRPQAYKFASQAVMGSAKMVLETGKHPGELKDMVCSPGGTTIEAVK
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCHHHHHH
VLEEEGFRASVIKAICACIEKSKKMSE
HHHHCCCHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKKIGFIGAGNMASAMIGGIVNSKLVEPNMVIASAYSQGTLDRIDANFGINTTKDSKEVT
CCCEEEEECCHHHHHHHHHHHHCCCCCCCEEEEECCCCCCHHHHCCCCCCCCCCCCHHHH
RTSDIVIVAVKPDIYDDILEEIKDFIDDNKIIVTIAAGKSIKDIESIIGEDKKIVRTMPN
CCCCEEEEEECCCHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHCCCHHHHHCCCC
TPALVNEAMSSLSINKNINKEDLEAVTEVFNSFGNTEVVPEYLIEAVIGASGSAPAYVFL
CHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCHHHHH
FIEAIADAAVIAGMPRPQAYKFASQAVMGSAKMVLETGKHPGELKDMVCSPGGTTIEAVK
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCHHHHHH
VLEEEGFRASVIKAICACIEKSKKMSE
HHHHCCCHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 6296787; 9278503 [H]