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The map label for this gene is folP [C]

Identifier: 126699054

GI number: 126699054

Start: 1680199

End: 1681002

Strand: Direct

Name: folP [C]

Synonym: CD1450

Alternate gene names: 126699054

Gene position: 1680199-1681002 (Clockwise)

Preceding gene: 126699053

Following gene: 126699055

Centisome position: 39.16

GC content: 32.71

Gene sequence:

>804_bases
GTGTCATTAATTGTGTTTGATTATGGTAAAAGAACTTATATAATGGGAATATTAAATGTAACTCCAGATAGTTTTTCTGA
TGGAGGAGATTTTAATAACTTGGACATAGCAATACAACATGCAAAAGATATGGTTGACCAAGGTGCAGATATAATAGACC
TAGGAGGAGAGTCTACACGCCCAGGTCATAGCTATGTAGACTCAGACGAAGAGCTAAGAAGAGTAATCCCTGTAATAAAA
AAACTTAAACAGGAATTGGATATACCAATATCAATAGACACTTATAAGGCAGATGTTGCAGAAGAAGCATTAAAATTAGG
TGTCACTATGGTAAATGATGTTTGGGGTCTTAGAAAAGATAAAAATATGGCTTCTGTAATAGGAAAATATGATGCAGAAG
TGTGTATAATGCATAATCAAGATGGGACAAACTATGACAAAGATATAATGGAGTCAATAAAAGACTTTTTTAAGGTAAGT
ATAGAAATGGCAATGAGTTGTGGTGTAAAAAAAGAAAAAATAGTACTTGACCCAGGTGTAGGATTTGGCAAGGATTTTGA
ACAAAATATTGAAGTATTGAGAAGATTAAATGAATTAAAAGATTTAGGGTATCCTATTTTGCTTGGGACATCCAGAAAAT
CAGTAATAGGAAAAGTACTTCCAGTTGAGCCTAAAAAAAGATTAGAAGGTACAATAGCTACTACTGTTCTTGGTATAAGA
GATGGCGTAGATATAGTTAGAGTACATGATGTTTATGAAAATTTAATGGCAGCTAGAATGACTGATGCAATATATAGAAA
GTAG

Upstream 100 bases:

>100_bases
GGACATTGCGTCTAGAGCCGAGGCTATGAGTTTGATTACTATGAAGTAGCAATTTATTATAGATATAATCATTTATTGAG
ATAAAATTTAATTTAAGGGA

Downstream 100 bases:

>100_bases
GTATAATATAATGGATAAAATATTACTTAGTAATCTAGGATTCTATGGATATCATGGTGTTCTTAAAGAAGAAAATTTTC
TAGGTCAGAAATTCTTTGTC

Product: dihydropteroate synthase

Products: NA

Alternate protein names: DHPS; Dihydropteroate pyrophosphorylase [H]

Number of amino acids: Translated: 267; Mature: 266

Protein sequence:

>267_residues
MSLIVFDYGKRTYIMGILNVTPDSFSDGGDFNNLDIAIQHAKDMVDQGADIIDLGGESTRPGHSYVDSDEELRRVIPVIK
KLKQELDIPISIDTYKADVAEEALKLGVTMVNDVWGLRKDKNMASVIGKYDAEVCIMHNQDGTNYDKDIMESIKDFFKVS
IEMAMSCGVKKEKIVLDPGVGFGKDFEQNIEVLRRLNELKDLGYPILLGTSRKSVIGKVLPVEPKKRLEGTIATTVLGIR
DGVDIVRVHDVYENLMAARMTDAIYRK

Sequences:

>Translated_267_residues
MSLIVFDYGKRTYIMGILNVTPDSFSDGGDFNNLDIAIQHAKDMVDQGADIIDLGGESTRPGHSYVDSDEELRRVIPVIK
KLKQELDIPISIDTYKADVAEEALKLGVTMVNDVWGLRKDKNMASVIGKYDAEVCIMHNQDGTNYDKDIMESIKDFFKVS
IEMAMSCGVKKEKIVLDPGVGFGKDFEQNIEVLRRLNELKDLGYPILLGTSRKSVIGKVLPVEPKKRLEGTIATTVLGIR
DGVDIVRVHDVYENLMAARMTDAIYRK
>Mature_266_residues
SLIVFDYGKRTYIMGILNVTPDSFSDGGDFNNLDIAIQHAKDMVDQGADIIDLGGESTRPGHSYVDSDEELRRVIPVIKK
LKQELDIPISIDTYKADVAEEALKLGVTMVNDVWGLRKDKNMASVIGKYDAEVCIMHNQDGTNYDKDIMESIKDFFKVSI
EMAMSCGVKKEKIVLDPGVGFGKDFEQNIEVLRRLNELKDLGYPILLGTSRKSVIGKVLPVEPKKRLEGTIATTVLGIRD
GVDIVRVHDVYENLMAARMTDAIYRK

Specific function: DHPS catalyzes the formation of the immediate precursor of folic acid. It is implicated in resistance to sulfonamide [H]

COG id: COG0294

COG function: function code H; Dihydropteroate synthase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 pterin-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87082224, Length=258, Percent_Identity=43.0232558139535, Blast_Score=221, Evalue=4e-59,
Organism=Saccharomyces cerevisiae, GI6324073, Length=320, Percent_Identity=34.0625, Blast_Score=154, Evalue=1e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006390
- InterPro:   IPR011005
- InterPro:   IPR000489 [H]

Pfam domain/function: PF00809 Pterin_bind [H]

EC number: =2.5.1.15 [H]

Molecular weight: Translated: 29834; Mature: 29703

Theoretical pI: Translated: 4.97; Mature: 4.97

Prosite motif: PS50972 PTERIN_BINDING ; PS00792 DHPS_1 ; PS00793 DHPS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLIVFDYGKRTYIMGILNVTPDSFSDGGDFNNLDIAIQHAKDMVDQGADIIDLGGESTR
CEEEEEECCCEEEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEECCCCCCC
PGHSYVDSDEELRRVIPVIKKLKQELDIPISIDTYKADVAEEALKLGVTMVNDVWGLRKD
CCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEECHHHHHHHHHHHHHHHHHHHHHHCCCCC
KNMASVIGKYDAEVCIMHNQDGTNYDKDIMESIKDFFKVSIEMAMSCGVKKEKIVLDPGV
CHHHHHHHCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCC
GFGKDFEQNIEVLRRLNELKDLGYPILLGTSRKSVIGKVLPVEPKKRLEGTIATTVLGIR
CCCCCHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHCCCCCCHHHHHCHHHHHHHHHHC
DGVDIVRVHDVYENLMAARMTDAIYRK
CCCHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SLIVFDYGKRTYIMGILNVTPDSFSDGGDFNNLDIAIQHAKDMVDQGADIIDLGGESTR
EEEEEECCCEEEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEECCCCCCC
PGHSYVDSDEELRRVIPVIKKLKQELDIPISIDTYKADVAEEALKLGVTMVNDVWGLRKD
CCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEECHHHHHHHHHHHHHHHHHHHHHHCCCCC
KNMASVIGKYDAEVCIMHNQDGTNYDKDIMESIKDFFKVSIEMAMSCGVKKEKIVLDPGV
CHHHHHHHCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCC
GFGKDFEQNIEVLRRLNELKDLGYPILLGTSRKSVIGKVLPVEPKKRLEGTIATTVLGIR
CCCCCHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHCCCCCCHHHHHCHHHHHHHHHHC
DGVDIVRVHDVYENLMAARMTDAIYRK
CCCHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8396545 [H]