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The map label for this gene is dapA

Identifier: 126697181

GI number: 126697181

Start: 1567946

End: 1568848

Strand: Reverse

Name: dapA

Synonym: P9301_18431

Alternate gene names: 126697181

Gene position: 1568848-1567946 (Counterclockwise)

Preceding gene: 126697182

Following gene: 126697180

Centisome position: 95.55

GC content: 37.65

Gene sequence:

>903_bases
ATGATTACAGACAAAACTGAGTGTAATAATCCACTATTTGGAAGAATATTGACTGCAATGGTTACTCCATTCACTGAGAA
TGGAGATGTTGATTATGAACTAGCCATAAAACTTTCAAATTATCTTTTCGAGAACGGTTCCGATGGAATTGTGTTATGCG
GTACTACTGGAGAATCTCCGACTCTTTCATGGGCTGAACAGCATGAGTTATTTATTGCGGTAAAAGGATCTTTGGATGCA
AGCTGTAAAGTAATAGTTGGCACTGGTAGCAATTGTACAAGCGAAGCTGTGGAAGCTACAAAAAAAGCTTATGACTCTGG
TGCCGACGGTGCTTTGGTTGTTGTTCCTTATTACAATAAGCCGCCTCAAGAAGGTCTTTATAAACATTTTAGTTCTATTG
CTAAATCTGCAAAGGATTTGCCTCTTATGCTCTACAACATTCCTGGTAGAACAGGATGCAATTTATTACCTGATACTGTG
AAGAAACTTATGGATTTCTCAAATATTCTCAGTATTAAAGCTGCAAGCGGTAGAATAGAAGAAGTAACAGAACTAAGAGC
TATTTGTGGCTCTGAACTCTCTGTATATAGTGGCGACGATTCATTGTTGCTTCCAATGTTATCTGTAGGTGCTGTAGGAG
TAGTAAGTGTTGCAAGTCATTTAGTTGGATTGCAATTGAAAGAGATGATTTATTCTTTTCAAAGTGGAAAGGTTTCCAAT
GCTCTTGCTATTCATGAAAAACTTCAGCCTCTTTTCAAAGCACTCTTTATGACTACTAATCCAATCCCAATTAAGGCTGC
TTTGGAGCTATCTGGATGGGATGTAGGTAATCCTAGAAGTCCTTTGTCACCATTAACCAATGACATGAAAAAGCAACTAT
CTTTTATCCTGAAATCCCTATAA

Upstream 100 bases:

>100_bases
GTCAGTCTCATGGATTAGAATTATGGTTATGTGGAGATCAAATAAGAAAAGGAGCAGCTCTGAATGCTGTTCAAATAGCT
GAGTTATTAATTCCAAAAAA

Downstream 100 bases:

>100_bases
TAGGGATTATATTTAACTTGATAATTAAATTTAAATAAACCTTATTTGATTACAAGCAGGCCTTCATAAATTTTCAAAAT
TATGCAATCAAGTACAAATT

Product: dihydrodipicolinate synthase

Products: NA

Alternate protein names: DHDPS

Number of amino acids: Translated: 300; Mature: 300

Protein sequence:

>300_residues
MITDKTECNNPLFGRILTAMVTPFTENGDVDYELAIKLSNYLFENGSDGIVLCGTTGESPTLSWAEQHELFIAVKGSLDA
SCKVIVGTGSNCTSEAVEATKKAYDSGADGALVVVPYYNKPPQEGLYKHFSSIAKSAKDLPLMLYNIPGRTGCNLLPDTV
KKLMDFSNILSIKAASGRIEEVTELRAICGSELSVYSGDDSLLLPMLSVGAVGVVSVASHLVGLQLKEMIYSFQSGKVSN
ALAIHEKLQPLFKALFMTTNPIPIKAALELSGWDVGNPRSPLSPLTNDMKKQLSFILKSL

Sequences:

>Translated_300_residues
MITDKTECNNPLFGRILTAMVTPFTENGDVDYELAIKLSNYLFENGSDGIVLCGTTGESPTLSWAEQHELFIAVKGSLDA
SCKVIVGTGSNCTSEAVEATKKAYDSGADGALVVVPYYNKPPQEGLYKHFSSIAKSAKDLPLMLYNIPGRTGCNLLPDTV
KKLMDFSNILSIKAASGRIEEVTELRAICGSELSVYSGDDSLLLPMLSVGAVGVVSVASHLVGLQLKEMIYSFQSGKVSN
ALAIHEKLQPLFKALFMTTNPIPIKAALELSGWDVGNPRSPLSPLTNDMKKQLSFILKSL
>Mature_300_residues
MITDKTECNNPLFGRILTAMVTPFTENGDVDYELAIKLSNYLFENGSDGIVLCGTTGESPTLSWAEQHELFIAVKGSLDA
SCKVIVGTGSNCTSEAVEATKKAYDSGADGALVVVPYYNKPPQEGLYKHFSSIAKSAKDLPLMLYNIPGRTGCNLLPDTV
KKLMDFSNILSIKAASGRIEEVTELRAICGSELSVYSGDDSLLLPMLSVGAVGVVSVASHLVGLQLKEMIYSFQSGKVSN
ALAIHEKLQPLFKALFMTTNPIPIKAALELSGWDVGNPRSPLSPLTNDMKKQLSFILKSL

Specific function: Biosynthesis of diaminopimelate and lysine from aspartate semialdehyde; first step. [C]

COG id: COG0329

COG function: function code EM; Dihydrodipicolinate synthase/N-acetylneuraminate lyase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHDPS family

Homologues:

Organism=Homo sapiens, GI31543060, Length=278, Percent_Identity=26.6187050359712, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI13540533, Length=299, Percent_Identity=28.7625418060201, Blast_Score=88, Evalue=1e-17,
Organism=Escherichia coli, GI1788823, Length=288, Percent_Identity=38.5416666666667, Blast_Score=209, Evalue=2e-55,
Organism=Escherichia coli, GI1786463, Length=284, Percent_Identity=30.6338028169014, Blast_Score=111, Evalue=5e-26,
Organism=Escherichia coli, GI87082415, Length=244, Percent_Identity=29.9180327868852, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI1789620, Length=234, Percent_Identity=25.6410256410256, Blast_Score=95, Evalue=6e-21,

Paralogues:

None

Copy number: 840 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): DAPA_PROM0 (A3PFE1)

Other databases:

- EMBL:   CP000576
- RefSeq:   YP_001092067.1
- ProteinModelPortal:   A3PFE1
- SMR:   A3PFE1
- STRING:   A3PFE1
- GeneID:   4911165
- GenomeReviews:   CP000576_GR
- KEGG:   pmg:P9301_18431
- eggNOG:   COG0329
- HOGENOM:   HBG358848
- OMA:   GMYRHFK
- ProtClustDB:   PRK03170
- BioCyc:   PMAR167546:P9301ORF_1884-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00418
- InterPro:   IPR013785
- InterPro:   IPR005263
- InterPro:   IPR002220
- InterPro:   IPR020625
- InterPro:   IPR020624
- Gene3D:   G3DSA:3.20.20.70
- PANTHER:   PTHR12128
- PRINTS:   PR00146
- TIGRFAMs:   TIGR00674

Pfam domain/function: PF00701 DHDPS

EC number: =4.2.1.52

Molecular weight: Translated: 32260; Mature: 32260

Theoretical pI: Translated: 5.39; Mature: 5.39

Prosite motif: PS00665 DHDPS_1; PS00666 DHDPS_2

Important sites: ACT_SITE 173-173 BINDING 117-117

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MITDKTECNNPLFGRILTAMVTPFTENGDVDYELAIKLSNYLFENGSDGIVLCGTTGESP
CCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCEEEEEEEHHHHHCCCCCCEEEEECCCCCC
TLSWAEQHELFIAVKGSLDASCKVIVGTGSNCTSEAVEATKKAYDSGADGALVVVPYYNK
CCCCCCCCEEEEEEECCCCCCEEEEEECCCCCHHHHHHHHHHHHCCCCCCEEEEEECCCC
PPQEGLYKHFSSIAKSAKDLPLMLYNIPGRTGCNLLPDTVKKLMDFSNILSIKAASGRIE
CCHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHEEECCCCCHH
EVTELRAICGSELSVYSGDDSLLLPMLSVGAVGVVSVASHLVGLQLKEMIYSFQSGKVSN
HHHHHHHHHCCCCEEEECCCCHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHH
ALAIHEKLQPLFKALFMTTNPIPIKAALELSGWDVGNPRSPLSPLTNDMKKQLSFILKSL
HHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MITDKTECNNPLFGRILTAMVTPFTENGDVDYELAIKLSNYLFENGSDGIVLCGTTGESP
CCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCEEEEEEEHHHHHCCCCCCEEEEECCCCCC
TLSWAEQHELFIAVKGSLDASCKVIVGTGSNCTSEAVEATKKAYDSGADGALVVVPYYNK
CCCCCCCCEEEEEEECCCCCCEEEEEECCCCCHHHHHHHHHHHHCCCCCCEEEEEECCCC
PPQEGLYKHFSSIAKSAKDLPLMLYNIPGRTGCNLLPDTVKKLMDFSNILSIKAASGRIE
CCHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHEEECCCCCHH
EVTELRAICGSELSVYSGDDSLLLPMLSVGAVGVVSVASHLVGLQLKEMIYSFQSGKVSN
HHHHHHHHHCCCCEEEECCCCHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHH
ALAIHEKLQPLFKALFMTTNPIPIKAALELSGWDVGNPRSPLSPLTNDMKKQLSFILKSL
HHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA