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The map label for this gene is thrS

Identifier: 126698152

GI number: 126698152

Start: 683462

End: 685381

Strand: Direct

Name: thrS

Synonym: CD0574

Alternate gene names: 126698152

Gene position: 683462-685381 (Clockwise)

Preceding gene: 126698151

Following gene: 126698153

Centisome position: 15.93

GC content: 31.98

Gene sequence:

>1920_bases
ATGATTAAAGTTGCTTTAAAAGATGGCTCAATAAAAGAATTTGAAAATGCTATTTCTGTTATGGATGTAGCTAAATCCAT
TAGTGAAGGATTAGCTAGAAATGTGGTAGCAGCGTCTGTGAACGGAGAGGTTGTAGGTCTGGACCACATTATAGATACTG
ATTGTGACTTGAATTTATTTAAGTTTGAAGATAAAGAAGGTAAGGAAGTTTTTAGACATACATCAGCGCATATATTAGCT
CAAGCTATAAAAAGACTTTACCCAGAAGCAAAGCTTGCTATAGGACCAAGTATAGAAAATGGATTCTACTATGATATAGA
TTTAGACCATAGATTAGTTCCAGAGGACCTAGAGAAAATAGAAGCTGAAATGAAAAAAATAGCTAAAGAAGATTTAAAAA
TAGAAAGATTTGAACTTCCTAGAAATGAAGCTTTAGAGCTTATGAAAGAACAAGGAGAAGACTATAAGGTAGAACTTATT
TCTGATTTACCTGAAAGTGAAATAATATCTTTCTACAAGCAAGGTGATTTTACTGATTTATGTAGAGGACCACATTTACC
ATCTACTAAAAAGGTAAAAGCTGTTAAATTACAAAGTGTAGCAGGTGCATATTGGCGTGGTGACGAAAATAATAAGATGC
TTCAAAGAATATATGGAACTTCTTTTGAGAAAAACAAAGACTTAGAAGAGTACTTACATTTACTAGAAGAAGCTAAAAAG
AGAGACCACAGAAAATTAGGTAAAGAATTAGGATTATTTATGATACCTGAAGAAGGTCCAGGATTCCCTATGTTTTTACC
AAAAGGTATGGAACTTAAAAATGAATTATTAAAATTCTGGAGAGAAATACACAGAAAAGCTGGATATATTGAGATAGAAT
CTCCAATCATATTAAATAGAAAATTATGGGAGACTTCAGGACACTGGTATCATTACAAAGAAAATATGTATACAGTTAAA
ATAGATGATGAGGATTATGCTATAAAACCTATGAACTGTCCTGGTGGATTAATTTACTATAACTCTCAACTACATTCATA
TAGAGATTTCCCAATGAGAGTTGCAGAGCTTGGTAGAGTTCATAGACATGAGTTATCTGGTGCATTACAAGGATTAATGA
GAGTTAGAGCATTTACTCAAGACGATTCACATATATTCATGTTACCAGAGCAAATTAAGGACGAAATAAAAGGAGTAGCT
AACTTAATAGATGGTATATACAAAACTTTTGGATTTGAATATAATTTAGAATTATCTACAAGACCAGAGAACTCTATGGG
AAGCGACGAAGAGTGGGAAGCAGCAGAAAATGGATTAAGAGAAGCTTTAGAAGAGTTAGGTCTACCATATACTATTAATG
AGGGTGATGGAGCATTCTATGGTCCTAAGATAGACTTCCATCTAAAAGATTGTTTAGGAAGAACTTGGCAATGTGGTACT
ATCCAATTAGATATGCAGCTTCCAAGACAATTTGATAATACTTATATTGGTCAAGATGGTGAAAAGCATAGACCAGTTAT
GATTCATAGGGTTGCTTTTGGTAGTATAGAAAGATTTATAGGTATATTAATAGAGCATTATGCTGGTAAATTCCCAGTTT
GGTTATCTCCAACTCAAGTTAAGATACTTCCTATATCTGATAAATTTATGGATTATGCAAATGAAGTTAAGAAAGAGTTA
TTTGATAAGGGTATAAGAGTTGAATTAGATGATAGAGCTGAAAAAATTGGATTTAAGATAAGAGAAGCTCAGCTTGAAAA
AGTGCCATACATGTTAATAGTAGGTGAAAAAGAAGTAGCTGATAATAATGTTTCTGTTAGATCAAGAGATAAAGGTGAAA
TAGGTAGTATTAAATTAGATGAATTTATAGCTAGTATTTCAAAAGAAATTGAATCAAGAGAAAGTATTATTCAAGACTAA

Upstream 100 bases:

>100_bases
AACTTGGGTGGAACCGCGAATTAATATCGTCCCAAACATATTTGGGGCGATTTTTTATTACAAAAAATCTAAAAATTATT
TCAATAAGGAGGAAAAAACA

Downstream 100 bases:

>100_bases
TATATAATATATTAGTAGCTAAGATATTGTTATATAAGATAAGTTTAATCAATATGTTGATATGTTGATGCATAGTGATT
AAATTTATGAAAAGATGAGT

Product: threonyl-tRNA synthetase

Products: NA

Alternate protein names: Threonine--tRNA ligase; ThrRS

Number of amino acids: Translated: 639; Mature: 639

Protein sequence:

>639_residues
MIKVALKDGSIKEFENAISVMDVAKSISEGLARNVVAASVNGEVVGLDHIIDTDCDLNLFKFEDKEGKEVFRHTSAHILA
QAIKRLYPEAKLAIGPSIENGFYYDIDLDHRLVPEDLEKIEAEMKKIAKEDLKIERFELPRNEALELMKEQGEDYKVELI
SDLPESEIISFYKQGDFTDLCRGPHLPSTKKVKAVKLQSVAGAYWRGDENNKMLQRIYGTSFEKNKDLEEYLHLLEEAKK
RDHRKLGKELGLFMIPEEGPGFPMFLPKGMELKNELLKFWREIHRKAGYIEIESPIILNRKLWETSGHWYHYKENMYTVK
IDDEDYAIKPMNCPGGLIYYNSQLHSYRDFPMRVAELGRVHRHELSGALQGLMRVRAFTQDDSHIFMLPEQIKDEIKGVA
NLIDGIYKTFGFEYNLELSTRPENSMGSDEEWEAAENGLREALEELGLPYTINEGDGAFYGPKIDFHLKDCLGRTWQCGT
IQLDMQLPRQFDNTYIGQDGEKHRPVMIHRVAFGSIERFIGILIEHYAGKFPVWLSPTQVKILPISDKFMDYANEVKKEL
FDKGIRVELDDRAEKIGFKIREAQLEKVPYMLIVGEKEVADNNVSVRSRDKGEIGSIKLDEFIASISKEIESRESIIQD

Sequences:

>Translated_639_residues
MIKVALKDGSIKEFENAISVMDVAKSISEGLARNVVAASVNGEVVGLDHIIDTDCDLNLFKFEDKEGKEVFRHTSAHILA
QAIKRLYPEAKLAIGPSIENGFYYDIDLDHRLVPEDLEKIEAEMKKIAKEDLKIERFELPRNEALELMKEQGEDYKVELI
SDLPESEIISFYKQGDFTDLCRGPHLPSTKKVKAVKLQSVAGAYWRGDENNKMLQRIYGTSFEKNKDLEEYLHLLEEAKK
RDHRKLGKELGLFMIPEEGPGFPMFLPKGMELKNELLKFWREIHRKAGYIEIESPIILNRKLWETSGHWYHYKENMYTVK
IDDEDYAIKPMNCPGGLIYYNSQLHSYRDFPMRVAELGRVHRHELSGALQGLMRVRAFTQDDSHIFMLPEQIKDEIKGVA
NLIDGIYKTFGFEYNLELSTRPENSMGSDEEWEAAENGLREALEELGLPYTINEGDGAFYGPKIDFHLKDCLGRTWQCGT
IQLDMQLPRQFDNTYIGQDGEKHRPVMIHRVAFGSIERFIGILIEHYAGKFPVWLSPTQVKILPISDKFMDYANEVKKEL
FDKGIRVELDDRAEKIGFKIREAQLEKVPYMLIVGEKEVADNNVSVRSRDKGEIGSIKLDEFIASISKEIESRESIIQD
>Mature_639_residues
MIKVALKDGSIKEFENAISVMDVAKSISEGLARNVVAASVNGEVVGLDHIIDTDCDLNLFKFEDKEGKEVFRHTSAHILA
QAIKRLYPEAKLAIGPSIENGFYYDIDLDHRLVPEDLEKIEAEMKKIAKEDLKIERFELPRNEALELMKEQGEDYKVELI
SDLPESEIISFYKQGDFTDLCRGPHLPSTKKVKAVKLQSVAGAYWRGDENNKMLQRIYGTSFEKNKDLEEYLHLLEEAKK
RDHRKLGKELGLFMIPEEGPGFPMFLPKGMELKNELLKFWREIHRKAGYIEIESPIILNRKLWETSGHWYHYKENMYTVK
IDDEDYAIKPMNCPGGLIYYNSQLHSYRDFPMRVAELGRVHRHELSGALQGLMRVRAFTQDDSHIFMLPEQIKDEIKGVA
NLIDGIYKTFGFEYNLELSTRPENSMGSDEEWEAAENGLREALEELGLPYTINEGDGAFYGPKIDFHLKDCLGRTWQCGT
IQLDMQLPRQFDNTYIGQDGEKHRPVMIHRVAFGSIERFIGILIEHYAGKFPVWLSPTQVKILPISDKFMDYANEVKKEL
FDKGIRVELDDRAEKIGFKIREAQLEKVPYMLIVGEKEVADNNVSVRSRDKGEIGSIKLDEFIASISKEIESRESIIQD

Specific function: Thrs Is Also A Translational Repressor Protein, It Controls The Translation Of Its Own Gene By Binding To Its mRNA. [C]

COG id: COG0441

COG function: function code J; Threonyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family

Homologues:

Organism=Homo sapiens, GI38202255, Length=640, Percent_Identity=44.21875, Blast_Score=551, Evalue=1e-156,
Organism=Homo sapiens, GI38570111, Length=621, Percent_Identity=44.7665056360709, Blast_Score=541, Evalue=1e-154,
Organism=Homo sapiens, GI20070344, Length=643, Percent_Identity=38.8802488335925, Blast_Score=461, Evalue=1e-130,
Organism=Escherichia coli, GI1788013, Length=635, Percent_Identity=48.503937007874, Blast_Score=639, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71984184, Length=631, Percent_Identity=43.7400950871632, Blast_Score=561, Evalue=1e-160,
Organism=Caenorhabditis elegans, GI71984192, Length=631, Percent_Identity=43.7400950871632, Blast_Score=560, Evalue=1e-160,
Organism=Saccharomyces cerevisiae, GI6322112, Length=649, Percent_Identity=41.2942989214176, Blast_Score=519, Evalue=1e-148,
Organism=Saccharomyces cerevisiae, GI6322654, Length=390, Percent_Identity=41.025641025641, Blast_Score=303, Evalue=5e-83,
Organism=Drosophila melanogaster, GI24583842, Length=630, Percent_Identity=46.031746031746, Blast_Score=583, Evalue=1e-166,
Organism=Drosophila melanogaster, GI28574141, Length=630, Percent_Identity=46.031746031746, Blast_Score=583, Evalue=1e-166,
Organism=Drosophila melanogaster, GI24583839, Length=630, Percent_Identity=46.031746031746, Blast_Score=583, Evalue=1e-166,
Organism=Drosophila melanogaster, GI24664387, Length=189, Percent_Identity=30.6878306878307, Blast_Score=75, Evalue=2e-13,

Paralogues:

None

Copy number: 700 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): SYT_CLOD6 (Q189B8)

Other databases:

- EMBL:   AM180355
- RefSeq:   YP_001087049.1
- ProteinModelPortal:   Q189B8
- SMR:   Q189B8
- STRING:   Q189B8
- GeneID:   4913359
- GenomeReviews:   AM180355_GR
- KEGG:   cdf:CD0574
- NMPDR:   fig|1496.1.peg.1602
- eggNOG:   COG0441
- HOGENOM:   HBG352811
- OMA:   GFEYEVE
- ProtClustDB:   PRK00413
- GO:   GO:0005737
- HAMAP:   MF_00184_B
- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR004154
- InterPro:   IPR012675
- InterPro:   IPR004095
- InterPro:   IPR012676
- InterPro:   IPR002320
- InterPro:   IPR018163
- InterPro:   IPR012947
- Gene3D:   G3DSA:3.40.50.800
- Gene3D:   G3DSA:3.10.20.30
- PRINTS:   PR01047
- SMART:   SM00863
- TIGRFAMs:   TIGR00418

Pfam domain/function: PF03129 HGTP_anticodon; PF02824 TGS; PF00587 tRNA-synt_2b; PF07973 tRNA_SAD; SSF52954 Anticodon_bd; SSF81271 TGS-like; SSF55186 Thr/Ala-tRNA-synth_IIc_edit

EC number: =6.1.1.3

Molecular weight: Translated: 73545; Mature: 73545

Theoretical pI: Translated: 5.12; Mature: 5.12

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKVALKDGSIKEFENAISVMDVAKSISEGLARNVVAASVNGEVVGLDHIIDTDCDLNLF
CEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCEEEEHHEECCCCCCEEE
KFEDKEGKEVFRHTSAHILAQAIKRLYPEAKLAIGPSIENGFYYDIDLDHRLVPEDLEKI
EECCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCEEEEECCCCCCCHHHHHHH
EAEMKKIAKEDLKIERFELPRNEALELMKEQGEDYKVELISDLPESEIISFYKQGDFTDL
HHHHHHHHHHCCCEEEECCCHHHHHHHHHHCCCCEEEEEHHCCCHHHHHHHHHCCCHHHH
CRGPHLPSTKKVKAVKLQSVAGAYWRGDENNKMLQRIYGTSFEKNKDLEEYLHLLEEAKK
HCCCCCCCCCCCHHEEHHHHCCHHCCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHH
RDHRKLGKELGLFMIPEEGPGFPMFLPKGMELKNELLKFWREIHRKAGYIEIESPIILNR
HHHHHHHHHCCEEEECCCCCCCCEECCCCCHHHHHHHHHHHHHHHHCCEEEECCCEEECC
KLWETSGHWYHYKENMYTVKIDDEDYAIKPMNCPGGLIYYNSQLHSYRDFPMRVAELGRV
HHCCCCCCEEEEECCEEEEEECCCCCEEEECCCCCCEEEECCCHHCCCCCHHHHHHHHHH
HRHELSGALQGLMRVRAFTQDDSHIFMLPEQIKDEIKGVANLIDGIYKTFGFEYNLELST
HHHHHHHHHHHHHHHHHHCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHCCEEEEEECC
RPENSMGSDEEWEAAENGLREALEELGLPYTINEGDGAFYGPKIDFHLKDCLGRTWQCGT
CCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEECCCCCEECCEEEEEHHHHCCCCCCCCE
IQLDMQLPRQFDNTYIGQDGEKHRPVMIHRVAFGSIERFIGILIEHYAGKFPVWLSPTQV
EEEEECCCHHHCCCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHCCCCCEEECCCEE
KILPISDKFMDYANEVKKELFDKGIRVELDDRAEKIGFKIREAQLEKVPYMLIVGEKEVA
EEEECCHHHHHHHHHHHHHHHCCCCEEEECCHHHHHCCHHHHHHHHHCCEEEEECCHHHC
DNNVSVRSRDKGEIGSIKLDEFIASISKEIESRESIIQD
CCCCEEECCCCCCCCCEEHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MIKVALKDGSIKEFENAISVMDVAKSISEGLARNVVAASVNGEVVGLDHIIDTDCDLNLF
CEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCEEEEHHEECCCCCCEEE
KFEDKEGKEVFRHTSAHILAQAIKRLYPEAKLAIGPSIENGFYYDIDLDHRLVPEDLEKI
EECCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCEEEEECCCCCCCHHHHHHH
EAEMKKIAKEDLKIERFELPRNEALELMKEQGEDYKVELISDLPESEIISFYKQGDFTDL
HHHHHHHHHHCCCEEEECCCHHHHHHHHHHCCCCEEEEEHHCCCHHHHHHHHHCCCHHHH
CRGPHLPSTKKVKAVKLQSVAGAYWRGDENNKMLQRIYGTSFEKNKDLEEYLHLLEEAKK
HCCCCCCCCCCCHHEEHHHHCCHHCCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHH
RDHRKLGKELGLFMIPEEGPGFPMFLPKGMELKNELLKFWREIHRKAGYIEIESPIILNR
HHHHHHHHHCCEEEECCCCCCCCEECCCCCHHHHHHHHHHHHHHHHCCEEEECCCEEECC
KLWETSGHWYHYKENMYTVKIDDEDYAIKPMNCPGGLIYYNSQLHSYRDFPMRVAELGRV
HHCCCCCCEEEEECCEEEEEECCCCCEEEECCCCCCEEEECCCHHCCCCCHHHHHHHHHH
HRHELSGALQGLMRVRAFTQDDSHIFMLPEQIKDEIKGVANLIDGIYKTFGFEYNLELST
HHHHHHHHHHHHHHHHHHCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHCCEEEEEECC
RPENSMGSDEEWEAAENGLREALEELGLPYTINEGDGAFYGPKIDFHLKDCLGRTWQCGT
CCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEECCCCCEECCEEEEEHHHHCCCCCCCCE
IQLDMQLPRQFDNTYIGQDGEKHRPVMIHRVAFGSIERFIGILIEHYAGKFPVWLSPTQV
EEEEECCCHHHCCCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHCCCCCEEECCCEE
KILPISDKFMDYANEVKKELFDKGIRVELDDRAEKIGFKIREAQLEKVPYMLIVGEKEVA
EEEECCHHHHHHHHHHHHHHHCCCCEEEECCHHHHHCCHHHHHHHHHCCEEEEECCHHHC
DNNVSVRSRDKGEIGSIKLDEFIASISKEIESRESIIQD
CCCCEEECCCCCCCCCEEHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA