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The map label for this gene is gmd [H]

Identifier: 126696782

GI number: 126696782

Start: 1214430

End: 1215524

Strand: Direct

Name: gmd [H]

Synonym: P9301_14441

Alternate gene names: 126696782

Gene position: 1214430-1215524 (Clockwise)

Preceding gene: 126696780

Following gene: 126696783

Centisome position: 73.97

GC content: 32.69

Gene sequence:

>1095_bases
ATGACTAAAAAAGTTGCTCTTATTACGGGAATAACTGGACAGGATGGAAGTTATCTTGGTGAATTCTTGTTATCAAAAGG
TTACGAAGTACATGGAATTAAAAGAAGATCTAGTTCTTTCAATACTGAAAGAATTGATCATCTTTACCAAGATCCACACA
AAAGCAAATGTAGGTTTTTCTTGCATTATGGAGATTTAACTGACAGCACAAATATTCTAAAGTTAATAGAAAAAATCCAA
CCAGATGAAATATATAATCTTGGAGCACAAAGCCACGTCGCAGTTAGTTTCGAATCTCCTGAATATACAGCTAATAGCGA
TGCACTGGGGACCTTAAGAATTTTAGAAGCAGTAAAAATTTTAAAGTTAATAAATAAAACTAAGGTTTATCAGGCAAGTA
CTTCAGAATTATTTGGTAAAGTACAAGAAATTCCTCAAACAGAATCCACTCCTTTTTATCCTGCAAGTCCATATGGTGTG
GCAAAGTTATATGCTTATTGGATTACTGTTAACTACAGAGAATCTTATGGGATGTTTGCATCAAACGGAATATTATTTAA
TCATGAAAGTCCCAGGAGAGGTGAAACATTTGTTACGAGAAAAATCACAAGAGGTTTAGCAAGAATAGATCAAGGATTAG
ACGAAATATTATATTTAGGTAATCTAGATGCAAAACGAGATTGGGGACATGCAAAAGATTACGTCGAAGTTCAATGGAAA
ATATTGCAACATTCTAAACCTGATGATTTTGTAATCGCTACTGGTAGACAAGAAAGTGTTAGAAGATTTGTTGAACTTGC
ATCAATTGAACTTGGATGGGGAGGCATTATTTGGGAAGGTGAAGGAGAGAATGAAATTGGCAAAAGAAAAGATAGTAGTA
AAATTGTTATTAAGGTAGATAAACGATATTTCAGGCCTAGCGAGGTACAAGAATTACTTGGTAATAACTTTAAGGCAAAA
AAAATTCTAGGATGGGAATCAAAGATAACTCTAGAAAAGCTTATCAAAGAAATGATCCAAAATGATAAAGAATTAGCTGC
TAAAGAATCATTATTAAAAAGGGAAGGTTATAAGATAAATAGCTCAAATGAATAA

Upstream 100 bases:

>100_bases
AAATTTAAAAATTTTTAAATCTTAAAAAGAAAATAATTAAATTAATTCCTTTTTGAGGGAAATTAATATATTAAATACTT
TAATCACATATAATTTGATA

Downstream 100 bases:

>100_bases
GAAGATGAAAAAGTTAATTTCTAAGGAAGATAGTTTTTTTGTCGCAGGACACAATGGAATGGTGGGAAGTGCAGTAATAC
GCAGCTTAAAAAAAAAGGGC

Product: gdpmannose 4,6-dehydratase

Products: NA

Alternate protein names: GDP-D-mannose dehydratase [H]

Number of amino acids: Translated: 364; Mature: 363

Protein sequence:

>364_residues
MTKKVALITGITGQDGSYLGEFLLSKGYEVHGIKRRSSSFNTERIDHLYQDPHKSKCRFFLHYGDLTDSTNILKLIEKIQ
PDEIYNLGAQSHVAVSFESPEYTANSDALGTLRILEAVKILKLINKTKVYQASTSELFGKVQEIPQTESTPFYPASPYGV
AKLYAYWITVNYRESYGMFASNGILFNHESPRRGETFVTRKITRGLARIDQGLDEILYLGNLDAKRDWGHAKDYVEVQWK
ILQHSKPDDFVIATGRQESVRRFVELASIELGWGGIIWEGEGENEIGKRKDSSKIVIKVDKRYFRPSEVQELLGNNFKAK
KILGWESKITLEKLIKEMIQNDKELAAKESLLKREGYKINSSNE

Sequences:

>Translated_364_residues
MTKKVALITGITGQDGSYLGEFLLSKGYEVHGIKRRSSSFNTERIDHLYQDPHKSKCRFFLHYGDLTDSTNILKLIEKIQ
PDEIYNLGAQSHVAVSFESPEYTANSDALGTLRILEAVKILKLINKTKVYQASTSELFGKVQEIPQTESTPFYPASPYGV
AKLYAYWITVNYRESYGMFASNGILFNHESPRRGETFVTRKITRGLARIDQGLDEILYLGNLDAKRDWGHAKDYVEVQWK
ILQHSKPDDFVIATGRQESVRRFVELASIELGWGGIIWEGEGENEIGKRKDSSKIVIKVDKRYFRPSEVQELLGNNFKAK
KILGWESKITLEKLIKEMIQNDKELAAKESLLKREGYKINSSNE
>Mature_363_residues
TKKVALITGITGQDGSYLGEFLLSKGYEVHGIKRRSSSFNTERIDHLYQDPHKSKCRFFLHYGDLTDSTNILKLIEKIQP
DEIYNLGAQSHVAVSFESPEYTANSDALGTLRILEAVKILKLINKTKVYQASTSELFGKVQEIPQTESTPFYPASPYGVA
KLYAYWITVNYRESYGMFASNGILFNHESPRRGETFVTRKITRGLARIDQGLDEILYLGNLDAKRDWGHAKDYVEVQWKI
LQHSKPDDFVIATGRQESVRRFVELASIELGWGGIIWEGEGENEIGKRKDSSKIVIKVDKRYFRPSEVQELLGNNFKAKK
ILGWESKITLEKLIKEMIQNDKELAAKESLLKREGYKINSSNE

Specific function: Biosynthesis of the slime polysaccharide colanic acid. First of the three steps in the biosynthesis of GDP-fucose from GDP-mannose. [C]

COG id: COG1089

COG function: function code M; GDP-D-mannose dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GDP-mannose 4,6-dehydratase family [H]

Homologues:

Organism=Homo sapiens, GI4504031, Length=344, Percent_Identity=62.5, Blast_Score=451, Evalue=1e-127,
Organism=Escherichia coli, GI1788366, Length=367, Percent_Identity=64.5776566757493, Blast_Score=506, Evalue=1e-144,
Organism=Escherichia coli, GI1788353, Length=301, Percent_Identity=22.2591362126246, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI48994969, Length=250, Percent_Identity=24.8, Blast_Score=62, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI17539424, Length=343, Percent_Identity=65.0145772594752, Blast_Score=470, Evalue=1e-133,
Organism=Caenorhabditis elegans, GI133901790, Length=343, Percent_Identity=65.0145772594752, Blast_Score=470, Evalue=1e-133,
Organism=Caenorhabditis elegans, GI133901788, Length=343, Percent_Identity=65.0145772594752, Blast_Score=470, Evalue=1e-133,
Organism=Caenorhabditis elegans, GI17539422, Length=343, Percent_Identity=65.0145772594752, Blast_Score=470, Evalue=1e-133,
Organism=Caenorhabditis elegans, GI133901786, Length=343, Percent_Identity=65.0145772594752, Blast_Score=469, Evalue=1e-133,
Organism=Caenorhabditis elegans, GI17507723, Length=351, Percent_Identity=63.5327635327635, Blast_Score=466, Evalue=1e-131,
Organism=Drosophila melanogaster, GI24158427, Length=349, Percent_Identity=56.7335243553009, Blast_Score=414, Evalue=1e-116,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001509
- InterPro:   IPR006368
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: =4.2.1.47 [H]

Molecular weight: Translated: 41559; Mature: 41428

Theoretical pI: Translated: 9.14; Mature: 9.14

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
0.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKKVALITGITGQDGSYLGEFLLSKGYEVHGIKRRSSSFNTERIDHLYQDPHKSKCRFF
CCCEEEEEEECCCCCHHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHCCCCCCCEEEE
LHYGDLTDSTNILKLIEKIQPDEIYNLGAQSHVAVSFESPEYTANSDALGTLRILEAVKI
EEECCCCCCHHHHHHHHHCCCCHHHHCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHH
LKLINKTKVYQASTSELFGKVQEIPQTESTPFYPASPYGVAKLYAYWITVNYRESYGMFA
HHHHHHHHHEECHHHHHHHHHHHCCCCCCCCCCCCCCCHHHEEEEEEEEEEEHHCCCEEE
SNGILFNHESPRRGETFVTRKITRGLARIDQGLDEILYLGNLDAKRDWGHAKDYVEVQWK
CCCEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHE
ILQHSKPDDFVIATGRQESVRRFVELASIELGWGGIIWEGEGENEIGKRKDSSKIVIKVD
EECCCCCCCEEEECCCHHHHHHHHHHHHEEECCCEEEECCCCCCCCCCCCCCCEEEEEEC
KRYFRPSEVQELLGNNFKAKKILGWESKITLEKLIKEMIQNDKELAAKESLLKREGYKIN
CCCCCHHHHHHHHCCCCCCCEEECCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCC
SSNE
CCCC
>Mature Secondary Structure 
TKKVALITGITGQDGSYLGEFLLSKGYEVHGIKRRSSSFNTERIDHLYQDPHKSKCRFF
CCEEEEEEECCCCCHHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHCCCCCCCEEEE
LHYGDLTDSTNILKLIEKIQPDEIYNLGAQSHVAVSFESPEYTANSDALGTLRILEAVKI
EEECCCCCCHHHHHHHHHCCCCHHHHCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHH
LKLINKTKVYQASTSELFGKVQEIPQTESTPFYPASPYGVAKLYAYWITVNYRESYGMFA
HHHHHHHHHEECHHHHHHHHHHHCCCCCCCCCCCCCCCHHHEEEEEEEEEEEHHCCCEEE
SNGILFNHESPRRGETFVTRKITRGLARIDQGLDEILYLGNLDAKRDWGHAKDYVEVQWK
CCCEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHE
ILQHSKPDDFVIATGRQESVRRFVELASIELGWGGIIWEGEGENEIGKRKDSSKIVIKVD
EECCCCCCCEEEECCCHHHHHHHHHHHHEEECCCEEEECCCCCCCCCCCCCCCEEEEEEC
KRYFRPSEVQELLGNNFKAKKILGWESKITLEKLIKEMIQNDKELAAKESLLKREGYKIN
CCCCCHHHHHHHHCCCCCCCEEECCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCC
SSNE
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]