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The map label for this gene is dxr [H]

Identifier: 126696669

GI number: 126696669

Start: 1113081

End: 1114295

Strand: Direct

Name: dxr [H]

Synonym: P9301_13311

Alternate gene names: 126696669

Gene position: 1113081-1114295 (Clockwise)

Preceding gene: 126696668

Following gene: 126696671

Centisome position: 67.79

GC content: 35.47

Gene sequence:

>1215_bases
GTGCTCGGTTCTACTGGTTCAATAGGGACTCAAACTCTCGAGATAGCTAGTGAGCAGCCTGATAAATTTAAAGCCGTAGC
TCTTTCTGCAGGAAGAAATATTAATTTATTAACTGAACAAGTTAAAACTCATAAACCAGAGGTAGTTGCAATTGAGGATG
AAAGTCTTATAGAAGATTTAAAAGATAATATTAATAACTTAGATTTGGATGATGTTCCCCTGGTGTTAGGTGGAAAGCAG
GGGATTAACGCAGTTGCAGCATGGGATAAGGCAGATACTGTGGTAACAGGGATAGTAGGCTGTGCAGGCTTAATTCCAAC
AATGTCAGCAATTAATGCGGGGAAAAATATTGCACTTGCTAACAAAGAAACTTTAATTGCTGCAGGACCAATTGTTATTC
CTGCATTAAAGAAAAATAATAGTAGGCTTTTACCTGCTGATTCAGAACACTCTGCTATCTTTCAATGTTTACAAGGATTA
CCAAATTATGAAAATGCAGATTTTTCAACAGGAGATATTCCTAAGGGTTTAAAAGCTATACATTTAACAGCTTCTGGTGG
TGCTTTCAGAGATTGGGCCGTTGAGGATTTAAAGCATGTCACAGTGGAAGATGCGACTTCACATCCTAATTGGGATATGG
GAAAAAAAATAACTGTAGATTCTGCAACTCTTATGAATAAAGGATTAGAAGTTATTGAAGCTCATTATTTATTTGGGACC
TCTTATGAAGATATCGAAATAGTTATCCACCCTCAAAGTATTATTCATTCAATGATTGAGATGGAAGATTCTTCTGTATT
AGCTCAATTAGGTTGGCCAGATATGAAACTACCCATTTTATATGCGATGAGTTGGCCTGAAAGATTTAAAACAAATTGGA
AAAGATTAAACCTAAGTGAAATTGGAAAATTAACTTTTAAAGAGCCAGACGAGTTTAAATATCCATGCATGGGACTTGCA
TATGCTGCAGGAAAATCCTCTGGGACTATGCCTGCAGTCTTAAATGCTGCTAATGAAATGGCTGTTGAACAATTCCTCAA
AGAAAAAATTTCTTTTCAACAAATTCCAACATTTATAAGTAAAGCGTGTGAATCACATATGGAGAATTTGAATTTGAGTC
CCGAATTGGAGGATATTCTTGAAGTAGACAATTGGGCCAGACTTTTTATTGAGCAAGAAATTAAAAAAGGGAAAAAATAC
GTAAGTATTAGATAA

Upstream 100 bases:

>100_bases
TAAATTTTAAGAAAAAAACCAATTTGAAATTTTTGTTTTTTAAATACACCTTTAAATGGGAAGATATTAGAAATATGAGA
GAAAATTGAAATACATTACT

Downstream 100 bases:

>100_bases
AAGTCAATATAAAAAAACATCTAAATAATTAAACCCATTTTATCCCTTCTAAATAATTCCTAATAACCCCTTTATTGCAA
TTAGTTTTTAGTATTTGCGT

Product: 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Products: NA

Alternate protein names: DXP reductoisomerase; 1-deoxyxylulose-5-phosphate reductoisomerase; 2-C-methyl-D-erythritol 4-phosphate synthase [H]

Number of amino acids: Translated: 404; Mature: 404

Protein sequence:

>404_residues
MLGSTGSIGTQTLEIASEQPDKFKAVALSAGRNINLLTEQVKTHKPEVVAIEDESLIEDLKDNINNLDLDDVPLVLGGKQ
GINAVAAWDKADTVVTGIVGCAGLIPTMSAINAGKNIALANKETLIAAGPIVIPALKKNNSRLLPADSEHSAIFQCLQGL
PNYENADFSTGDIPKGLKAIHLTASGGAFRDWAVEDLKHVTVEDATSHPNWDMGKKITVDSATLMNKGLEVIEAHYLFGT
SYEDIEIVIHPQSIIHSMIEMEDSSVLAQLGWPDMKLPILYAMSWPERFKTNWKRLNLSEIGKLTFKEPDEFKYPCMGLA
YAAGKSSGTMPAVLNAANEMAVEQFLKEKISFQQIPTFISKACESHMENLNLSPELEDILEVDNWARLFIEQEIKKGKKY
VSIR

Sequences:

>Translated_404_residues
MLGSTGSIGTQTLEIASEQPDKFKAVALSAGRNINLLTEQVKTHKPEVVAIEDESLIEDLKDNINNLDLDDVPLVLGGKQ
GINAVAAWDKADTVVTGIVGCAGLIPTMSAINAGKNIALANKETLIAAGPIVIPALKKNNSRLLPADSEHSAIFQCLQGL
PNYENADFSTGDIPKGLKAIHLTASGGAFRDWAVEDLKHVTVEDATSHPNWDMGKKITVDSATLMNKGLEVIEAHYLFGT
SYEDIEIVIHPQSIIHSMIEMEDSSVLAQLGWPDMKLPILYAMSWPERFKTNWKRLNLSEIGKLTFKEPDEFKYPCMGLA
YAAGKSSGTMPAVLNAANEMAVEQFLKEKISFQQIPTFISKACESHMENLNLSPELEDILEVDNWARLFIEQEIKKGKKY
VSIR
>Mature_404_residues
MLGSTGSIGTQTLEIASEQPDKFKAVALSAGRNINLLTEQVKTHKPEVVAIEDESLIEDLKDNINNLDLDDVPLVLGGKQ
GINAVAAWDKADTVVTGIVGCAGLIPTMSAINAGKNIALANKETLIAAGPIVIPALKKNNSRLLPADSEHSAIFQCLQGL
PNYENADFSTGDIPKGLKAIHLTASGGAFRDWAVEDLKHVTVEDATSHPNWDMGKKITVDSATLMNKGLEVIEAHYLFGT
SYEDIEIVIHPQSIIHSMIEMEDSSVLAQLGWPDMKLPILYAMSWPERFKTNWKRLNLSEIGKLTFKEPDEFKYPCMGLA
YAAGKSSGTMPAVLNAANEMAVEQFLKEKISFQQIPTFISKACESHMENLNLSPELEDILEVDNWARLFIEQEIKKGKKY
VSIR

Specific function: Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) [H]

COG id: COG0743

COG function: function code I; 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DXR family [H]

Homologues:

Organism=Escherichia coli, GI1786369, Length=399, Percent_Identity=42.8571428571429, Blast_Score=309, Evalue=2e-85,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003821
- InterPro:   IPR013644
- InterPro:   IPR013512
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08436 DXP_redisom_C; PF02670 DXP_reductoisom [H]

EC number: =1.1.1.267 [H]

Molecular weight: Translated: 44302; Mature: 44302

Theoretical pI: Translated: 4.79; Mature: 4.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLGSTGSIGTQTLEIASEQPDKFKAVALSAGRNINLLTEQVKTHKPEVVAIEDESLIEDL
CCCCCCCCCCEEEEECCCCCCCEEEEEEECCCCCHHHHHHHHCCCCCEEEECCHHHHHHH
KDNINNLDLDDVPLVLGGKQGINAVAAWDKADTVVTGIVGCAGLIPTMSAINAGKNIALA
HHCCCCCCCCCCCEEECCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEE
NKETLIAAGPIVIPALKKNNSRLLPADSEHSAIFQCLQGLPNYENADFSTGDIPKGLKAI
CCCEEEEECCEEEEEECCCCCEECCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEE
HLTASGGAFRDWAVEDLKHVTVEDATSHPNWDMGKKITVDSATLMNKGLEVIEAHYLFGT
EEEECCCCCHHHHHHHHHHCEEECCCCCCCCCCCCEEEECHHHHHHCCHHHHHHHHHCCC
SYEDIEIVIHPQSIIHSMIEMEDSSVLAQLGWPDMKLPILYAMSWPERFKTNWKRLNLSE
CCCCEEEEECCHHHHHHHHHCCCCHHHHHCCCCCCCCCEEEEECCCHHHHCCHHEECHHH
IGKLTFKEPDEFKYPCMGLAYAAGKSSGTMPAVLNAANEMAVEQFLKEKISFQQIPTFIS
HCCCCCCCCCCCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KACESHMENLNLSPELEDILEVDNWARLFIEQEIKKGKKYVSIR
HHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEECC
>Mature Secondary Structure
MLGSTGSIGTQTLEIASEQPDKFKAVALSAGRNINLLTEQVKTHKPEVVAIEDESLIEDL
CCCCCCCCCCEEEEECCCCCCCEEEEEEECCCCCHHHHHHHHCCCCCEEEECCHHHHHHH
KDNINNLDLDDVPLVLGGKQGINAVAAWDKADTVVTGIVGCAGLIPTMSAINAGKNIALA
HHCCCCCCCCCCCEEECCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEE
NKETLIAAGPIVIPALKKNNSRLLPADSEHSAIFQCLQGLPNYENADFSTGDIPKGLKAI
CCCEEEEECCEEEEEECCCCCEECCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEE
HLTASGGAFRDWAVEDLKHVTVEDATSHPNWDMGKKITVDSATLMNKGLEVIEAHYLFGT
EEEECCCCCHHHHHHHHHHCEEECCCCCCCCCCCCEEEECHHHHHHCCHHHHHHHHHCCC
SYEDIEIVIHPQSIIHSMIEMEDSSVLAQLGWPDMKLPILYAMSWPERFKTNWKRLNLSE
CCCCEEEEECCHHHHHHHHHCCCCHHHHHCCCCCCCCCEEEEECCCHHHHCCHHEECHHH
IGKLTFKEPDEFKYPCMGLAYAAGKSSGTMPAVLNAANEMAVEQFLKEKISFQQIPTFIS
HCCCCCCCCCCCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KACESHMENLNLSPELEDILEVDNWARLFIEQEIKKGKKYVSIR
HHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA