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The map label for this gene is fhs

Identifier: 126698298

GI number: 126698298

Start: 879545

End: 881221

Strand: Direct

Name: fhs

Synonym: CD0718

Alternate gene names: 126698298

Gene position: 879545-881221 (Clockwise)

Preceding gene: 126698297

Following gene: 126698299

Centisome position: 20.5

GC content: 35.3

Gene sequence:

>1677_bases
ATGGGATTTAAATCTGACATTGAAATAGCTCAAGAAGCTAAGCCTCAAGATATTAGAGAGGTTGCAAAAAAATTAGGACT
AGGTGAAGATGATGTAGAACTTTATGGTAAATACAAAGCAAAAGTTGACTACAATCTACTAAAAAGAGAGACTGGTAAAA
AAGCTAAGTTAATACTAACTACAGCTATAAACCCAACTCCAGCAGGTGAAGGAAAAACTACTACTACTATAGGTGTTGCT
GATGCATTTGCTAAACTAGACAAAAATGTATTAGTTGCTTTAAGAGAACCATCTCTAGGACCAGTATTTGGTGTTAAAGG
TGGAGCAGCTGGTGGAGGATATGCACAAGTTGTTCCTATGGAAGATATAAACTTACACTTCACAGGAGATTTTCACGCTA
TAGGAGCTGCTAACAATCTTTTAGCTGCTATGCTTGATAACCATATTCACCAAGGAAATGCACTTAGAATAGACCCTAAG
AAAATAACTTGGAGAAGATGTGTAGACATGAACGATAGACAACTTAGAAATATCGTTGATGGTATGGGTAAAAAAGGTGA
TGGAGCAGTTAGACAAGATGGATTCGATATAACTGTTGCTTCTGAAATAATGGCAGCGTTCTGTTTGGCAAGTGATATAT
CTGATTTAAAAGAAAGATTAGGAAACATAATAGTTGGATACAGCTACGAAGGTGAACCTGTAACAGCTAGACAATTAAAA
GCTAATGGTGCTATGGCTGCATTATTAAAAGATGCTTTAAAACCAAACCTAGTTCAAACTCTTGAAGGAACACCATCATT
TGTACACGGTGGACCATTCGCAAATATAGCTCATGGATGTAACTCTGTTATAGCTACAAGAATGGCTATGCACTTTGCAG
ATTATGTAATAACTGAGGCTGGTTTCGGTGCTGACCTTGGAGCAGAAAAATTCTTAGATATAAAATGTAGAATGGCAAAC
TTAAAACCAGATGCTGTTATAATAGTTGCTACTGTAAGAGCATTAAAATACAATGGTGGAGTTGCTAAAGCAGACTTAAA
TAACGAAAACCTAGAAGCTCTTGAAAAAGGACTTCCAAACTTATTAAAACATGTTGAAAACATAACTCAAGTATATGGAT
TACCAGCAGTTGTTGCAATCAACAGATTCCCACTTGATACTGAAGCTGAACTTAAACTTGTTGAAGACAAGTGTAAGGAA
TTAGGTGTTAATGTTGCTCTTTCTGAAGTATGGGCAAAAGGTGGAGAAGGTGGAATTGCAGTAGCTAAAGAAGTTTTAAG
ATTATTGGATGAAGAAGAAAATAACTTTAGATTCTGCTATGAAGATGATTTATCTATAAAAGACAAGATAAATGCTATAG
CTACTAAGATTTATGGAGCAGATGGTGTAGATTATACTCCTGAAGCTGATAAGGAAATAGCTAACTTAGAAAAACTTGGA
TTTACTAAAGTTCCAGTATGTATGGCTAAGACTCAATATTCTTTAACTGATGACCAAACTAAATTAGGTAGACCAACAGG
ATTTAGAATAACTGTAAGACAAGCAACAATTTCAGCAGGAGCTGGATTTATAGTTGCACTTACTGGAGAAATAATGAAGA
TGCCAGGATTACCAAAAGTTCCAGCAGCAGAAAAAATAGATGTTGATGAAAATGGAGTAATAGCTGGATTATTCTAA

Upstream 100 bases:

>100_bases
CATGTATAATTATCTTATAAAATATAATTTTTACATATTAATACAATTTTTACAAAAATTATATTTTAAATCTATTTAGG
TTGTGGGAGGAGATTCAGTT

Downstream 100 bases:

>100_bases
GGAAATTAATTTATAAATAAAGAGTAGGAGATATCTTAAAATAGTTCGTAAAATATCTCGAACAATTTGAGATATTTTCC
TACATCCTTTCAAGGAGGAT

Product: formate--tetrahydrofolate ligase

Products: NA

Alternate protein names: Formyltetrahydrofolate synthetase; FHS; FTHFS

Number of amino acids: Translated: 558; Mature: 557

Protein sequence:

>558_residues
MGFKSDIEIAQEAKPQDIREVAKKLGLGEDDVELYGKYKAKVDYNLLKRETGKKAKLILTTAINPTPAGEGKTTTTIGVA
DAFAKLDKNVLVALREPSLGPVFGVKGGAAGGGYAQVVPMEDINLHFTGDFHAIGAANNLLAAMLDNHIHQGNALRIDPK
KITWRRCVDMNDRQLRNIVDGMGKKGDGAVRQDGFDITVASEIMAAFCLASDISDLKERLGNIIVGYSYEGEPVTARQLK
ANGAMAALLKDALKPNLVQTLEGTPSFVHGGPFANIAHGCNSVIATRMAMHFADYVITEAGFGADLGAEKFLDIKCRMAN
LKPDAVIIVATVRALKYNGGVAKADLNNENLEALEKGLPNLLKHVENITQVYGLPAVVAINRFPLDTEAELKLVEDKCKE
LGVNVALSEVWAKGGEGGIAVAKEVLRLLDEEENNFRFCYEDDLSIKDKINAIATKIYGADGVDYTPEADKEIANLEKLG
FTKVPVCMAKTQYSLTDDQTKLGRPTGFRITVRQATISAGAGFIVALTGEIMKMPGLPKVPAAEKIDVDENGVIAGLF

Sequences:

>Translated_558_residues
MGFKSDIEIAQEAKPQDIREVAKKLGLGEDDVELYGKYKAKVDYNLLKRETGKKAKLILTTAINPTPAGEGKTTTTIGVA
DAFAKLDKNVLVALREPSLGPVFGVKGGAAGGGYAQVVPMEDINLHFTGDFHAIGAANNLLAAMLDNHIHQGNALRIDPK
KITWRRCVDMNDRQLRNIVDGMGKKGDGAVRQDGFDITVASEIMAAFCLASDISDLKERLGNIIVGYSYEGEPVTARQLK
ANGAMAALLKDALKPNLVQTLEGTPSFVHGGPFANIAHGCNSVIATRMAMHFADYVITEAGFGADLGAEKFLDIKCRMAN
LKPDAVIIVATVRALKYNGGVAKADLNNENLEALEKGLPNLLKHVENITQVYGLPAVVAINRFPLDTEAELKLVEDKCKE
LGVNVALSEVWAKGGEGGIAVAKEVLRLLDEEENNFRFCYEDDLSIKDKINAIATKIYGADGVDYTPEADKEIANLEKLG
FTKVPVCMAKTQYSLTDDQTKLGRPTGFRITVRQATISAGAGFIVALTGEIMKMPGLPKVPAAEKIDVDENGVIAGLF
>Mature_557_residues
GFKSDIEIAQEAKPQDIREVAKKLGLGEDDVELYGKYKAKVDYNLLKRETGKKAKLILTTAINPTPAGEGKTTTTIGVAD
AFAKLDKNVLVALREPSLGPVFGVKGGAAGGGYAQVVPMEDINLHFTGDFHAIGAANNLLAAMLDNHIHQGNALRIDPKK
ITWRRCVDMNDRQLRNIVDGMGKKGDGAVRQDGFDITVASEIMAAFCLASDISDLKERLGNIIVGYSYEGEPVTARQLKA
NGAMAALLKDALKPNLVQTLEGTPSFVHGGPFANIAHGCNSVIATRMAMHFADYVITEAGFGADLGAEKFLDIKCRMANL
KPDAVIIVATVRALKYNGGVAKADLNNENLEALEKGLPNLLKHVENITQVYGLPAVVAINRFPLDTEAELKLVEDKCKEL
GVNVALSEVWAKGGEGGIAVAKEVLRLLDEEENNFRFCYEDDLSIKDKINAIATKIYGADGVDYTPEADKEIANLEKLGF
TKVPVCMAKTQYSLTDDQTKLGRPTGFRITVRQATISAGAGFIVALTGEIMKMPGLPKVPAAEKIDVDENGVIAGLF

Specific function: Unknown

COG id: COG2759

COG function: function code F; Formyltetrahydrofolate synthetase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the formate--tetrahydrofolate ligase family

Homologues:

Organism=Homo sapiens, GI222136639, Length=621, Percent_Identity=44.7665056360709, Blast_Score=474, Evalue=1e-134,
Organism=Homo sapiens, GI36796743, Length=620, Percent_Identity=44.0322580645161, Blast_Score=448, Evalue=1e-126,
Organism=Homo sapiens, GI310124614, Length=86, Percent_Identity=41.8604651162791, Blast_Score=71, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17568737, Length=623, Percent_Identity=43.4991974317817, Blast_Score=470, Evalue=1e-132,
Organism=Caenorhabditis elegans, GI17568739, Length=623, Percent_Identity=43.4991974317817, Blast_Score=470, Evalue=1e-132,
Organism=Saccharomyces cerevisiae, GI6319558, Length=632, Percent_Identity=42.5632911392405, Blast_Score=461, Evalue=1e-130,
Organism=Saccharomyces cerevisiae, GI6321643, Length=627, Percent_Identity=42.7432216905901, Blast_Score=452, Evalue=1e-128,
Organism=Drosophila melanogaster, GI62472483, Length=620, Percent_Identity=44.8387096774194, Blast_Score=483, Evalue=1e-136,
Organism=Drosophila melanogaster, GI45551871, Length=620, Percent_Identity=44.8387096774194, Blast_Score=483, Evalue=1e-136,
Organism=Drosophila melanogaster, GI24645718, Length=620, Percent_Identity=44.8387096774194, Blast_Score=482, Evalue=1e-136,
Organism=Drosophila melanogaster, GI17137370, Length=620, Percent_Identity=44.8387096774194, Blast_Score=482, Evalue=1e-136,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FTHS_CLOD6 (Q189R2)

Other databases:

- EMBL:   AM180355
- RefSeq:   YP_001087195.1
- ProteinModelPortal:   Q189R2
- SMR:   Q189R2
- STRING:   Q189R2
- GeneID:   4916827
- GenomeReviews:   AM180355_GR
- KEGG:   cdf:CD0718
- NMPDR:   fig|1496.1.peg.1932
- eggNOG:   COG2759
- HOGENOM:   HBG677721
- OMA:   KMPGLPK
- ProtClustDB:   PRK13505
- HAMAP:   MF_01543
- InterPro:   IPR000559
- InterPro:   IPR020628

Pfam domain/function: PF01268 FTHFS

EC number: =6.3.4.3

Molecular weight: Translated: 59987; Mature: 59855

Theoretical pI: Translated: 5.60; Mature: 5.60

Prosite motif: PS00721 FTHFS_1; PS00722 FTHFS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGFKSDIEIAQEAKPQDIREVAKKLGLGEDDVELYGKYKAKVDYNLLKRETGKKAKLILT
CCCCCCCHHHHCCCCHHHHHHHHHCCCCCCCHHEEEEEEEEECHHHHHHCCCCCEEEEEE
TAINPTPAGEGKTTTTIGVADAFAKLDKNVLVALREPSLGPVFGVKGGAAGGGYAQVVPM
EECCCCCCCCCCCEEEEEHHHHHHHCCCCEEEEEECCCCCCEEECCCCCCCCCCEEEEEE
EDINLHFTGDFHAIGAANNLLAAMLDNHIHQGNALRIDPKKITWRRCVDMNDRQLRNIVD
CCCEEEEECCEEEECCHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHCCCCHHHHHHHHH
GMGKKGDGAVRQDGFDITVASEIMAAFCLASDISDLKERLGNIIVGYSYEGEPVTARQLK
HCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCHHHHH
ANGAMAALLKDALKPNLVQTLEGTPSFVHGGPFANIAHGCNSVIATRMAMHFADYVITEA
CCCHHHHHHHHHHCCCHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCC
GFGADLGAEKFLDIKCRMANLKPDAVIIVATVRALKYNGGVAKADLNNENLEALEKGLPN
CCCCCCCCCCEEEEEEEEECCCCCCEEEEEEEEHHEECCCEEEECCCCCHHHHHHHCHHH
LLKHVENITQVYGLPAVVAINRFPLDTEAELKLVEDKCKELGVNVALSEVWAKGGEGGIA
HHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHHHHHCCCCCEEHHHHHCCCCCCHH
VAKEVLRLLDEEENNFRFCYEDDLSIKDKINAIATKIYGADGVDYTPEADKEIANLEKLG
HHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHHEECCCCCCCCCCCHHHHHHHHHCC
FTKVPVCMAKTQYSLTDDQTKLGRPTGFRITVRQATISAGAGFIVALTGEIMKMPGLPKV
CCCCCCEEECCCCCCCCCHHHCCCCCCEEEEEEEEEECCCCCEEEEEECHHHHCCCCCCC
PAAEKIDVDENGVIAGLF
CCCCCCCCCCCCEEEECC
>Mature Secondary Structure 
GFKSDIEIAQEAKPQDIREVAKKLGLGEDDVELYGKYKAKVDYNLLKRETGKKAKLILT
CCCCCCHHHHCCCCHHHHHHHHHCCCCCCCHHEEEEEEEEECHHHHHHCCCCCEEEEEE
TAINPTPAGEGKTTTTIGVADAFAKLDKNVLVALREPSLGPVFGVKGGAAGGGYAQVVPM
EECCCCCCCCCCCEEEEEHHHHHHHCCCCEEEEEECCCCCCEEECCCCCCCCCCEEEEEE
EDINLHFTGDFHAIGAANNLLAAMLDNHIHQGNALRIDPKKITWRRCVDMNDRQLRNIVD
CCCEEEEECCEEEECCHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHCCCCHHHHHHHHH
GMGKKGDGAVRQDGFDITVASEIMAAFCLASDISDLKERLGNIIVGYSYEGEPVTARQLK
HCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCHHHHH
ANGAMAALLKDALKPNLVQTLEGTPSFVHGGPFANIAHGCNSVIATRMAMHFADYVITEA
CCCHHHHHHHHHHCCCHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCC
GFGADLGAEKFLDIKCRMANLKPDAVIIVATVRALKYNGGVAKADLNNENLEALEKGLPN
CCCCCCCCCCEEEEEEEEECCCCCCEEEEEEEEHHEECCCEEEECCCCCHHHHHHHCHHH
LLKHVENITQVYGLPAVVAINRFPLDTEAELKLVEDKCKELGVNVALSEVWAKGGEGGIA
HHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHHHHHCCCCCEEHHHHHCCCCCCHH
VAKEVLRLLDEEENNFRFCYEDDLSIKDKINAIATKIYGADGVDYTPEADKEIANLEKLG
HHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHHEECCCCCCCCCCCHHHHHHHHHCC
FTKVPVCMAKTQYSLTDDQTKLGRPTGFRITVRQATISAGAGFIVALTGEIMKMPGLPKV
CCCCCCEEECCCCCCCCCHHHCCCCCCEEEEEEEEEECCCCCEEEEEECHHHHCCCCCCC
PAAEKIDVDENGVIAGLF
CCCCCCCCCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA