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The map label for this gene is ispD

Identifier: 126697613

GI number: 126697613

Start: 71715

End: 72428

Strand: Direct

Name: ispD

Synonym: CD0047

Alternate gene names: 126697613

Gene position: 71715-72428 (Clockwise)

Preceding gene: 126697612

Following gene: 126697614

Centisome position: 1.67

GC content: 28.29

Gene sequence:

>714_bases
ATGTATAGTGTTATAATTGTTGCAGCGGGAAGCGGAAGGAGAATGAACTTAGATATAAACAAACAGTTCATAAAATTAAG
AGAAAAAGAAATTATTGCTCATACAATTCAAGTTTTTTATGAAAATATAAATATAGATGAAATAGTGGTATGTATAAAAA
AAGAAGAAGAAGATTTTTTTAAAGAAAATATAATAAATAAGTATAACTTTAAAAATATAAAAATAGCATATGGCGGAAAA
GAAAGACAGGACTCAATATATAATGGTTTAAAAAAATTAGATAAAAATTGTGATATAGTACTTATCCATGATGGAGCAAG
ACCATTTGTCGACCATAGAATAATCAACGAATCTATAAAGGTAGCTAAAGAAAAAAAGGCTGTGGTTGTAGGTGTTCCAG
TAAGTGATACTATAAAGATAGTGTCAGATGGAACAGTAAAAGAAACTCCAGAAAGAAATTTGCTGTGGGCAGCACAAACC
CCTCAAACCTTTGAATATAATCTCATAATAGATGCTTATGAACAAGCATATAAGAACAATTATTATGGTACTGATGATTC
AATGTTGGTAGAAAATATAGGTCAAAGTGTCACTATGGTAATGGGTTCTTATGAAAACATAAAAATAACTAGTCCAGAAG
ATTTAAATATAGCAGAACAAATATTAAATATGGAAAAAAGAGATGAAGTTAACAGTAGAAGGAGAATTATATGA

Upstream 100 bases:

>100_bases
ATACAACTGAAAATTTAATATATAATTAATCAGATGGTTAAAATAAAAATATTAAAAGTTTTAATAAATGATGGTTAAAA
ATAAAATACGAGGTGATACC

Downstream 100 bases:

>100_bases
GAATAGGATTAGGATATGATGTACACAAATTAACAGAGGATAGAAAACTTATAATCGGTGGTGTAGAGATACCACACGAT
AAAGGTTTGTTGGGTCATTC

Product: 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase

Products: NA

Alternate protein names: 4-diphosphocytidyl-2C-methyl-D-erythritol synthase; MEP cytidylyltransferase; MCT

Number of amino acids: Translated: 237; Mature: 237

Protein sequence:

>237_residues
MYSVIIVAAGSGRRMNLDINKQFIKLREKEIIAHTIQVFYENINIDEIVVCIKKEEEDFFKENIINKYNFKNIKIAYGGK
ERQDSIYNGLKKLDKNCDIVLIHDGARPFVDHRIINESIKVAKEKKAVVVGVPVSDTIKIVSDGTVKETPERNLLWAAQT
PQTFEYNLIIDAYEQAYKNNYYGTDDSMLVENIGQSVTMVMGSYENIKITSPEDLNIAEQILNMEKRDEVNSRRRII

Sequences:

>Translated_237_residues
MYSVIIVAAGSGRRMNLDINKQFIKLREKEIIAHTIQVFYENINIDEIVVCIKKEEEDFFKENIINKYNFKNIKIAYGGK
ERQDSIYNGLKKLDKNCDIVLIHDGARPFVDHRIINESIKVAKEKKAVVVGVPVSDTIKIVSDGTVKETPERNLLWAAQT
PQTFEYNLIIDAYEQAYKNNYYGTDDSMLVENIGQSVTMVMGSYENIKITSPEDLNIAEQILNMEKRDEVNSRRRII
>Mature_237_residues
MYSVIIVAAGSGRRMNLDINKQFIKLREKEIIAHTIQVFYENINIDEIVVCIKKEEEDFFKENIINKYNFKNIKIAYGGK
ERQDSIYNGLKKLDKNCDIVLIHDGARPFVDHRIINESIKVAKEKKAVVVGVPVSDTIKIVSDGTVKETPERNLLWAAQT
PQTFEYNLIIDAYEQAYKNNYYGTDDSMLVENIGQSVTMVMGSYENIKITSPEDLNIAEQILNMEKRDEVNSRRRII

Specific function: Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP)

COG id: COG1211

COG function: function code I; 4-diphosphocytidyl-2-methyl-D-erithritol synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ispD family

Homologues:

Organism=Homo sapiens, GI157412259, Length=231, Percent_Identity=31.6017316017316, Blast_Score=111, Evalue=6e-25,
Organism=Homo sapiens, GI157671913, Length=212, Percent_Identity=29.2452830188679, Blast_Score=84, Evalue=1e-16,
Organism=Escherichia coli, GI1789104, Length=220, Percent_Identity=30.4545454545455, Blast_Score=119, Evalue=2e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ISPD_CLOD6 (Q18CD1)

Other databases:

- EMBL:   AM180355
- RefSeq:   YP_001086510.1
- ProteinModelPortal:   Q18CD1
- SMR:   Q18CD1
- STRING:   Q18CD1
- GeneID:   4916635
- GenomeReviews:   AM180355_GR
- KEGG:   cdf:CD0047
- NMPDR:   fig|1496.1.peg.102
- eggNOG:   COG1211
- HOGENOM:   HBG672839
- OMA:   YQASEMP
- ProtClustDB:   CLSK2534351
- HAMAP:   MF_00108
- InterPro:   IPR001228
- InterPro:   IPR018294
- TIGRFAMs:   TIGR00453

Pfam domain/function: PF01128 IspD

EC number: =2.7.7.60

Molecular weight: Translated: 27301; Mature: 27301

Theoretical pI: Translated: 5.84; Mature: 5.84

Prosite motif: PS01295 ISPD

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYSVIIVAAGSGRRMNLDINKQFIKLREKEIIAHTIQVFYENINIDEIVVCIKKEEEDFF
CEEEEEEECCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCHHHHH
KENIINKYNFKNIKIAYGGKERQDSIYNGLKKLDKNCDIVLIHDGARPFVDHRIINESIK
HHHHCCCCCCCEEEEEECCCCHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHH
VAKEKKAVVVGVPVSDTIKIVSDGTVKETPERNLLWAAQTPQTFEYNLIIDAYEQAYKNN
HHHCCCEEEEEECCCCEEEEEECCCCCCCCCCCEEEEECCCCCEEEEEEEEHHHHHHCCC
YYGTDDSMLVENIGQSVTMVMGSYENIKITSPEDLNIAEQILNMEKRDEVNSRRRII
CCCCCCHHHHHHCCCCEEEEECCCCCEEEECCCCCCHHHHHHCCHHHHHHHHHCCCC
>Mature Secondary Structure
MYSVIIVAAGSGRRMNLDINKQFIKLREKEIIAHTIQVFYENINIDEIVVCIKKEEEDFF
CEEEEEEECCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCHHHHH
KENIINKYNFKNIKIAYGGKERQDSIYNGLKKLDKNCDIVLIHDGARPFVDHRIINESIK
HHHHCCCCCCCEEEEEECCCCHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHH
VAKEKKAVVVGVPVSDTIKIVSDGTVKETPERNLLWAAQTPQTFEYNLIIDAYEQAYKNN
HHHCCCEEEEEECCCCEEEEEECCCCCCCCCCCEEEEECCCCCEEEEEEEEHHHHHHCCC
YYGTDDSMLVENIGQSVTMVMGSYENIKITSPEDLNIAEQILNMEKRDEVNSRRRII
CCCCCCHHHHHHCCCCEEEEECCCCCEEEECCCCCCHHHHHHCCHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA