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The map label for this gene is glmS [H]

Identifier: 126697692

GI number: 126697692

Start: 163383

End: 165215

Strand: Direct

Name: glmS [H]

Synonym: CD0120

Alternate gene names: 126697692

Gene position: 163383-165215 (Clockwise)

Preceding gene: 126697691

Following gene: 126697693

Centisome position: 3.81

GC content: 31.7

Gene sequence:

>1833_bases
ATGTGTGGAATAGTTGGATATTTAGGAAGTAGAAAGGCAGCAGAAGTTATAGTAGAAGGGCTTTCTAAGCTAGAGTACAG
AGGTTATGACTCAGCAGGAGTAGCAGTTAATAGTTCTAATGAAAAAGAACTTAATATTAGAAAGTTTAAAGGTAGACTTT
CTGTACTTGCAGAAGACTTAGAAAAGAATCCTATTGATGGAAATTTAGGTATAGGGCATACGAGATGGGCAACTCATGGA
GAACCATCTGATGTAAACTCACATCCTCATTTTAATCAAGCCAAAACAATAGCAGTTGTTCATAATGGGATAATAGAAAA
CTATATGGAAATAAAAGAAGAATTAATTTCTGAAGGTGTTAAGTTTGAATCTCAAACAGATACAGAGGTAATAGCACATT
TAGTAGATAAATACTATGAGGGTAATTTATTAGATGCTGTATACAAAACTATATCAAAATTAAGAGGAGCTTATGCATTA
GGTGTTATATGTAAAGAACATGGAAATGAATTAGTTGCAGTAAGAAAAGATAGTCCTCTTGTAGTTGGTGTTGGTGAAGG
TGAAAACTTTATAGCATCAGATATACCTGCATTATTAAAATATACTAGAGATGTTTATTTCTTAGAAAATGGAGAAGTAG
TTCATCTAAAAGACGAAAATGTAACAGTTTATGACTCTAATAGAAATCTTGTTGAAAAAGAAGTATTTCATGTAACTTGG
GATGTAGAAGCTGCGTCTAAAGGTGGATATGACTACTTTATGTCAAAAGAAATTCATGAGCAACCAACAGGAGTAAGAGA
AACTTTAGAAAGAAGACTTGATGATAATGGAAATATAATTCTAGACAGTATAAATATTTCTAAAGAAGACTTAGAAAAAA
TAAATAAAGTTTATATAGTGGCTTGTGGAACAGCATATAATGCTGGATTACTTGGTAAGTATGCCATAGAAAAATTTGTA
AATATACCAGTAATAACTGATATAGCATCAGAATTTAGATATAGCGACCCATTTGTAGATGAAAATTCATTAGTAATATT
AGTTAGTCAATCTGGTGAGACAGCAGATACTCTAGCAGTATTAAGAGATTCAAAGGCTAAAGGAGCAAGAATACTTTCAA
TAACTAATGTTGTAGGTTCATCTATAGCAAGAGAATCAGATGATGTATTCTATACTTGGGCAGGACCTGAAGTAGCAGTT
GCATCAACTAAGGCATATACTACTCAAATAACTTCTTTATACATGATAGCTTTAGACTTTGCTATCAAAAAAGGAACAAT
AACTAGAGAATTTTATGATAGTATGATTTCTAAGATGAAAGAAATACCATCAAAAATACAAGAAATACTAGACAATGAAG
AATATATAAAAGAAGTTGCTAAAACAGTTGTTAGTTCTGAACATGCATTCTATTTAGGAAGAGGTATAGACTATAGCTTA
GCAATGGAAGGTTCATTGAAATTAAAAGAGATTTCATATATACATGCAGAAGCTTTTGCAGCAGGAGAGCTAAAGCATGG
AACAATAGCTTTAATAGAAAAAGGAACTCCTGTAATTGCCATAGCTACTCAAGAAAAGTTATTTGAAAAAATGGTTTCTA
ATATGGAAGAAGTAAGAGCAAGAGGAGCTTATGTAGTAGCAATAGCTCAAAGCCATAATAAGGATGTTGAGAAAGCTGCT
GATAAAATAATCTATATACCAAATTCAGATGATATTTTATCACCAATATTAGCAGTTGTACCAATGCAATTACTTGCTTA
TCATGTCTCTGTACTAAGAGGATGCGATGTAGATAAGCCAAGAAATCTAGCTAAATCAGTAACAGTTGAATAA

Upstream 100 bases:

>100_bases
AAATAATAGGAGCAATCCTATGGACAAAGGGAAGCCAAAGTAAACTTATATGACCTAACTCTTAAAATATATAAATAATA
TTTTTAGGAGGACACAAATA

Downstream 100 bases:

>100_bases
AAACAGATTAAAAATTAAATAGATAATATTTATTGAAAAGAACTCATCCTGTTATTTGTATTTTATAGGATGAGTTTTTT
AGATAAATATTAAATTTGTT

Product: glucosamine--fructose-6-phosphate aminotransferase

Products: NA

Alternate protein names: D-fructose-6-phosphate amidotransferase; GFAT; Glucosamine-6-phosphate synthase; Hexosephosphate aminotransferase; L-glutamine-D-fructose-6-phosphate amidotransferase [H]

Number of amino acids: Translated: 610; Mature: 610

Protein sequence:

>610_residues
MCGIVGYLGSRKAAEVIVEGLSKLEYRGYDSAGVAVNSSNEKELNIRKFKGRLSVLAEDLEKNPIDGNLGIGHTRWATHG
EPSDVNSHPHFNQAKTIAVVHNGIIENYMEIKEELISEGVKFESQTDTEVIAHLVDKYYEGNLLDAVYKTISKLRGAYAL
GVICKEHGNELVAVRKDSPLVVGVGEGENFIASDIPALLKYTRDVYFLENGEVVHLKDENVTVYDSNRNLVEKEVFHVTW
DVEAASKGGYDYFMSKEIHEQPTGVRETLERRLDDNGNIILDSINISKEDLEKINKVYIVACGTAYNAGLLGKYAIEKFV
NIPVITDIASEFRYSDPFVDENSLVILVSQSGETADTLAVLRDSKAKGARILSITNVVGSSIARESDDVFYTWAGPEVAV
ASTKAYTTQITSLYMIALDFAIKKGTITREFYDSMISKMKEIPSKIQEILDNEEYIKEVAKTVVSSEHAFYLGRGIDYSL
AMEGSLKLKEISYIHAEAFAAGELKHGTIALIEKGTPVIAIATQEKLFEKMVSNMEEVRARGAYVVAIAQSHNKDVEKAA
DKIIYIPNSDDILSPILAVVPMQLLAYHVSVLRGCDVDKPRNLAKSVTVE

Sequences:

>Translated_610_residues
MCGIVGYLGSRKAAEVIVEGLSKLEYRGYDSAGVAVNSSNEKELNIRKFKGRLSVLAEDLEKNPIDGNLGIGHTRWATHG
EPSDVNSHPHFNQAKTIAVVHNGIIENYMEIKEELISEGVKFESQTDTEVIAHLVDKYYEGNLLDAVYKTISKLRGAYAL
GVICKEHGNELVAVRKDSPLVVGVGEGENFIASDIPALLKYTRDVYFLENGEVVHLKDENVTVYDSNRNLVEKEVFHVTW
DVEAASKGGYDYFMSKEIHEQPTGVRETLERRLDDNGNIILDSINISKEDLEKINKVYIVACGTAYNAGLLGKYAIEKFV
NIPVITDIASEFRYSDPFVDENSLVILVSQSGETADTLAVLRDSKAKGARILSITNVVGSSIARESDDVFYTWAGPEVAV
ASTKAYTTQITSLYMIALDFAIKKGTITREFYDSMISKMKEIPSKIQEILDNEEYIKEVAKTVVSSEHAFYLGRGIDYSL
AMEGSLKLKEISYIHAEAFAAGELKHGTIALIEKGTPVIAIATQEKLFEKMVSNMEEVRARGAYVVAIAQSHNKDVEKAA
DKIIYIPNSDDILSPILAVVPMQLLAYHVSVLRGCDVDKPRNLAKSVTVE
>Mature_610_residues
MCGIVGYLGSRKAAEVIVEGLSKLEYRGYDSAGVAVNSSNEKELNIRKFKGRLSVLAEDLEKNPIDGNLGIGHTRWATHG
EPSDVNSHPHFNQAKTIAVVHNGIIENYMEIKEELISEGVKFESQTDTEVIAHLVDKYYEGNLLDAVYKTISKLRGAYAL
GVICKEHGNELVAVRKDSPLVVGVGEGENFIASDIPALLKYTRDVYFLENGEVVHLKDENVTVYDSNRNLVEKEVFHVTW
DVEAASKGGYDYFMSKEIHEQPTGVRETLERRLDDNGNIILDSINISKEDLEKINKVYIVACGTAYNAGLLGKYAIEKFV
NIPVITDIASEFRYSDPFVDENSLVILVSQSGETADTLAVLRDSKAKGARILSITNVVGSSIARESDDVFYTWAGPEVAV
ASTKAYTTQITSLYMIALDFAIKKGTITREFYDSMISKMKEIPSKIQEILDNEEYIKEVAKTVVSSEHAFYLGRGIDYSL
AMEGSLKLKEISYIHAEAFAAGELKHGTIALIEKGTPVIAIATQEKLFEKMVSNMEEVRARGAYVVAIAQSHNKDVEKAA
DKIIYIPNSDDILSPILAVVPMQLLAYHVSVLRGCDVDKPRNLAKSVTVE

Specific function: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source [H]

COG id: COG0449

COG function: function code M; Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 SIS domains [H]

Homologues:

Organism=Homo sapiens, GI205277386, Length=682, Percent_Identity=36.5102639296188, Blast_Score=424, Evalue=1e-118,
Organism=Homo sapiens, GI4826742, Length=683, Percent_Identity=34.9926793557833, Blast_Score=422, Evalue=1e-118,
Organism=Homo sapiens, GI29570798, Length=264, Percent_Identity=27.2727272727273, Blast_Score=69, Evalue=9e-12,
Organism=Escherichia coli, GI1790167, Length=614, Percent_Identity=47.2312703583062, Blast_Score=551, Evalue=1e-158,
Organism=Escherichia coli, GI1788651, Length=242, Percent_Identity=29.7520661157025, Blast_Score=89, Evalue=6e-19,
Organism=Escherichia coli, GI87082251, Length=315, Percent_Identity=22.2222222222222, Blast_Score=75, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17532899, Length=430, Percent_Identity=35.5813953488372, Blast_Score=300, Evalue=2e-81,
Organism=Caenorhabditis elegans, GI17532897, Length=430, Percent_Identity=35.5813953488372, Blast_Score=299, Evalue=3e-81,
Organism=Caenorhabditis elegans, GI17539970, Length=431, Percent_Identity=35.7308584686775, Blast_Score=296, Evalue=3e-80,
Organism=Saccharomyces cerevisiae, GI6322745, Length=433, Percent_Identity=36.7205542725173, Blast_Score=287, Evalue=4e-78,
Organism=Saccharomyces cerevisiae, GI6323731, Length=429, Percent_Identity=29.6037296037296, Blast_Score=205, Evalue=1e-53,
Organism=Saccharomyces cerevisiae, GI6323730, Length=205, Percent_Identity=40, Blast_Score=124, Evalue=4e-29,
Organism=Drosophila melanogaster, GI21357745, Length=684, Percent_Identity=34.9415204678363, Blast_Score=425, Evalue=1e-119,
Organism=Drosophila melanogaster, GI28573187, Length=275, Percent_Identity=28.7272727272727, Blast_Score=82, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24659598, Length=123, Percent_Identity=32.520325203252, Blast_Score=73, Evalue=7e-13,
Organism=Drosophila melanogaster, GI24659604, Length=121, Percent_Identity=32.2314049586777, Blast_Score=70, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000583
- InterPro:   IPR017932
- InterPro:   IPR005855
- InterPro:   IPR001347 [H]

Pfam domain/function: PF00310 GATase_2; PF01380 SIS [H]

EC number: =2.6.1.16 [H]

Molecular weight: Translated: 67427; Mature: 67427

Theoretical pI: Translated: 4.97; Mature: 4.97

Prosite motif: PS00443 GATASE_TYPE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCGIVGYLGSRKAAEVIVEGLSKLEYRGYDSAGVAVNSSNEKELNIRKFKGRLSVLAEDL
CCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCEEECCCCCCCCHHHHHHHHHHHHHHHH
EKNPIDGNLGIGHTRWATHGEPSDVNSHPHFNQAKTIAVVHNGIIENYMEIKEELISEGV
HCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHCCC
KFESQTDTEVIAHLVDKYYEGNLLDAVYKTISKLRGAYALGVICKEHGNELVAVRKDSPL
CCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCHHEEHHHHHCCCEEEEEECCCCE
VVGVGEGENFIASDIPALLKYTRDVYFLENGEVVHLKDENVTVYDSNRNLVEKEVFHVTW
EEEECCCCCCHHHHHHHHHHHCCCEEEEECCCEEEEECCCEEEEECCCCCCCCEEEEEEE
DVEAASKGGYDYFMSKEIHEQPTGVRETLERRLDDNGNIILDSINISKEDLEKINKVYIV
EEEECCCCCCHHHHCCHHHCCCCCHHHHHHHHCCCCCCEEEEECCCCHHHHHHCCEEEEE
ACGTAYNAGLLGKYAIEKFVNIPVITDIASEFRYSDPFVDENSLVILVSQSGETADTLAV
EECCCCCCCCHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCHHHHHH
LRDSKAKGARILSITNVVGSSIARESDDVFYTWAGPEVAVASTKAYTTQITSLYMIALDF
HHCCCCCCCEEEEEHHHHHHHHCCCCCCEEEEECCCEEEEEECHHHHHHHHHHHHHHHHH
AIKKGTITREFYDSMISKMKEIPSKIQEILDNEEYIKEVAKTVVSSEHAFYLGRGIDYSL
HHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCEEEEECCCCEEE
AMEGSLKLKEISYIHAEAFAAGELKHGTIALIEKGTPVIAIATQEKLFEKMVSNMEEVRA
EECCCEEEHHHHHHHHHHHHCCCCCCCEEEEEECCCCEEEEECHHHHHHHHHHHHHHHHH
RGAYVVAIAQSHNKDVEKAADKIIYIPNSDDILSPILAVVPMQLLAYHVSVLRGCDVDKP
CCEEEEEEECCCCCCHHHHCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
RNLAKSVTVE
HHHHHCCCCC
>Mature Secondary Structure
MCGIVGYLGSRKAAEVIVEGLSKLEYRGYDSAGVAVNSSNEKELNIRKFKGRLSVLAEDL
CCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCEEECCCCCCCCHHHHHHHHHHHHHHHH
EKNPIDGNLGIGHTRWATHGEPSDVNSHPHFNQAKTIAVVHNGIIENYMEIKEELISEGV
HCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHCCC
KFESQTDTEVIAHLVDKYYEGNLLDAVYKTISKLRGAYALGVICKEHGNELVAVRKDSPL
CCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCHHEEHHHHHCCCEEEEEECCCCE
VVGVGEGENFIASDIPALLKYTRDVYFLENGEVVHLKDENVTVYDSNRNLVEKEVFHVTW
EEEECCCCCCHHHHHHHHHHHCCCEEEEECCCEEEEECCCEEEEECCCCCCCCEEEEEEE
DVEAASKGGYDYFMSKEIHEQPTGVRETLERRLDDNGNIILDSINISKEDLEKINKVYIV
EEEECCCCCCHHHHCCHHHCCCCCHHHHHHHHCCCCCCEEEEECCCCHHHHHHCCEEEEE
ACGTAYNAGLLGKYAIEKFVNIPVITDIASEFRYSDPFVDENSLVILVSQSGETADTLAV
EECCCCCCCCHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCHHHHHH
LRDSKAKGARILSITNVVGSSIARESDDVFYTWAGPEVAVASTKAYTTQITSLYMIALDF
HHCCCCCCCEEEEEHHHHHHHHCCCCCCEEEEECCCEEEEEECHHHHHHHHHHHHHHHHH
AIKKGTITREFYDSMISKMKEIPSKIQEILDNEEYIKEVAKTVVSSEHAFYLGRGIDYSL
HHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCEEEEECCCCEEE
AMEGSLKLKEISYIHAEAFAAGELKHGTIALIEKGTPVIAIATQEKLFEKMVSNMEEVRA
EECCCEEEHHHHHHHHHHHHCCCCCCCEEEEEECCCCEEEEECHHHHHHHHHHHHHHHHH
RGAYVVAIAQSHNKDVEKAADKIIYIPNSDDILSPILAVVPMQLLAYHVSVLRGCDVDKP
CCEEEEEEECCCCCCHHHHCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
RNLAKSVTVE
HHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11997336 [H]