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The map label for this gene is nrdZ [H]

Identifier: 126698858

GI number: 126698858

Start: 1465808

End: 1467997

Strand: Direct

Name: nrdZ [H]

Synonym: CD1261

Alternate gene names: 126698858

Gene position: 1465808-1467997 (Clockwise)

Preceding gene: 126698857

Following gene: 126698859

Centisome position: 34.17

GC content: 29.36

Gene sequence:

>2190_bases
ATGAAGTACATAATAAAAAGAGATGGTACAAAAGAACTTTTTAGTAAAAGTAAGATTGAAGATGCTGTCTATAAAGCTAG
TATAAATAGTGAAGGTGGCGTAGATAGAGAGTTGGCATATGATATATCAAGAAAAATAGCTAATGACTATAATTCTATGG
AAAAATGCTTATCCGTAGAAGAAATACAAGATATAGTTGAAGTACTACTTATGGAATCAAATAGAAAAGATATAGCAAAA
CACTACATATTATATAGAGAAAGACGCTCTGAAATAAGGACTAAAGCTTGGGAGTTTGATGAATTACAAAAATCAATATG
GAAGAACAAGTATAGACATAATGGTGAGAGTTTTGATGAATGGATAAAGAGAATTTCAAATAATAGTTCAAGAATATCAA
AACTAATAAGACAAAAAAGATTTCTATTTGCTGGAAGAATTTTAGCAAATAGAGGATTACAGAAAGAGGGAAAAAAAGTA
ACATATTCTAATTGCTATGTAATAGAACCACCAAAAGATAGCATAGAAGATATATTTGATACTGCAAAAAAACTTGCTAG
AACTTTTAGTTATGGTGGAGGAGTTGGAATTGATATTTCAAAGCTAAGACCAAAAGGAGCGAAAGTTAACAATGCTGCAA
AACATACGACTGGAGCAGTCTCTTTTATGGAACTTTACAGTATGACAACTGGCTTAATTGGTCAAAGAGGGAGAAGAGGA
GCTCTTATGATTTCTATGGATGTAAATCATCCAGAGATAGAAGACTTTATAGATATAAAAACAGATTTGGAGAAGGTTAC
TAAAGCAAATATTTCTGTGAGAGTAACAGATGAATTTATGCAAGCTGTAAGAGAAAAAAAGTTATATAATTGTACTTTTG
AAGTTGAAACTACTGGAGAAAAAATAGTTAAGATAGTAAATGCTTATGATTTATTTAATAAATTTGTGAAAAATAACTGG
GATTATGCAGAACCAGGTATATTGTTTTGGGATAAAATAAAAACATATAATTTTATGAGTGAAGATAAGAACTTTTGCTT
TTCAGGAGTAAATCCTTGTGCAGAAGAACCACTTCCAAGTGGAGGAAGTTGTCTACTTGGCTCAATAAACTTGTCAGAGT
TTATAATACAACCATTTGGTGAACATGCTACTTTTGATATTAATAAACTAAAATCTTGCGTTAGAGAAGCTGTAGTAGCT
TTAAATGATGTCTTAGATGAGGGATTGAACTTGCATCCATTACAAGAACAAAGAGATAGTGTACATAAGTATAGACAGAT
AGGTTTAGGTGTAATGGGTATAGCTGATATGCTTATAAAAATGGGAATAAGATATGGTTCTGATGAATCTTTAGAACTAT
GTGATTTAATTGGTAAGACTATGTTAAATGAAGCTGTGAAGCAATCAGCATTAATTGCTAAAGAATATGGAACATTTAGT
GAGTATAAATATGAAAATATTTCTAAATCTAAGTTTTTTATAGAAAATCTAAATGAAGACACTAAGGAAATGGTTAAAAA
GTATGGGCTTAGAAATTCACAACTTTTAACCATACCTCCTACAGGTTCCATATCTACAATGATAGGTATCAGTGGTGGAA
TAGAACCTATATTTAATCTTTCATATATAAGAAAAACTGAAAGCTTGCATGATGAGGATGTGTATTATAAAGTATATACT
CCAATTGTTAAAGAGTATATGGACAAGAAAGGTATTACAGATGAAGAATGTTTACCAGATTTTTTTGTTACTGCTATGAA
TATAGGATATGAAGAAAGAATAAACATGCAAAAAGTATGGCAAAAGTATATTGATGCTTCTATATCATCTACAATAAATA
TACCTTTTGAAACTACAGTTGAAGATGTTTTCAATATATATATTAAGGCATGGGAGGCTGGTCTTAAAGGAGTAACAATA
TTTAGAGATGGATGTAAAAGGAGTGGAATTTTAATAAATGAAAAAAAGGAAGAAAATAATAAAGAAGATAAAAAAGAAAA
TAGTAAAAAAGAATATTATAAAAATAATAAAAAAGAAAAAGATAATAAAGATGAAAAAGCCAAAGAAATAATAAATAAAA
ATTTTGAAGAAGATGAAAAATTTGTGTGCCCTGAGTGTGGAAGTGAAGGAATTGCACATACAGGTGGATGTAGTATATGT
TTAAAATGTGGCTATAGTGGATGCAATTAA

Upstream 100 bases:

>100_bases
TAGATAATTAATATGAAAATATACAAATATATAAAAAGTTTGTTTAGAGTTATAGTTAATGTGTGTATTAATTTAATACT
AATTTATTGGAGGTTTAAAA

Downstream 100 bases:

>100_bases
ACTCTAATTAAAAAATTTTAATATATTTAAAAATTAAATTTTTAAAAACGAAAGATGAGGGAATGGTATGCAGGATAAAA
GTGTGAGGGAGATTAAAGAA

Product: ribonucleotide-diphosphate reductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 729; Mature: 729

Protein sequence:

>729_residues
MKYIIKRDGTKELFSKSKIEDAVYKASINSEGGVDRELAYDISRKIANDYNSMEKCLSVEEIQDIVEVLLMESNRKDIAK
HYILYRERRSEIRTKAWEFDELQKSIWKNKYRHNGESFDEWIKRISNNSSRISKLIRQKRFLFAGRILANRGLQKEGKKV
TYSNCYVIEPPKDSIEDIFDTAKKLARTFSYGGGVGIDISKLRPKGAKVNNAAKHTTGAVSFMELYSMTTGLIGQRGRRG
ALMISMDVNHPEIEDFIDIKTDLEKVTKANISVRVTDEFMQAVREKKLYNCTFEVETTGEKIVKIVNAYDLFNKFVKNNW
DYAEPGILFWDKIKTYNFMSEDKNFCFSGVNPCAEEPLPSGGSCLLGSINLSEFIIQPFGEHATFDINKLKSCVREAVVA
LNDVLDEGLNLHPLQEQRDSVHKYRQIGLGVMGIADMLIKMGIRYGSDESLELCDLIGKTMLNEAVKQSALIAKEYGTFS
EYKYENISKSKFFIENLNEDTKEMVKKYGLRNSQLLTIPPTGSISTMIGISGGIEPIFNLSYIRKTESLHDEDVYYKVYT
PIVKEYMDKKGITDEECLPDFFVTAMNIGYEERINMQKVWQKYIDASISSTINIPFETTVEDVFNIYIKAWEAGLKGVTI
FRDGCKRSGILINEKKEENNKEDKKENSKKEYYKNNKKEKDNKDEKAKEIINKNFEEDEKFVCPECGSEGIAHTGGCSIC
LKCGYSGCN

Sequences:

>Translated_729_residues
MKYIIKRDGTKELFSKSKIEDAVYKASINSEGGVDRELAYDISRKIANDYNSMEKCLSVEEIQDIVEVLLMESNRKDIAK
HYILYRERRSEIRTKAWEFDELQKSIWKNKYRHNGESFDEWIKRISNNSSRISKLIRQKRFLFAGRILANRGLQKEGKKV
TYSNCYVIEPPKDSIEDIFDTAKKLARTFSYGGGVGIDISKLRPKGAKVNNAAKHTTGAVSFMELYSMTTGLIGQRGRRG
ALMISMDVNHPEIEDFIDIKTDLEKVTKANISVRVTDEFMQAVREKKLYNCTFEVETTGEKIVKIVNAYDLFNKFVKNNW
DYAEPGILFWDKIKTYNFMSEDKNFCFSGVNPCAEEPLPSGGSCLLGSINLSEFIIQPFGEHATFDINKLKSCVREAVVA
LNDVLDEGLNLHPLQEQRDSVHKYRQIGLGVMGIADMLIKMGIRYGSDESLELCDLIGKTMLNEAVKQSALIAKEYGTFS
EYKYENISKSKFFIENLNEDTKEMVKKYGLRNSQLLTIPPTGSISTMIGISGGIEPIFNLSYIRKTESLHDEDVYYKVYT
PIVKEYMDKKGITDEECLPDFFVTAMNIGYEERINMQKVWQKYIDASISSTINIPFETTVEDVFNIYIKAWEAGLKGVTI
FRDGCKRSGILINEKKEENNKEDKKENSKKEYYKNNKKEKDNKDEKAKEIINKNFEEDEKFVCPECGSEGIAHTGGCSIC
LKCGYSGCN
>Mature_729_residues
MKYIIKRDGTKELFSKSKIEDAVYKASINSEGGVDRELAYDISRKIANDYNSMEKCLSVEEIQDIVEVLLMESNRKDIAK
HYILYRERRSEIRTKAWEFDELQKSIWKNKYRHNGESFDEWIKRISNNSSRISKLIRQKRFLFAGRILANRGLQKEGKKV
TYSNCYVIEPPKDSIEDIFDTAKKLARTFSYGGGVGIDISKLRPKGAKVNNAAKHTTGAVSFMELYSMTTGLIGQRGRRG
ALMISMDVNHPEIEDFIDIKTDLEKVTKANISVRVTDEFMQAVREKKLYNCTFEVETTGEKIVKIVNAYDLFNKFVKNNW
DYAEPGILFWDKIKTYNFMSEDKNFCFSGVNPCAEEPLPSGGSCLLGSINLSEFIIQPFGEHATFDINKLKSCVREAVVA
LNDVLDEGLNLHPLQEQRDSVHKYRQIGLGVMGIADMLIKMGIRYGSDESLELCDLIGKTMLNEAVKQSALIAKEYGTFS
EYKYENISKSKFFIENLNEDTKEMVKKYGLRNSQLLTIPPTGSISTMIGISGGIEPIFNLSYIRKTESLHDEDVYYKVYT
PIVKEYMDKKGITDEECLPDFFVTAMNIGYEERINMQKVWQKYIDASISSTINIPFETTVEDVFNIYIKAWEAGLKGVTI
FRDGCKRSGILINEKKEENNKEDKKENSKKEYYKNNKKEKDNKDEKAKEIINKNFEEDEKFVCPECGSEGIAHTGGCSIC
LKCGYSGCN

Specific function: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides [H]

COG id: COG0209

COG function: function code F; Ribonucleotide reductase, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-cone domain [H]

Homologues:

Organism=Homo sapiens, GI4506749, Length=561, Percent_Identity=24.9554367201426, Blast_Score=142, Evalue=2e-33,
Organism=Escherichia coli, GI1789030, Length=573, Percent_Identity=24.78184991274, Blast_Score=121, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI17555242, Length=561, Percent_Identity=23.3511586452763, Blast_Score=132, Evalue=7e-31,
Organism=Saccharomyces cerevisiae, GI6320914, Length=576, Percent_Identity=23.9583333333333, Blast_Score=129, Evalue=1e-30,
Organism=Saccharomyces cerevisiae, GI6322123, Length=577, Percent_Identity=24.0901213171577, Blast_Score=127, Evalue=5e-30,
Organism=Drosophila melanogaster, GI17352481, Length=605, Percent_Identity=23.6363636363636, Blast_Score=130, Evalue=3e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005144
- InterPro:   IPR013344
- InterPro:   IPR013509
- InterPro:   IPR000788
- InterPro:   IPR008926 [H]

Pfam domain/function: PF03477 ATP-cone; PF02867 Ribonuc_red_lgC; PF00317 Ribonuc_red_lgN [H]

EC number: =1.17.4.1 [H]

Molecular weight: Translated: 83384; Mature: 83384

Theoretical pI: Translated: 6.95; Mature: 6.95

Prosite motif: PS51161 ATP_CONE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKYIIKRDGTKELFSKSKIEDAVYKASINSEGGVDRELAYDISRKIANDYNSMEKCLSVE
CCEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCHH
EIQDIVEVLLMESNRKDIAKHYILYRERRSEIRTKAWEFDELQKSIWKNKYRHNGESFDE
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCHHH
WIKRISNNSSRISKLIRQKRFLFAGRILANRGLQKEGKKVTYSNCYVIEPPKDSIEDIFD
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCEEEECCCHHHHHHHHH
TAKKLARTFSYGGGVGIDISKLRPKGAKVNNAAKHTTGAVSFMELYSMTTGLIGQRGRRG
HHHHHHHHHCCCCCCCCCHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
ALMISMDVNHPEIEDFIDIKTDLEKVTKANISVRVTDEFMQAVREKKLYNCTFEVETTGE
EEEEEECCCCCCHHHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHEEEEEEECCHH
KIVKIVNAYDLFNKFVKNNWDYAEPGILFWDKIKTYNFMSEDKNFCFSGVNPCAEEPLPS
HHHHHHHHHHHHHHHHHCCCCCCCCCEEEEHHHHHHHHHHCCCCCEECCCCHHHCCCCCC
GGSCLLGSINLSEFIIQPFGEHATFDINKLKSCVREAVVALNDVLDEGLNLHPLQEQRDS
CCCEEEECCCHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHH
VHKYRQIGLGVMGIADMLIKMGIRYGSDESLELCDLIGKTMLNEAVKQSALIAKEYGTFS
HHHHHHHCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
EYKYENISKSKFFIENLNEDTKEMVKKYGLRNSQLLTIPPTGSISTMIGISGGIEPIFNL
HHHHCCCCHHHHHHHHCCHHHHHHHHHHCCCCCEEEEECCCCCCHHEEECCCCCCHHHHH
SYIRKTESLHDEDVYYKVYTPIVKEYMDKKGITDEECLPDFFVTAMNIGYEERINMQKVW
HHHHHHHCCCCCCCEEEHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCHHHCCCHHHHH
QKYIDASISSTINIPFETTVEDVFNIYIKAWEAGLKGVTIFRDGCKRSGILINEKKEENN
HHHHHHHHCCEEECCHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCEEEECCHHCCC
KEDKKENSKKEYYKNNKKEKDNKDEKAKEIINKNFEEDEKFVCPECGSEGIAHTGGCSIC
CHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCCEECCCCCCCCCCCCCCCHHH
LKCGYSGCN
EECCCCCCC
>Mature Secondary Structure
MKYIIKRDGTKELFSKSKIEDAVYKASINSEGGVDRELAYDISRKIANDYNSMEKCLSVE
CCEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCHH
EIQDIVEVLLMESNRKDIAKHYILYRERRSEIRTKAWEFDELQKSIWKNKYRHNGESFDE
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCHHH
WIKRISNNSSRISKLIRQKRFLFAGRILANRGLQKEGKKVTYSNCYVIEPPKDSIEDIFD
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCEEEECCCHHHHHHHHH
TAKKLARTFSYGGGVGIDISKLRPKGAKVNNAAKHTTGAVSFMELYSMTTGLIGQRGRRG
HHHHHHHHHCCCCCCCCCHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
ALMISMDVNHPEIEDFIDIKTDLEKVTKANISVRVTDEFMQAVREKKLYNCTFEVETTGE
EEEEEECCCCCCHHHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHEEEEEEECCHH
KIVKIVNAYDLFNKFVKNNWDYAEPGILFWDKIKTYNFMSEDKNFCFSGVNPCAEEPLPS
HHHHHHHHHHHHHHHHHCCCCCCCCCEEEEHHHHHHHHHHCCCCCEECCCCHHHCCCCCC
GGSCLLGSINLSEFIIQPFGEHATFDINKLKSCVREAVVALNDVLDEGLNLHPLQEQRDS
CCCEEEECCCHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHH
VHKYRQIGLGVMGIADMLIKMGIRYGSDESLELCDLIGKTMLNEAVKQSALIAKEYGTFS
HHHHHHHCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
EYKYENISKSKFFIENLNEDTKEMVKKYGLRNSQLLTIPPTGSISTMIGISGGIEPIFNL
HHHHCCCCHHHHHHHHCCHHHHHHHHHHCCCCCEEEEECCCCCCHHEEECCCCCCHHHHH
SYIRKTESLHDEDVYYKVYTPIVKEYMDKKGITDEECLPDFFVTAMNIGYEERINMQKVW
HHHHHHHCCCCCCCEEEHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCHHHCCCHHHHH
QKYIDASISSTINIPFETTVEDVFNIYIKAWEAGLKGVTIFRDGCKRSGILINEKKEENN
HHHHHHHHCCEEECCHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCEEEECCHHCCC
KEDKKENSKKEYYKNNKKEKDNKDEKAKEIINKNFEEDEKFVCPECGSEGIAHTGGCSIC
CHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCCEECCCCCCCCCCCCCCCHHH
LKCGYSGCN
EECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]