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The map label for this gene is yitJ [H]

Identifier: 126698302

GI number: 126698302

Start: 883669

End: 884550

Strand: Direct

Name: yitJ [H]

Synonym: CD0722

Alternate gene names: 126698302

Gene position: 883669-884550 (Clockwise)

Preceding gene: 126698301

Following gene: 126698303

Centisome position: 20.6

GC content: 36.39

Gene sequence:

>882_bases
ATGAGCTTATTAAGAGAAACATTAGAAAGTGGAAAATTTGCAGTTACTACTGAAATGGCTCCTCCAAAAGGGACTGACCT
TTCACATTTAATAGAATGTGCAAAGCCGTTAGTTGGAAGAGTTCATGCAGCAAATGTAACAGACTTTCAATCGGCAGTTA
TGAGAGCAACTTCTCTTGCTACATGTAAATTATTAAAAGATGCTGGATTAGAGCCAGTTATTCAAATAACAGGGAGAGAT
AGAAATAGAATAGCTATACAAGGAGAAATGTTGTCAGCAGGTGTATTTGGGATAAACAATCTGTTGGCACTAACAGGAGA
CCATACTAGCGTAGGAGACCATCCACAAGCTAAGGGAGTGTTTGATTTAGATTCTGTGGGGATACTTCAAACTGCTGAGA
CTTTAATGGCAGGTACGGACATGGCTGGTAATAAGTTAAAAGGTTCTCCAGATTTTTATCTAGGAGCATCAGTAACTCCA
GAATATTCTCCAATAGAAGTTCAATTATTAAAAATGAAAAAGAAAATAAAAGCAGGGGCTAAATTTTTCCAAACACAAGC
ACTTTATGACATAAATACAATGAGAAAGTTTAGAGAATTAACAAGGGATATGGATTGCAAGGTATTAGCAGGAATAGTAC
CTTTAAAATCACCAGGAATGGCTAAATTTATGACTGCAAATGTACCAGGAATATTTGTTCCAGATGAACAAATCGAAAGA
TTAAGAGCAGCTGGAAAAGAAAACTGGGTAAGTGAAGGAATAAAAATGGCAGGGGAACTTATCAAACAATTAAAAGAAGA
AGATTTATGTGATGGTGTTCATATAATGGCAATTGGGGCAGAAGAGAATATACCTGCTATACTGGATGCCGCAGGTTTAT
AG

Upstream 100 bases:

>100_bases
CTAAGCAAAATAATCCAAGAAGTTTAAGTGCAAAGAAAAAGAAAGAAGCAGCAGCAAATTCATAAAAGTTTTTTTTAGAA
GGTTAAAAGGGGGATTAGAG

Downstream 100 bases:

>100_bases
TATTGCAAGATTGTAGATTATATTAGGTTTGGGGGAATTAAAGATGAAGATAGTAGTAGTAGGTGGTGGACCAGGAGGAT
ATGTAGCAGCTATAAAAGCT

Product: methylenetetrahydrofolate reductase

Products: NA

Alternate protein names: Homocysteine S-methyltransferase; S-methylmethionine:homocysteine methyltransferase; 5,10-methylenetetrahydrofolate reductase [H]

Number of amino acids: Translated: 293; Mature: 292

Protein sequence:

>293_residues
MSLLRETLESGKFAVTTEMAPPKGTDLSHLIECAKPLVGRVHAANVTDFQSAVMRATSLATCKLLKDAGLEPVIQITGRD
RNRIAIQGEMLSAGVFGINNLLALTGDHTSVGDHPQAKGVFDLDSVGILQTAETLMAGTDMAGNKLKGSPDFYLGASVTP
EYSPIEVQLLKMKKKIKAGAKFFQTQALYDINTMRKFRELTRDMDCKVLAGIVPLKSPGMAKFMTANVPGIFVPDEQIER
LRAAGKENWVSEGIKMAGELIKQLKEEDLCDGVHIMAIGAEENIPAILDAAGL

Sequences:

>Translated_293_residues
MSLLRETLESGKFAVTTEMAPPKGTDLSHLIECAKPLVGRVHAANVTDFQSAVMRATSLATCKLLKDAGLEPVIQITGRD
RNRIAIQGEMLSAGVFGINNLLALTGDHTSVGDHPQAKGVFDLDSVGILQTAETLMAGTDMAGNKLKGSPDFYLGASVTP
EYSPIEVQLLKMKKKIKAGAKFFQTQALYDINTMRKFRELTRDMDCKVLAGIVPLKSPGMAKFMTANVPGIFVPDEQIER
LRAAGKENWVSEGIKMAGELIKQLKEEDLCDGVHIMAIGAEENIPAILDAAGL
>Mature_292_residues
SLLRETLESGKFAVTTEMAPPKGTDLSHLIECAKPLVGRVHAANVTDFQSAVMRATSLATCKLLKDAGLEPVIQITGRDR
NRIAIQGEMLSAGVFGINNLLALTGDHTSVGDHPQAKGVFDLDSVGILQTAETLMAGTDMAGNKLKGSPDFYLGASVTPE
YSPIEVQLLKMKKKIKAGAKFFQTQALYDINTMRKFRELTRDMDCKVLAGIVPLKSPGMAKFMTANVPGIFVPDEQIERL
RAAGKENWVSEGIKMAGELIKQLKEEDLCDGVHIMAIGAEENIPAILDAAGL

Specific function: Methionine biosynthesis. [C]

COG id: COG0685

COG function: function code E; 5,10-methylenetetrahydrofolate reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Hcy-binding domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003171
- InterPro:   IPR003726 [H]

Pfam domain/function: PF02219 MTHFR; PF02574 S-methyl_trans [H]

EC number: =2.1.1.10; =1.5.1.20 [H]

Molecular weight: Translated: 31569; Mature: 31438

Theoretical pI: Translated: 6.37; Mature: 6.37

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLLRETLESGKFAVTTEMAPPKGTDLSHLIECAKPLVGRVHAANVTDFQSAVMRATSLA
CHHHHHHHHCCCEEEEECCCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHH
TCKLLKDAGLEPVIQITGRDRNRIAIQGEMLSAGVFGINNLLALTGDHTSVGDHPQAKGV
HHHHHHHCCCCEEEEEECCCCCEEEEECCCHHCCHHHHCCEEEEECCCCCCCCCCCCCCC
FDLDSVGILQTAETLMAGTDMAGNKLKGSPDFYLGASVTPEYSPIEVQLLKMKKKIKAGA
CCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHH
KFFQTQALYDINTMRKFRELTRDMDCKVLAGIVPLKSPGMAKFMTANVPGIFVPDEQIER
HHHHHHHHHHHHHHHHHHHHHHCCCCEEHHCCCCCCCCCCCEEEECCCCEEECCHHHHHH
LRAAGKENWVSEGIKMAGELIKQLKEEDLCDGVHIMAIGAEENIPAILDAAGL
HHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHCCCC
>Mature Secondary Structure 
SLLRETLESGKFAVTTEMAPPKGTDLSHLIECAKPLVGRVHAANVTDFQSAVMRATSLA
HHHHHHHHCCCEEEEECCCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHH
TCKLLKDAGLEPVIQITGRDRNRIAIQGEMLSAGVFGINNLLALTGDHTSVGDHPQAKGV
HHHHHHHCCCCEEEEEECCCCCEEEEECCCHHCCHHHHCCEEEEECCCCCCCCCCCCCCC
FDLDSVGILQTAETLMAGTDMAGNKLKGSPDFYLGASVTPEYSPIEVQLLKMKKKIKAGA
CCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHH
KFFQTQALYDINTMRKFRELTRDMDCKVLAGIVPLKSPGMAKFMTANVPGIFVPDEQIER
HHHHHHHHHHHHHHHHHHHHHHCCCCEEHHCCCCCCCCCCCEEEECCCCEEECCHHHHHH
LRAAGKENWVSEGIKMAGELIKQLKEEDLCDGVHIMAIGAEENIPAILDAAGL
HHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9353932; 9384377 [H]