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The map label for this gene is ycbM [H]

Identifier: 126698222

GI number: 126698222

Start: 766504

End: 767421

Strand: Direct

Name: ycbM [H]

Synonym: CD0644

Alternate gene names: 126698222

Gene position: 766504-767421 (Clockwise)

Preceding gene: 126698221

Following gene: 126698223

Centisome position: 17.87

GC content: 27.78

Gene sequence:

>918_bases
ATGGAGTTATTTTTAGTTGTAATTTCTATTGTACTATTTGCTCTCTACTTAAAAGAACGAAATAAATCAAAGAAAATGGA
AAGTGATTATAAGTATATCAATTCAAGACTTCGTGACATAACAAATGATGATGAAATTAATTATATTTTAGTACCATCTG
ATATTTCGATTGTAAAAGAAACGGCAGTAGATATAAATAAACTTCTTGAAAAGTTTTACAGTAGGCAAATTAATTATAAT
AGAAGTGAAAAAGCGATATTGCAAATATTTACAAACATATCACACGATTTACGAACTCCCATCACAGTATTAAAGGGTTA
TATTGAAATGCTATATCTTCAAAGTCAAAAAGAAGAATTATCTTCTTCAATGAGAGCAACTGTGGAAAAAATGCAAACAA
ATTCAAATGAGCTTGTTAATTCAATAAATAACCTGTTTAATATGGCAAAAATCCAATCTGGAGATATGATATTAAATCTT
CAAAAATCCAATCTAACACAATTATGTCATGAGATTATTTTAGAGTTTTATGATTTGCTAGATAAAGAAAACTTTAATGT
TGAAGTTAATATTGAAGATAGACCTATATATGCAAATGTTGACACAGAAGCATTACAACGTATACTCAAAAATTTAATTG
ATAATGCTATAAAATATGGTTCAGATGGTAGATTTTTAGGGATTTCACTATATGAAAAGGAAAAACATGTTTTTATAGAT
ATTGAGGATAAAGGTTCAGGTATTTCTGAAACTGAAAAAGAGCATATTTTCACAAGAGCTTATACTGCTGACAGAAAAAA
AGGCAATGGTTTAGGTTTGGCTATTTCTCAAGGGCTTGCAAACTCTATGGGAGGTTCAATTTATGTAAATAGTAGACCTA
ATGTAAAAACAGTTTTTACGGTAAAATTGAAAAGTTAG

Upstream 100 bases:

>100_bases
CTCATATTAACAGGTTAAGAAATAAATTGTCTGATGGTATGGAAAAAAATAATTATATTAAAACTCTTTGGGGAATTGGC
TACAAAATGGAGGAAGAATA

Downstream 100 bases:

>100_bases
AAAAAAGTTAGATTTAAAAGAGAGAAAAGATAATTTTATTTTGTATACTGTTTTTAGAAAGGAGGGAGTATGATGAACTA
TATCATAGAGACCCATCAAT

Product: two-component sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 305; Mature: 305

Protein sequence:

>305_residues
MELFLVVISIVLFALYLKERNKSKKMESDYKYINSRLRDITNDDEINYILVPSDISIVKETAVDINKLLEKFYSRQINYN
RSEKAILQIFTNISHDLRTPITVLKGYIEMLYLQSQKEELSSSMRATVEKMQTNSNELVNSINNLFNMAKIQSGDMILNL
QKSNLTQLCHEIILEFYDLLDKENFNVEVNIEDRPIYANVDTEALQRILKNLIDNAIKYGSDGRFLGISLYEKEKHVFID
IEDKGSGISETEKEHIFTRAYTADRKKGNGLGLAISQGLANSMGGSIYVNSRPNVKTVFTVKLKS

Sequences:

>Translated_305_residues
MELFLVVISIVLFALYLKERNKSKKMESDYKYINSRLRDITNDDEINYILVPSDISIVKETAVDINKLLEKFYSRQINYN
RSEKAILQIFTNISHDLRTPITVLKGYIEMLYLQSQKEELSSSMRATVEKMQTNSNELVNSINNLFNMAKIQSGDMILNL
QKSNLTQLCHEIILEFYDLLDKENFNVEVNIEDRPIYANVDTEALQRILKNLIDNAIKYGSDGRFLGISLYEKEKHVFID
IEDKGSGISETEKEHIFTRAYTADRKKGNGLGLAISQGLANSMGGSIYVNSRPNVKTVFTVKLKS
>Mature_305_residues
MELFLVVISIVLFALYLKERNKSKKMESDYKYINSRLRDITNDDEINYILVPSDISIVKETAVDINKLLEKFYSRQINYN
RSEKAILQIFTNISHDLRTPITVLKGYIEMLYLQSQKEELSSSMRATVEKMQTNSNELVNSINNLFNMAKIQSGDMILNL
QKSNLTQLCHEIILEFYDLLDKENFNVEVNIEDRPIYANVDTEALQRILKNLIDNAIKYGSDGRFLGISLYEKEKHVFID
IEDKGSGISETEKEHIFTRAYTADRKKGNGLGLAISQGLANSMGGSIYVNSRPNVKTVFTVKLKS

Specific function: Member of the two-component regulatory system ycbM/ycbL. Probably activates ycbL by phosphorylation [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1786912, Length=222, Percent_Identity=31.5315315315315, Blast_Score=102, Evalue=3e-23,
Organism=Escherichia coli, GI1789149, Length=222, Percent_Identity=29.2792792792793, Blast_Score=95, Evalue=5e-21,
Organism=Escherichia coli, GI1788713, Length=280, Percent_Identity=27.1428571428571, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI145693157, Length=220, Percent_Identity=27.2727272727273, Blast_Score=85, Evalue=6e-18,
Organism=Escherichia coli, GI48994928, Length=234, Percent_Identity=27.3504273504274, Blast_Score=82, Evalue=3e-17,
Organism=Escherichia coli, GI1788549, Length=271, Percent_Identity=25.4612546125461, Blast_Score=75, Evalue=5e-15,
Organism=Escherichia coli, GI1788393, Length=246, Percent_Identity=22.7642276422764, Blast_Score=75, Evalue=6e-15,
Organism=Escherichia coli, GI1786600, Length=206, Percent_Identity=25.7281553398058, Blast_Score=75, Evalue=6e-15,
Organism=Escherichia coli, GI87081816, Length=258, Percent_Identity=23.2558139534884, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1786783, Length=299, Percent_Identity=22.0735785953177, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1787894, Length=209, Percent_Identity=25.3588516746411, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1788279, Length=207, Percent_Identity=30.9178743961353, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1790346, Length=220, Percent_Identity=26.3636363636364, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI1787374, Length=225, Percent_Identity=23.5555555555556, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1790551, Length=307, Percent_Identity=23.4527687296417, Blast_Score=65, Evalue=5e-12,
Organism=Escherichia coli, GI1790436, Length=237, Percent_Identity=24.8945147679325, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI87082128, Length=239, Percent_Identity=22.1757322175732, Blast_Score=63, Evalue=3e-11,
Organism=Escherichia coli, GI1789403, Length=283, Percent_Identity=21.9081272084806, Blast_Score=62, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 34993; Mature: 34993

Theoretical pI: Translated: 6.55; Mature: 6.55

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELFLVVISIVLFALYLKERNKSKKMESDYKYINSRLRDITNDDEINYILVPSDISIVKE
CHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCHHHHHH
TAVDINKLLEKFYSRQINYNRSEKAILQIFTNISHDLRTPITVLKGYIEMLYLQSQKEEL
HHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCHHHCCHHHHHHHHHHHHHHHHHHHHH
SSSMRATVEKMQTNSNELVNSINNLFNMAKIQSGDMILNLQKSNLTQLCHEIILEFYDLL
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCEEEEECHHHHHHHHHHHHHHHHHHH
DKENFNVEVNIEDRPIYANVDTEALQRILKNLIDNAIKYGSDGRFLGISLYEKEKHVFID
CCCCCEEEEEECCCCEEECCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCEEEEE
IEDKGSGISETEKEHIFTRAYTADRKKGNGLGLAISQGLANSMGGSIYVNSRPNVKTVFT
EECCCCCCCCHHHHHHHHHHHHCCCCCCCCCEEEEHHHHHHHCCCEEEECCCCCEEEEEE
VKLKS
EEECC
>Mature Secondary Structure
MELFLVVISIVLFALYLKERNKSKKMESDYKYINSRLRDITNDDEINYILVPSDISIVKE
CHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCHHHHHH
TAVDINKLLEKFYSRQINYNRSEKAILQIFTNISHDLRTPITVLKGYIEMLYLQSQKEEL
HHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCHHHCCHHHHHHHHHHHHHHHHHHHHH
SSSMRATVEKMQTNSNELVNSINNLFNMAKIQSGDMILNLQKSNLTQLCHEIILEFYDLL
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCEEEEECHHHHHHHHHHHHHHHHHHH
DKENFNVEVNIEDRPIYANVDTEALQRILKNLIDNAIKYGSDGRFLGISLYEKEKHVFID
CCCCCEEEEEECCCCEEECCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCEEEEE
IEDKGSGISETEKEHIFTRAYTADRKKGNGLGLAISQGLANSMGGSIYVNSRPNVKTVFT
EECCCCCCCCHHHHHHHHHHHHCCCCCCCCCEEEEHHHHHHHCCCEEEECCCCCEEEEEE
VKLKS
EEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7704254; 9384377 [H]