Click here to switch to the map view.

The map label for this gene is bioA [H]

Identifier: 126697000

GI number: 126697000

Start: 1392469

End: 1393770

Strand: Direct

Name: bioA [H]

Synonym: P9301_16621

Alternate gene names: 126697000

Gene position: 1392469-1393770 (Clockwise)

Preceding gene: 126696999

Following gene: 126697003

Centisome position: 84.81

GC content: 33.33

Gene sequence:

>1302_bases
ATGAAACCTTTGGATTCAAAAACTCCAAATCAAGATTGGCACCCAAATATTTGGCCACCTTTTACTCAAGTCAATAAGAG
TAAGCCGCAAATAGAAGTAACTCATGGTAAAGATGCCCTCCTATTTACTAAAAATCCTAAAAAAGAGCTAATAGATGCAA
TTAGTAGTTGGTGGGTAACTCTTCATGGTCATAGTAACGAATATATTGCAGATGCCATTTTTAATCAATCAAAAAAACTT
GAGCAAGTTATATTTGCTGATTTTTTACATCCACAGGCAAAAAAATTGGCGGAAAGACTTAGTGAATTAACAAAACTAGA
AAGATTATTCTTTTCTGATAACGGTTCTACTGCAGTGGAAGTCGCTTTAAAAATTGCCTTCCAATCATGGCAAAATAAAG
GAGAGACAAGAACTCAAATAGTGGCTTTTGATGGCGCCTATCATGGCGATACATTTGGAGCAATGGCTTTAGGTGAAAGA
AATATTTTTAATGAGAATTTCGATAATCTTATGTTCCCAGTTAGGAGAGTCCCATGGCCTTCAACTTGGATAAATGATGA
AGAAGTAGAAAATAAAGAAAATGAGGCGATCCAAAAATTAGAAACTCTACTTAAAACTCCCACAGTAGCAGTGATCCTTG
AGCCACTTGTTCAAGGAGCAGGAGGAATGAATATGGTTAGGCCTCAATTTATAAAAAGAGTTTCAGAAATTATAAAAAAT
AATAATTCTTTGTTAATTGCCGATGAAGTTTTGACTGGGTTTGGAAGATGTGGAAGCCTTTTTGCGTTTCAAAAGGCAAA
AATCATTCCAGATTTAATCAGTATTTCAAAAGGCTTAACTGGTGGATTTTTACCAATGGGAATAACTTTATGTAAAGAAA
AAATTTTCCAATCTTTTGTTGATGATTCCCCAAGAAAAACTTTTTGGCATGGACATAGTTTTACTGCTAATCCTTTAGGT
TGTGCTGCGGCAAACGCTAGTCTTGATTTATTAGAAAAAGAACCACACAAATACCTTTCATTTGAAGAAAAACATTTATC
TCATTTAATTAAATTTAAAAATTTACATCATATAAAAAAGATAAGGGTATCCGGCACAATTGCTGCCTTCGATTTAGATA
TTGGGAACAAAAAAGGTTATTTCAATAATATTGGAAAAGAAATAAAGAGTCTTGCAATGGAGCAAGGTTTATTTATTAGA
CCCCTAGGGAATGTTATTTATCTCTTGCCACCTCTCTGTATAACCGATGATCAATTAGAAAAAAGTTACTGGATAATAAG
GCAAATCTTAGAAAATCTTTAG

Upstream 100 bases:

>100_bases
TTATATAAAAAAAATGGACTCAAATAATTTAGATAAACTATGGGAAGAACTTGAAATTAAAAATAAATTAATCTCACTTT
TAAATTCCAAAATAAGTTAA

Downstream 100 bases:

>100_bases
ATACAAATTTAAGGTCCCTGCAGTATTGCATTTTCCACATCTTCTCTATTAATGCAATAGGAAAATAGTCTTTTAGTTTC
TTCTCCTTCGCTTTCCCAGA

Product: putative diaminopelargonic acid synthase

Products: NA

Alternate protein names: 7,8-diamino-pelargonic acid aminotransferase; DAPA AT; DAPA aminotransferase; Diaminopelargonic acid synthase [H]

Number of amino acids: Translated: 433; Mature: 433

Protein sequence:

>433_residues
MKPLDSKTPNQDWHPNIWPPFTQVNKSKPQIEVTHGKDALLFTKNPKKELIDAISSWWVTLHGHSNEYIADAIFNQSKKL
EQVIFADFLHPQAKKLAERLSELTKLERLFFSDNGSTAVEVALKIAFQSWQNKGETRTQIVAFDGAYHGDTFGAMALGER
NIFNENFDNLMFPVRRVPWPSTWINDEEVENKENEAIQKLETLLKTPTVAVILEPLVQGAGGMNMVRPQFIKRVSEIIKN
NNSLLIADEVLTGFGRCGSLFAFQKAKIIPDLISISKGLTGGFLPMGITLCKEKIFQSFVDDSPRKTFWHGHSFTANPLG
CAAANASLDLLEKEPHKYLSFEEKHLSHLIKFKNLHHIKKIRVSGTIAAFDLDIGNKKGYFNNIGKEIKSLAMEQGLFIR
PLGNVIYLLPPLCITDDQLEKSYWIIRQILENL

Sequences:

>Translated_433_residues
MKPLDSKTPNQDWHPNIWPPFTQVNKSKPQIEVTHGKDALLFTKNPKKELIDAISSWWVTLHGHSNEYIADAIFNQSKKL
EQVIFADFLHPQAKKLAERLSELTKLERLFFSDNGSTAVEVALKIAFQSWQNKGETRTQIVAFDGAYHGDTFGAMALGER
NIFNENFDNLMFPVRRVPWPSTWINDEEVENKENEAIQKLETLLKTPTVAVILEPLVQGAGGMNMVRPQFIKRVSEIIKN
NNSLLIADEVLTGFGRCGSLFAFQKAKIIPDLISISKGLTGGFLPMGITLCKEKIFQSFVDDSPRKTFWHGHSFTANPLG
CAAANASLDLLEKEPHKYLSFEEKHLSHLIKFKNLHHIKKIRVSGTIAAFDLDIGNKKGYFNNIGKEIKSLAMEQGLFIR
PLGNVIYLLPPLCITDDQLEKSYWIIRQILENL
>Mature_433_residues
MKPLDSKTPNQDWHPNIWPPFTQVNKSKPQIEVTHGKDALLFTKNPKKELIDAISSWWVTLHGHSNEYIADAIFNQSKKL
EQVIFADFLHPQAKKLAERLSELTKLERLFFSDNGSTAVEVALKIAFQSWQNKGETRTQIVAFDGAYHGDTFGAMALGER
NIFNENFDNLMFPVRRVPWPSTWINDEEVENKENEAIQKLETLLKTPTVAVILEPLVQGAGGMNMVRPQFIKRVSEIIKN
NNSLLIADEVLTGFGRCGSLFAFQKAKIIPDLISISKGLTGGFLPMGITLCKEKIFQSFVDDSPRKTFWHGHSFTANPLG
CAAANASLDLLEKEPHKYLSFEEKHLSHLIKFKNLHHIKKIRVSGTIAAFDLDIGNKKGYFNNIGKEIKSLAMEQGLFIR
PLGNVIYLLPPLCITDDQLEKSYWIIRQILENL

Specific function: Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor [H]

COG id: COG0161

COG function: function code H; Adenosylmethionine-8-amino-7-oxononanoate aminotransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=413, Percent_Identity=26.3922518159806, Blast_Score=111, Evalue=1e-24,
Organism=Homo sapiens, GI13994255, Length=380, Percent_Identity=25.5263157894737, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI284507298, Length=331, Percent_Identity=27.4924471299094, Blast_Score=99, Evalue=5e-21,
Organism=Homo sapiens, GI37574042, Length=442, Percent_Identity=23.9819004524887, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI226442709, Length=399, Percent_Identity=24.3107769423559, Blast_Score=86, Evalue=8e-17,
Organism=Homo sapiens, GI226442705, Length=374, Percent_Identity=24.5989304812834, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI24119277, Length=409, Percent_Identity=22.9828850855746, Blast_Score=81, Evalue=2e-15,
Organism=Escherichia coli, GI1786991, Length=415, Percent_Identity=34.2168674698795, Blast_Score=235, Evalue=4e-63,
Organism=Escherichia coli, GI145693181, Length=395, Percent_Identity=30.379746835443, Blast_Score=154, Evalue=1e-38,
Organism=Escherichia coli, GI1788044, Length=378, Percent_Identity=27.2486772486773, Blast_Score=134, Evalue=2e-32,
Organism=Escherichia coli, GI1789759, Length=381, Percent_Identity=26.7716535433071, Blast_Score=132, Evalue=3e-32,
Organism=Escherichia coli, GI1789016, Length=402, Percent_Identity=28.1094527363184, Blast_Score=130, Evalue=2e-31,
Organism=Escherichia coli, GI1787560, Length=397, Percent_Identity=27.7078085642317, Blast_Score=114, Evalue=9e-27,
Organism=Caenorhabditis elegans, GI25144271, Length=387, Percent_Identity=25.0645994832041, Blast_Score=111, Evalue=9e-25,
Organism=Caenorhabditis elegans, GI32564660, Length=447, Percent_Identity=25.7270693512304, Blast_Score=106, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI25144274, Length=235, Percent_Identity=30.6382978723404, Blast_Score=103, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI71992977, Length=411, Percent_Identity=22.8710462287105, Blast_Score=77, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6324386, Length=471, Percent_Identity=30.3609341825902, Blast_Score=206, Evalue=6e-54,
Organism=Saccharomyces cerevisiae, GI6324432, Length=431, Percent_Identity=27.8422273781903, Blast_Score=127, Evalue=2e-30,
Organism=Saccharomyces cerevisiae, GI6323470, Length=405, Percent_Identity=26.6666666666667, Blast_Score=123, Evalue=5e-29,
Organism=Drosophila melanogaster, GI21357415, Length=398, Percent_Identity=25.8793969849246, Blast_Score=112, Evalue=5e-25,
Organism=Drosophila melanogaster, GI161085790, Length=398, Percent_Identity=24.3718592964824, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI28574759, Length=393, Percent_Identity=24.6819338422392, Blast_Score=97, Evalue=3e-20,
Organism=Drosophila melanogaster, GI21356575, Length=428, Percent_Identity=24.0654205607477, Blast_Score=95, Evalue=9e-20,
Organism=Drosophila melanogaster, GI281366494, Length=202, Percent_Identity=28.2178217821782, Blast_Score=69, Evalue=5e-12,
Organism=Drosophila melanogaster, GI24667139, Length=202, Percent_Identity=28.2178217821782, Blast_Score=69, Evalue=5e-12,
Organism=Drosophila melanogaster, GI24667143, Length=202, Percent_Identity=28.2178217821782, Blast_Score=69, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005814
- InterPro:   IPR005815
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.62 [H]

Molecular weight: Translated: 49040; Mature: 49040

Theoretical pI: Translated: 8.33; Mature: 8.33

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPLDSKTPNQDWHPNIWPPFTQVNKSKPQIEVTHGKDALLFTKNPKKELIDAISSWWVT
CCCCCCCCCCCCCCCCCCCCHHHCCCCCCEEEEECCCCEEEEECCCHHHHHHHHHHCEEE
LHGHSNEYIADAIFNQSKKLEQVIFADFLHPQAKKLAERLSELTKLERLFFSDNGSTAVE
EECCCCCHHHHHHHCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHH
VALKIAFQSWQNKGETRTQIVAFDGAYHGDTFGAMALGERNIFNENFDNLMFPVRRVPWP
HHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCHHHHHCCCCCCCCCHHHHHHHHHCCCCC
STWINDEEVENKENEAIQKLETLLKTPTVAVILEPLVQGAGGMNMVRPQFIKRVSEIIKN
CCCCCCHHHCCHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHC
NNSLLIADEVLTGFGRCGSLFAFQKAKIIPDLISISKGLTGGFLPMGITLCKEKIFQSFV
CCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
DDSPRKTFWHGHSFTANPLGCAAANASLDLLEKEPHKYLSFEEKHLSHLIKFKNLHHIKK
CCCCCCEEECCCCCCCCCCCHHHCCCCHHHHHCCCHHHHCHHHHHHHHHHHHHHHHHHHH
IRVSGTIAAFDLDIGNKKGYFNNIGKEIKSLAMEQGLFIRPLGNVIYLLPPLCITDDQLE
EEECCEEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCEEEECCCCHHHCCCCCCCCHHHH
KSYWIIRQILENL
HHHHHHHHHHHHC
>Mature Secondary Structure
MKPLDSKTPNQDWHPNIWPPFTQVNKSKPQIEVTHGKDALLFTKNPKKELIDAISSWWVT
CCCCCCCCCCCCCCCCCCCCHHHCCCCCCEEEEECCCCEEEEECCCHHHHHHHHHHCEEE
LHGHSNEYIADAIFNQSKKLEQVIFADFLHPQAKKLAERLSELTKLERLFFSDNGSTAVE
EECCCCCHHHHHHHCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHH
VALKIAFQSWQNKGETRTQIVAFDGAYHGDTFGAMALGERNIFNENFDNLMFPVRRVPWP
HHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCHHHHHCCCCCCCCCHHHHHHHHHCCCCC
STWINDEEVENKENEAIQKLETLLKTPTVAVILEPLVQGAGGMNMVRPQFIKRVSEIIKN
CCCCCCHHHCCHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHC
NNSLLIADEVLTGFGRCGSLFAFQKAKIIPDLISISKGLTGGFLPMGITLCKEKIFQSFV
CCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
DDSPRKTFWHGHSFTANPLGCAAANASLDLLEKEPHKYLSFEEKHLSHLIKFKNLHHIKK
CCCCCCEEECCCCCCCCCCCHHHCCCCHHHHHCCCHHHHCHHHHHHHHHHHHHHHHHHHH
IRVSGTIAAFDLDIGNKKGYFNNIGKEIKSLAMEQGLFIRPLGNVIYLLPPLCITDDQLE
EEECCEEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCEEEECCCCHHHCCCCCCCCHHHH
KSYWIIRQILENL
HHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2110099 [H]