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The map label for this gene is ispA [C]

Identifier: 126698801

GI number: 126698801

Start: 1403174

End: 1404061

Strand: Direct

Name: ispA [C]

Synonym: CD1205

Alternate gene names: 126698801

Gene position: 1403174-1404061 (Clockwise)

Preceding gene: 126698800

Following gene: 126698802

Centisome position: 32.71

GC content: 30.97

Gene sequence:

>888_bases
TTGGAATTTAAACAATGTCTAAAAGAAAAAGCAAGTTTTGTAGAAAAAGTACTTAAAGAATATATGCCTAAAGAAGAAGG
GTATCAAAAAACTGTTATTGAAGCTATGAACTATAGCTTAAGTGCTGGAGGTAAAAGATTAAGACCAATACTTACATTGG
AGGCTTGTAAAATAGTTGGAGGTAATGAAGATGAAGCTATTCCTTTTGCTATTGCAATTGAAATGATACATACATATTCA
CTAATACATGATGATTTGCCAGCTCTTGACAATGATGATTTAAGAAGAGGAAGACCAACAAATCATAAAGTATATGGAGA
AGCTATGGGGATTTTAGCAGGAGATGCTTTGTTAAACTATGCTTTTGAAGTAATGCTTGCAGGCTCAATCAATAAAGAAA
ATCCAGAAAAGTATCTAAAAGCTATAAATGAAATTGCCAAAGGTGCTGGTATATATGGAATGATAGGTGGTCAAGTAGTA
GATGTAGAAAGCGAAAACAAACAAATTGAAAAAGAAAAATTAGATTATATACATATGAATAAAACTGCTGCAATGATGGT
AGGCTGTATGAGAGCAGGAGCTACTATAGGTGGAGCAAATTCTGAACAAATGGAAGAAATAACTAAATATGCAAAAAATA
TCGGATTATCATTCCAGATAGTAGATGATATACTAGACATAGTAGGAGATGAAGCTAAGTTAGGTAAAAAGGTTGGAAGT
GATATAGAAAATCATAAGTCAACATACCCATCTCTTTTAGGTTTAGATAAATCTAAAGAAATTGCACATAATTTGATTGA
TGAAGCAAAGAAAAGTATAGAAAAATTATCTGATGATGTAGATTTTTTAAAGGGATTGGCTGAATATATAATAGATAGAG
AATACTAA

Upstream 100 bases:

>100_bases
ATAAACATTGTAATAAGCTTTTAGATGATGCTAAATTGAAAATAAGTAAATTTAATCAATTGGGAATAGAAGAAGACTTT
AAAATAGAGGAGGAATAAAA

Downstream 100 bases:

>100_bases
AATATACAGCTAAAATCGAGGAGGGAAAAATGGATTTTTTTTCGGAGATTTTTAACAATGGGGCTTTGGGAATAAGTCTG
ATTGCTTGTTTCTTAGCACA

Product: geranyltranstransferase

Products: NA

Alternate protein names: FPP synthase; (2E,6E)-farnesyl diphosphate synthase; Geranyltranstransferase [H]

Number of amino acids: Translated: 295; Mature: 295

Protein sequence:

>295_residues
MEFKQCLKEKASFVEKVLKEYMPKEEGYQKTVIEAMNYSLSAGGKRLRPILTLEACKIVGGNEDEAIPFAIAIEMIHTYS
LIHDDLPALDNDDLRRGRPTNHKVYGEAMGILAGDALLNYAFEVMLAGSINKENPEKYLKAINEIAKGAGIYGMIGGQVV
DVESENKQIEKEKLDYIHMNKTAAMMVGCMRAGATIGGANSEQMEEITKYAKNIGLSFQIVDDILDIVGDEAKLGKKVGS
DIENHKSTYPSLLGLDKSKEIAHNLIDEAKKSIEKLSDDVDFLKGLAEYIIDREY

Sequences:

>Translated_295_residues
MEFKQCLKEKASFVEKVLKEYMPKEEGYQKTVIEAMNYSLSAGGKRLRPILTLEACKIVGGNEDEAIPFAIAIEMIHTYS
LIHDDLPALDNDDLRRGRPTNHKVYGEAMGILAGDALLNYAFEVMLAGSINKENPEKYLKAINEIAKGAGIYGMIGGQVV
DVESENKQIEKEKLDYIHMNKTAAMMVGCMRAGATIGGANSEQMEEITKYAKNIGLSFQIVDDILDIVGDEAKLGKKVGS
DIENHKSTYPSLLGLDKSKEIAHNLIDEAKKSIEKLSDDVDFLKGLAEYIIDREY
>Mature_295_residues
MEFKQCLKEKASFVEKVLKEYMPKEEGYQKTVIEAMNYSLSAGGKRLRPILTLEACKIVGGNEDEAIPFAIAIEMIHTYS
LIHDDLPALDNDDLRRGRPTNHKVYGEAMGILAGDALLNYAFEVMLAGSINKENPEKYLKAINEIAKGAGIYGMIGGQVV
DVESENKQIEKEKLDYIHMNKTAAMMVGCMRAGATIGGANSEQMEEITKYAKNIGLSFQIVDDILDIVGDEAKLGKKVGS
DIENHKSTYPSLLGLDKSKEIAHNLIDEAKKSIEKLSDDVDFLKGLAEYIIDREY

Specific function: Unknown

COG id: COG0142

COG function: function code H; Geranylgeranyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FPP/GGPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI50659086, Length=237, Percent_Identity=31.2236286919831, Blast_Score=97, Evalue=2e-20,
Organism=Escherichia coli, GI1786623, Length=297, Percent_Identity=41.7508417508418, Blast_Score=213, Evalue=1e-56,
Organism=Escherichia coli, GI1789578, Length=216, Percent_Identity=32.8703703703704, Blast_Score=115, Evalue=5e-27,
Organism=Caenorhabditis elegans, GI17505681, Length=266, Percent_Identity=26.3157894736842, Blast_Score=89, Evalue=4e-18,
Organism=Drosophila melanogaster, GI24651612, Length=253, Percent_Identity=27.6679841897233, Blast_Score=100, Evalue=1e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000092
- InterPro:   IPR017446
- InterPro:   IPR008949 [H]

Pfam domain/function: PF00348 polyprenyl_synt [H]

EC number: =2.5.1.10 [H]

Molecular weight: Translated: 32690; Mature: 32690

Theoretical pI: Translated: 4.81; Mature: 4.81

Prosite motif: PS00723 POLYPRENYL_SYNTHET_1 ; PS00444 POLYPRENYL_SYNTHET_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEFKQCLKEKASFVEKVLKEYMPKEEGYQKTVIEAMNYSLSAGGKRLRPILTLEACKIVG
CCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCHHHCCCCHHHHHHHHHHHHHCC
GNEDEAIPFAIAIEMIHTYSLIHDDLPALDNDDLRRGRPTNHKVYGEAMGILAGDALLNY
CCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCCCCCHHHHHHHHHHHHHHHHHH
AFEVMLAGSINKENPEKYLKAINEIAKGAGIYGMIGGQVVDVESENKQIEKEKLDYIHMN
HHHHHHCCCCCCCCHHHHHHHHHHHHHCCCEEEECCCEEEECCCCHHHHHHHHHHHHCCC
KTAAMMVGCMRAGATIGGANSEQMEEITKYAKNIGLSFQIVDDILDIVGDEAKLGKKVGS
HHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHHHCC
DIENHKSTYPSLLGLDKSKEIAHNLIDEAKKSIEKLSDDVDFLKGLAEYIIDREY
HHHHHHHHCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MEFKQCLKEKASFVEKVLKEYMPKEEGYQKTVIEAMNYSLSAGGKRLRPILTLEACKIVG
CCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCHHHCCCCHHHHHHHHHHHHHCC
GNEDEAIPFAIAIEMIHTYSLIHDDLPALDNDDLRRGRPTNHKVYGEAMGILAGDALLNY
CCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCCCCCHHHHHHHHHHHHHHHHHH
AFEVMLAGSINKENPEKYLKAINEIAKGAGIYGMIGGQVVDVESENKQIEKEKLDYIHMN
HHHHHHCCCCCCCCHHHHHHHHHHHHHCCCEEEECCCEEEECCCCHHHHHHHHHHHHCCC
KTAAMMVGCMRAGATIGGANSEQMEEITKYAKNIGLSFQIVDDILDIVGDEAKLGKKVGS
HHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHHHCC
DIENHKSTYPSLLGLDKSKEIAHNLIDEAKKSIEKLSDDVDFLKGLAEYIIDREY
HHHHHHHHCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8486607; 7918490 [H]