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The map label for this gene is folE

Identifier: 126699053

GI number: 126699053

Start: 1679575

End: 1680147

Strand: Direct

Name: folE

Synonym: CD1449

Alternate gene names: 126699053

Gene position: 1679575-1680147 (Clockwise)

Preceding gene: 126699052

Following gene: 126699054

Centisome position: 39.15

GC content: 35.08

Gene sequence:

>573_bases
ATGAATAAAGTTGATAAAGAAAAGATACAACATGCAGTAAGAGAAATACTAGAGGCAATTGGGGAAGACCCAGATAGAGA
AGGTCTAATCGAAACTCCAAATAGAGTTGCTAGGATGTATGAAGAGATATTCTCTGGTCTTAGTGAAGAACCAAGAGACC
ATTTAAAAGTTCTTTTTGCAGATGAAAAACATGAAGAGTTAGTATTGGTAAAAGATATTCCATTTTATTCATGTTGTGAG
CATCATCTAGTTCCTTTCTTTGGAAAAGCTCATATTGCTTATTTACCAAAAGGAGGAAGACTTACAGGGCTTTCTAAACT
TGCTAGAGTAATAGATACATTGGCAAAAAGACCACAATTACAAGAAAGAATCACTAAAAATGCTGCAGATATAATAATGG
AAGAATTACAACCTTATGGTGTCTTAGTAGTAGTAGAAGCTGAACATATGTGCATGACAATGAGAGGCGTAAAAAAACCA
GGTTCAAAAACTGTTACATCAGCAGTGAGAGGAATATTTGAAAAGGACATTGCGTCTAGAGCCGAGGCTATGAGTTTGAT
TACTATGAAGTAG

Upstream 100 bases:

>100_bases
CAAAGACTTTTAGATGTTTATAATTATATTTTTAAAGAAATTGAGACAAAAGAGGTTATAAAACTAATCTTCTAGTCACA
AATCAATGGGGGGAGTTTAA

Downstream 100 bases:

>100_bases
CAATTTATTATAGATATAATCATTTATTGAGATAAAATTTAATTTAAGGGAGTGTCATTAATTGTGTTTGATTATGGTAA
AAGAACTTATATAATGGGAA

Product: GTP cyclohydrolase I

Products: NA

Alternate protein names: GTP cyclohydrolase I; GTP-CH-I

Number of amino acids: Translated: 190; Mature: 190

Protein sequence:

>190_residues
MNKVDKEKIQHAVREILEAIGEDPDREGLIETPNRVARMYEEIFSGLSEEPRDHLKVLFADEKHEELVLVKDIPFYSCCE
HHLVPFFGKAHIAYLPKGGRLTGLSKLARVIDTLAKRPQLQERITKNAADIIMEELQPYGVLVVVEAEHMCMTMRGVKKP
GSKTVTSAVRGIFEKDIASRAEAMSLITMK

Sequences:

>Translated_190_residues
MNKVDKEKIQHAVREILEAIGEDPDREGLIETPNRVARMYEEIFSGLSEEPRDHLKVLFADEKHEELVLVKDIPFYSCCE
HHLVPFFGKAHIAYLPKGGRLTGLSKLARVIDTLAKRPQLQERITKNAADIIMEELQPYGVLVVVEAEHMCMTMRGVKKP
GSKTVTSAVRGIFEKDIASRAEAMSLITMK
>Mature_190_residues
MNKVDKEKIQHAVREILEAIGEDPDREGLIETPNRVARMYEEIFSGLSEEPRDHLKVLFADEKHEELVLVKDIPFYSCCE
HHLVPFFGKAHIAYLPKGGRLTGLSKLARVIDTLAKRPQLQERITKNAADIIMEELQPYGVLVVVEAEHMCMTMRGVKKP
GSKTVTSAVRGIFEKDIASRAEAMSLITMK

Specific function: Tetrahydrofolate biosynthesis; first step. [C]

COG id: COG0302

COG function: function code H; GTP cyclohydrolase I

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP cyclohydrolase I family

Homologues:

Organism=Homo sapiens, GI66932968, Length=186, Percent_Identity=48.9247311827957, Blast_Score=177, Evalue=6e-45,
Organism=Homo sapiens, GI4503949, Length=186, Percent_Identity=48.9247311827957, Blast_Score=177, Evalue=6e-45,
Organism=Homo sapiens, GI66932970, Length=156, Percent_Identity=44.8717948717949, Blast_Score=132, Evalue=2e-31,
Organism=Homo sapiens, GI66932972, Length=146, Percent_Identity=47.2602739726027, Blast_Score=132, Evalue=3e-31,
Organism=Escherichia coli, GI1788476, Length=184, Percent_Identity=36.4130434782609, Blast_Score=114, Evalue=4e-27,
Organism=Caenorhabditis elegans, GI17560486, Length=178, Percent_Identity=44.9438202247191, Blast_Score=171, Evalue=2e-43,
Organism=Saccharomyces cerevisiae, GI6321706, Length=182, Percent_Identity=46.1538461538462, Blast_Score=159, Evalue=2e-40,
Organism=Drosophila melanogaster, GI24656782, Length=179, Percent_Identity=48.0446927374302, Blast_Score=162, Evalue=8e-41,
Organism=Drosophila melanogaster, GI24656796, Length=179, Percent_Identity=48.0446927374302, Blast_Score=162, Evalue=2e-40,
Organism=Drosophila melanogaster, GI24656791, Length=179, Percent_Identity=48.0446927374302, Blast_Score=161, Evalue=3e-40,

Paralogues:

None

Copy number: 420 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): GCH1_CLOD6 (Q18BW7)

Other databases:

- EMBL:   AM180355
- RefSeq:   YP_001087950.1
- ProteinModelPortal:   Q18BW7
- SMR:   Q18BW7
- STRING:   Q18BW7
- GeneID:   4915721
- GenomeReviews:   AM180355_GR
- KEGG:   cdf:CD1449
- NMPDR:   fig|1496.1.peg.3571
- eggNOG:   COG0302
- HOGENOM:   HBG370191
- OMA:   MYVEEIF
- ProtClustDB:   PRK09347
- GO:   GO:0005737
- HAMAP:   MF_00223
- InterPro:   IPR001474
- InterPro:   IPR020602
- InterPro:   IPR018234
- TIGRFAMs:   TIGR00063

Pfam domain/function: PF01227 GTP_cyclohydroI

EC number: =3.5.4.16

Molecular weight: Translated: 21468; Mature: 21468

Theoretical pI: Translated: 6.88; Mature: 6.88

Prosite motif: PS00859 GTP_CYCLOHYDROL_1_1; PS00860 GTP_CYCLOHYDROL_1_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKVDKEKIQHAVREILEAIGEDPDREGLIETPNRVARMYEEIFSGLSEEPRDHLKVLFA
CCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHEEHHC
DEKHEELVLVKDIPFYSCCEHHLVPFFGKAHIAYLPKGGRLTGLSKLARVIDTLAKRPQL
CCCCCCEEEEECCCHHHHHHHCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHCCCHH
QERITKNAADIIMEELQPYGVLVVVEAEHMCMTMRGVKKPGSKTVTSAVRGIFEKDIASR
HHHHHHHHHHHHHHHCCCCCEEEEEECHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
AEAMSLITMK
HHHHHHHCCC
>Mature Secondary Structure
MNKVDKEKIQHAVREILEAIGEDPDREGLIETPNRVARMYEEIFSGLSEEPRDHLKVLFA
CCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHEEHHC
DEKHEELVLVKDIPFYSCCEHHLVPFFGKAHIAYLPKGGRLTGLSKLARVIDTLAKRPQL
CCCCCCEEEEECCCHHHHHHHCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHCCCHH
QERITKNAADIIMEELQPYGVLVVVEAEHMCMTMRGVKKPGSKTVTSAVRGIFEKDIASR
HHHHHHHHHHHHHHHCCCCCEEEEEECHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
AEAMSLITMK
HHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA