Click here to switch to the map view.

The map label for this gene is sip2 [H]

Identifier: 126698133

GI number: 126698133

Start: 660690

End: 661226

Strand: Direct

Name: sip2 [H]

Synonym: CD0554

Alternate gene names: 126698133

Gene position: 660690-661226 (Clockwise)

Preceding gene: 126698132

Following gene: 126698134

Centisome position: 15.4

GC content: 33.33

Gene sequence:

>537_bases
GTGGGTGAAGCAGTTAAAAAAGAAGTTGTAGAATGGATAAAAGTGATTGTCATAGCTCTTGTTTTGGCATTTGCAATAAC
TCGTTTTATAGTGCCAACAATAGTCAAAGGAGAATCAATGTATCCTACATTAGTTGAACGTGATTATTTGATAGTTAACA
GAATTGCGTACAAGGTAGGAGAGCCAAAATACAAAGATATAATAGTATTCAAAACCGACTTAACAGAGGAAAATGGAAAG
AAAAAAGATTTAGTAAAAAGAGTTATCGGGGTTCCTGGTGACCATGTAAAAATACAAGACTCCAAGGTATATGTAAATGA
TAAGTTGTTAGATGAGACTTCCTATATACATAATAATCGTACTGATGGAGATATTGATATCGTAGTTCCAGAAGGAAAAT
TATTTGCAATGGGAGATAATAGAGAAAAAAGTTTAGATAGTAGATACGATGAGGTTGGATTGGTCGACGAGCATACCATT
TTAGGAAAGGTTCTAGTCAGATTGTATCCATTTTCTAAGATAGGAACTATTGACTAA

Upstream 100 bases:

>100_bases
AACTATTAGAAAAAAGAAGTATAATATTTATATTGTAGGTTTATGGTAGATTATTTTGCTGTAGATTGACTTAATATTTA
ACACAGAGGAGACGATTTTA

Downstream 100 bases:

>100_bases
ACATATAAAATTTGGAGCAATCGCTGATTAGCTGAAATCACCAGACCATACACAATAGTTGTCTATATAAAAAAGACAAC
ACCTTATTTAGTAGACTTAT

Product: signal peptidase I

Products: NA

Alternate protein names: SPase IB; Leader peptidase IB [H]

Number of amino acids: Translated: 178; Mature: 177

Protein sequence:

>178_residues
MGEAVKKEVVEWIKVIVIALVLAFAITRFIVPTIVKGESMYPTLVERDYLIVNRIAYKVGEPKYKDIIVFKTDLTEENGK
KKDLVKRVIGVPGDHVKIQDSKVYVNDKLLDETSYIHNNRTDGDIDIVVPEGKLFAMGDNREKSLDSRYDEVGLVDEHTI
LGKVLVRLYPFSKIGTID

Sequences:

>Translated_178_residues
MGEAVKKEVVEWIKVIVIALVLAFAITRFIVPTIVKGESMYPTLVERDYLIVNRIAYKVGEPKYKDIIVFKTDLTEENGK
KKDLVKRVIGVPGDHVKIQDSKVYVNDKLLDETSYIHNNRTDGDIDIVVPEGKLFAMGDNREKSLDSRYDEVGLVDEHTI
LGKVLVRLYPFSKIGTID
>Mature_177_residues
GEAVKKEVVEWIKVIVIALVLAFAITRFIVPTIVKGESMYPTLVERDYLIVNRIAYKVGEPKYKDIIVFKTDLTEENGKK
KDLVKRVIGVPGDHVKIQDSKVYVNDKLLDETSYIHNNRTDGDIDIVVPEGKLFAMGDNREKSLDSRYDEVGLVDEHTIL
GKVLVRLYPFSKIGTID

Specific function: Essential for cell viability [H]

COG id: COG0681

COG function: function code U; Signal peptidase I

Gene ontology:

Cell location: Cell membrane; Single-pass type II membrane protein (Potential) [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S26 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000223
- InterPro:   IPR019758
- InterPro:   IPR019757
- InterPro:   IPR019756
- InterPro:   IPR019759
- InterPro:   IPR015927
- InterPro:   IPR011056 [H]

Pfam domain/function: PF00717 Peptidase_S24 [H]

EC number: =3.4.21.89 [H]

Molecular weight: Translated: 20195; Mature: 20064

Theoretical pI: Translated: 6.29; Mature: 6.29

Prosite motif: PS00501 SPASE_I_1 ; PS00760 SPASE_I_2 ; PS00761 SPASE_I_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGEAVKKEVVEWIKVIVIALVLAFAITRFIVPTIVKGESMYPTLVERDYLIVNRIAYKVG
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCHHHHHHHHHHCC
EPKYKDIIVFKTDLTEENGKKKDLVKRVIGVPGDHVKIQDSKVYVNDKLLDETSYIHNNR
CCCCCEEEEEEECCCCCCCCHHHHHHHHHCCCCCCEEEECCEEEECCHHHHHHHHHCCCC
TDGDIDIVVPEGKLFAMGDNREKSLDSRYDEVGLVDEHTILGKVLVRLYPFSKIGTID
CCCCEEEEECCCEEEEECCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
GEAVKKEVVEWIKVIVIALVLAFAITRFIVPTIVKGESMYPTLVERDYLIVNRIAYKVG
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCHHHHHHHHHHCC
EPKYKDIIVFKTDLTEENGKKKDLVKRVIGVPGDHVKIQDSKVYVNDKLLDETSYIHNNR
CCCCCEEEEEEECCCCCCCCHHHHHHHHHCCCCCCEEEECCEEEECCHHHHHHHHHCCCC
TDGDIDIVVPEGKLFAMGDNREKSLDSRYDEVGLVDEHTILGKVLVRLYPFSKIGTID
CCCCEEEEECCCEEEEECCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA