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The map label for this gene is pepB

Identifier: 126696856

GI number: 126696856

Start: 1284709

End: 1286181

Strand: Direct

Name: pepB

Synonym: P9301_15181

Alternate gene names: 126696856

Gene position: 1284709-1286181 (Clockwise)

Preceding gene: 126696855

Following gene: 126696864

Centisome position: 78.25

GC content: 34.49

Gene sequence:

>1473_bases
ATGCAATTTTCCACATTCCAAAAAAATCTAGATAACTGGCAAGGTGCTTCATTAATTTTTGGAGTTTTAGAAGAAGAAAT
TGCGAGCCAACTTGAAAAAATAAAATTTGTTATTGACCCAAAATTATTACTAAAAAAAGTTTCTCAAAAAAATTTCAAAG
GAGAGAAAGGAAAAACTTTAAGCTTTGAATTTCTAGATCAAAAATTAGAAACTTTAATCATAGTTGGTCTTGGCAAATCA
AAAGACCTTAATAAAAGTGATATAGAAAACTCTATAGGAAATCTAGTTAGGAAAACCATTGATAAAAATGAAAAAATCAG
CATCTTGCTACCTTGGGAATTTATAAATTCACAACTAGAAATAAATCAATTAGCAGAGTCAGCCAGATTATCTGCCTATA
AGGACAACAGATTCAACAAGAAAAAAGATGAAAAGAAAGTTCTTAAAGAAATTGAGTTTTTGAATTTAAAAAAATTTGAG
AATATTAGCTTTAAAGAGACAGCACAAATATGTGAAGGTGTAGAACTAGCTAGAAGACTTGTAGCAGCCCCTCCAAATAG
TCTTACGCCTCAGGAAATGTCTATACAAGCTTCTCAAATAGCTAAAGATCATGGTTTGGAAGTAAAAATTTTAGAGGCAA
AAGATTGTGAAGATTTAGGAATGGGTGCATATTTAGCTGTAGCAAAAGGTTCTGATCTAAATCCTAAATTTATACATCTT
ACTTTAAAGTCAGATGGGCCTATTAAAGAAAAGATTGCGCTTGTTGGGAAGGGTTTAACCTTTGACTCTGGAGGATACAA
CCTGAAAGTAGGAGCCTCTCAAATTGAGATGATGAAATATGATATGGGTGGAAGCGCTGCTGTTTTAGGAGCAGCAAAAG
CACTTGGAGCAATAAAACCAAAGGGACTAGAAATACATTTTATTGTGGCATCCTGCGAAAATATGATAAATGGATCTGCA
GTACATCCTGGAGATGTAGTCAAGGCATCTAATGGTAAGACAATTGAAATAAATAACACTGATGCAGAGGGCAGACTCAC
ATTAGCTGATGCTTTAACTTACGCATCAAATTTAAAACCGGATTCAATAATAGATCTTGCCACTTTAACAGGAGCTATTG
TTGTGGCATTAGGAAATGACGTAGCTGGATTCTGGAGCAATAATGATGATCTAGCAAATGATCTAAAAGCTGCGTCAGCC
CAGGCTGGTGAAGAATTATGGCAAATGCCTTTACAAAAATCTTATAAAGAAGGGCTAAAGTCTCATATAGCTGATATGAA
AAATACGGGGCCTAGAGCAGGTGGGTCAATAACTGCTGCTTTGTTTTTAGAGGAATTCTTTGATCCAGAGATTAAATGGG
CTCATGTTGATATTGCTGGGACTTGTTGGACTGATAAGAATAAGGGGATTAATCCATCAGGTGCAACCGGTTTTGGAGTT
AAAACTCTTGTTCAATGGATTAAAAATAAATAA

Upstream 100 bases:

>100_bases
ACTGATATATTTATGGTTACCACCTTTTAATAAAGAAACTCGAGATAGGTGGGCAACCACTTTCATAAACAACTAAAAGT
TAATTAAATCCATTTAAAAA

Downstream 100 bases:

>100_bases
CTAAATTTAAAATTATTCATTCCAAAGATTTGTTGATCTAGCGTTATCACCCCACAATTTATCCAACCTCTGATCTCTCC
CACAAGAGAATCTATAAAAC

Product: leucyl aminopeptidase

Products: NA

Alternate protein names: Leucine aminopeptidase; LAP; Leucyl aminopeptidase

Number of amino acids: Translated: 490; Mature: 490

Protein sequence:

>490_residues
MQFSTFQKNLDNWQGASLIFGVLEEEIASQLEKIKFVIDPKLLLKKVSQKNFKGEKGKTLSFEFLDQKLETLIIVGLGKS
KDLNKSDIENSIGNLVRKTIDKNEKISILLPWEFINSQLEINQLAESARLSAYKDNRFNKKKDEKKVLKEIEFLNLKKFE
NISFKETAQICEGVELARRLVAAPPNSLTPQEMSIQASQIAKDHGLEVKILEAKDCEDLGMGAYLAVAKGSDLNPKFIHL
TLKSDGPIKEKIALVGKGLTFDSGGYNLKVGASQIEMMKYDMGGSAAVLGAAKALGAIKPKGLEIHFIVASCENMINGSA
VHPGDVVKASNGKTIEINNTDAEGRLTLADALTYASNLKPDSIIDLATLTGAIVVALGNDVAGFWSNNDDLANDLKAASA
QAGEELWQMPLQKSYKEGLKSHIADMKNTGPRAGGSITAALFLEEFFDPEIKWAHVDIAGTCWTDKNKGINPSGATGFGV
KTLVQWIKNK

Sequences:

>Translated_490_residues
MQFSTFQKNLDNWQGASLIFGVLEEEIASQLEKIKFVIDPKLLLKKVSQKNFKGEKGKTLSFEFLDQKLETLIIVGLGKS
KDLNKSDIENSIGNLVRKTIDKNEKISILLPWEFINSQLEINQLAESARLSAYKDNRFNKKKDEKKVLKEIEFLNLKKFE
NISFKETAQICEGVELARRLVAAPPNSLTPQEMSIQASQIAKDHGLEVKILEAKDCEDLGMGAYLAVAKGSDLNPKFIHL
TLKSDGPIKEKIALVGKGLTFDSGGYNLKVGASQIEMMKYDMGGSAAVLGAAKALGAIKPKGLEIHFIVASCENMINGSA
VHPGDVVKASNGKTIEINNTDAEGRLTLADALTYASNLKPDSIIDLATLTGAIVVALGNDVAGFWSNNDDLANDLKAASA
QAGEELWQMPLQKSYKEGLKSHIADMKNTGPRAGGSITAALFLEEFFDPEIKWAHVDIAGTCWTDKNKGINPSGATGFGV
KTLVQWIKNK
>Mature_490_residues
MQFSTFQKNLDNWQGASLIFGVLEEEIASQLEKIKFVIDPKLLLKKVSQKNFKGEKGKTLSFEFLDQKLETLIIVGLGKS
KDLNKSDIENSIGNLVRKTIDKNEKISILLPWEFINSQLEINQLAESARLSAYKDNRFNKKKDEKKVLKEIEFLNLKKFE
NISFKETAQICEGVELARRLVAAPPNSLTPQEMSIQASQIAKDHGLEVKILEAKDCEDLGMGAYLAVAKGSDLNPKFIHL
TLKSDGPIKEKIALVGKGLTFDSGGYNLKVGASQIEMMKYDMGGSAAVLGAAKALGAIKPKGLEIHFIVASCENMINGSA
VHPGDVVKASNGKTIEINNTDAEGRLTLADALTYASNLKPDSIIDLATLTGAIVVALGNDVAGFWSNNDDLANDLKAASA
QAGEELWQMPLQKSYKEGLKSHIADMKNTGPRAGGSITAALFLEEFFDPEIKWAHVDIAGTCWTDKNKGINPSGATGFGV
KTLVQWIKNK

Specific function: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family

Homologues:

Organism=Homo sapiens, GI41393561, Length=467, Percent_Identity=34.9036402569593, Blast_Score=223, Evalue=4e-58,
Organism=Homo sapiens, GI47155554, Length=417, Percent_Identity=31.6546762589928, Blast_Score=148, Evalue=9e-36,
Organism=Escherichia coli, GI1790710, Length=511, Percent_Identity=34.6379647749511, Blast_Score=263, Evalue=2e-71,
Organism=Escherichia coli, GI87082123, Length=329, Percent_Identity=37.3860182370821, Blast_Score=186, Evalue=3e-48,
Organism=Caenorhabditis elegans, GI17556903, Length=317, Percent_Identity=34.384858044164, Blast_Score=145, Evalue=4e-35,
Organism=Caenorhabditis elegans, GI17565172, Length=255, Percent_Identity=30.9803921568627, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI21355725, Length=318, Percent_Identity=33.6477987421384, Blast_Score=169, Evalue=3e-42,
Organism=Drosophila melanogaster, GI24661038, Length=316, Percent_Identity=33.8607594936709, Blast_Score=169, Evalue=3e-42,
Organism=Drosophila melanogaster, GI161077148, Length=456, Percent_Identity=28.0701754385965, Blast_Score=166, Evalue=3e-41,
Organism=Drosophila melanogaster, GI20130057, Length=456, Percent_Identity=28.0701754385965, Blast_Score=166, Evalue=3e-41,
Organism=Drosophila melanogaster, GI20129969, Length=461, Percent_Identity=27.3318872017354, Blast_Score=164, Evalue=1e-40,
Organism=Drosophila melanogaster, GI24662227, Length=457, Percent_Identity=27.5711159737418, Blast_Score=162, Evalue=6e-40,
Organism=Drosophila melanogaster, GI21355645, Length=461, Percent_Identity=26.6811279826464, Blast_Score=154, Evalue=2e-37,
Organism=Drosophila melanogaster, GI24662223, Length=461, Percent_Identity=26.6811279826464, Blast_Score=154, Evalue=2e-37,
Organism=Drosophila melanogaster, GI20129963, Length=463, Percent_Identity=29.1576673866091, Blast_Score=153, Evalue=3e-37,
Organism=Drosophila melanogaster, GI19922386, Length=453, Percent_Identity=27.1523178807947, Blast_Score=145, Evalue=5e-35,
Organism=Drosophila melanogaster, GI21357381, Length=323, Percent_Identity=31.8885448916409, Blast_Score=134, Evalue=2e-31,
Organism=Drosophila melanogaster, GI221379063, Length=323, Percent_Identity=31.8885448916409, Blast_Score=134, Evalue=2e-31,
Organism=Drosophila melanogaster, GI221379062, Length=323, Percent_Identity=31.8885448916409, Blast_Score=134, Evalue=2e-31,
Organism=Drosophila melanogaster, GI24646701, Length=281, Percent_Identity=28.1138790035587, Blast_Score=86, Evalue=8e-17,
Organism=Drosophila melanogaster, GI24646703, Length=281, Percent_Identity=28.1138790035587, Blast_Score=86, Evalue=8e-17,
Organism=Drosophila melanogaster, GI21358201, Length=281, Percent_Identity=28.1138790035587, Blast_Score=86, Evalue=8e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AMPA_PROM0 (A3PEG6)

Other databases:

- EMBL:   CP000576
- RefSeq:   YP_001091742.1
- ProteinModelPortal:   A3PEG6
- SMR:   A3PEG6
- STRING:   A3PEG6
- MEROPS:   M17.002
- GeneID:   4912576
- GenomeReviews:   CP000576_GR
- KEGG:   pmg:P9301_15181
- eggNOG:   COG0260
- HOGENOM:   HBG742580
- OMA:   NMHLMRY
- ProtClustDB:   PRK00913
- BioCyc:   PMAR167546:P9301ORF_1547-MONOMER
- GO:   GO:0005737
- GO:   GO:0006508
- HAMAP:   MF_00181
- InterPro:   IPR011356
- InterPro:   IPR000819
- InterPro:   IPR023042
- InterPro:   IPR008283
- PANTHER:   PTHR11963:SF3
- PRINTS:   PR00481

Pfam domain/function: PF00883 Peptidase_M17; PF02789 Peptidase_M17_N

EC number: =3.4.11.1; =3.4.11.10

Molecular weight: Translated: 53444; Mature: 53444

Theoretical pI: Translated: 7.12; Mature: 7.12

Prosite motif: PS00631 CYTOSOL_AP

Important sites: ACT_SITE 269-269 ACT_SITE 345-345

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQFSTFQKNLDNWQGASLIFGVLEEEIASQLEKIKFVIDPKLLLKKVSQKNFKGEKGKTL
CCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHEECHHHHHHHHHHCCCCCCCCCEE
SFEFLDQKLETLIIVGLGKSKDLNKSDIENSIGNLVRKTIDKNEKISILLPWEFINSQLE
EHHHHHHCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEECHHHHCCCHH
INQLAESARLSAYKDNRFNKKKDEKKVLKEIEFLNLKKFENISFKETAQICEGVELARRL
HHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCHHHHCCCCHHHHHHHHHHHHHHHHH
VAAPPNSLTPQEMSIQASQIAKDHGLEVKILEAKDCEDLGMGAYLAVAKGSDLNPKFIHL
HCCCCCCCCCHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCEEEEEECCCCCCCEEEEE
TLKSDGPIKEKIALVGKGLTFDSGGYNLKVGASQIEMMKYDMGGSAAVLGAAKALGAIKP
EECCCCCHHHHHHHHCCCCEECCCCCEEEECHHHEEEEEECCCCCHHHHHHHHHHCCCCC
KGLEIHFIVASCENMINGSAVHPGDVVKASNGKTIEINNTDAEGRLTLADALTYASNLKP
CCEEEEEEEEEHHHHCCCCCCCCCCEEECCCCCEEEEECCCCCCEEEHHHHHHHHHCCCC
DSIIDLATLTGAIVVALGNDVAGFWSNNDDLANDLKAASAQAGEELWQMPLQKSYKEGLK
CHHHHHHHHHCEEEEEECCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SHIADMKNTGPRAGGSITAALFLEEFFDPEIKWAHVDIAGTCWTDKNKGINPSGATGFGV
HHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCEEEEEEEEEEEECCCCCCCCCCCCCCCCH
KTLVQWIKNK
HHHHHHHHCC
>Mature Secondary Structure
MQFSTFQKNLDNWQGASLIFGVLEEEIASQLEKIKFVIDPKLLLKKVSQKNFKGEKGKTL
CCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHEECHHHHHHHHHHCCCCCCCCCEE
SFEFLDQKLETLIIVGLGKSKDLNKSDIENSIGNLVRKTIDKNEKISILLPWEFINSQLE
EHHHHHHCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEECHHHHCCCHH
INQLAESARLSAYKDNRFNKKKDEKKVLKEIEFLNLKKFENISFKETAQICEGVELARRL
HHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCHHHHCCCCHHHHHHHHHHHHHHHHH
VAAPPNSLTPQEMSIQASQIAKDHGLEVKILEAKDCEDLGMGAYLAVAKGSDLNPKFIHL
HCCCCCCCCCHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCEEEEEECCCCCCCEEEEE
TLKSDGPIKEKIALVGKGLTFDSGGYNLKVGASQIEMMKYDMGGSAAVLGAAKALGAIKP
EECCCCCHHHHHHHHCCCCEECCCCCEEEECHHHEEEEEECCCCCHHHHHHHHHHCCCCC
KGLEIHFIVASCENMINGSAVHPGDVVKASNGKTIEINNTDAEGRLTLADALTYASNLKP
CCEEEEEEEEEHHHHCCCCCCCCCCEEECCCCCEEEEECCCCCCEEEHHHHHHHHHCCCC
DSIIDLATLTGAIVVALGNDVAGFWSNNDDLANDLKAASAQAGEELWQMPLQKSYKEGLK
CHHHHHHHHHCEEEEEECCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SHIADMKNTGPRAGGSITAALFLEEFFDPEIKWAHVDIAGTCWTDKNKGINPSGATGFGV
HHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCEEEEEEEEEEEECCCCCCCCCCCCCCCCH
KTLVQWIKNK
HHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA