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The map label for this gene is pyrD

Identifier: 126697759

GI number: 126697759

Start: 244200

End: 245102

Strand: Direct

Name: pyrD

Synonym: CD0186

Alternate gene names: 126697759

Gene position: 244200-245102 (Clockwise)

Preceding gene: 126697758

Following gene: 126697760

Centisome position: 5.69

GC content: 32.67

Gene sequence:

>903_bases
ATGGGTAATTTAAGTGTGAAATTTGGAAGTGTAGAATTTAAAAATCCAGTAATAATGGCGTCTGGAACTTTTGGATTTGG
AAAAGAATATAATGAGATTTATGATATACAAAAACTTGGTGGTATAAGTAGCAAGGGTCTTACTTTAAATAAAAAACCTG
GTAACAATGGTATGAGAGTTCATGAGACATCATCCGGTATGATGAATAGTGTTGGGCTTGAAAACCCTGGAGTTCAAGGA
TTTATAGACTATGAATTACCTTTTTTTAGTAAACTAGACTTAGTCAGAATAGCTAATGTTGGAGGTGGGACATTAGAAGA
CTACTTATTAGGGGTTCAAATGTTAAATGACAAGCCTATAGACATTATTGAATTAAATATATCTTGCCCAAATGTCAAAG
CTGGTGGAATGGCTTTTGGTATAAAAAATGAAGTGGCAAGAGAAGTTGTTCGTGAGGTAAGAAACATAACGAAACTGCCT
TTAGTAATAAAATTATCACCCAATGCAGAAGATATTGTAGGAATGGCAAAAGTTTGTGAAGAAGAAGGTGCTGATGGAGT
TTCATTAGTTAATACTTTTAAAGCAATGGCAATTGATATAAAAAATAGAAGACCAGTATTTGAAAATGTATATGCTGGGT
TATCTGGACCAGCTATAAAACCTATAGCTTTGAGAATGGTACATGAAGTGTGTAAAAATGTAAATATACCTGTAATGGGG
ATGGGCGGAATAACTAAAGCCACAGATGCTATAGAGTTTATAATGGCAGGAGCTACTTGTATCCAAGTTGGAACTGCAAA
TTTTATTAATCCTAGAATAGGTATTGAAATAATAGATGGAATTAATGAATTTATGGATAGAGAAGGAATAAAAAGTTTAG
ACGAAATAAGAGGAATTATATAA

Upstream 100 bases:

>100_bases
GGAGTAGGTGCCTGTTTAGTATGTACGTGTAAAACTAATGGAGGAAATAAAAAGACTTGTAAAGATGGTCCAGTGTTCTG
GGGAGAGGACGTGATTTTTA

Downstream 100 bases:

>100_bases
GGTAGAATAAATAGTATTTTAAAGATAAAAAATATAGATTAAATAAACAATAATTTTATAACATTAACATGGAGGAAAAA
TAATATGAGTAAAGTAGATG

Product: dihydroorotate dehydrogenase 1B

Products: NA

Alternate protein names: DHOdehase; DHOD; DHODase; Dihydroorotate oxidase

Number of amino acids: Translated: 300; Mature: 299

Protein sequence:

>300_residues
MGNLSVKFGSVEFKNPVIMASGTFGFGKEYNEIYDIQKLGGISSKGLTLNKKPGNNGMRVHETSSGMMNSVGLENPGVQG
FIDYELPFFSKLDLVRIANVGGGTLEDYLLGVQMLNDKPIDIIELNISCPNVKAGGMAFGIKNEVAREVVREVRNITKLP
LVIKLSPNAEDIVGMAKVCEEEGADGVSLVNTFKAMAIDIKNRRPVFENVYAGLSGPAIKPIALRMVHEVCKNVNIPVMG
MGGITKATDAIEFIMAGATCIQVGTANFINPRIGIEIIDGINEFMDREGIKSLDEIRGII

Sequences:

>Translated_300_residues
MGNLSVKFGSVEFKNPVIMASGTFGFGKEYNEIYDIQKLGGISSKGLTLNKKPGNNGMRVHETSSGMMNSVGLENPGVQG
FIDYELPFFSKLDLVRIANVGGGTLEDYLLGVQMLNDKPIDIIELNISCPNVKAGGMAFGIKNEVAREVVREVRNITKLP
LVIKLSPNAEDIVGMAKVCEEEGADGVSLVNTFKAMAIDIKNRRPVFENVYAGLSGPAIKPIALRMVHEVCKNVNIPVMG
MGGITKATDAIEFIMAGATCIQVGTANFINPRIGIEIIDGINEFMDREGIKSLDEIRGII
>Mature_299_residues
GNLSVKFGSVEFKNPVIMASGTFGFGKEYNEIYDIQKLGGISSKGLTLNKKPGNNGMRVHETSSGMMNSVGLENPGVQGF
IDYELPFFSKLDLVRIANVGGGTLEDYLLGVQMLNDKPIDIIELNISCPNVKAGGMAFGIKNEVAREVVREVRNITKLPL
VIKLSPNAEDIVGMAKVCEEEGADGVSLVNTFKAMAIDIKNRRPVFENVYAGLSGPAIKPIALRMVHEVCKNVNIPVMGM
GGITKATDAIEFIMAGATCIQVGTANFINPRIGIEIIDGINEFMDREGIKSLDEIRGII

Specific function: Unknown

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily

Homologues:

Organism=Homo sapiens, GI119943098, Length=175, Percent_Identity=33.7142857142857, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI45006951, Length=294, Percent_Identity=25.5102040816327, Blast_Score=69, Evalue=5e-12,
Organism=Escherichia coli, GI87082059, Length=324, Percent_Identity=27.7777777777778, Blast_Score=108, Evalue=5e-25,
Organism=Caenorhabditis elegans, GI71984108, Length=157, Percent_Identity=36.3057324840764, Blast_Score=100, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6322633, Length=323, Percent_Identity=28.7925696594427, Blast_Score=95, Evalue=1e-20,
Organism=Drosophila melanogaster, GI24640763, Length=158, Percent_Identity=36.7088607594937, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI18858217, Length=158, Percent_Identity=36.7088607594937, Blast_Score=100, Evalue=1e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYRD_CLOD6 (Q18CS6)

Other databases:

- EMBL:   AM180355
- RefSeq:   YP_001086656.1
- ProteinModelPortal:   Q18CS6
- SMR:   Q18CS6
- STRING:   Q18CS6
- GeneID:   4915022
- GenomeReviews:   AM180355_GR
- KEGG:   cdf:CD0186
- NMPDR:   fig|1496.1.peg.1477
- eggNOG:   COG0167
- HOGENOM:   HBG472415
- OMA:   AYTLKTI
- ProtClustDB:   PRK07259
- GO:   GO:0005737
- HAMAP:   MF_00224_B
- InterPro:   IPR013785
- InterPro:   IPR005720
- InterPro:   IPR012135
- Gene3D:   G3DSA:3.20.20.70
- PIRSF:   PIRSF000164
- TIGRFAMs:   TIGR01037

Pfam domain/function: PF01180 DHO_dh

EC number: =1.3.3.1

Molecular weight: Translated: 32370; Mature: 32239

Theoretical pI: Translated: 5.23; Mature: 5.23

Prosite motif: PS00911 DHODEHASE_1; PS00912 DHODEHASE_2

Important sites: ACT_SITE 129-129

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGNLSVKFGSVEFKNPVIMASGTFGFGKEYNEIYDIQKLGGISSKGLTLNKKPGNNGMRV
CCCCEEEECCEEECCCEEEEECCCCCCCHHHHHHHHHHHCCCCCCCEEEECCCCCCCCEE
HETSSGMMNSVGLENPGVQGFIDYELPFFSKLDLVRIANVGGGTLEDYLLGVQMLNDKPI
EECCCCCHHHCCCCCCCCCEEEECCCCCCCCCCEEEEECCCCCHHHHHHHHHHHCCCCCC
DIIELNISCPNVKAGGMAFGIKNEVAREVVREVRNITKLPLVIKLSPNAEDIVGMAKVCE
EEEEEEEECCCCCCCCEEECHHHHHHHHHHHHHHHHHHCCEEEEECCCHHHHHHHHHHHH
EEGADGVSLVNTFKAMAIDIKNRRPVFENVYAGLSGPAIKPIALRMVHEVCKNVNIPVMG
HCCCCCHHHHHHHHHHEEECCCCCCHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCEEE
MGGITKATDAIEFIMAGATCIQVGTANFINPRIGIEIIDGINEFMDREGIKSLDEIRGII
CCCCCHHHHHHHHHHHCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
GNLSVKFGSVEFKNPVIMASGTFGFGKEYNEIYDIQKLGGISSKGLTLNKKPGNNGMRV
CCCEEEECCEEECCCEEEEECCCCCCCHHHHHHHHHHHCCCCCCCEEEECCCCCCCCEE
HETSSGMMNSVGLENPGVQGFIDYELPFFSKLDLVRIANVGGGTLEDYLLGVQMLNDKPI
EECCCCCHHHCCCCCCCCCEEEECCCCCCCCCCEEEEECCCCCHHHHHHHHHHHCCCCCC
DIIELNISCPNVKAGGMAFGIKNEVAREVVREVRNITKLPLVIKLSPNAEDIVGMAKVCE
EEEEEEEECCCCCCCCEEECHHHHHHHHHHHHHHHHHHCCEEEEECCCHHHHHHHHHHHH
EEGADGVSLVNTFKAMAIDIKNRRPVFENVYAGLSGPAIKPIALRMVHEVCKNVNIPVMG
HCCCCCHHHHHHHHHHEEECCCCCCHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCEEE
MGGITKATDAIEFIMAGATCIQVGTANFINPRIGIEIIDGINEFMDREGIKSLDEIRGII
CCCCCHHHHHHHHHHHCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA