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The map label for this gene is purH [H]

Identifier: 126698421

GI number: 126698421

Start: 1016637

End: 1017812

Strand: Direct

Name: purH [H]

Synonym: CD0841

Alternate gene names: 126698421

Gene position: 1016637-1017812 (Clockwise)

Preceding gene: 126698420

Following gene: 126698422

Centisome position: 23.7

GC content: 32.48

Gene sequence:

>1176_bases
ATGGCAAGAGAACTAGAATTAAAGTATGGCTGTAATCCAAATCAAAAACCATCAAAGATTTATATGAAGAATGGAGAACT
TCCTATAGAGGTATTAAATGGAAAACCTGGATACATAAATTTTTTAGATGCATTTAATAGTTGGCAACTTGTGAAGGAAT
TAAAAGAAGCTACAGGTCTTCCAGCAGCAACTTCATTTAAACATGTAAGTCCAGCAGGAGCAGCAGTAGGGGTACCTTTA
TCAGATACTTTAAAGCAAATATATTTTGTTGATGATTTAGAGCTTTCTCCATTAGCTTGTGCTTATGCAATGGCAAGAGG
AGCAGATAGAATGTCTTCTTATGGCGATTTTATAGCACTTTCAGATGTATGTGATAAGGAGACTGCAACTATTATAGCAA
GAGAGGTTTCTGATGGTATAATAGCTCCAGGATATACAGAGGAAGCCCTTGAAATATTAAAAGGAAAGCGTAAAGGTAAC
TATAATATTGTAAAAATAGATGAAAATTATACTCCTGAACCTATTGAAACAAAGGATGTTTATGGAATTACTTTTGAACA
AGGTAGAAATGAAATATTAATAAATGAAGACCTATTAAAAGATATTCCAACTGATAATAAAATTTTTACAGATAGTGCAA
AACGTGATTTAATTATAGCTCTTATTACATTAAAATATACACAATCAAATTCTGTTTGTTATGCTAAAGATGGACAAGTA
ATAGGGGTAGGTGCAGGTCAACAATCACGTATTCATTGTACTAGACTTGCAGGTAACAAAGCTGATACTTGGTATCTTCG
TCAACATCCTAAAGTATTAAACTTAAAATTTAAAAAGGATATAGGTCGTCCAGATAGAGATAACACTATTGATGTATATC
TTTCTGATGATTATATGGATGTGCTTGCTGATGGCATATGGCAAAACTTTTTTGAAGAAAAACCAGAGCCTCTAACTGGA
GAAGGAAAAAGAGCATGGCTTAAAACTTTAACAGGAGTAGCACTTGGTTCAGATGCATTTTTCCCATTTGGAGATAATAT
AGAACGTGCAAAAAGAAGTGGAGTAAGTTTTATAGCACAACCAGGTGGTTCTATTCGTGATGATAATGTTATATTAACTT
GTAATAAGTATAACATAGTCATGGCATTTACTAAAAATAGATTATTCCATCATTAA

Upstream 100 bases:

>100_bases
AATGGATAAATATGCCATATAATTTTATTAGTACGAATAATTTAATTAATATAGGATTAATCAAACTTATGATTAATTTA
TTATAGAGAGGGATGAGTAT

Downstream 100 bases:

>100_bases
AATACTGAAAGTATAAAGATAATATAGATTAAGTAAAAATCTACAACAAGTTTTGTTGTAGATTTTTTTATTTGCTGTAT
AATTTTAAATAGAACTTTAT

Product: 5-aminoimidazole-4-carboxamide ribonucleotide transformylase

Products: NA

Alternate protein names: Phosphoribosylaminoimidazolecarboxamide formyltransferase; AICAR transformylase; IMP cyclohydrolase; ATIC; IMP synthase; Inosinicase [H]

Number of amino acids: Translated: 391; Mature: 390

Protein sequence:

>391_residues
MARELELKYGCNPNQKPSKIYMKNGELPIEVLNGKPGYINFLDAFNSWQLVKELKEATGLPAATSFKHVSPAGAAVGVPL
SDTLKQIYFVDDLELSPLACAYAMARGADRMSSYGDFIALSDVCDKETATIIAREVSDGIIAPGYTEEALEILKGKRKGN
YNIVKIDENYTPEPIETKDVYGITFEQGRNEILINEDLLKDIPTDNKIFTDSAKRDLIIALITLKYTQSNSVCYAKDGQV
IGVGAGQQSRIHCTRLAGNKADTWYLRQHPKVLNLKFKKDIGRPDRDNTIDVYLSDDYMDVLADGIWQNFFEEKPEPLTG
EGKRAWLKTLTGVALGSDAFFPFGDNIERAKRSGVSFIAQPGGSIRDDNVILTCNKYNIVMAFTKNRLFHH

Sequences:

>Translated_391_residues
MARELELKYGCNPNQKPSKIYMKNGELPIEVLNGKPGYINFLDAFNSWQLVKELKEATGLPAATSFKHVSPAGAAVGVPL
SDTLKQIYFVDDLELSPLACAYAMARGADRMSSYGDFIALSDVCDKETATIIAREVSDGIIAPGYTEEALEILKGKRKGN
YNIVKIDENYTPEPIETKDVYGITFEQGRNEILINEDLLKDIPTDNKIFTDSAKRDLIIALITLKYTQSNSVCYAKDGQV
IGVGAGQQSRIHCTRLAGNKADTWYLRQHPKVLNLKFKKDIGRPDRDNTIDVYLSDDYMDVLADGIWQNFFEEKPEPLTG
EGKRAWLKTLTGVALGSDAFFPFGDNIERAKRSGVSFIAQPGGSIRDDNVILTCNKYNIVMAFTKNRLFHH
>Mature_390_residues
ARELELKYGCNPNQKPSKIYMKNGELPIEVLNGKPGYINFLDAFNSWQLVKELKEATGLPAATSFKHVSPAGAAVGVPLS
DTLKQIYFVDDLELSPLACAYAMARGADRMSSYGDFIALSDVCDKETATIIAREVSDGIIAPGYTEEALEILKGKRKGNY
NIVKIDENYTPEPIETKDVYGITFEQGRNEILINEDLLKDIPTDNKIFTDSAKRDLIIALITLKYTQSNSVCYAKDGQVI
GVGAGQQSRIHCTRLAGNKADTWYLRQHPKVLNLKFKKDIGRPDRDNTIDVYLSDDYMDVLADGIWQNFFEEKPEPLTGE
GKRAWLKTLTGVALGSDAFFPFGDNIERAKRSGVSFIAQPGGSIRDDNVILTCNKYNIVMAFTKNRLFHH

Specific function: De novo purine biosynthesis; ninth step. De novo purine biosynthesis; tenth step. [C]

COG id: COG0138

COG function: function code F; AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purH family [H]

Homologues:

Organism=Homo sapiens, GI20127454, Length=390, Percent_Identity=56.4102564102564, Blast_Score=464, Evalue=1e-131,
Organism=Escherichia coli, GI1790439, Length=271, Percent_Identity=29.1512915129151, Blast_Score=92, Evalue=6e-20,
Organism=Caenorhabditis elegans, GI71985564, Length=394, Percent_Identity=52.7918781725888, Blast_Score=401, Evalue=1e-112,
Organism=Caenorhabditis elegans, GI71985556, Length=420, Percent_Identity=47.1428571428571, Blast_Score=379, Evalue=1e-105,
Organism=Caenorhabditis elegans, GI71985574, Length=298, Percent_Identity=55.7046979865772, Blast_Score=309, Evalue=1e-84,
Organism=Saccharomyces cerevisiae, GI6323056, Length=390, Percent_Identity=57.1794871794872, Blast_Score=469, Evalue=1e-133,
Organism=Saccharomyces cerevisiae, GI6323768, Length=391, Percent_Identity=56.5217391304348, Blast_Score=462, Evalue=1e-131,
Organism=Drosophila melanogaster, GI24649832, Length=390, Percent_Identity=58.2051282051282, Blast_Score=475, Evalue=1e-134,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 640 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002695
- InterPro:   IPR013982
- InterPro:   IPR016193
- InterPro:   IPR011607 [H]

Pfam domain/function: PF01808 AICARFT_IMPCHas; PF02142 MGS [H]

EC number: =2.1.2.3; =3.5.4.10 [H]

Molecular weight: Translated: 43570; Mature: 43439

Theoretical pI: Translated: 5.79; Mature: 5.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARELELKYGCNPNQKPSKIYMKNGELPIEVLNGKPGYINFLDAFNSWQLVKELKEATGL
CCCEEEEEECCCCCCCCCEEEEECCCCEEEEECCCCCEEEHHHHCCHHHHHHHHHHHCCC
PAATSFKHVSPAGAAVGVPLSDTLKQIYFVDDLELSPLACAYAMARGADRMSSYGDFIAL
CCCCCCCCCCCCCCEECCCHHHHHHHEEEECCCCCCHHHHHHHHHHCHHHHHHCCCEEEE
SDVCDKETATIIAREVSDGIIAPGYTEEALEILKGKRKGNYNIVKIDENYTPEPIETKDV
HHHCCCHHHEEEEEHHCCCCCCCCCCHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCE
YGITFEQGRNEILINEDLLKDIPTDNKIFTDSAKRDLIIALITLKYTQSNSVCYAKDGQV
EEEEEECCCCEEEECHHHHHHCCCCCEEECCCCCCCEEEEEEEEEEECCCCEEEECCCCE
IGVGAGQQSRIHCTRLAGNKADTWYLRQHPKVLNLKFKKDIGRPDRDNTIDVYLSDDYMD
EEECCCCCCCEEEEEECCCCCCEEEEECCCEEEEEEEHHHCCCCCCCCEEEEEECCCHHH
VLADGIWQNFFEEKPEPLTGEGKRAWLKTLTGVALGSDAFFPFGDNIERAKRSGVSFIAQ
HHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHEECCCCCCCCCCCHHHHHHCCCEEEEC
PGGSIRDDNVILTCNKYNIVMAFTKNRLFHH
CCCCCCCCCEEEEECCEEEEEEEECCCCCCC
>Mature Secondary Structure 
ARELELKYGCNPNQKPSKIYMKNGELPIEVLNGKPGYINFLDAFNSWQLVKELKEATGL
CCEEEEEECCCCCCCCCEEEEECCCCEEEEECCCCCEEEHHHHCCHHHHHHHHHHHCCC
PAATSFKHVSPAGAAVGVPLSDTLKQIYFVDDLELSPLACAYAMARGADRMSSYGDFIAL
CCCCCCCCCCCCCCEECCCHHHHHHHEEEECCCCCCHHHHHHHHHHCHHHHHHCCCEEEE
SDVCDKETATIIAREVSDGIIAPGYTEEALEILKGKRKGNYNIVKIDENYTPEPIETKDV
HHHCCCHHHEEEEEHHCCCCCCCCCCHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCE
YGITFEQGRNEILINEDLLKDIPTDNKIFTDSAKRDLIIALITLKYTQSNSVCYAKDGQV
EEEEEECCCCEEEECHHHHHHCCCCCEEECCCCCCCEEEEEEEEEEECCCCEEEECCCCE
IGVGAGQQSRIHCTRLAGNKADTWYLRQHPKVLNLKFKKDIGRPDRDNTIDVYLSDDYMD
EEECCCCCCCEEEEEECCCCCCEEEEECCCEEEEEEEHHHCCCCCCCCEEEEEECCCHHH
VLADGIWQNFFEEKPEPLTGEGKRAWLKTLTGVALGSDAFFPFGDNIERAKRSGVSFIAQ
HHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHEECCCCCCCCCCCHHHHHHCCCEEEEC
PGGSIRDDNVILTCNKYNIVMAFTKNRLFHH
CCCCCCCCCEEEEECCEEEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA