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The map label for this gene is aroE

Identifier: 126697234

GI number: 126697234

Start: 1627395

End: 1628255

Strand: Direct

Name: aroE

Synonym: P9301_18961

Alternate gene names: 126697234

Gene position: 1627395-1628255 (Clockwise)

Preceding gene: 126697232

Following gene: 126697235

Centisome position: 99.12

GC content: 29.5

Gene sequence:

>861_bases
ATGATTTCAAGTAAGACATCTTTTATAGCATTAATCGGCAATCCAGTAAGCCATTCCTTCTCGCCGATTATGCAAAATGC
TGCATTCCAATATTTAGGCTTAGATTTAATTTATTTTGCTATACCTTGCAAAGATGAAGATCTAGAATTGGTTTTGAATT
CTTTGAAAAAAATTAATTGCAAAGGTTTAAATATTACAATTCCCCATAAAGAAAAAGTATTTAACTTATGTAGTGAAATT
TCACCTATAGCAAGAAAACTTAAAGCCATTAATACCCTGAAATTAAATTCTGAAAATGAATGGAGCGCAACTAATACCGA
TTTAGAAGGATTTATTTATCCATTAAAAAATTTAAACTTAGCGAAGAAAAAATCAATAGTTCTTGGCTCCGGGGGTGCAG
CAAAATCTGTTATTCAAGGTTTAATAAATTTAAATCTTTCAAAAATTTCAGTAATAGGACGCAACAAATCATCACTAGAT
GAATTAATAAAAAACTTTGGAAATCAAATTGAACTTCACAGCTTCTTAAGTAACGATAATCAAACTCAAAATTTAATTGA
AGAAGCAGATTTAATTATAAATACAACACCAGTAGGAATGAAAACAGCTAAAAATGAAATGAATTTATTGCCATATGGAG
ATTATTTTTGGAGATCTCTTAACTCAAAAACTATTGTTTATGATTTAATATATAATCCCGCTCCGACTCATCTATTAAAA
TTTAGCGCCAATAAAGGATGCATGACTATCGATGGTTTGCAAATGCTTGTTGCTCAGGGATTGAAATCATTATCATTTTG
GACAAATGGCTTAGAAGTACCATTTCATATCATGAATGATGCTCTCAAAAATCATCTTTAA

Upstream 100 bases:

>100_bases
ATTTGTTACTCTCCATAATCGGTCATTGACGTCATTATTGTTACTCAAAGATGGGGTGTGGTTCCCGAACAGATCATTAT
TTTAAAGAAAAATTCTAAAC

Downstream 100 bases:

>100_bases
AATAATGCTAATTTTCAAGGAACTGCACATCATGATGTATCGTTAGATATGAACAGACGCTCATGACATCATTTATATGA
GCCAAAGACCTTGTCTGAAA

Product: shikimate 5-dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 286; Mature: 286

Protein sequence:

>286_residues
MISSKTSFIALIGNPVSHSFSPIMQNAAFQYLGLDLIYFAIPCKDEDLELVLNSLKKINCKGLNITIPHKEKVFNLCSEI
SPIARKLKAINTLKLNSENEWSATNTDLEGFIYPLKNLNLAKKKSIVLGSGGAAKSVIQGLINLNLSKISVIGRNKSSLD
ELIKNFGNQIELHSFLSNDNQTQNLIEEADLIINTTPVGMKTAKNEMNLLPYGDYFWRSLNSKTIVYDLIYNPAPTHLLK
FSANKGCMTIDGLQMLVAQGLKSLSFWTNGLEVPFHIMNDALKNHL

Sequences:

>Translated_286_residues
MISSKTSFIALIGNPVSHSFSPIMQNAAFQYLGLDLIYFAIPCKDEDLELVLNSLKKINCKGLNITIPHKEKVFNLCSEI
SPIARKLKAINTLKLNSENEWSATNTDLEGFIYPLKNLNLAKKKSIVLGSGGAAKSVIQGLINLNLSKISVIGRNKSSLD
ELIKNFGNQIELHSFLSNDNQTQNLIEEADLIINTTPVGMKTAKNEMNLLPYGDYFWRSLNSKTIVYDLIYNPAPTHLLK
FSANKGCMTIDGLQMLVAQGLKSLSFWTNGLEVPFHIMNDALKNHL
>Mature_286_residues
MISSKTSFIALIGNPVSHSFSPIMQNAAFQYLGLDLIYFAIPCKDEDLELVLNSLKKINCKGLNITIPHKEKVFNLCSEI
SPIARKLKAINTLKLNSENEWSATNTDLEGFIYPLKNLNLAKKKSIVLGSGGAAKSVIQGLINLNLSKISVIGRNKSSLD
ELIKNFGNQIELHSFLSNDNQTQNLIEEADLIINTTPVGMKTAKNEMNLLPYGDYFWRSLNSKTIVYDLIYNPAPTHLLK
FSANKGCMTIDGLQMLVAQGLKSLSFWTNGLEVPFHIMNDALKNHL

Specific function: Aromatic amino acids biosynthesis; shikimate pathway; fourth step. [C]

COG id: COG0169

COG function: function code E; Shikimate 5-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the shikimate dehydrogenase family

Homologues:

Organism=Escherichia coli, GI1787983, Length=293, Percent_Identity=28.3276450511945, Blast_Score=123, Evalue=1e-29,
Organism=Escherichia coli, GI1789675, Length=261, Percent_Identity=28.3524904214559, Blast_Score=97, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6320332, Length=282, Percent_Identity=26.5957446808511, Blast_Score=80, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AROE_PROM0 (A3PFJ4)

Other databases:

- EMBL:   CP000576
- RefSeq:   YP_001092120.1
- ProteinModelPortal:   A3PFJ4
- STRING:   A3PFJ4
- GeneID:   4912680
- GenomeReviews:   CP000576_GR
- KEGG:   pmg:P9301_18961
- eggNOG:   COG0169
- HOGENOM:   HBG553408
- OMA:   CALRSIN
- ProtClustDB:   PRK00258
- BioCyc:   PMAR167546:P9301ORF_1938-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00222
- InterPro:   IPR016040
- InterPro:   IPR011342
- InterPro:   IPR013708
- InterPro:   IPR022893
- InterPro:   IPR006151
- Gene3D:   G3DSA:3.40.50.720
- TIGRFAMs:   TIGR00507

Pfam domain/function: PF01488 Shikimate_DH; PF08501 Shikimate_dh_N

EC number: =1.1.1.25

Molecular weight: Translated: 31773; Mature: 31773

Theoretical pI: Translated: 8.84; Mature: 8.84

Prosite motif: NA

Important sites: ACT_SITE 70-70

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MISSKTSFIALIGNPVSHSFSPIMQNAAFQYLGLDLIYFAIPCKDEDLELVLNSLKKINC
CCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHCCEEEEEEECCCCCHHHHHHHHHHHCCC
KGLNITIPHKEKVFNLCSEISPIARKLKAINTLKLNSENEWSATNTDLEGFIYPLKNLNL
CCCEEECCCHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCCCCCCCCEEEECCCCCC
AKKKSIVLGSGGAAKSVIQGLINLNLSKISVIGRNKSSLDELIKNFGNQIELHSFLSNDN
HHHCEEEEECCCHHHHHHHHHHHCCHHEEEEECCCHHHHHHHHHHHCCEEEEHHHHCCCC
QTQNLIEEADLIINTTPVGMKTAKNEMNLLPYGDYFWRSLNSKTIVYDLIYNPAPTHLLK
HHHHHHHHCCEEEECCCCCCHHCCCCCCCCCCCHHHHHHCCCCEEEEEEECCCCCCCEEE
FSANKGCMTIDGLQMLVAQGLKSLSFWTNGLEVPFHIMNDALKNHL
EECCCCCEEHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCC
>Mature Secondary Structure
MISSKTSFIALIGNPVSHSFSPIMQNAAFQYLGLDLIYFAIPCKDEDLELVLNSLKKINC
CCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHCCEEEEEEECCCCCHHHHHHHHHHHCCC
KGLNITIPHKEKVFNLCSEISPIARKLKAINTLKLNSENEWSATNTDLEGFIYPLKNLNL
CCCEEECCCHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCCCCCCCCEEEECCCCCC
AKKKSIVLGSGGAAKSVIQGLINLNLSKISVIGRNKSSLDELIKNFGNQIELHSFLSNDN
HHHCEEEEECCCHHHHHHHHHHHCCHHEEEEECCCHHHHHHHHHHHCCEEEEHHHHCCCC
QTQNLIEEADLIINTTPVGMKTAKNEMNLLPYGDYFWRSLNSKTIVYDLIYNPAPTHLLK
HHHHHHHHCCEEEECCCCCCHHCCCCCCCCCCCHHHHHHCCCCEEEEEEECCCCCCCEEE
FSANKGCMTIDGLQMLVAQGLKSLSFWTNGLEVPFHIMNDALKNHL
EECCCCCEEHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA