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The map label for this gene is guaA

Identifier: 126697769

GI number: 126697769

Start: 256539

End: 258074

Strand: Direct

Name: guaA

Synonym: CD0198

Alternate gene names: 126697769

Gene position: 256539-258074 (Clockwise)

Preceding gene: 126697768

Following gene: 126697770

Centisome position: 5.98

GC content: 31.12

Gene sequence:

>1536_bases
ATGAAACATGAATTAGTACTTGTAATAGATTTTGGAGGACAATATAATCAGTTGATAGCTAGAAGAGTTAGAGAAAACAA
CGTATATTGTGAAATACTTCCATGTACTGCAAGCATAGAAAGAATAAAAGAAAAAAATCCTAAAGGGATAATATTTACAG
GCGGTCCAAATAGTGCGTATTTAGAAGATTCTCCAACAATATCAAAAGAAATATTTGAACTAGGAGTACCAATACTTGGA
ATATGCTATGGTATTCAAATAATGTCTCATGTATTGGGTGGAGTTGTAAGAAAAGGTAATAAACAAGAAAAAGAATATGG
AAAAACAGCTATAACTTATGGAAAATCATCATTATTTGAAGGAATAACTACAAATAGTGTATGGATGAGTCACACAGATT
TAATAGAAAAAGTTCCAGAAGGATTTACTATAGTTGCAAATACTAATGATTGTCCAGTAGCAGCTATGGAAAATGTAGAA
CGAAACCTATATGGAGTTCAATTCCATCCAGAGGTAGAACACTGTTTGGAAGGGGACAAGATACTTACAAACTTCTTATA
TAATATTTGTAAAGTAAAAGGTGACTGGACTACAGATTCATTCATAGAAGATAAAATAAAAGAATTAAAAGAAAAAATAG
GCGATAAAAAAGCTTTATGTGCTTTAAGTGGAGGAGTTGATTCTTCTGTTGCTGCAGTTCTTATTCATAAAGCAATTGGG
GACAACTTAACTTGTATATTTGTTGACCATGGTTTACTTAGAAAAAATGAAGGAAATGATGTAGAAAGAATATTTAGAGA
GAAATTTGATATAAATTTAATAAGAGTTAATGCAGAAGATAGATTCTTATCTAAATTAAAAGGAGTTTCTGAACCAGAAG
CTAAGAGAAAAATAATAGGTGAAGAATTTATAAGAGTATTTGAAGAAGAATCAAATAAATTAGGAAAAATGGATTTCTTA
GTACAAGGAACAATCTATCCAGATGTTATAGAAAGTGGACATGGAAATGCTGCTACTATAAAGTCTCATCATAATGTTGG
TGGAATCCCAGAAGATGTAGACTTCCAAGAAATTGTAGAACCATTAAGAGAGTTATTTAAGGATGAAGTTAGAAAAATAG
GATTAGAGCTTGGTATAGAAGAAGGATTAATATTTAGACATCCTTTCCCAGGACCAGGTCTAGGAATAAGAGTTATAGGT
GATGTAACTAAAGAAAAATGTGATATATTAAGAGAAGCTGATGCTGTTTATATGGACGAGCTTAGAAAAGCAGGTTTATA
TAGAGAAATATGGCAAGCTTTTGCAACATTACCAGATGTTAAGACTGTTGGAGTTATGGGTGATGAAAGAACATATGCTT
ATTTAGTTGGTTTAAGAGCAGTTACTTCTTCTGATGGAATGACTTCTGACTGGTATAAGATGCCTTATGATGTATTAGAA
AGAATTTCTAATAGAATAATAAATGAAGTTGATGGAGTAAATAGAGTAGTTTATGATATAACTTCTAAGCCTCCTGGAAC
TATTGAATGGGAATAA

Upstream 100 bases:

>100_bases
TATACAGGTTTTTTGTGTAAAAAGATTTAATATAATTTAGACTGTATTGTGTTAAAATAAATATATAAAAACTATATTAT
ACAAGGAGAGATGTGAATTT

Downstream 100 bases:

>100_bases
AATATAGAATGCCAAAAATCCACATAAATACAGGATTTAAGGTCTCTCTTACTTCTATGTTATACTGGTTTGATACCTAT
CAATATTTGCCAGTATCTTA

Product: GMP synthase

Products: NA

Alternate protein names: GMP synthetase; Glutamine amidotransferase

Number of amino acids: Translated: 511; Mature: 511

Protein sequence:

>511_residues
MKHELVLVIDFGGQYNQLIARRVRENNVYCEILPCTASIERIKEKNPKGIIFTGGPNSAYLEDSPTISKEIFELGVPILG
ICYGIQIMSHVLGGVVRKGNKQEKEYGKTAITYGKSSLFEGITTNSVWMSHTDLIEKVPEGFTIVANTNDCPVAAMENVE
RNLYGVQFHPEVEHCLEGDKILTNFLYNICKVKGDWTTDSFIEDKIKELKEKIGDKKALCALSGGVDSSVAAVLIHKAIG
DNLTCIFVDHGLLRKNEGNDVERIFREKFDINLIRVNAEDRFLSKLKGVSEPEAKRKIIGEEFIRVFEEESNKLGKMDFL
VQGTIYPDVIESGHGNAATIKSHHNVGGIPEDVDFQEIVEPLRELFKDEVRKIGLELGIEEGLIFRHPFPGPGLGIRVIG
DVTKEKCDILREADAVYMDELRKAGLYREIWQAFATLPDVKTVGVMGDERTYAYLVGLRAVTSSDGMTSDWYKMPYDVLE
RISNRIINEVDGVNRVVYDITSKPPGTIEWE

Sequences:

>Translated_511_residues
MKHELVLVIDFGGQYNQLIARRVRENNVYCEILPCTASIERIKEKNPKGIIFTGGPNSAYLEDSPTISKEIFELGVPILG
ICYGIQIMSHVLGGVVRKGNKQEKEYGKTAITYGKSSLFEGITTNSVWMSHTDLIEKVPEGFTIVANTNDCPVAAMENVE
RNLYGVQFHPEVEHCLEGDKILTNFLYNICKVKGDWTTDSFIEDKIKELKEKIGDKKALCALSGGVDSSVAAVLIHKAIG
DNLTCIFVDHGLLRKNEGNDVERIFREKFDINLIRVNAEDRFLSKLKGVSEPEAKRKIIGEEFIRVFEEESNKLGKMDFL
VQGTIYPDVIESGHGNAATIKSHHNVGGIPEDVDFQEIVEPLRELFKDEVRKIGLELGIEEGLIFRHPFPGPGLGIRVIG
DVTKEKCDILREADAVYMDELRKAGLYREIWQAFATLPDVKTVGVMGDERTYAYLVGLRAVTSSDGMTSDWYKMPYDVLE
RISNRIINEVDGVNRVVYDITSKPPGTIEWE
>Mature_511_residues
MKHELVLVIDFGGQYNQLIARRVRENNVYCEILPCTASIERIKEKNPKGIIFTGGPNSAYLEDSPTISKEIFELGVPILG
ICYGIQIMSHVLGGVVRKGNKQEKEYGKTAITYGKSSLFEGITTNSVWMSHTDLIEKVPEGFTIVANTNDCPVAAMENVE
RNLYGVQFHPEVEHCLEGDKILTNFLYNICKVKGDWTTDSFIEDKIKELKEKIGDKKALCALSGGVDSSVAAVLIHKAIG
DNLTCIFVDHGLLRKNEGNDVERIFREKFDINLIRVNAEDRFLSKLKGVSEPEAKRKIIGEEFIRVFEEESNKLGKMDFL
VQGTIYPDVIESGHGNAATIKSHHNVGGIPEDVDFQEIVEPLRELFKDEVRKIGLELGIEEGLIFRHPFPGPGLGIRVIG
DVTKEKCDILREADAVYMDELRKAGLYREIWQAFATLPDVKTVGVMGDERTYAYLVGLRAVTSSDGMTSDWYKMPYDVLE
RISNRIINEVDGVNRVVYDITSKPPGTIEWE

Specific function: Catalyzes the synthesis of GMP from XMP

COG id: COG0519

COG function: function code F; GMP synthase, PP-ATPase domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GMP-binding domain

Homologues:

Organism=Homo sapiens, GI4504035, Length=549, Percent_Identity=37.1584699453552, Blast_Score=300, Evalue=3e-81,
Organism=Escherichia coli, GI1788854, Length=522, Percent_Identity=52.6819923371648, Blast_Score=564, Evalue=1e-162,
Organism=Caenorhabditis elegans, GI71992717, Length=570, Percent_Identity=35.0877192982456, Blast_Score=293, Evalue=1e-79,
Organism=Caenorhabditis elegans, GI133901714, Length=570, Percent_Identity=35.0877192982456, Blast_Score=293, Evalue=2e-79,
Organism=Caenorhabditis elegans, GI71992710, Length=570, Percent_Identity=35.0877192982456, Blast_Score=293, Evalue=2e-79,
Organism=Saccharomyces cerevisiae, GI6323873, Length=516, Percent_Identity=49.2248062015504, Blast_Score=528, Evalue=1e-150,
Organism=Drosophila melanogaster, GI281365319, Length=551, Percent_Identity=35.934664246824, Blast_Score=292, Evalue=4e-79,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GUAA_CLOD6 (Q18CT8)

Other databases:

- EMBL:   AM180355
- RefSeq:   YP_001086666.1
- ProteinModelPortal:   Q18CT8
- SMR:   Q18CT8
- STRING:   Q18CT8
- GeneID:   4915467
- GenomeReviews:   AM180355_GR
- KEGG:   cdf:CD0198
- NMPDR:   fig|1496.1.peg.1465
- eggNOG:   COG0519
- HOGENOM:   HBG391775
- OMA:   MKLVEPL
- ProtClustDB:   PRK00074
- HAMAP:   MF_00344
- InterPro:   IPR001317
- InterPro:   IPR011702
- InterPro:   IPR017926
- InterPro:   IPR000991
- InterPro:   IPR001674
- InterPro:   IPR004739
- InterPro:   IPR022955
- InterPro:   IPR022310
- InterPro:   IPR014729
- Gene3D:   G3DSA:3.40.50.620
- PRINTS:   PR00099
- PRINTS:   PR00096
- TIGRFAMs:   TIGR00884
- TIGRFAMs:   TIGR00888

Pfam domain/function: PF00117 GATase; PF00958 GMP_synt_C; PF02540 NAD_synthase

EC number: =6.3.5.2

Molecular weight: Translated: 57325; Mature: 57325

Theoretical pI: Translated: 5.03; Mature: 5.03

Prosite motif: PS51273 GATASE_TYPE_1; PS00442 GATASE_TYPE_I

Important sites: ACT_SITE 82-82 ACT_SITE 169-169 ACT_SITE 171-171

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKHELVLVIDFGGQYNQLIARRVRENNVYCEILPCTASIERIKEKNPKGIIFTGGPNSAY
CCCEEEEEEECCCCHHHHHHHHHHCCCCEEEEEECHHHHHHHHCCCCCEEEEECCCCCCC
LEDSPTISKEIFELGVPILGICYGIQIMSHVLGGVVRKGNKQEKEYGKTAITYGKSSLFE
CCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCHHEECCCHHHHC
GITTNSVWMSHTDLIEKVPEGFTIVANTNDCPVAAMENVERNLYGVQFHPEVEHCLEGDK
CCCCCCEEEHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHEEEEEECCCHHHHHCCHH
ILTNFLYNICKVKGDWTTDSFIEDKIKELKEKIGDKKALCALSGGVDSSVAAVLIHKAIG
HHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHC
DNLTCIFVDHGLLRKNEGNDVERIFREKFDINLIRVNAEDRFLSKLKGVSEPEAKRKIIG
CCEEEEEEECCCEECCCCCHHHHHHHHHCCEEEEEECCHHHHHHHHCCCCCCHHHHHHHH
EEFIRVFEEESNKLGKMDFLVQGTIYPDVIESGHGNAATIKSHHNVGGIPEDVDFQEIVE
HHHHHHHHHHCCCCCCEEEEEECCCCHHHHHCCCCCEEEEECCCCCCCCCCCCCHHHHHH
PLRELFKDEVRKIGLELGIEEGLIFRHPFPGPGLGIRVIGDVTKEKCDILREADAVYMDE
HHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCEEEECHHHHHHHHHHHHHHHHHHHH
LRKAGLYREIWQAFATLPDVKTVGVMGDERTYAYLVGLRAVTSSDGMTSDWYKMPYDVLE
HHHCCHHHHHHHHHHCCCCCCEEECCCCCCCEEEEEEHHHEECCCCCCCHHHCCCHHHHH
RISNRIINEVDGVNRVVYDITSKPPGTIEWE
HHHHHHHHHHCCCCEEEEEECCCCCCCCCCC
>Mature Secondary Structure
MKHELVLVIDFGGQYNQLIARRVRENNVYCEILPCTASIERIKEKNPKGIIFTGGPNSAY
CCCEEEEEEECCCCHHHHHHHHHHCCCCEEEEEECHHHHHHHHCCCCCEEEEECCCCCCC
LEDSPTISKEIFELGVPILGICYGIQIMSHVLGGVVRKGNKQEKEYGKTAITYGKSSLFE
CCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCHHEECCCHHHHC
GITTNSVWMSHTDLIEKVPEGFTIVANTNDCPVAAMENVERNLYGVQFHPEVEHCLEGDK
CCCCCCEEEHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHEEEEEECCCHHHHHCCHH
ILTNFLYNICKVKGDWTTDSFIEDKIKELKEKIGDKKALCALSGGVDSSVAAVLIHKAIG
HHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHC
DNLTCIFVDHGLLRKNEGNDVERIFREKFDINLIRVNAEDRFLSKLKGVSEPEAKRKIIG
CCEEEEEEECCCEECCCCCHHHHHHHHHCCEEEEEECCHHHHHHHHCCCCCCHHHHHHHH
EEFIRVFEEESNKLGKMDFLVQGTIYPDVIESGHGNAATIKSHHNVGGIPEDVDFQEIVE
HHHHHHHHHHCCCCCCEEEEEECCCCHHHHHCCCCCEEEEECCCCCCCCCCCCCHHHHHH
PLRELFKDEVRKIGLELGIEEGLIFRHPFPGPGLGIRVIGDVTKEKCDILREADAVYMDE
HHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCEEEECHHHHHHHHHHHHHHHHHHHH
LRKAGLYREIWQAFATLPDVKTVGVMGDERTYAYLVGLRAVTSSDGMTSDWYKMPYDVLE
HHHCCHHHHHHHHHHCCCCCCEEECCCCCCCEEEEEEHHHEECCCCCCCHHHCCCHHHHH
RISNRIINEVDGVNRVVYDITSKPPGTIEWE
HHHHHHHHHHCCCCEEEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA