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The map label for this gene is groEL

Identifier: 126696964

GI number: 126696964

Start: 1359597

End: 1361234

Strand: Reverse

Name: groEL

Synonym: P9301_16261

Alternate gene names: 126696964

Gene position: 1361234-1359597 (Counterclockwise)

Preceding gene: 126696965

Following gene: 126696961

Centisome position: 82.91

GC content: 39.44

Gene sequence:

>1638_bases
ATGGCTAAAAGAATTATTTACAATGAGCAAGCTCGTAGAGCGCTCGAGAGAGGAATTGATATCCTTGCTGAGTCTGTGGC
TGTAACGCTCGGACCAAAAGGAAGAAATGTTGTACTAGAAAAAAAATTTGGTGCTCCACAAATCATCAACGATGGTGTGA
CAATTGCTAAGGAGATCGAGTTAGAGGATCACATTGAAAACACAGGTGTCGCTTTAATTAGACAAGCTGCTTCAAAAACT
AATGATGCAGCTGGAGATGGTACTACAACAGCCACTGTTTTAGCACATGCAATGGTTAAGGCAGGTTTGAGAAACGTTGC
TGCAGGAGCTAATGCAATTACCCTGAAAAAAGGAATTGACAAAGCTACTGAATTTCTTGTTGGTAAAATTCAGGAAAATT
CCAAACCTATTAGTGACAGCAATGCCATAGCTCAATGCGGAACTATAGCGGCTGGGAACGATGATGAAGTAGGTCAAATG
ATTGCCAATGCTATGGATAAAGTTGGTAAAGAAGGTGTTATCTCCTTAGAAGAAGGAAAATCAATGACTACTGAATTAGA
AGTTACAGAGGGTATGCGCTTTGACAAAGGCTATATTTCACCTTACTTCGCAACAGACACAGAGAGAATGGAGGCTGTTT
TAGATGAACCATATATTCTCCTGACTGATAAAAAAATAGCCTTAGTCCAAGATTTAGTTCCCGTATTAGAACAAATAGCT
AAAACTGGTAAACCACTAGTCATTATCGCTGAAGATATTGAAAAAGAGGCTTTAGCAACTCTTGTTGTTAATAGATTACG
AGGTGTGTTAAATGTTGCTGCAGTAAAAGCTCCTGGATTTGGTGATAGAAGAAAGGCCATGCTTGAAGATATGGCTGTTT
TAACTAATGGACAACTTATAACTGAAGATGCAGGCTTGAAATTAGAGAATGCTACCTTGGATATGCTTGGAACTGGTAGA
AGAATAACTATCAACAAAGAGACTACAACTATTGTGGCTGAAGGTAATGAGCAAGCAGTTAAAGCTAGATGTGATCAGAT
TAAGAAGCAAATGGATGAAACAGATTCATCATACGATAAAGAAAAGCTTCAAGAACGTCTTGCTAAATTAGCTGGAGGTG
TAGCAGTTATTAAGGTTGGTGCTGCTACTGAAACTGAGATGAAGGATAAAAAACTTCGTCTTGAGGATGCTATTAATGCA
ACAAAAGCAGCTGTTGAGGAAGGAATTGTACCTGGAGGAGGAACAACTCTCGCTCATTTATCTCCTATTCTAAAAGAATG
GGCAGATAAAAATTTAGAAGGAGAGGAATTAATTGGAGCTAACATCGTTGAAGCTTCACTGACTGCTCCTCTTATGAGAA
TCGCTGAGAATGCAGGTTCTAATGGAGCTGTGATTGCTGAAAATGTAAAAACTAAACCATTTAATGATGGCTTCAATGCT
GCTACTGGAGAATATGTAGATATGTCCTCTGCTGGTATAGTTGATCCTGCAAAAGTTACACGTTCAGGATTGCAAAATGC
AGCTTCAATTGCAGGGATGGTTCTAACCACCGAATGCATAGTTGCAGATTTACCTGAGAAAAAGGATTCAGCTGCTCCAG
CAGGCGCTCCTGGTATGGGTGGCGACTTTGATTACTAA

Upstream 100 bases:

>100_bases
ATGAATATGTCTTACTCTCAGAAAAGGATATTTTAGCTGTAGTAAGCTAAAGTATTTTTTTAAAAATTATTAAAACTTAT
TACTAAATTACTGCCTAAAC

Downstream 100 bases:

>100_bases
ACTAAACAATAGTTTGCAATAAATTTTTGAAAGGGATCATTCAAAATGGTCCCTTTTTTCAAGTTTTATGAAATCCAACC
AGCGCTAAGAATAATTGCTA

Product: chaperonin GroEL

Products: NA

Alternate protein names: GroEL protein 2; Protein Cpn60 2

Number of amino acids: Translated: 545; Mature: 544

Protein sequence:

>545_residues
MAKRIIYNEQARRALERGIDILAESVAVTLGPKGRNVVLEKKFGAPQIINDGVTIAKEIELEDHIENTGVALIRQAASKT
NDAAGDGTTTATVLAHAMVKAGLRNVAAGANAITLKKGIDKATEFLVGKIQENSKPISDSNAIAQCGTIAAGNDDEVGQM
IANAMDKVGKEGVISLEEGKSMTTELEVTEGMRFDKGYISPYFATDTERMEAVLDEPYILLTDKKIALVQDLVPVLEQIA
KTGKPLVIIAEDIEKEALATLVVNRLRGVLNVAAVKAPGFGDRRKAMLEDMAVLTNGQLITEDAGLKLENATLDMLGTGR
RITINKETTTIVAEGNEQAVKARCDQIKKQMDETDSSYDKEKLQERLAKLAGGVAVIKVGAATETEMKDKKLRLEDAINA
TKAAVEEGIVPGGGTTLAHLSPILKEWADKNLEGEELIGANIVEASLTAPLMRIAENAGSNGAVIAENVKTKPFNDGFNA
ATGEYVDMSSAGIVDPAKVTRSGLQNAASIAGMVLTTECIVADLPEKKDSAAPAGAPGMGGDFDY

Sequences:

>Translated_545_residues
MAKRIIYNEQARRALERGIDILAESVAVTLGPKGRNVVLEKKFGAPQIINDGVTIAKEIELEDHIENTGVALIRQAASKT
NDAAGDGTTTATVLAHAMVKAGLRNVAAGANAITLKKGIDKATEFLVGKIQENSKPISDSNAIAQCGTIAAGNDDEVGQM
IANAMDKVGKEGVISLEEGKSMTTELEVTEGMRFDKGYISPYFATDTERMEAVLDEPYILLTDKKIALVQDLVPVLEQIA
KTGKPLVIIAEDIEKEALATLVVNRLRGVLNVAAVKAPGFGDRRKAMLEDMAVLTNGQLITEDAGLKLENATLDMLGTGR
RITINKETTTIVAEGNEQAVKARCDQIKKQMDETDSSYDKEKLQERLAKLAGGVAVIKVGAATETEMKDKKLRLEDAINA
TKAAVEEGIVPGGGTTLAHLSPILKEWADKNLEGEELIGANIVEASLTAPLMRIAENAGSNGAVIAENVKTKPFNDGFNA
ATGEYVDMSSAGIVDPAKVTRSGLQNAASIAGMVLTTECIVADLPEKKDSAAPAGAPGMGGDFDY
>Mature_544_residues
AKRIIYNEQARRALERGIDILAESVAVTLGPKGRNVVLEKKFGAPQIINDGVTIAKEIELEDHIENTGVALIRQAASKTN
DAAGDGTTTATVLAHAMVKAGLRNVAAGANAITLKKGIDKATEFLVGKIQENSKPISDSNAIAQCGTIAAGNDDEVGQMI
ANAMDKVGKEGVISLEEGKSMTTELEVTEGMRFDKGYISPYFATDTERMEAVLDEPYILLTDKKIALVQDLVPVLEQIAK
TGKPLVIIAEDIEKEALATLVVNRLRGVLNVAAVKAPGFGDRRKAMLEDMAVLTNGQLITEDAGLKLENATLDMLGTGRR
ITINKETTTIVAEGNEQAVKARCDQIKKQMDETDSSYDKEKLQERLAKLAGGVAVIKVGAATETEMKDKKLRLEDAINAT
KAAVEEGIVPGGGTTLAHLSPILKEWADKNLEGEELIGANIVEASLTAPLMRIAENAGSNGAVIAENVKTKPFNDGFNAA
TGEYVDMSSAGIVDPAKVTRSGLQNAASIAGMVLTTECIVADLPEKKDSAAPAGAPGMGGDFDY

Specific function: Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions

COG id: COG0459

COG function: function code O; Chaperonin GroEL (HSP60 family)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chaperonin (HSP60) family

Homologues:

Organism=Homo sapiens, GI41399285, Length=531, Percent_Identity=44.0677966101695, Blast_Score=451, Evalue=1e-127,
Organism=Homo sapiens, GI31542947, Length=531, Percent_Identity=44.0677966101695, Blast_Score=451, Evalue=1e-127,
Organism=Escherichia coli, GI1790586, Length=531, Percent_Identity=56.6854990583804, Blast_Score=584, Evalue=1e-168,
Organism=Caenorhabditis elegans, GI17555558, Length=530, Percent_Identity=44.7169811320755, Blast_Score=455, Evalue=1e-128,
Organism=Caenorhabditis elegans, GI193210679, Length=211, Percent_Identity=41.7061611374408, Blast_Score=166, Evalue=3e-41,
Organism=Saccharomyces cerevisiae, GI6323288, Length=526, Percent_Identity=49.0494296577947, Blast_Score=494, Evalue=1e-140,
Organism=Saccharomyces cerevisiae, GI6322524, Length=580, Percent_Identity=22.2413793103448, Blast_Score=77, Evalue=8e-15,
Organism=Drosophila melanogaster, GI24641193, Length=528, Percent_Identity=46.0227272727273, Blast_Score=465, Evalue=1e-131,
Organism=Drosophila melanogaster, GI24641191, Length=528, Percent_Identity=46.0227272727273, Blast_Score=465, Evalue=1e-131,
Organism=Drosophila melanogaster, GI45550936, Length=526, Percent_Identity=42.9657794676806, Blast_Score=432, Evalue=1e-121,
Organism=Drosophila melanogaster, GI45550132, Length=526, Percent_Identity=42.9657794676806, Blast_Score=432, Evalue=1e-121,
Organism=Drosophila melanogaster, GI45550935, Length=526, Percent_Identity=42.9657794676806, Blast_Score=432, Evalue=1e-121,
Organism=Drosophila melanogaster, GI17864606, Length=526, Percent_Identity=37.8326996197719, Blast_Score=368, Evalue=1e-102,
Organism=Drosophila melanogaster, GI24584129, Length=530, Percent_Identity=34.3396226415094, Blast_Score=293, Evalue=2e-79,
Organism=Drosophila melanogaster, GI19921262, Length=530, Percent_Identity=34.3396226415094, Blast_Score=293, Evalue=2e-79,

Paralogues:

None

Copy number: 2180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 15012 Molecules/Cell In: Growth Phase,

Swissprot (AC and ID): CH602_PROM0 (A3PES4)

Other databases:

- EMBL:   CP000576
- RefSeq:   YP_001091850.1
- ProteinModelPortal:   A3PES4
- SMR:   A3PES4
- STRING:   A3PES4
- GeneID:   4911391
- GenomeReviews:   CP000576_GR
- KEGG:   pmg:P9301_16261
- eggNOG:   COG0459
- HOGENOM:   HBG625289
- OMA:   KPFNDGF
- ProtClustDB:   PRK00013
- BioCyc:   PMAR167546:P9301ORF_1658-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00600
- InterPro:   IPR018370
- InterPro:   IPR001844
- InterPro:   IPR002423
- PANTHER:   PTHR11353
- PRINTS:   PR00298
- TIGRFAMs:   TIGR02348

Pfam domain/function: PF00118 Cpn60_TCP1; SSF48592 GroEL-ATPase

EC number: NA

Molecular weight: Translated: 57668; Mature: 57536

Theoretical pI: Translated: 4.64; Mature: 4.64

Prosite motif: PS00296 CHAPERONINS_CPN60

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKRIIYNEQARRALERGIDILAESVAVTLGPKGRNVVLEKKFGAPQIINDGVTIAKEIE
CCCCEEECHHHHHHHHHHHHHHHHHHEEEECCCCCEEEEEECCCCCCEECCCCEEEEECC
LEDHIENTGVALIRQAASKTNDAAGDGTTTATVLAHAMVKAGLRNVAAGANAITLKKGID
HHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEHHHHH
KATEFLVGKIQENSKPISDSNAIAQCGTIAAGNDDEVGQMIANAMDKVGKEGVISLEEGK
HHHHHHHHHHHCCCCCCCCCCHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEECCCC
SMTTELEVTEGMRFDKGYISPYFATDTERMEAVLDEPYILLTDKKIALVQDLVPVLEQIA
CCEEEEEHHCCCEECCCCCCCEECCCHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHH
KTGKPLVIIAEDIEKEALATLVVNRLRGVLNVAAVKAPGFGDRRKAMLEDMAVLTNGQLI
HCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCEEE
TEDAGLKLENATLDMLGTGRRITINKETTTIVAEGNEQAVKARCDQIKKQMDETDSSYDK
ECCCCCEEECCEEEEECCCCEEEEECCEEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCH
EKLQERLAKLAGGVAVIKVGAATETEMKDKKLRLEDAINATKAAVEEGIVPGGGTTLAHL
HHHHHHHHHHHCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHH
SPILKEWADKNLEGEELIGANIVEASLTAPLMRIAENAGSNGAVIAENVKTKPFNDGFNA
HHHHHHHHCCCCCCHHHHCCHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCCCCCC
ATGEYVDMSSAGIVDPAKVTRSGLQNAASIAGMVLTTECIVADLPEKKDSAAPAGAPGMG
CCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
GDFDY
CCCCC
>Mature Secondary Structure 
AKRIIYNEQARRALERGIDILAESVAVTLGPKGRNVVLEKKFGAPQIINDGVTIAKEIE
CCCEEECHHHHHHHHHHHHHHHHHHEEEECCCCCEEEEEECCCCCCEECCCCEEEEECC
LEDHIENTGVALIRQAASKTNDAAGDGTTTATVLAHAMVKAGLRNVAAGANAITLKKGID
HHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEHHHHH
KATEFLVGKIQENSKPISDSNAIAQCGTIAAGNDDEVGQMIANAMDKVGKEGVISLEEGK
HHHHHHHHHHHCCCCCCCCCCHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEECCCC
SMTTELEVTEGMRFDKGYISPYFATDTERMEAVLDEPYILLTDKKIALVQDLVPVLEQIA
CCEEEEEHHCCCEECCCCCCCEECCCHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHH
KTGKPLVIIAEDIEKEALATLVVNRLRGVLNVAAVKAPGFGDRRKAMLEDMAVLTNGQLI
HCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCEEE
TEDAGLKLENATLDMLGTGRRITINKETTTIVAEGNEQAVKARCDQIKKQMDETDSSYDK
ECCCCCEEECCEEEEECCCCEEEEECCEEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCH
EKLQERLAKLAGGVAVIKVGAATETEMKDKKLRLEDAINATKAAVEEGIVPGGGTTLAHL
HHHHHHHHHHHCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHH
SPILKEWADKNLEGEELIGANIVEASLTAPLMRIAENAGSNGAVIAENVKTKPFNDGFNA
HHHHHHHHCCCCCCHHHHCCHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCCCCCC
ATGEYVDMSSAGIVDPAKVTRSGLQNAASIAGMVLTTECIVADLPEKKDSAAPAGAPGMG
CCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
GDFDY
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA