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The map label for this gene is lytC [H]

Identifier: 126698829

GI number: 126698829

Start: 1432373

End: 1433800

Strand: Direct

Name: lytC [H]

Synonym: CD1233

Alternate gene names: 126698829

Gene position: 1432373-1433800 (Clockwise)

Preceding gene: 126698826

Following gene: 126698833

Centisome position: 33.39

GC content: 28.64

Gene sequence:

>1428_bases
ATGAAAATTAAAAAATTATTAACAATAGGGTTATCTTTATCTATATTTATTGCTAGTTGCCCTATATCTGCAAATGCTCT
TGATAAAATTGAATCAATTAAAGGTGCAGATAAATACGAAACTGCTGGTATAATTGCAGACAAACAAAACTATACTACAG
CTATATTAATTAATGCAGACAGTACAATGGCTGATGGATTAAGTGCAAGTGGACTTGCAGGAGCTATAAACGCTCCAATT
CTTTTGACTAAGAAAAATAACATACCAAATGCTACACTTAAAAGATTAGAAAAGGCAAAAAAAGTATATATAATTGGAGG
AGAAAACTCTATTGATAAATATACTGAAACTGTTCTAAAAGGCAAAGGAATAGAGATTAAAAGACTTCAAGGTAGTGATA
GAATTAAGACAAGCTATAATGTCGCAAAAGAAATAAATTCAATTAACAAAGTAAATAAAGTCATATTGACTAATGCATTT
AAAGGAGAGCCTGATGCAATGAGTGCTGCACCTGTAGCAGTTAGAGATAAAGCAGCTATAGTATTAACTGATGGAAAAAG
TGTTCCATTTAATACAACTGGTGTAGAAAGTTATGTAATAGGTGGTACTTCATCAATGAATGACAAAATAGTTAAGGATA
CTAATTCAACTAGATTAGGTGGGACAGATAGATATGATACTAACAAAAAGATAATAAATAAATTTTATAGTGGAGTAAAA
GAATTTTATATAGCAAGTGGTACTGATTTAGTGTATGCTCTTGTTGGTTCTACTGTTGCTAAAAATAATGCTATTGTGTT
AGTTGATAATGATAGTAATAAAAGTGTATTGAAAAGTACAACTAAATTAACTGCTATAGGAAATTTGAGTGATAGTATAT
TACAGCAGTGTTTAAATGTAACAAAAAATATAGGCGATTCTAATACTGGAAGAGAATATACAGTAGAAGATGCTGCTAAT
GCAGTGAAAAAACTATTAGGTGTGAAGAAATTTTATTACGAACCTAATTATTCAGAAGATGAAGATTTAATATTTCTACT
AGATAAAAATTTTGATTTTTCAGGAAAAGAGTACTATGTATTTGCTTACATTAAACAGGGTGCAGAGGGTGATGTTAGAT
ACTGTGTAGCTAAAAATGATATGAGCAAAGTTTATACATATGATGTTAATGGTAATATGAAAGTATGTAATCCAGATGAT
TATAAAAATAAAGGAAGTATAACAGAAGAACAAGCAAAACAGATAGCATTAAAAGAATGTGCTAAGAGACATAAAGTCAG
TATCAATAACTTAGTAGTTGATATGATAGATTTTAGAGATGATATATATAGTGGTAATGTCTATGCTGTTAAAATCAATT
CAAAAAATAGTAATGGTACTTTTGGTTGGTTTTTTATAGATATAGAAACTGGGAAAATTTATAATTAA

Upstream 100 bases:

>100_bases
AATATTATATTAAGTAATAATAACTTTTTAAATTTATGGTAATGTTTTCCTGAAAAGTATTATATAATTTAGGTGAAAAT
ATTTAAGAGAAGGAGATATT

Downstream 100 bases:

>100_bases
AATTAGAACTTTTAAACAAGTGTTTTTAATTATATAATTTGCCATAATATGTTATAATATTTTTAGCAAGAAGATTTAAC
TTACAATCTATAGAGTGGAG

Product: cell surface protein

Products: NA

Alternate protein names: Cell wall hydrolase; Cell wall-associated polypeptide CWBP49; CWBP49; Major autolysin [H]

Number of amino acids: Translated: 475; Mature: 475

Protein sequence:

>475_residues
MKIKKLLTIGLSLSIFIASCPISANALDKIESIKGADKYETAGIIADKQNYTTAILINADSTMADGLSASGLAGAINAPI
LLTKKNNIPNATLKRLEKAKKVYIIGGENSIDKYTETVLKGKGIEIKRLQGSDRIKTSYNVAKEINSINKVNKVILTNAF
KGEPDAMSAAPVAVRDKAAIVLTDGKSVPFNTTGVESYVIGGTSSMNDKIVKDTNSTRLGGTDRYDTNKKIINKFYSGVK
EFYIASGTDLVYALVGSTVAKNNAIVLVDNDSNKSVLKSTTKLTAIGNLSDSILQQCLNVTKNIGDSNTGREYTVEDAAN
AVKKLLGVKKFYYEPNYSEDEDLIFLLDKNFDFSGKEYYVFAYIKQGAEGDVRYCVAKNDMSKVYTYDVNGNMKVCNPDD
YKNKGSITEEQAKQIALKECAKRHKVSINNLVVDMIDFRDDIYSGNVYAVKINSKNSNGTFGWFFIDIETGKIYN

Sequences:

>Translated_475_residues
MKIKKLLTIGLSLSIFIASCPISANALDKIESIKGADKYETAGIIADKQNYTTAILINADSTMADGLSASGLAGAINAPI
LLTKKNNIPNATLKRLEKAKKVYIIGGENSIDKYTETVLKGKGIEIKRLQGSDRIKTSYNVAKEINSINKVNKVILTNAF
KGEPDAMSAAPVAVRDKAAIVLTDGKSVPFNTTGVESYVIGGTSSMNDKIVKDTNSTRLGGTDRYDTNKKIINKFYSGVK
EFYIASGTDLVYALVGSTVAKNNAIVLVDNDSNKSVLKSTTKLTAIGNLSDSILQQCLNVTKNIGDSNTGREYTVEDAAN
AVKKLLGVKKFYYEPNYSEDEDLIFLLDKNFDFSGKEYYVFAYIKQGAEGDVRYCVAKNDMSKVYTYDVNGNMKVCNPDD
YKNKGSITEEQAKQIALKECAKRHKVSINNLVVDMIDFRDDIYSGNVYAVKINSKNSNGTFGWFFIDIETGKIYN
>Mature_475_residues
MKIKKLLTIGLSLSIFIASCPISANALDKIESIKGADKYETAGIIADKQNYTTAILINADSTMADGLSASGLAGAINAPI
LLTKKNNIPNATLKRLEKAKKVYIIGGENSIDKYTETVLKGKGIEIKRLQGSDRIKTSYNVAKEINSINKVNKVILTNAF
KGEPDAMSAAPVAVRDKAAIVLTDGKSVPFNTTGVESYVIGGTSSMNDKIVKDTNSTRLGGTDRYDTNKKIINKFYSGVK
EFYIASGTDLVYALVGSTVAKNNAIVLVDNDSNKSVLKSTTKLTAIGNLSDSILQQCLNVTKNIGDSNTGREYTVEDAAN
AVKKLLGVKKFYYEPNYSEDEDLIFLLDKNFDFSGKEYYVFAYIKQGAEGDVRYCVAKNDMSKVYTYDVNGNMKVCNPDD
YKNKGSITEEQAKQIALKECAKRHKVSINNLVVDMIDFRDDIYSGNVYAVKINSKNSNGTFGWFFIDIETGKIYN

Specific function: Autolysins are involved in some important biological processes such as cell separation, cell-wall turnover, competence for genetic transformation, formation of the flagella - in particular of its basal body - and sporulation. Has a high affinity for teich

COG id: COG2247

COG function: function code M; Putative cell wall-binding domain

Gene ontology:

Cell location: Secreted, cell wall [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the N-acetylmuramoyl-L-alanine amidase 3 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007253
- InterPro:   IPR002508 [H]

Pfam domain/function: PF01520 Amidase_3; PF04122 CW_binding_2 [H]

EC number: =3.5.1.28 [H]

Molecular weight: Translated: 52006; Mature: 52006

Theoretical pI: Translated: 9.20; Mature: 9.20

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIKKLLTIGLSLSIFIASCPISANALDKIESIKGADKYETAGIIADKQNYTTAILINAD
CCHHHEEEECCEEEEEEEECCCCCHHHHHHHHHCCCCCCCCCEEEEECCCCEEEEEEECC
STMADGLSASGLAGAINAPILLTKKNNIPNATLKRLEKAKKVYIIGGENSIDKYTETVLK
CCHHCCCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHCCEEEEECCCCCHHHHHHHHHC
GKGIEIKRLQGSDRIKTSYNVAKEINSINKVNKVILTNAFKGEPDAMSAAPVAVRDKAAI
CCCCEEEEECCCCCCCHHHHHHHHHHHHHHHCEEEEECCCCCCCCCCCCCCEEEECCEEE
VLTDGKSVPFNTTGVESYVIGGTSSMNDKIVKDTNSTRLGGTDRYDTNKKIINKFYSGVK
EEECCCCCCCCCCCCCEEEECCCCCCCCCEEECCCCCCCCCCCCCCCCHHHHHHHHHHHH
EFYIASGTDLVYALVGSTVAKNNAIVLVDNDSNKSVLKSTTKLTAIGNLSDSILQQCLNV
HEEEECCCCEEHEECCCHHCCCCEEEEEECCCCCHHHHHCEEEEEECCCCHHHHHHHHHH
TKNIGDSNTGREYTVEDAANAVKKLLGVKKFYYEPNYSEDEDLIFLLDKNFDFSGKEYYV
HHCCCCCCCCCEEEHHHHHHHHHHHHCCHHEEECCCCCCCCCEEEEEECCCCCCCCEEEE
FAYIKQGAEGDVRYCVAKNDMSKVYTYDVNGNMKVCNPDDYKNKGSITEEQAKQIALKEC
EEEEECCCCCCEEEEEECCCCCEEEEEECCCCEEECCCCCCCCCCCCCHHHHHHHHHHHH
AKRHKVSINNLVVDMIDFRDDIYSGNVYAVKINSKNSNGTFGWFFIDIETGKIYN
HHHHCCCHHHEEEEEHHHCCHHCCCCEEEEEEECCCCCCEEEEEEEEEECCCCCC
>Mature Secondary Structure
MKIKKLLTIGLSLSIFIASCPISANALDKIESIKGADKYETAGIIADKQNYTTAILINAD
CCHHHEEEECCEEEEEEEECCCCCHHHHHHHHHCCCCCCCCCEEEEECCCCEEEEEEECC
STMADGLSASGLAGAINAPILLTKKNNIPNATLKRLEKAKKVYIIGGENSIDKYTETVLK
CCHHCCCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHCCEEEEECCCCCHHHHHHHHHC
GKGIEIKRLQGSDRIKTSYNVAKEINSINKVNKVILTNAFKGEPDAMSAAPVAVRDKAAI
CCCCEEEEECCCCCCCHHHHHHHHHHHHHHHCEEEEECCCCCCCCCCCCCCEEEECCEEE
VLTDGKSVPFNTTGVESYVIGGTSSMNDKIVKDTNSTRLGGTDRYDTNKKIINKFYSGVK
EEECCCCCCCCCCCCCEEEECCCCCCCCCEEECCCCCCCCCCCCCCCCHHHHHHHHHHHH
EFYIASGTDLVYALVGSTVAKNNAIVLVDNDSNKSVLKSTTKLTAIGNLSDSILQQCLNV
HEEEECCCCEEHEECCCHHCCCCEEEEEECCCCCHHHHHCEEEEEECCCCHHHHHHHHHH
TKNIGDSNTGREYTVEDAANAVKKLLGVKKFYYEPNYSEDEDLIFLLDKNFDFSGKEYYV
HHCCCCCCCCCEEEHHHHHHHHHHHHCCHHEEECCCCCCCCCEEEEEECCCCCCCCEEEE
FAYIKQGAEGDVRYCVAKNDMSKVYTYDVNGNMKVCNPDDYKNKGSITEEQAKQIALKEC
EEEEECCCCCCEEEEEECCCCCEEEEEECCCCEEECCCCCCCCCCCCCHHHHHHHHHHHH
AKRHKVSINNLVVDMIDFRDDIYSGNVYAVKINSKNSNGTFGWFFIDIETGKIYN
HHHHCCCHHHEEEEEHHHCCHHCCCCEEEEEEECCCCCCEEEEEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1357079; 1682302; 9384377 [H]