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The map label for this gene is purD [H]

Identifier: 126696864

GI number: 126696864

Start: 1293197

End: 1294528

Strand: Direct

Name: purD [H]

Synonym: P9301_15261

Alternate gene names: 126696864

Gene position: 1293197-1294528 (Clockwise)

Preceding gene: 126696856

Following gene: 126696865

Centisome position: 78.76

GC content: 31.31

Gene sequence:

>1332_bases
ATGGGAATTCATTCACCAAGTTCTAAGAGCTTTAGTAGATTAGAAAATATTTTAATAATTGGAAATGGCGGGAGAGAAAA
CTCTTTAGCTTGGGCTATTCAAAAAAATGAATTAGTCAAAAAAGTTTATTTAGTACCCGGTAACGCTGGTTCAGAAAGAA
TAAATAAATGTAAAAGAATTAAAATTGATATAAATAATGAAAATGAACTGGTCGAAAAGCTTGATTTTCTTAAAATAGAT
TTAGTTGTAATTGGACCAGAAATACCTCTTGCGAATGGATTAGCTGATTTACTTCGAAAAAAAGATTTTAAAGTATTTGG
TCCTAACAAAGATGGAGCAAAATTAGAATTTAGCAAATCTTGGGCTAAGGAATTTATGCAAAAAGCAAATATTCCAACTG
CAAACTTTTGGAAAGTCAACTCTTTAGAAGAAGCCAAAAAAATTATCAATTCATCATCAATCCCACTAGTAGTAAAAGCT
GATGGTTTAGCTTCTGGTAAAGGTGTTTTTATTCCTAATTCAAAAGATGAATGCTTCAAAGCAGCAGAATCAATTTTTAA
TGGTAAATTTGGCAACTCTGGAAATATAGTTGTTTTAGAAGAAAAAATTCAAGGACCAGAAGTTTCAGTTTTTGCTTTAT
GTGATGGAGAGAGATATACATTACTTCCAACCGCACAAGATCACAAAAGGCTTAACGAGAAAGATAAAGGCCCAAATACA
GGAGGTATGGGAGCTTATTCGCCTGCACCATTATTAACACAAGATTACCTTGATAAAATTATCAAAGAGATAATTGAACC
TACAATCAACGAACTCAATAAAAGAAATATTGACTATAGAGGCGTAATTTACTTTGGGTTAATGATCACAAAATCTGGAC
CCAAAGTTATAGAATATAATTGCAGATTTGGTGATCCAGAATGCCAAACAATCATGCCCTTGATGGATCAAAATTTTGTA
TTTCTTTTAGAAAAATGCTCAATGGGAAATTTGACTGGTGACGAAAAAATTAGTACTTCTGATAAAGTTAGTGGTTGTGT
AATAGCGACCTCAAAAGGTTATCCTCACGAATATAAAACTGGTTTTCAAATAAAAATAGGTAAGATTGACTCAAATGATT
GTCAAATTTTTGACTCAGGTACTTCTTTAAGTGCAAATGGGAAATTATTAACTGATGGAGGAAGAGTCTTAAGTATTGTC
TGTCAAGATAGAGATTTTAATATGGTTTTTGAAAGGGCATACAAAAATTTAAAAGAAATTGATTTTGAAGGTATTTACTT
CAGAAATGACATAGGTCATCAAGTCAGAAAAAACTTTTCCAAGGAGAATTAA

Upstream 100 bases:

>100_bases
TTTTGTAATTAACATAATTATTAGAGATCAAGTTCAAAAGATTTGATTTCATTTTAGCTGATTATTTATCGAAACCTCAT
AACCTTAAAGAAACAACTAT

Downstream 100 bases:

>100_bases
GCTCATGGTGGATACCAATAATCAAGAAAATAGAAAATACAATATCACTGATAACGAAGTTATGGATAATAACTATTGGA
TTAATGGAATCCTTGCTTGG

Product: phosphoribosylglycinamide synthetase

Products: NA

Alternate protein names: GARS; Glycinamide ribonucleotide synthetase; Phosphoribosylglycinamide synthetase [H]

Number of amino acids: Translated: 443; Mature: 442

Protein sequence:

>443_residues
MGIHSPSSKSFSRLENILIIGNGGRENSLAWAIQKNELVKKVYLVPGNAGSERINKCKRIKIDINNENELVEKLDFLKID
LVVIGPEIPLANGLADLLRKKDFKVFGPNKDGAKLEFSKSWAKEFMQKANIPTANFWKVNSLEEAKKIINSSSIPLVVKA
DGLASGKGVFIPNSKDECFKAAESIFNGKFGNSGNIVVLEEKIQGPEVSVFALCDGERYTLLPTAQDHKRLNEKDKGPNT
GGMGAYSPAPLLTQDYLDKIIKEIIEPTINELNKRNIDYRGVIYFGLMITKSGPKVIEYNCRFGDPECQTIMPLMDQNFV
FLLEKCSMGNLTGDEKISTSDKVSGCVIATSKGYPHEYKTGFQIKIGKIDSNDCQIFDSGTSLSANGKLLTDGGRVLSIV
CQDRDFNMVFERAYKNLKEIDFEGIYFRNDIGHQVRKNFSKEN

Sequences:

>Translated_443_residues
MGIHSPSSKSFSRLENILIIGNGGRENSLAWAIQKNELVKKVYLVPGNAGSERINKCKRIKIDINNENELVEKLDFLKID
LVVIGPEIPLANGLADLLRKKDFKVFGPNKDGAKLEFSKSWAKEFMQKANIPTANFWKVNSLEEAKKIINSSSIPLVVKA
DGLASGKGVFIPNSKDECFKAAESIFNGKFGNSGNIVVLEEKIQGPEVSVFALCDGERYTLLPTAQDHKRLNEKDKGPNT
GGMGAYSPAPLLTQDYLDKIIKEIIEPTINELNKRNIDYRGVIYFGLMITKSGPKVIEYNCRFGDPECQTIMPLMDQNFV
FLLEKCSMGNLTGDEKISTSDKVSGCVIATSKGYPHEYKTGFQIKIGKIDSNDCQIFDSGTSLSANGKLLTDGGRVLSIV
CQDRDFNMVFERAYKNLKEIDFEGIYFRNDIGHQVRKNFSKEN
>Mature_442_residues
GIHSPSSKSFSRLENILIIGNGGRENSLAWAIQKNELVKKVYLVPGNAGSERINKCKRIKIDINNENELVEKLDFLKIDL
VVIGPEIPLANGLADLLRKKDFKVFGPNKDGAKLEFSKSWAKEFMQKANIPTANFWKVNSLEEAKKIINSSSIPLVVKAD
GLASGKGVFIPNSKDECFKAAESIFNGKFGNSGNIVVLEEKIQGPEVSVFALCDGERYTLLPTAQDHKRLNEKDKGPNTG
GMGAYSPAPLLTQDYLDKIIKEIIEPTINELNKRNIDYRGVIYFGLMITKSGPKVIEYNCRFGDPECQTIMPLMDQNFVF
LLEKCSMGNLTGDEKISTSDKVSGCVIATSKGYPHEYKTGFQIKIGKIDSNDCQIFDSGTSLSANGKLLTDGGRVLSIVC
QDRDFNMVFERAYKNLKEIDFEGIYFRNDIGHQVRKNFSKEN

Specific function: De novo purine biosynthesis; second step. [C]

COG id: COG0151

COG function: function code F; Phosphoribosylamine-glycine ligase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-grasp domain [H]

Homologues:

Organism=Homo sapiens, GI28416899, Length=420, Percent_Identity=42.3809523809524, Blast_Score=343, Evalue=2e-94,
Organism=Homo sapiens, GI4503915, Length=420, Percent_Identity=42.3809523809524, Blast_Score=343, Evalue=2e-94,
Organism=Homo sapiens, GI209869995, Length=420, Percent_Identity=42.3809523809524, Blast_Score=343, Evalue=2e-94,
Organism=Homo sapiens, GI209869993, Length=420, Percent_Identity=42.3809523809524, Blast_Score=343, Evalue=2e-94,
Organism=Escherichia coli, GI1790438, Length=420, Percent_Identity=39.5238095238095, Blast_Score=315, Evalue=3e-87,
Organism=Caenorhabditis elegans, GI17567511, Length=431, Percent_Identity=42.2273781902552, Blast_Score=290, Evalue=9e-79,
Organism=Saccharomyces cerevisiae, GI6321203, Length=446, Percent_Identity=37.6681614349776, Blast_Score=289, Evalue=6e-79,
Organism=Drosophila melanogaster, GI62471619, Length=434, Percent_Identity=39.8617511520737, Blast_Score=297, Evalue=1e-80,
Organism=Drosophila melanogaster, GI24582400, Length=432, Percent_Identity=40.0462962962963, Blast_Score=294, Evalue=8e-80,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR020561
- InterPro:   IPR000115
- InterPro:   IPR020560
- InterPro:   IPR020559
- InterPro:   IPR020562
- InterPro:   IPR011054 [H]

Pfam domain/function: PF01071 GARS_A; PF02843 GARS_C; PF02844 GARS_N [H]

EC number: =6.3.4.13 [H]

Molecular weight: Translated: 49309; Mature: 49178

Theoretical pI: Translated: 8.29; Mature: 8.29

Prosite motif: PS50975 ATP_GRASP ; PS00184 GARS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGIHSPSSKSFSRLENILIIGNGGRENSLAWAIQKNELVKKVYLVPGNAGSERINKCKRI
CCCCCCCCHHHHHCCCEEEEECCCCCCCEEEEEECCCEEEEEEEECCCCCHHHHCCCEEE
KIDINNENELVEKLDFLKIDLVVIGPEIPLANGLADLLRKKDFKVFGPNKDGAKLEFSKS
EEEECCCHHHHHHHCCEEEEEEEECCCCCCHHHHHHHHHCCCCEEECCCCCCCEEEECHH
WAKEFMQKANIPTANFWKVNSLEEAKKIINSSSIPLVVKADGLASGKGVFIPNSKDECFK
HHHHHHHHCCCCCCCEEECCCHHHHHHHHCCCCCEEEEEECCCCCCCEEECCCCHHHHHH
AAESIFNGKFGNSGNIVVLEEKIQGPEVSVFALCDGERYTLLPTAQDHKRLNEKDKGPNT
HHHHHHCCCCCCCCCEEEEECCCCCCCEEEEEEECCCEEEEECCCHHHHHCCCCCCCCCC
GGMGAYSPAPLLTQDYLDKIIKEIIEPTINELNKRNIDYRGVIYFGLMITKSGPKVIEYN
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEEECCCCEEEEEE
CRFGDPECQTIMPLMDQNFVFLLEKCSMGNLTGDEKISTSDKVSGCVIATSKGYPHEYKT
CCCCCCCHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCC
GFQIKIGKIDSNDCQIFDSGTSLSANGKLLTDGGRVLSIVCQDRDFNMVFERAYKNLKEI
CEEEEEEEECCCCCEEEECCCEECCCCEEEECCCEEEEEEECCCCCHHHHHHHHHHHHHC
DFEGIYFRNDIGHQVRKNFSKEN
CCCCEEEECCHHHHHHHHCCCCC
>Mature Secondary Structure 
GIHSPSSKSFSRLENILIIGNGGRENSLAWAIQKNELVKKVYLVPGNAGSERINKCKRI
CCCCCCCHHHHHCCCEEEEECCCCCCCEEEEEECCCEEEEEEEECCCCCHHHHCCCEEE
KIDINNENELVEKLDFLKIDLVVIGPEIPLANGLADLLRKKDFKVFGPNKDGAKLEFSKS
EEEECCCHHHHHHHCCEEEEEEEECCCCCCHHHHHHHHHCCCCEEECCCCCCCEEEECHH
WAKEFMQKANIPTANFWKVNSLEEAKKIINSSSIPLVVKADGLASGKGVFIPNSKDECFK
HHHHHHHHCCCCCCCEEECCCHHHHHHHHCCCCCEEEEEECCCCCCCEEECCCCHHHHHH
AAESIFNGKFGNSGNIVVLEEKIQGPEVSVFALCDGERYTLLPTAQDHKRLNEKDKGPNT
HHHHHHCCCCCCCCCEEEEECCCCCCCEEEEEEECCCEEEEECCCHHHHHCCCCCCCCCC
GGMGAYSPAPLLTQDYLDKIIKEIIEPTINELNKRNIDYRGVIYFGLMITKSGPKVIEYN
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEEECCCCEEEEEE
CRFGDPECQTIMPLMDQNFVFLLEKCSMGNLTGDEKISTSDKVSGCVIATSKGYPHEYKT
CCCCCCCHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCC
GFQIKIGKIDSNDCQIFDSGTSLSANGKLLTDGGRVLSIVCQDRDFNMVFERAYKNLKEI
CEEEEEEEECCCCCEEEECCCEECCCCEEEECCCEEEEEEECCCCCHHHHHHHHHHHHHC
DFEGIYFRNDIGHQVRKNFSKEN
CCCCEEEECCHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11759840 [H]