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The map label for this gene is sam1

Identifier: 126697155

GI number: 126697155

Start: 1537826

End: 1539244

Strand: Reverse

Name: sam1

Synonym: P9301_18171

Alternate gene names: 126697155

Gene position: 1539244-1537826 (Counterclockwise)

Preceding gene: 126697157

Following gene: 126697154

Centisome position: 93.75

GC content: 34.95

Gene sequence:

>1419_bases
ATGGTTATTGCAAATTCAGTTAAAACATCAACACCGAAATTCATCATTTCTGATATTTCACTATCAGATTTTGGTCGTAA
AGAAATTAAAATTGCCGAAACTGAAATGCCAGGATTAATGGCACTTAGAGATAAATATCAATCTGAAAAGCCATTGAAAG
GTGCAAAAATAGCTGGAAGCCTTCATATGACTATTCAGACAGCAGTCTTAATAGAAACTCTTGTTGATCTTGGTGCAGAA
GTGAAATGGGCTTCATGCAATATTTTTTCAACTCAAGATCATGCAGCTGCAGCAATCGCAGATCAAGGAATTTCTGTATT
TGCAAAAAAAGGTGAGACTCTGGATGAATATTGGCAATATACCCACTATATCCTTGATTGGGGTTCAGACTTCCCAAATA
TGATTCTTGATGATGGGGGGGATGCAACTGGTTTATTGATACTAGGTAGTAAAGCAGAAAAAGATTTATCTGTTTTAGAT
AACCCGAGTAACGAAGAAGAAATTGCTTTATTCAACTCTATTAAGTCTAAGTTGAAAAATGATGGTGAATTCTATTCTAG
AATTAAGAGTAATATCATTGGTGTCACTGAAGAAACTACAACTGGAGTAGCAAGACTTTATCAACTTCAAAAGCAAAATG
CTTTACCTTTCCCAGCTATAAACGTTAATGATTCAGTGACAAAAAGCAAATTTGATAATTTATATGGCTGCCGAGAATCT
TTAGTTGATAGTATCAAGCGTGCCACCGATGTAATGATTGCTGGAAAAACTGCATTAGTAATGGGTTTTGGAGATGTAGG
TAAAGGTTCAGCACAGTCATTGAGAGGACTTGGTGCCATTGTAAAAGTTGCAGAAATTGATCCAATTTGTGCCCTTCAAG
CAGCCATGGAAGGTTACAGCGTTGTCAGGTTAGAAGATGTTGTTGAAGATATAGATATATTTGTTACGGCCACTGGTAAC
TATCAGGTAATAACCCATGAAAATCTAGTCAAAATGAAGGATGAGGCTATAGTTTGCAATATTGGGCATTTTGATAATGA
GATTGATGTTGCCTCTTTAAAGAATTATCAATGGGAAAATATTAAGCCGCAGGTTGATCATATAACTTTACCGAGCGGAA
ATAAAATTATTCTTTTAGCAGAAGGTAGATTAGTTAACCTAGGCTGTGCAACTGGGCATCCAAGTTTTGTTATGAGTAAT
TCGTTCACTAACCAAGTATTAGCTCAAATTGAACTTTTTAATAAGTCGGAGCAATATGCTAAAGAAGTTTATGTTCTACC
AAAACATCTTGATGAAATGGTGGCCAGATTACATTTAGATAAAATAGGGGCAAAATTAACAAAATTAACTAAAGAACAGG
CTGATTATATTAGTGTTTCGGTTGAGGGACCATATAAATCAGAATTTTATAGATACTAA

Upstream 100 bases:

>100_bases
AGAGTTTTATTCCTAAATTTAAAGTCTCTTTTAAATTCTCAACAAACACAAAATTATGCAAAAATCACTTATAGTTTAAT
GGGTATAGATTCCGATAGAA

Downstream 100 bases:

>100_bases
GTTTGAACTTAATTTTTGTAAATTTTCTTACCTCGATTCCCGATTATATAAGTTTGGCGGTTGAGAAGAATTCTGCTGTT
GCATACCTTACTATATGTTT

Product: S-adenosyl-L-homocysteine hydrolase

Products: NA

Alternate protein names: S-adenosyl-L-homocysteine hydrolase; AdoHcyase

Number of amino acids: Translated: 472; Mature: 472

Protein sequence:

>472_residues
MVIANSVKTSTPKFIISDISLSDFGRKEIKIAETEMPGLMALRDKYQSEKPLKGAKIAGSLHMTIQTAVLIETLVDLGAE
VKWASCNIFSTQDHAAAAIADQGISVFAKKGETLDEYWQYTHYILDWGSDFPNMILDDGGDATGLLILGSKAEKDLSVLD
NPSNEEEIALFNSIKSKLKNDGEFYSRIKSNIIGVTEETTTGVARLYQLQKQNALPFPAINVNDSVTKSKFDNLYGCRES
LVDSIKRATDVMIAGKTALVMGFGDVGKGSAQSLRGLGAIVKVAEIDPICALQAAMEGYSVVRLEDVVEDIDIFVTATGN
YQVITHENLVKMKDEAIVCNIGHFDNEIDVASLKNYQWENIKPQVDHITLPSGNKIILLAEGRLVNLGCATGHPSFVMSN
SFTNQVLAQIELFNKSEQYAKEVYVLPKHLDEMVARLHLDKIGAKLTKLTKEQADYISVSVEGPYKSEFYRY

Sequences:

>Translated_472_residues
MVIANSVKTSTPKFIISDISLSDFGRKEIKIAETEMPGLMALRDKYQSEKPLKGAKIAGSLHMTIQTAVLIETLVDLGAE
VKWASCNIFSTQDHAAAAIADQGISVFAKKGETLDEYWQYTHYILDWGSDFPNMILDDGGDATGLLILGSKAEKDLSVLD
NPSNEEEIALFNSIKSKLKNDGEFYSRIKSNIIGVTEETTTGVARLYQLQKQNALPFPAINVNDSVTKSKFDNLYGCRES
LVDSIKRATDVMIAGKTALVMGFGDVGKGSAQSLRGLGAIVKVAEIDPICALQAAMEGYSVVRLEDVVEDIDIFVTATGN
YQVITHENLVKMKDEAIVCNIGHFDNEIDVASLKNYQWENIKPQVDHITLPSGNKIILLAEGRLVNLGCATGHPSFVMSN
SFTNQVLAQIELFNKSEQYAKEVYVLPKHLDEMVARLHLDKIGAKLTKLTKEQADYISVSVEGPYKSEFYRY
>Mature_472_residues
MVIANSVKTSTPKFIISDISLSDFGRKEIKIAETEMPGLMALRDKYQSEKPLKGAKIAGSLHMTIQTAVLIETLVDLGAE
VKWASCNIFSTQDHAAAAIADQGISVFAKKGETLDEYWQYTHYILDWGSDFPNMILDDGGDATGLLILGSKAEKDLSVLD
NPSNEEEIALFNSIKSKLKNDGEFYSRIKSNIIGVTEETTTGVARLYQLQKQNALPFPAINVNDSVTKSKFDNLYGCRES
LVDSIKRATDVMIAGKTALVMGFGDVGKGSAQSLRGLGAIVKVAEIDPICALQAAMEGYSVVRLEDVVEDIDIFVTATGN
YQVITHENLVKMKDEAIVCNIGHFDNEIDVASLKNYQWENIKPQVDHITLPSGNKIILLAEGRLVNLGCATGHPSFVMSN
SFTNQVLAQIELFNKSEQYAKEVYVLPKHLDEMVARLHLDKIGAKLTKLTKEQADYISVSVEGPYKSEFYRY

Specific function: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine

COG id: COG0499

COG function: function code H; S-adenosylhomocysteine hydrolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenosylhomocysteinase family

Homologues:

Organism=Homo sapiens, GI9951915, Length=461, Percent_Identity=57.7006507592191, Blast_Score=500, Evalue=1e-141,
Organism=Homo sapiens, GI239937451, Length=439, Percent_Identity=58.3143507972665, Blast_Score=479, Evalue=1e-135,
Organism=Homo sapiens, GI24308043, Length=462, Percent_Identity=50, Blast_Score=460, Evalue=1e-129,
Organism=Homo sapiens, GI195539337, Length=462, Percent_Identity=50, Blast_Score=460, Evalue=1e-129,
Organism=Homo sapiens, GI298286489, Length=462, Percent_Identity=50, Blast_Score=459, Evalue=1e-129,
Organism=Homo sapiens, GI195539349, Length=462, Percent_Identity=50, Blast_Score=459, Evalue=1e-129,
Organism=Homo sapiens, GI21361647, Length=462, Percent_Identity=48.2683982683983, Blast_Score=438, Evalue=1e-123,
Organism=Caenorhabditis elegans, GI17506425, Length=469, Percent_Identity=57.3560767590618, Blast_Score=502, Evalue=1e-142,
Organism=Saccharomyces cerevisiae, GI6320882, Length=477, Percent_Identity=56.6037735849057, Blast_Score=488, Evalue=1e-138,
Organism=Drosophila melanogaster, GI24642172, Length=466, Percent_Identity=59.4420600858369, Blast_Score=513, Evalue=1e-146,
Organism=Drosophila melanogaster, GI24656245, Length=452, Percent_Identity=50.8849557522124, Blast_Score=455, Evalue=1e-128,
Organism=Drosophila melanogaster, GI45553387, Length=461, Percent_Identity=50.1084598698482, Blast_Score=441, Evalue=1e-124,
Organism=Drosophila melanogaster, GI45553385, Length=460, Percent_Identity=50, Blast_Score=438, Evalue=1e-123,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SAHH_PROM0 (A3PFB5)

Other databases:

- EMBL:   CP000576
- RefSeq:   YP_001092041.1
- ProteinModelPortal:   A3PFB5
- SMR:   A3PFB5
- STRING:   A3PFB5
- GeneID:   4911466
- GenomeReviews:   CP000576_GR
- KEGG:   pmg:P9301_18171
- eggNOG:   COG0499
- HOGENOM:   HBG352029
- OMA:   YWWCTDQ
- ProtClustDB:   PRK05476
- BioCyc:   PMAR167546:P9301ORF_1856-MONOMER
- GO:   GO:0005737
- GO:   GO:0005488
- HAMAP:   MF_00563
- InterPro:   IPR000043
- InterPro:   IPR015878
- InterPro:   IPR020082
- PANTHER:   PTHR23420
- PIRSF:   PIRSF001109
- TIGRFAMs:   TIGR00936

Pfam domain/function: PF05221 AdoHcyase; PF00670 AdoHcyase_NAD

EC number: =3.3.1.1

Molecular weight: Translated: 51982; Mature: 51982

Theoretical pI: Translated: 4.97; Mature: 4.97

Prosite motif: PS00738 ADOHCYASE_1; PS00739 ADOHCYASE_2

Important sites: BINDING 64-64 BINDING 138-138 BINDING 198-198 BINDING 228-228 BINDING 232-232 BINDING 233-233 BINDING 285-285 BINDING 320-320 BINDING 386-386

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVIANSVKTSTPKFIISDISLSDFGRKEIKIAETEMPGLMALRDKYQSEKPLKGAKIAGS
CEEECCCCCCCCCEEEEECCCCCCCCCEEEEECCCCCCHHHHHHHHCCCCCCCCCEEECE
LHMTIQTAVLIETLVDLGAEVKWASCNIFSTQDHAAAAIADQGISVFAKKGETLDEYWQY
EEHHHHHHHHHHHHHHCCCCEEEEEEEEECCCCCHHHHHHHCCCCEEECCCCCHHHHHHH
THYILDWGSDFPNMILDDGGDATGLLILGSKAEKDLSVLDNPSNEEEIALFNSIKSKLKN
HHHEEECCCCCCCCEEECCCCEEEEEEECCCCCCCHHHHCCCCCCHHHHHHHHHHHHHCC
DGEFYSRIKSNIIGVTEETTTGVARLYQLQKQNALPFPAINVNDSVTKSKFDNLYGCRES
CHHHHHHHHHHEECCCCCHHHHHHHHHHHHHCCCCCCCEECCCCCHHHHHHHHHHHHHHH
LVDSIKRATDVMIAGKTALVMGFGDVGKGSAQSLRGLGAIVKVAEIDPICALQAAMEGYS
HHHHHHHHHHEEEECCEEEEEECCCCCCCCHHHHHHHHHHEEEECCCCHHHHHHHHCCCE
VVRLEDVVEDIDIFVTATGNYQVITHENLVKMKDEAIVCNIGHFDNEIDVASLKNYQWEN
EEEHHHHHCCCEEEEEECCCEEEEECCCCEEECCCEEEEECCCCCCCCCHHHHCCCCCCC
IKPQVDHITLPSGNKIILLAEGRLVNLGCATGHPSFVMSNSFTNQVLAQIELFNKSEQYA
CCCCCCEEECCCCCEEEEEECCEEEEEEECCCCCCEEEECCHHHHHHHHHHHHCCCHHHH
KEVYVLPKHLDEMVARLHLDKIGAKLTKLTKEQADYISVSVEGPYKSEFYRY
HHHEECHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCC
>Mature Secondary Structure
MVIANSVKTSTPKFIISDISLSDFGRKEIKIAETEMPGLMALRDKYQSEKPLKGAKIAGS
CEEECCCCCCCCCEEEEECCCCCCCCCEEEEECCCCCCHHHHHHHHCCCCCCCCCEEECE
LHMTIQTAVLIETLVDLGAEVKWASCNIFSTQDHAAAAIADQGISVFAKKGETLDEYWQY
EEHHHHHHHHHHHHHHCCCCEEEEEEEEECCCCCHHHHHHHCCCCEEECCCCCHHHHHHH
THYILDWGSDFPNMILDDGGDATGLLILGSKAEKDLSVLDNPSNEEEIALFNSIKSKLKN
HHHEEECCCCCCCCEEECCCCEEEEEEECCCCCCCHHHHCCCCCCHHHHHHHHHHHHHCC
DGEFYSRIKSNIIGVTEETTTGVARLYQLQKQNALPFPAINVNDSVTKSKFDNLYGCRES
CHHHHHHHHHHEECCCCCHHHHHHHHHHHHHCCCCCCCEECCCCCHHHHHHHHHHHHHHH
LVDSIKRATDVMIAGKTALVMGFGDVGKGSAQSLRGLGAIVKVAEIDPICALQAAMEGYS
HHHHHHHHHHEEEECCEEEEEECCCCCCCCHHHHHHHHHHEEEECCCCHHHHHHHHCCCE
VVRLEDVVEDIDIFVTATGNYQVITHENLVKMKDEAIVCNIGHFDNEIDVASLKNYQWEN
EEEHHHHHCCCEEEEEECCCEEEEECCCCEEECCCEEEEECCCCCCCCCHHHHCCCCCCC
IKPQVDHITLPSGNKIILLAEGRLVNLGCATGHPSFVMSNSFTNQVLAQIELFNKSEQYA
CCCCCCEEECCCCCEEEEEECCEEEEEEECCCCCCEEEECCHHHHHHHHHHHHCCCHHHH
KEVYVLPKHLDEMVARLHLDKIGAKLTKLTKEQADYISVSVEGPYKSEFYRY
HHHEECHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA