| Definition | Clostridium difficile 630 chromosome, complete genome. |
|---|---|
| Accession | NC_009089 |
| Length | 4,290,252 |
Click here to switch to the map view.
The map label for this gene is polA [H]
Identifier: 126698722
GI number: 126698722
Start: 1326574
End: 1329222
Strand: Direct
Name: polA [H]
Synonym: CD1128
Alternate gene names: 126698722
Gene position: 1326574-1329222 (Clockwise)
Preceding gene: 126698721
Following gene: 126698723
Centisome position: 30.92
GC content: 28.16
Gene sequence:
>2649_bases TTGGAAAAAAAATTAATTATAATAGATGGAAATTCAATAATAAATAGAGCTTTTTATGCTCTTCCAGAAATGAATAATAA AGAAGGGCTAAAGACCAATGCAATATATGGATTTACAACAATGCTATTTAAAATGATAGATATATATAAACCAACACATA TAAGTGTAGCATTTGACAGAAAAGCACCTACATTTAGACATTTAGAATATAAAGAGTATAAGGCTGGAAGAAAGGGAATG CCAGATGAACTGGCAGAACAATTACAGCCATTAAAAGACCTTTTAGATAAATTTAGAATAAATAGATTGGAAATAGATGG CTATGAGGCAGATGATATTATAGGTACTGTTTCTAAAAAAGCAGAAGAAAATGGATATAAGGTATACATAGTAACTGGAG ACAAAGATGCTATTCAACTTGCTTCAGACAATACAACTACTCTTATAACAAAAAAAGGAGTTGGAGAAGTTGAAGAATAC AACTTTAATTCTGTAATTGAAAAATACGAGATGACTCCAACACAATTTATCGATTTAAAGGGTCTTATGGGAGACAAGTC TGATAATATACCTGGAGTACCTGGAATAGGTGAAAAAACAGGTATAAAGCTTATAAAAGAGTTTTCTAGTATAGAGAATC TAATAGAGAATACAGATAAGCTTAAAGGTAGTGTAAAAAAGAAAATAGAGGAAAACAAAGAAATAGCTATTCAAAGTAAA AGACTTGCAACAATTATAAGAGATGTGCCAATAGAAGTGGATTTAGATAGTATGATTTTTGGCGATTATGATAAAGATGA ACTTTTAGATAAATTTAGATACTTTGGATTTACAAGTCTCTTATCAAGATTAGTTGATTTGGTCGATTCAGATGACACAG AACACGTAGAAGAAAAAATAGAAATATTAAAATTAAAAGATATAGAAAAATTTATAGATGAAGTAAACAAAAAAGGACAA GTTATTTTAAAAACTGTTAGAGGACAAGGTAATATACTTGAAAAAAATATAATATATATTTTTATAAGTGTAGATGGAGA AAAAATATATTATGTAGATTCAAATGAAGTGTCAAAGTTAGATAGTATATTTTCAAATAATGAAATTAAAAAGTATGGAT ATAATTTAAAAGATGATTATATATCTTTAAAACCATATAATATAAACTTAGAAAATATGTATTTTGATATAACAATAGCT GAGTACTTAATAGATTCAACTTCATCTACCTCATATGATTGTAGTGCAATAGCTATGAAGTATTTATCAAAAAAGGTTAA ATCAAAAGAAGAATTATTAGGAAAGGGTGTTAAATCTAAAAACTATGAGGATTTAGAATTTGAGGATTTAGCAGAGTATA TGGGTCAAATAATATGCACAGTTAAAGAAACAGTTCCTATGATGGAAAGAAGTCTAATGGATATGAGTATGGATGGTCTT TTTTATCATGTAGAGATGCCTTTAGTAGAAGTCTTAGGTCATATGGAGTATGAAGGTATAAAAGTAGACAAAAGTATATT GGATGAATTGAGTGTTGAATTTAAAGAAATAATAGCTACATTAGAAAAGGAAATTTATGAATTATCAGGAGAGCCATTCA ATATAAATTCACCAAAACAATTGGGTGTTATATTATTTGAAAAATTAGAGCTTCCAATAATTAAAAAAACTAAAACTGGA TATTCAACTAATGCAGATGTTTTAGAAAAATTAAGAGATAAGCATCCAATAATAGATAAGATAACTGAGTATAGACAAAT AGTAAAGTTAAATTCTACTTACGTTGAAGGACTTTTAAATATAATAAATCCAGAAAGTAATAGAATACATTCATCATTTA ATCAAACTATAACGACTACAGGAAGAATTTCATCTACAGAACCAAATCTTCAAAATATACCTATAAAAATGGAAATGGGT AGAAAAATAAGAAAAGTGTTTATTGCAGATGATAACTGTAAGTTGGTTGATGCCGATTACTCACAAGTAGAGCTAAGAGT TCTTGCACATATGAGTCAGGATGAAAATATGATAGAAGCATTTAAACATCATGAAGATATTCATACCAAAACAGCTTCAC AAGTTTTTAATGTTCCTATGGAAGATGTTACTAGTGAATTGAGAGGTGCAGCTAAAGCTGTAAACTTTGGTATTATATAT GGTAAAAGTGACTTTGGTCTAGCTGATGATTTAAATATACCTGTTCCAAAGGCGAAAGAATATATCGAAAGTTATTTTGC TAAATACCATAAAATAAAAGAGTTTATGGACACAACAGTAGAAAAGGCTAGTGAGGATGGATATGCTGTAACAATTTTAA ACAGAAGAAGATATATACCAGAAATAAAGTCAAGCAATTTTATGGAAAGAAATAGAGGAAAGAGATTTGCAATGAATGCA CCAATACAAGGAAGTGCAGCAGATATAATAAAAATTGCTATGATAAATGTTCATAAAAAATTGGAAGAGAACAATTTGAA ATCAAAACTTATACTACAAGTTCACGACGAGTTGATAGTTGAAGCAATTGATGATGAAATAGATATAGTTAAGAAAATAG TAAAAGAAGAAATGGAAAATGCTGTAAATATGGATGTTCACTTAGATGTAGATTTAAATGTAGGTAGTTCTTGGTATGAG ACAAAGTAG
Upstream 100 bases:
>100_bases TTAATATACTATTATTATTATTATGGGAATATTAAATAACAGTATATTGGTATATAATATATATGTTACAAAAATAGATA ATTTTTAGGAGTGATATAAT
Downstream 100 bases:
>100_bases GTGATTTTATGTTGATATTAGGACTTACAGGAGGAATAGGCTGTGGAAAAAGCAGCCTATCAAATATATTTAGAAATCTT AACATTCCTATAGTGGATGC
Product: DNA polymerase I
Products: NA
Alternate protein names: POL I [H]
Number of amino acids: Translated: 882; Mature: 882
Protein sequence:
>882_residues MEKKLIIIDGNSIINRAFYALPEMNNKEGLKTNAIYGFTTMLFKMIDIYKPTHISVAFDRKAPTFRHLEYKEYKAGRKGM PDELAEQLQPLKDLLDKFRINRLEIDGYEADDIIGTVSKKAEENGYKVYIVTGDKDAIQLASDNTTTLITKKGVGEVEEY NFNSVIEKYEMTPTQFIDLKGLMGDKSDNIPGVPGIGEKTGIKLIKEFSSIENLIENTDKLKGSVKKKIEENKEIAIQSK RLATIIRDVPIEVDLDSMIFGDYDKDELLDKFRYFGFTSLLSRLVDLVDSDDTEHVEEKIEILKLKDIEKFIDEVNKKGQ VILKTVRGQGNILEKNIIYIFISVDGEKIYYVDSNEVSKLDSIFSNNEIKKYGYNLKDDYISLKPYNINLENMYFDITIA EYLIDSTSSTSYDCSAIAMKYLSKKVKSKEELLGKGVKSKNYEDLEFEDLAEYMGQIICTVKETVPMMERSLMDMSMDGL FYHVEMPLVEVLGHMEYEGIKVDKSILDELSVEFKEIIATLEKEIYELSGEPFNINSPKQLGVILFEKLELPIIKKTKTG YSTNADVLEKLRDKHPIIDKITEYRQIVKLNSTYVEGLLNIINPESNRIHSSFNQTITTTGRISSTEPNLQNIPIKMEMG RKIRKVFIADDNCKLVDADYSQVELRVLAHMSQDENMIEAFKHHEDIHTKTASQVFNVPMEDVTSELRGAAKAVNFGIIY GKSDFGLADDLNIPVPKAKEYIESYFAKYHKIKEFMDTTVEKASEDGYAVTILNRRRYIPEIKSSNFMERNRGKRFAMNA PIQGSAADIIKIAMINVHKKLEENNLKSKLILQVHDELIVEAIDDEIDIVKKIVKEEMENAVNMDVHLDVDLNVGSSWYE TK
Sequences:
>Translated_882_residues MEKKLIIIDGNSIINRAFYALPEMNNKEGLKTNAIYGFTTMLFKMIDIYKPTHISVAFDRKAPTFRHLEYKEYKAGRKGM PDELAEQLQPLKDLLDKFRINRLEIDGYEADDIIGTVSKKAEENGYKVYIVTGDKDAIQLASDNTTTLITKKGVGEVEEY NFNSVIEKYEMTPTQFIDLKGLMGDKSDNIPGVPGIGEKTGIKLIKEFSSIENLIENTDKLKGSVKKKIEENKEIAIQSK RLATIIRDVPIEVDLDSMIFGDYDKDELLDKFRYFGFTSLLSRLVDLVDSDDTEHVEEKIEILKLKDIEKFIDEVNKKGQ VILKTVRGQGNILEKNIIYIFISVDGEKIYYVDSNEVSKLDSIFSNNEIKKYGYNLKDDYISLKPYNINLENMYFDITIA EYLIDSTSSTSYDCSAIAMKYLSKKVKSKEELLGKGVKSKNYEDLEFEDLAEYMGQIICTVKETVPMMERSLMDMSMDGL FYHVEMPLVEVLGHMEYEGIKVDKSILDELSVEFKEIIATLEKEIYELSGEPFNINSPKQLGVILFEKLELPIIKKTKTG YSTNADVLEKLRDKHPIIDKITEYRQIVKLNSTYVEGLLNIINPESNRIHSSFNQTITTTGRISSTEPNLQNIPIKMEMG RKIRKVFIADDNCKLVDADYSQVELRVLAHMSQDENMIEAFKHHEDIHTKTASQVFNVPMEDVTSELRGAAKAVNFGIIY GKSDFGLADDLNIPVPKAKEYIESYFAKYHKIKEFMDTTVEKASEDGYAVTILNRRRYIPEIKSSNFMERNRGKRFAMNA PIQGSAADIIKIAMINVHKKLEENNLKSKLILQVHDELIVEAIDDEIDIVKKIVKEEMENAVNMDVHLDVDLNVGSSWYE TK >Mature_882_residues MEKKLIIIDGNSIINRAFYALPEMNNKEGLKTNAIYGFTTMLFKMIDIYKPTHISVAFDRKAPTFRHLEYKEYKAGRKGM PDELAEQLQPLKDLLDKFRINRLEIDGYEADDIIGTVSKKAEENGYKVYIVTGDKDAIQLASDNTTTLITKKGVGEVEEY NFNSVIEKYEMTPTQFIDLKGLMGDKSDNIPGVPGIGEKTGIKLIKEFSSIENLIENTDKLKGSVKKKIEENKEIAIQSK RLATIIRDVPIEVDLDSMIFGDYDKDELLDKFRYFGFTSLLSRLVDLVDSDDTEHVEEKIEILKLKDIEKFIDEVNKKGQ VILKTVRGQGNILEKNIIYIFISVDGEKIYYVDSNEVSKLDSIFSNNEIKKYGYNLKDDYISLKPYNINLENMYFDITIA EYLIDSTSSTSYDCSAIAMKYLSKKVKSKEELLGKGVKSKNYEDLEFEDLAEYMGQIICTVKETVPMMERSLMDMSMDGL FYHVEMPLVEVLGHMEYEGIKVDKSILDELSVEFKEIIATLEKEIYELSGEPFNINSPKQLGVILFEKLELPIIKKTKTG YSTNADVLEKLRDKHPIIDKITEYRQIVKLNSTYVEGLLNIINPESNRIHSSFNQTITTTGRISSTEPNLQNIPIKMEMG RKIRKVFIADDNCKLVDADYSQVELRVLAHMSQDENMIEAFKHHEDIHTKTASQVFNVPMEDVTSELRGAAKAVNFGIIY GKSDFGLADDLNIPVPKAKEYIESYFAKYHKIKEFMDTTVEKASEDGYAVTILNRRRYIPEIKSSNFMERNRGKRFAMNA PIQGSAADIIKIAMINVHKKLEENNLKSKLILQVHDELIVEAIDDEIDIVKKIVKEEMENAVNMDVHLDVDLNVGSSWYE TK
Specific function: In addition to polymerase activity, this DNA polymerase exhibits 3' to 5' and 5' to 3' exonuclease activity [H]
COG id: COG0749
COG function: function code L; DNA polymerase I - 3'-5' exonuclease and polymerase domains
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Contains 1 5'-3' exonuclease domain [H]
Homologues:
Organism=Homo sapiens, GI112420958, Length=440, Percent_Identity=35, Blast_Score=259, Evalue=1e-68, Organism=Homo sapiens, GI139394648, Length=637, Percent_Identity=29.1993720565149, Blast_Score=228, Evalue=3e-59, Organism=Escherichia coli, GI1790294, Length=926, Percent_Identity=37.2570194384449, Blast_Score=591, Evalue=1e-170, Organism=Escherichia coli, GI226510970, Length=211, Percent_Identity=30.3317535545024, Blast_Score=109, Evalue=1e-24, Organism=Caenorhabditis elegans, GI86563272, Length=426, Percent_Identity=30.7511737089202, Blast_Score=202, Evalue=9e-52, Organism=Drosophila melanogaster, GI17933644, Length=418, Percent_Identity=33.2535885167464, Blast_Score=214, Evalue=3e-55,
Paralogues:
None
Copy number: 400 Molecules/Cell In: Glucose minimal media [C]
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR002562 - InterPro: IPR020046 - InterPro: IPR020045 - InterPro: IPR002421 - InterPro: IPR020047 - InterPro: IPR019760 - InterPro: IPR001098 - InterPro: IPR018320 - InterPro: IPR002298 - InterPro: IPR008918 - InterPro: IPR003583 - InterPro: IPR012337 [H]
Pfam domain/function: PF01367 5_3_exonuc; PF02739 5_3_exonuc_N; PF00476 DNA_pol_A [H]
EC number: =2.7.7.7 [H]
Molecular weight: Translated: 100913; Mature: 100913
Theoretical pI: Translated: 4.91; Mature: 4.91
Prosite motif: PS00447 DNA_POLYMERASE_A
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.3 %Cys (Translated Protein) 3.3 %Met (Translated Protein) 3.6 %Cys+Met (Translated Protein) 0.3 %Cys (Mature Protein) 3.3 %Met (Mature Protein) 3.6 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MEKKLIIIDGNSIINRAFYALPEMNNKEGLKTNAIYGFTTMLFKMIDIYKPTHISVAFDR CCCEEEEECCCHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECC KAPTFRHLEYKEYKAGRKGMPDELAEQLQPLKDLLDKFRINRLEIDGYEADDIIGTVSKK CCCCHHCCCHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHH AEENGYKVYIVTGDKDAIQLASDNTTTLITKKGVGEVEEYNFNSVIEKYEMTPTQFIDLK HCCCCEEEEEEECCCCEEEEECCCCEEEEEECCCCCHHHCCHHHHHHHHCCCCHHEEECH GLMGDKSDNIPGVPGIGEKTGIKLIKEFSSIENLIENTDKLKGSVKKKIEENKEIAIQSK HCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHEEHHH RLATIIRDVPIEVDLDSMIFGDYDKDELLDKFRYFGFTSLLSRLVDLVDSDDTEHVEEKI HHHHHHHCCCCEEECCHHEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH EILKLKDIEKFIDEVNKKGQVILKTVRGQGNILEKNIIYIFISVDGEKIYYVDSNEVSKL HHHHHHHHHHHHHHHCCCCEEEEEEECCCCCEEECEEEEEEEEECCCEEEEECCCHHHHH DSIFSNNEIKKYGYNLKDDYISLKPYNINLENMYFDITIAEYLIDSTSSTSYDCSAIAMK HHHHCCCCHHHCCCCCCCCEEEEECEEEEHHHEEEEEEHHHHHHCCCCCCCCCHHHHHHH YLSKKVKSKEELLGKGVKSKNYEDLEFEDLAEYMGQIICTVKETVPMMERSLMDMSMDGL HHHHHHCCHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCE FYHVEMPLVEVLGHMEYEGIKVDKSILDELSVEFKEIIATLEKEIYELSGEPFNINSPKQ EEEECCHHHHHHCCCCCCCEEECHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHH LGVILFEKLELPIIKKTKTGYSTNADVLEKLRDKHPIIDKITEYRQIVKLNSTYVEGLLN HHHHHHHHCCCCEEEECCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHCHHHHHHHHH IINPESNRIHSSFNQTITTTGRISSTEPNLQNIPIKMEMGRKIRKVFIADDNCKLVDADY HCCCCCCHHHHHHCCEEEECCCCCCCCCCCCCCCEEHHCCCCEEEEEEECCCCEEEECCH SQVELRVLAHMSQDENMIEAFKHHEDIHTKTASQVFNVPMEDVTSELRGAAKAVNFGIIY HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHEEEEEEE GKSDFGLADDLNIPVPKAKEYIESYFAKYHKIKEFMDTTVEKASEDGYAVTILNRRRYIP CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCC EIKSSNFMERNRGKRFAMNAPIQGSAADIIKIAMINVHKKLEENNLKSKLILQVHDELIV CCCCCCCHHHCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH EAIDDEIDIVKKIVKEEMENAVNMDVHLDVDLNVGSSWYETK HHHCCHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCC >Mature Secondary Structure MEKKLIIIDGNSIINRAFYALPEMNNKEGLKTNAIYGFTTMLFKMIDIYKPTHISVAFDR CCCEEEEECCCHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECC KAPTFRHLEYKEYKAGRKGMPDELAEQLQPLKDLLDKFRINRLEIDGYEADDIIGTVSKK CCCCHHCCCHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHH AEENGYKVYIVTGDKDAIQLASDNTTTLITKKGVGEVEEYNFNSVIEKYEMTPTQFIDLK HCCCCEEEEEEECCCCEEEEECCCCEEEEEECCCCCHHHCCHHHHHHHHCCCCHHEEECH GLMGDKSDNIPGVPGIGEKTGIKLIKEFSSIENLIENTDKLKGSVKKKIEENKEIAIQSK HCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHEEHHH RLATIIRDVPIEVDLDSMIFGDYDKDELLDKFRYFGFTSLLSRLVDLVDSDDTEHVEEKI HHHHHHHCCCCEEECCHHEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH EILKLKDIEKFIDEVNKKGQVILKTVRGQGNILEKNIIYIFISVDGEKIYYVDSNEVSKL HHHHHHHHHHHHHHHCCCCEEEEEEECCCCCEEECEEEEEEEEECCCEEEEECCCHHHHH DSIFSNNEIKKYGYNLKDDYISLKPYNINLENMYFDITIAEYLIDSTSSTSYDCSAIAMK HHHHCCCCHHHCCCCCCCCEEEEECEEEEHHHEEEEEEHHHHHHCCCCCCCCCHHHHHHH YLSKKVKSKEELLGKGVKSKNYEDLEFEDLAEYMGQIICTVKETVPMMERSLMDMSMDGL HHHHHHCCHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCE FYHVEMPLVEVLGHMEYEGIKVDKSILDELSVEFKEIIATLEKEIYELSGEPFNINSPKQ EEEECCHHHHHHCCCCCCCEEECHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHH LGVILFEKLELPIIKKTKTGYSTNADVLEKLRDKHPIIDKITEYRQIVKLNSTYVEGLLN HHHHHHHHCCCCEEEECCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHCHHHHHHHHH IINPESNRIHSSFNQTITTTGRISSTEPNLQNIPIKMEMGRKIRKVFIADDNCKLVDADY HCCCCCCHHHHHHCCEEEECCCCCCCCCCCCCCCEEHHCCCCEEEEEEECCCCEEEECCH SQVELRVLAHMSQDENMIEAFKHHEDIHTKTASQVFNVPMEDVTSELRGAAKAVNFGIIY HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHEEEEEEE GKSDFGLADDLNIPVPKAKEYIESYFAKYHKIKEFMDTTVEKASEDGYAVTILNRRRYIP CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCC EIKSSNFMERNRGKRFAMNAPIQGSAADIIKIAMINVHKKLEENNLKSKLILQVHDELIV CCCCCCCHHHCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH EAIDDEIDIVKKIVKEEMENAVNMDVHLDVDLNVGSSWYETK HHHCCHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 9387221; 9384377 [H]