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The map label for this gene is comEC [H]

Identifier: 126698472

GI number: 126698472

Start: 1078053

End: 1078967

Strand: Direct

Name: comEC [H]

Synonym: CD0895

Alternate gene names: 126698472

Gene position: 1078053-1078967 (Clockwise)

Preceding gene: 126698471

Following gene: 126698473

Centisome position: 25.13

GC content: 28.2

Gene sequence:

>915_bases
ATGAGGAAAATAGTATTAAAAGATATCCTGTTTTTAGTTACTACATTATCTATAATAGTAATATTATTGCTTGTAACAAA
TATAACTGCTAATAGTAAGATAAAATCAACAAGTGAAACCTATTTAAAAAGTGACAAAAATAGTGTGAGTCAAAATGGCA
TCCAGAGTAACACAAAAAATACTGCATTTAAGACTACTATACTAAGCACTGGAAAGTCAGATTGTATATTAGTTGAGATA
GGTAACAAAGTCATAATGATTGATACAGGAGAAGATAAAAATGGAAAACAAATAGTTGATAGATTAAAAGAAAAAGGAAT
AAATACACTTGACTATTTGATTTTAACCCATCTAGATAAGGACCATATAGGTGGAGTAGATAGTGTGTTATCTAGTGTTA
AGGTAAAGAATATTATACAAGCAAATTATAAGAAAGATAGTAAGCAATATGATGAATATATTGACTCACTTAAAAAAGCT
GATATAGAACCAGTGCTACTAAAAGATAATATGAATATTGTAATCAATAGTGCAGAAATAAACATACATCCGGCTTCAAA
AAGCAAGTACGAGAGTTCAAATGATTATTCAATAATCACTAATATAAGCTATGGAGCATATAAGTTTTTATTTGCAGGAG
ATGCAGAGGAAGAAAGATTGTCAGAGTTTATAAATGGAAATACTTTAAAATATGATTTTGTTAAAATGCCTCATCATGGA
AGATATGACAAATTAACTGAAACATTTTTAGAGTCTATTTCACCCCAATATGCTGTTATTACATGTTCAGAGAAAAAAGA
ACCAGAGGAAGGTGTTTTAAAAATATTGGAAAGATTGAATATAAAAACATTTTTGACTTCTAATGGAGAGGTAGTTATCA
ATAGTGATGGTAAGACATTGAGTGTGAATCAATAA

Upstream 100 bases:

>100_bases
CAAATATGCCTAAAATTTGCCCTTTTTATATGTGTATTTTACAGAGTTAAGGTTGCTATACTATAAATATGTAATAAATA
AAATTTATAGGAGCTTTTGG

Downstream 100 bases:

>100_bases
TTTTTTTAAAAATATCTAAAAAAATTTAAAAAAATCATTAGCAAATATTACCCCTTAAACATAGTATATTTTAGGAGCTG
AAACTCCACATACAAAATGA

Product: metallo-beta-lactamase superfamily exported protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 304; Mature: 304

Protein sequence:

>304_residues
MRKIVLKDILFLVTTLSIIVILLLVTNITANSKIKSTSETYLKSDKNSVSQNGIQSNTKNTAFKTTILSTGKSDCILVEI
GNKVIMIDTGEDKNGKQIVDRLKEKGINTLDYLILTHLDKDHIGGVDSVLSSVKVKNIIQANYKKDSKQYDEYIDSLKKA
DIEPVLLKDNMNIVINSAEINIHPASKSKYESSNDYSIITNISYGAYKFLFAGDAEEERLSEFINGNTLKYDFVKMPHHG
RYDKLTETFLESISPQYAVITCSEKKEPEEGVLKILERLNIKTFLTSNGEVVINSDGKTLSVNQ

Sequences:

>Translated_304_residues
MRKIVLKDILFLVTTLSIIVILLLVTNITANSKIKSTSETYLKSDKNSVSQNGIQSNTKNTAFKTTILSTGKSDCILVEI
GNKVIMIDTGEDKNGKQIVDRLKEKGINTLDYLILTHLDKDHIGGVDSVLSSVKVKNIIQANYKKDSKQYDEYIDSLKKA
DIEPVLLKDNMNIVINSAEINIHPASKSKYESSNDYSIITNISYGAYKFLFAGDAEEERLSEFINGNTLKYDFVKMPHHG
RYDKLTETFLESISPQYAVITCSEKKEPEEGVLKILERLNIKTFLTSNGEVVINSDGKTLSVNQ
>Mature_304_residues
MRKIVLKDILFLVTTLSIIVILLLVTNITANSKIKSTSETYLKSDKNSVSQNGIQSNTKNTAFKTTILSTGKSDCILVEI
GNKVIMIDTGEDKNGKQIVDRLKEKGINTLDYLILTHLDKDHIGGVDSVLSSVKVKNIIQANYKKDSKQYDEYIDSLKKA
DIEPVLLKDNMNIVINSAEINIHPASKSKYESSNDYSIITNISYGAYKFLFAGDAEEERLSEFINGNTLKYDFVKMPHHG
RYDKLTETFLESISPQYAVITCSEKKEPEEGVLKILERLNIKTFLTSNGEVVINSDGKTLSVNQ

Specific function: The comE operon is required for the binding and uptake of transforming DNA. ComEC is required for internalization but is dispensable for DNA binding [H]

COG id: COG2333

COG function: function code R; Predicted hydrolase (metallo-beta-lactamase superfamily)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: To H.influenzae REC2, N.gonorrhoeae ComA and E.coli YcaI [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001279
- InterPro:   IPR004477
- InterPro:   IPR004797 [H]

Pfam domain/function: PF03772 Competence; PF00753 Lactamase_B [H]

EC number: NA

Molecular weight: Translated: 34028; Mature: 34028

Theoretical pI: Translated: 7.06; Mature: 7.06

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRKIVLKDILFLVTTLSIIVILLLVTNITANSKIKSTSETYLKSDKNSVSQNGIQSNTKN
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHCCCHHHHHCCCCCCCCC
TAFKTTILSTGKSDCILVEIGNKVIMIDTGEDKNGKQIVDRLKEKGINTLDYLILTHLDK
CEEEEEEEECCCCCEEEEEECCEEEEEECCCCCCHHHHHHHHHHCCCCHHHHHHHHHCCC
DHIGGVDSVLSSVKVKNIIQANYKKDSKQYDEYIDSLKKADIEPVLLKDNMNIVINSAEI
HHCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCEEEEECCCEEEEEEEEE
NIHPASKSKYESSNDYSIITNISYGAYKFLFAGDAEEERLSEFINGNTLKYDFVKMPHHG
EEECCCCCCCCCCCCEEEEEECCCCCEEEEEECCCCHHHHHHHHCCCCEEEEEEECCCCC
RYDKLTETFLESISPQYAVITCSEKKEPEEGVLKILERLNIKTFLTSNGEVVINSDGKTL
CHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHCCCEEEEECCCEEEEECCCCEE
SVNQ
ECCC
>Mature Secondary Structure
MRKIVLKDILFLVTTLSIIVILLLVTNITANSKIKSTSETYLKSDKNSVSQNGIQSNTKN
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHCCCHHHHHCCCCCCCCC
TAFKTTILSTGKSDCILVEIGNKVIMIDTGEDKNGKQIVDRLKEKGINTLDYLILTHLDK
CEEEEEEEECCCCCEEEEEECCEEEEEECCCCCCHHHHHHHHHHCCCCHHHHHHHHHCCC
DHIGGVDSVLSSVKVKNIIQANYKKDSKQYDEYIDSLKKADIEPVLLKDNMNIVINSAEI
HHCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCEEEEECCCEEEEEEEEE
NIHPASKSKYESSNDYSIITNISYGAYKFLFAGDAEEERLSEFINGNTLKYDFVKMPHHG
EEECCCCCCCCCCCCEEEEEECCCCCEEEEEECCCCHHHHHHHHCCCCEEEEEEECCCCC
RYDKLTETFLESISPQYAVITCSEKKEPEEGVLKILERLNIKTFLTSNGEVVINSDGKTL
CHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHCCCEEEEECCCEEEEECCCCEE
SVNQ
ECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7968523; 8969508; 9384377 [H]