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The map label for this gene is fusA [H]

Identifier: 126697588

GI number: 126697588

Start: 38528

End: 40468

Strand: Direct

Name: fusA [H]

Synonym: CD0022

Alternate gene names: 126697588

Gene position: 38528-40468 (Clockwise)

Preceding gene: 126697587

Following gene: 126697589

Centisome position: 0.9

GC content: 30.76

Gene sequence:

>1941_bases
GTGGGTGCTTATATGAAGGTTTATGATAGTAAAATGTTGAGAAATGTAGCGGTATTAGGACATAGCGGATGTGGAAAAAC
AAATCTAATCGAAACTATAGCTTACACAGCAAACACTAATAAGATACCTAAATTAACAGACAAGGTAAATATGACTTATA
GCATGGGATTAATACCTATAGAGTATAATGATTATAAGTTTAACTTATTGGATACCCCAGGATATTTTGACTTTAGCGGA
GACGTTGTGTCATCTCTTAGAGCAAGTGATGCAGCAATAATAGTAATAGATGCAACAGCGCCTATTCAAGTTGGTACAGA
GAAATCATTAGAACTAACTGAGAGTATTCCTAAGATAATGTTTATAAATAAAATAGATAATGAAAAGGCAAGATACAAAG
ATGCAATAGCAATGTTAAGAGAAAAATACAATAATAAGATAGTTCCTATGATAAGTCCTATATACAAAGATAAAAACTTT
GTAAAGTTACATAATGTTTTTGAAAACATAGATGATTTAGAAGGTGAATTTAAGGAACAAGCTATGAGTGTTAAAGAAGC
ATTAATGGAACTTATAGCAGAAACTGATGACCAAATATTAGATAAATATTTTAATGGAGAAGAACTAACTACAGAAGAGA
TACAAAAAGGTATTATTATAGGTATACAAAGAGGTGATATTATACCTGTAATATGTGGTTCAACTATAAATAATATAGGC
ACAAAGGAAATATTAGATACAATATCAAGTTATTTAGAACCTATCTTTACAGAGGAAAGCAAACCATTTAGGGGATTAGT
ATTTAAAACTATGGTTGACCCATTTGTTGGAAAGATGTCATATATAAAAATTACTGAGGGTGTACTTTCTAAGGATAAAG
ATGTTTTTAATATAAATAAAAATGTAAAAGAAAAAATAGCTAATATATATACATTGAGAAATAGTGAATTAGTAGAAATA
GAAAAAGCTAAAGCTGGTGATATAGTAGTTATAACTAAAGTTAATTCTCTAAAAACAGGAGACACTATATCTGCAGATAA
AGATGCAGAAGCTTTAGAAAAGATAGATTTTCCTAAACCACAAATATATTATGCAGTAACTCCTAAGAATAAAGGTGATG
AAGAAAAAGTAGCATCTGTATTAAATAAACTAGTAGAAGAGGACCCTACATTACATTGGTATAGAAATACAGAGACAAAA
CAAGCACTTTTAGGAGGTCAAGGAGAACTTCATATAAAAACAATTAAAAATAAAATGAAAGATAAGTTTGGTGTTGATGT
TGAATTGAATGACCTTAAAGTTCCTTATAGAGAAACTATAAAAGGAACAGCTGATGTACAAGGAAAACATAAAAAGCAAT
CAGGTGGTCATGGTCAATATGGAGACGTAAAAATAAGATTTGAAAGATGTGAATCTGATTTTGAATTTACAGAAGAAATA
TTTGGTGGTTCTGTACCAAAACAATATATACCAGCAGTTGAAAAAGGTTTAAAAGACTCTATGCAAAAAGGTATATTAGC
AGGATATCCTGTTACAAACATAAAAGCTACGCTTTATGATGGTTCATACCATGATGTAGACTCTTCTGAAATGGCCTTTA
AAATGGCAGCAAGTGCAGCCTTTAAAAAAGGTATGGAAGAAGCACACCCAATACTACTAGAACCTATAATGAAACTTAAG
ATAACTGTTCCAGAAGAATATATGGGAGATGTCATGGGTGATATAAATAAGAGAAGAGGAAAAATATTTGGAATGGAACC
AGATGACAAAGGGAAACAAATAATATTTGCAGAAGCTCCACAAGCAGAGACATTTAAATATGCAATAGATTTAAGAGCAA
TGACACAAGGTAGAGGATACTTTGAAATGGAATTAGAGAGATATGGAGAGGTTCCATCACAGTTTGCAGAAAAAATAATT
GGGCTAGCTACTGCAAAGTAA

Upstream 100 bases:

>100_bases
TAGTAAGGAAAATGTTATCTAAAAATTCTAAATATAGTAAATATTTTCCATAATATTTCTTAGGAAATAACAGCAAAGAT
AAAATACATAAATTTAAAAG

Downstream 100 bases:

>100_bases
TGAACAAAATAAATAGAAAAATAATTAATATATATTATTAAAAATATTTTTAGGGTTTTAACTAGGTATAGGTTTATGTT
AGGTAAACTTATACCTAGTT

Product: translation elongation factor

Products: GDP; phosphate

Alternate protein names: EF-G [H]

Number of amino acids: Translated: 646; Mature: 645

Protein sequence:

>646_residues
MGAYMKVYDSKMLRNVAVLGHSGCGKTNLIETIAYTANTNKIPKLTDKVNMTYSMGLIPIEYNDYKFNLLDTPGYFDFSG
DVVSSLRASDAAIIVIDATAPIQVGTEKSLELTESIPKIMFINKIDNEKARYKDAIAMLREKYNNKIVPMISPIYKDKNF
VKLHNVFENIDDLEGEFKEQAMSVKEALMELIAETDDQILDKYFNGEELTTEEIQKGIIIGIQRGDIIPVICGSTINNIG
TKEILDTISSYLEPIFTEESKPFRGLVFKTMVDPFVGKMSYIKITEGVLSKDKDVFNINKNVKEKIANIYTLRNSELVEI
EKAKAGDIVVITKVNSLKTGDTISADKDAEALEKIDFPKPQIYYAVTPKNKGDEEKVASVLNKLVEEDPTLHWYRNTETK
QALLGGQGELHIKTIKNKMKDKFGVDVELNDLKVPYRETIKGTADVQGKHKKQSGGHGQYGDVKIRFERCESDFEFTEEI
FGGSVPKQYIPAVEKGLKDSMQKGILAGYPVTNIKATLYDGSYHDVDSSEMAFKMAASAAFKKGMEEAHPILLEPIMKLK
ITVPEEYMGDVMGDINKRRGKIFGMEPDDKGKQIIFAEAPQAETFKYAIDLRAMTQGRGYFEMELERYGEVPSQFAEKII
GLATAK

Sequences:

>Translated_646_residues
MGAYMKVYDSKMLRNVAVLGHSGCGKTNLIETIAYTANTNKIPKLTDKVNMTYSMGLIPIEYNDYKFNLLDTPGYFDFSG
DVVSSLRASDAAIIVIDATAPIQVGTEKSLELTESIPKIMFINKIDNEKARYKDAIAMLREKYNNKIVPMISPIYKDKNF
VKLHNVFENIDDLEGEFKEQAMSVKEALMELIAETDDQILDKYFNGEELTTEEIQKGIIIGIQRGDIIPVICGSTINNIG
TKEILDTISSYLEPIFTEESKPFRGLVFKTMVDPFVGKMSYIKITEGVLSKDKDVFNINKNVKEKIANIYTLRNSELVEI
EKAKAGDIVVITKVNSLKTGDTISADKDAEALEKIDFPKPQIYYAVTPKNKGDEEKVASVLNKLVEEDPTLHWYRNTETK
QALLGGQGELHIKTIKNKMKDKFGVDVELNDLKVPYRETIKGTADVQGKHKKQSGGHGQYGDVKIRFERCESDFEFTEEI
FGGSVPKQYIPAVEKGLKDSMQKGILAGYPVTNIKATLYDGSYHDVDSSEMAFKMAASAAFKKGMEEAHPILLEPIMKLK
ITVPEEYMGDVMGDINKRRGKIFGMEPDDKGKQIIFAEAPQAETFKYAIDLRAMTQGRGYFEMELERYGEVPSQFAEKII
GLATAK
>Mature_645_residues
GAYMKVYDSKMLRNVAVLGHSGCGKTNLIETIAYTANTNKIPKLTDKVNMTYSMGLIPIEYNDYKFNLLDTPGYFDFSGD
VVSSLRASDAAIIVIDATAPIQVGTEKSLELTESIPKIMFINKIDNEKARYKDAIAMLREKYNNKIVPMISPIYKDKNFV
KLHNVFENIDDLEGEFKEQAMSVKEALMELIAETDDQILDKYFNGEELTTEEIQKGIIIGIQRGDIIPVICGSTINNIGT
KEILDTISSYLEPIFTEESKPFRGLVFKTMVDPFVGKMSYIKITEGVLSKDKDVFNINKNVKEKIANIYTLRNSELVEIE
KAKAGDIVVITKVNSLKTGDTISADKDAEALEKIDFPKPQIYYAVTPKNKGDEEKVASVLNKLVEEDPTLHWYRNTETKQ
ALLGGQGELHIKTIKNKMKDKFGVDVELNDLKVPYRETIKGTADVQGKHKKQSGGHGQYGDVKIRFERCESDFEFTEEIF
GGSVPKQYIPAVEKGLKDSMQKGILAGYPVTNIKATLYDGSYHDVDSSEMAFKMAASAAFKKGMEEAHPILLEPIMKLKI
TVPEEYMGDVMGDINKRRGKIFGMEPDDKGKQIIFAEAPQAETFKYAIDLRAMTQGRGYFEMELERYGEVPSQFAEKIIG
LATAK

Specific function: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and

COG id: COG0480

COG function: function code J; Translation elongation factors (GTPases)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding elongation factor family. EF-G/EF-2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI18390331, Length=696, Percent_Identity=28.448275862069, Blast_Score=311, Evalue=2e-84,
Organism=Homo sapiens, GI19923640, Length=701, Percent_Identity=26.3908701854494, Blast_Score=246, Evalue=6e-65,
Organism=Homo sapiens, GI25306287, Length=687, Percent_Identity=25.0363901018923, Blast_Score=214, Evalue=2e-55,
Organism=Homo sapiens, GI25306283, Length=379, Percent_Identity=26.9129287598945, Blast_Score=133, Evalue=7e-31,
Organism=Escherichia coli, GI1789738, Length=692, Percent_Identity=35.1156069364162, Blast_Score=417, Evalue=1e-117,
Organism=Escherichia coli, GI1790835, Length=458, Percent_Identity=22.9257641921397, Blast_Score=94, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17533571, Length=678, Percent_Identity=28.9085545722714, Blast_Score=299, Evalue=3e-81,
Organism=Caenorhabditis elegans, GI17556745, Length=685, Percent_Identity=21.8978102189781, Blast_Score=163, Evalue=3e-40,
Organism=Saccharomyces cerevisiae, GI6323098, Length=687, Percent_Identity=28.3842794759825, Blast_Score=285, Evalue=2e-77,
Organism=Saccharomyces cerevisiae, GI6322359, Length=781, Percent_Identity=24.583866837388, Blast_Score=202, Evalue=2e-52,
Organism=Drosophila melanogaster, GI24582462, Length=691, Percent_Identity=29.3777134587554, Blast_Score=332, Evalue=6e-91,
Organism=Drosophila melanogaster, GI221458488, Length=700, Percent_Identity=23.7142857142857, Blast_Score=198, Evalue=9e-51,

Paralogues:

None

Copy number: 1080 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2520 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 20 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 7984 Molecules/Cell In: Growth Phase, Gl

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009022
- InterPro:   IPR000795
- InterPro:   IPR020568
- InterPro:   IPR014721
- InterPro:   IPR005225
- InterPro:   IPR004540
- InterPro:   IPR000640
- InterPro:   IPR005517
- InterPro:   IPR004161
- InterPro:   IPR009000 [H]

Pfam domain/function: PF00679 EFG_C; PF03764 EFG_IV; PF00009 GTP_EFTU; PF03144 GTP_EFTU_D2 [H]

EC number: 3.6.5.3

Molecular weight: Translated: 72453; Mature: 72322

Theoretical pI: Translated: 5.27; Mature: 5.27

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGAYMKVYDSKMLRNVAVLGHSGCGKTNLIETIAYTANTNKIPKLTDKVNMTYSMGLIPI
CCCHHHHHHHHHHHHHHHEECCCCCCCHHHHHHEEECCCCCCCCCHHHCCEEEEEEEEEE
EYNDYKFNLLDTPGYFDFSGDVVSSLRASDAAIIVIDATAPIQVGTEKSLELTESIPKIM
EECCEEEEEECCCCCCCCCHHHHHHHCCCCCEEEEEECCCCEEECCCCCHHHHHCCCCEE
FINKIDNEKARYKDAIAMLREKYNNKIVPMISPIYKDKNFVKLHNVFENIDDLEGEFKEQ
EEECCCCHHHHHHHHHHHHHHHHCCCCCEEHHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
AMSVKEALMELIAETDDQILDKYFNGEELTTEEIQKGIIIGIQRGDIIPVICGSTINNIG
HHHHHHHHHHHHHCCHHHHHHHHCCCCCCCHHHHCCCEEEEEECCCEEEEECCCCCCCCC
TKEILDTISSYLEPIFTEESKPFRGLVFKTMVDPFVGKMSYIKITEGVLSKDKDVFNINK
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCEEEEEEEHHHHCCCCCEEECCH
NVKEKIANIYTLRNSELVEIEKAKAGDIVVITKVNSLKTGDTISADKDAEALEKIDFPKP
HHHHHHHHHEEECCCCEEEEECCCCCCEEEEEECCCCCCCCCCCCCCCHHHHHHCCCCCC
QIYYAVTPKNKGDEEKVASVLNKLVEEDPTLHWYRNTETKQALLGGQGELHIKTIKNKMK
EEEEEECCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHCCCCCEEHHHHHHHHH
DKFGVDVELNDLKVPYRETIKGTADVQGKHKKQSGGHGQYGDVKIRFERCESDFEFTEEI
HHHCCCEEECCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCHHHHHHH
FGGSVPKQYIPAVEKGLKDSMQKGILAGYPVTNIKATLYDGSYHDVDSSEMAFKMAASAA
HCCCCCHHHHHHHHHHHHHHHHCCCEECCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHH
FKKGMEEAHPILLEPIMKLKITVPEEYMGDVMGDINKRRGKIFGMEPDDKGKQIIFAEAP
HHHCHHHCCCHHHCCHHEEEEECCHHHHHHHHHHHHHHCCEEECCCCCCCCCEEEEECCC
QAETFKYAIDLRAMTQGRGYFEMELERYGEVPSQFAEKIIGLATAK
CCCEEEEEEEEEEHHCCCCEEEEEHHHHCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure 
GAYMKVYDSKMLRNVAVLGHSGCGKTNLIETIAYTANTNKIPKLTDKVNMTYSMGLIPI
CCHHHHHHHHHHHHHHHEECCCCCCCHHHHHHEEECCCCCCCCCHHHCCEEEEEEEEEE
EYNDYKFNLLDTPGYFDFSGDVVSSLRASDAAIIVIDATAPIQVGTEKSLELTESIPKIM
EECCEEEEEECCCCCCCCCHHHHHHHCCCCCEEEEEECCCCEEECCCCCHHHHHCCCCEE
FINKIDNEKARYKDAIAMLREKYNNKIVPMISPIYKDKNFVKLHNVFENIDDLEGEFKEQ
EEECCCCHHHHHHHHHHHHHHHHCCCCCEEHHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
AMSVKEALMELIAETDDQILDKYFNGEELTTEEIQKGIIIGIQRGDIIPVICGSTINNIG
HHHHHHHHHHHHHCCHHHHHHHHCCCCCCCHHHHCCCEEEEEECCCEEEEECCCCCCCCC
TKEILDTISSYLEPIFTEESKPFRGLVFKTMVDPFVGKMSYIKITEGVLSKDKDVFNINK
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCEEEEEEEHHHHCCCCCEEECCH
NVKEKIANIYTLRNSELVEIEKAKAGDIVVITKVNSLKTGDTISADKDAEALEKIDFPKP
HHHHHHHHHEEECCCCEEEEECCCCCCEEEEEECCCCCCCCCCCCCCCHHHHHHCCCCCC
QIYYAVTPKNKGDEEKVASVLNKLVEEDPTLHWYRNTETKQALLGGQGELHIKTIKNKMK
EEEEEECCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHCCCCCEEHHHHHHHHH
DKFGVDVELNDLKVPYRETIKGTADVQGKHKKQSGGHGQYGDVKIRFERCESDFEFTEEI
HHHCCCEEECCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCHHHHHHH
FGGSVPKQYIPAVEKGLKDSMQKGILAGYPVTNIKATLYDGSYHDVDSSEMAFKMAASAA
HCCCCCHHHHHHHHHHHHHHHHCCCEECCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHH
FKKGMEEAHPILLEPIMKLKITVPEEYMGDVMGDINKRRGKIFGMEPDDKGKQIIFAEAP
HHHCHHHCCCHHHCCHHEEEEECCHHHHHHHHHHHHHHCCEEECCCCCCCCCEEEEECCC
QAETFKYAIDLRAMTQGRGYFEMELERYGEVPSQFAEKIIGLATAK
CCCEEEEEEEEEEHHCCCCEEEEEHHHHCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: GTP; H2O

Specific reaction: GTP + H2O = GDP + phosphate

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA