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The map label for this gene is cysS

Identifier: 126696668

GI number: 126696668

Start: 1111514

End: 1112983

Strand: Direct

Name: cysS

Synonym: P9301_13301

Alternate gene names: 126696668

Gene position: 1111514-1112983 (Clockwise)

Preceding gene: 126696667

Following gene: 126696669

Centisome position: 67.7

GC content: 31.36

Gene sequence:

>1470_bases
ATGATCAAACTTTTTAATACTTTAAGCAAAAGAATTGAGGTTTTTAAGCCTATTGATGATGTAGTAAAAATTTATTGTTG
TGGAGTAACTGTTTATGATTTATGTCATCTTGGCCATGCCAGAAGTTACATAGCTTGGGATGTATTGAGAAGATTTTTAA
TTTACAGTGATTTCAAAGTGAAGTATGTTCAAAATTTCACAGATATTGATGACAAGATCTTAAAAAGAGCGAAAGAAGAA
AGTATTTCAATGAAGGAAGTATCTGAAAAGAATATTATTGAATTTCATAAAGATATGGATTCTTTAGGGATAATGCGTCC
GGATAGTATGCCAAGAGCAACGAATCATATATGCAATATCTGCGACTTAATAACAATCCTCGAGGACAAAGGTTATGCAT
ATTCTAGGGATGGAGATGTTTATTATTCTGTTTTTAAAAATCAAAATTATGGAAAGCTAAGTAATCAAAATATAGAAGAA
CAAAACATCAATCAGCAAGGAAGAATGGCTAATGAGGAAAATAGTAAAAAACTAAATCCGCAAGATTTTGCACTATGGAA
AAAAGCCAAAGATGATGAACCATTTTTTGATTCGCCATGGGGTAAAGGTAGGCCAGGGTGGCATATTGAATGTTCGGCAA
TGGTTAAAGATGAATTAGGAGATACTATTGATATCCATTTAGGAGGTTCTGATTTGATTTTTCCACATCATGAGAATGAA
ATCGCCCAATCAGAAGCCGCCAATGGCAAAAAGCTAGCGAACTATTGGTTACACAATGGGATGGTCAATGTAAATGGACA
AAAGATGAGTAAATCCCTTAAAAATTTTAAAACTATCAGAGAGCTAATTAATTCAGGTATAAGCCCTATGACTTTGCGAT
ATTTTGTTATGACTGTGAATTATAGAAAACCACTTGATTTTACTGAAGAAGCTTTAAGGAGTGCTTCAGAAGCTTGGAAA
AACATTAATGTAGCCCTTTCTTTTATGGACCTTACAAAAGGGTCTTTAAACTCTATTGATAAAAATGAACCTATCGAAGA
AGAATATAAAGAGAAAATAAGCTTTGAATTATCTCAAAAAAAGCTTAAATTTTCTGAGGCACTGGGAAATGACCTTAATA
CAGCAAGTGCTATTGCAATTATTTACGATTTAGCAAAACCATTAAAAAACTTTTTAAACCAATTTCAAAGAGTCGAAGGT
TTTAAAATAGACCAAAATGAAAAATTCTTTCTACTTGAGAATTTTAAAACTCTTGAAAAGTTGACTGAGGTACTTGGTCT
TAAAAAAGAGGTTTTAGTAAAAGAAAGTAAAATAACAGAAGAAGAAATATCAACGCTTATTAATGAAAGATTGAAAGCAA
AAAAGGAAAAGAATTATGCGAAGGCCGATGAAATAAGAAGTTTGTTAAAAGAAAAAGGTATTGAACTTATTGATCAATCA
AAGGAAATAACAACATGGATAAGGGTCTAA

Upstream 100 bases:

>100_bases
GGAAAATTGTGTAAAATTAAATGTACCTCTTTTGGTTGATATTGGAATTGGAGATAATTGGATGGAGACAAAATAAGCCT
TATGAAATACTTAGTTTAAG

Downstream 100 bases:

>100_bases
ATTTTAAGAAAAAAACCAATTTGAAATTTTTGTTTTTTAAATACACCTTTAAATGGGAAGATATTAGAAATATGAGAGAA
AATTGAAATACATTACTGTG

Product: cysteinyl-tRNA synthetase

Products: NA

Alternate protein names: Cysteine--tRNA ligase; CysRS

Number of amino acids: Translated: 489; Mature: 489

Protein sequence:

>489_residues
MIKLFNTLSKRIEVFKPIDDVVKIYCCGVTVYDLCHLGHARSYIAWDVLRRFLIYSDFKVKYVQNFTDIDDKILKRAKEE
SISMKEVSEKNIIEFHKDMDSLGIMRPDSMPRATNHICNICDLITILEDKGYAYSRDGDVYYSVFKNQNYGKLSNQNIEE
QNINQQGRMANEENSKKLNPQDFALWKKAKDDEPFFDSPWGKGRPGWHIECSAMVKDELGDTIDIHLGGSDLIFPHHENE
IAQSEAANGKKLANYWLHNGMVNVNGQKMSKSLKNFKTIRELINSGISPMTLRYFVMTVNYRKPLDFTEEALRSASEAWK
NINVALSFMDLTKGSLNSIDKNEPIEEEYKEKISFELSQKKLKFSEALGNDLNTASAIAIIYDLAKPLKNFLNQFQRVEG
FKIDQNEKFFLLENFKTLEKLTEVLGLKKEVLVKESKITEEEISTLINERLKAKKEKNYAKADEIRSLLKEKGIELIDQS
KEITTWIRV

Sequences:

>Translated_489_residues
MIKLFNTLSKRIEVFKPIDDVVKIYCCGVTVYDLCHLGHARSYIAWDVLRRFLIYSDFKVKYVQNFTDIDDKILKRAKEE
SISMKEVSEKNIIEFHKDMDSLGIMRPDSMPRATNHICNICDLITILEDKGYAYSRDGDVYYSVFKNQNYGKLSNQNIEE
QNINQQGRMANEENSKKLNPQDFALWKKAKDDEPFFDSPWGKGRPGWHIECSAMVKDELGDTIDIHLGGSDLIFPHHENE
IAQSEAANGKKLANYWLHNGMVNVNGQKMSKSLKNFKTIRELINSGISPMTLRYFVMTVNYRKPLDFTEEALRSASEAWK
NINVALSFMDLTKGSLNSIDKNEPIEEEYKEKISFELSQKKLKFSEALGNDLNTASAIAIIYDLAKPLKNFLNQFQRVEG
FKIDQNEKFFLLENFKTLEKLTEVLGLKKEVLVKESKITEEEISTLINERLKAKKEKNYAKADEIRSLLKEKGIELIDQS
KEITTWIRV
>Mature_489_residues
MIKLFNTLSKRIEVFKPIDDVVKIYCCGVTVYDLCHLGHARSYIAWDVLRRFLIYSDFKVKYVQNFTDIDDKILKRAKEE
SISMKEVSEKNIIEFHKDMDSLGIMRPDSMPRATNHICNICDLITILEDKGYAYSRDGDVYYSVFKNQNYGKLSNQNIEE
QNINQQGRMANEENSKKLNPQDFALWKKAKDDEPFFDSPWGKGRPGWHIECSAMVKDELGDTIDIHLGGSDLIFPHHENE
IAQSEAANGKKLANYWLHNGMVNVNGQKMSKSLKNFKTIRELINSGISPMTLRYFVMTVNYRKPLDFTEEALRSASEAWK
NINVALSFMDLTKGSLNSIDKNEPIEEEYKEKISFELSQKKLKFSEALGNDLNTASAIAIIYDLAKPLKNFLNQFQRVEG
FKIDQNEKFFLLENFKTLEKLTEVLGLKKEVLVKESKITEEEISTLINERLKAKKEKNYAKADEIRSLLKEKGIELIDQS
KEITTWIRV

Specific function: Unknown

COG id: COG0215

COG function: function code J; Cysteinyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I aminoacyl-tRNA synthetase family

Homologues:

Organism=Homo sapiens, GI13375695, Length=516, Percent_Identity=31.0077519379845, Blast_Score=233, Evalue=4e-61,
Organism=Homo sapiens, GI21269877, Length=296, Percent_Identity=36.4864864864865, Blast_Score=192, Evalue=7e-49,
Organism=Homo sapiens, GI10835051, Length=296, Percent_Identity=36.4864864864865, Blast_Score=192, Evalue=8e-49,
Organism=Homo sapiens, GI62240992, Length=296, Percent_Identity=36.4864864864865, Blast_Score=191, Evalue=9e-49,
Organism=Homo sapiens, GI303304987, Length=296, Percent_Identity=36.4864864864865, Blast_Score=191, Evalue=1e-48,
Organism=Escherichia coli, GI1786737, Length=497, Percent_Identity=42.4547283702213, Blast_Score=358, Evalue=1e-100,
Organism=Caenorhabditis elegans, GI17509797, Length=306, Percent_Identity=36.2745098039216, Blast_Score=169, Evalue=3e-42,
Organism=Caenorhabditis elegans, GI17509795, Length=306, Percent_Identity=36.2745098039216, Blast_Score=169, Evalue=3e-42,
Organism=Saccharomyces cerevisiae, GI6324082, Length=304, Percent_Identity=37.828947368421, Blast_Score=194, Evalue=3e-50,
Organism=Drosophila melanogaster, GI19922218, Length=521, Percent_Identity=32.0537428023033, Blast_Score=225, Evalue=6e-59,
Organism=Drosophila melanogaster, GI19922364, Length=307, Percent_Identity=38.4364820846906, Blast_Score=200, Evalue=2e-51,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SYC_PROM0 (A3PDX8)

Other databases:

- EMBL:   CP000576
- RefSeq:   YP_001091554.1
- ProteinModelPortal:   A3PDX8
- SMR:   A3PDX8
- STRING:   A3PDX8
- GeneID:   4910919
- GenomeReviews:   CP000576_GR
- KEGG:   pmg:P9301_13301
- eggNOG:   COG0215
- HOGENOM:   HBG327651
- OMA:   VVKIYCC
- ProtClustDB:   PRK00260
- BioCyc:   PMAR167546:P9301ORF_1351-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00041_B
- InterPro:   IPR015803
- InterPro:   IPR015273
- InterPro:   IPR014729
- InterPro:   IPR009080
- Gene3D:   G3DSA:3.40.50.620
- PANTHER:   PTHR10890
- PRINTS:   PR00983
- SMART:   SM00840
- TIGRFAMs:   TIGR00435

Pfam domain/function: PF09190 DALR_2; PF01406 tRNA-synt_1e; SSF47323 tRNAsyn_1a_bind

EC number: =6.1.1.16

Molecular weight: Translated: 56559; Mature: 56559

Theoretical pI: Translated: 7.00; Mature: 7.00

Prosite motif: PS00178 AA_TRNA_LIGASE_I

Important sites: BINDING 271-271

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKLFNTLSKRIEVFKPIDDVVKIYCCGVTVYDLCHLGHARSYIAWDVLRRFLIYSDFKV
CCCHHHHHHHHHHHHCCHHHHHHHHHCCHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCHH
KYVQNFTDIDDKILKRAKEESISMKEVSEKNIIEFHKDMDSLGIMRPDSMPRATNHICNI
HHHHHHCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHH
CDLITILEDKGYAYSRDGDVYYSVFKNQNYGKLSNQNIEEQNINQQGRMANEENSKKLNP
HHHHHHHHCCCCEECCCCCEEEEEECCCCCCCCCCCCCCHHCCCHHCCCCCCCCCCCCCC
QDFALWKKAKDDEPFFDSPWGKGRPGWHIECSAMVKDELGDTIDIHLGGSDLIFPHHENE
HHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEHHHHHHHCCCEEEEEECCCCEECCCCCCH
IAQSEAANGKKLANYWLHNGMVNVNGQKMSKSLKNFKTIRELINSGISPMTLRYFVMTVN
HHHHHCCCCHHHHHHHHHCCEEEECHHHHHHHHHHHHHHHHHHHCCCCHHEEEEEEEEEC
YRKPLDFTEEALRSASEAWKNINVALSFMDLTKGSLNSIDKNEPIEEEYKEKISFELSQK
CCCCCCHHHHHHHHHHHHHHCHHHEEEEEHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
KLKFSEALGNDLNTASAIAIIYDLAKPLKNFLNQFQRVEGFKIDQNEKFFLLENFKTLEK
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCCEEEEHHHHHHHH
LTEVLGLKKEVLVKESKITEEEISTLINERLKAKKEKNYAKADEIRSLLKEKGIELIDQS
HHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCHHHHHCC
KEITTWIRV
CHHHHHCCC
>Mature Secondary Structure
MIKLFNTLSKRIEVFKPIDDVVKIYCCGVTVYDLCHLGHARSYIAWDVLRRFLIYSDFKV
CCCHHHHHHHHHHHHCCHHHHHHHHHCCHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCHH
KYVQNFTDIDDKILKRAKEESISMKEVSEKNIIEFHKDMDSLGIMRPDSMPRATNHICNI
HHHHHHCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHH
CDLITILEDKGYAYSRDGDVYYSVFKNQNYGKLSNQNIEEQNINQQGRMANEENSKKLNP
HHHHHHHHCCCCEECCCCCEEEEEECCCCCCCCCCCCCCHHCCCHHCCCCCCCCCCCCCC
QDFALWKKAKDDEPFFDSPWGKGRPGWHIECSAMVKDELGDTIDIHLGGSDLIFPHHENE
HHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEHHHHHHHCCCEEEEEECCCCEECCCCCCH
IAQSEAANGKKLANYWLHNGMVNVNGQKMSKSLKNFKTIRELINSGISPMTLRYFVMTVN
HHHHHCCCCHHHHHHHHHCCEEEECHHHHHHHHHHHHHHHHHHHCCCCHHEEEEEEEEEC
YRKPLDFTEEALRSASEAWKNINVALSFMDLTKGSLNSIDKNEPIEEEYKEKISFELSQK
CCCCCCHHHHHHHHHHHHHHCHHHEEEEEHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
KLKFSEALGNDLNTASAIAIIYDLAKPLKNFLNQFQRVEGFKIDQNEKFFLLENFKTLEK
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCCEEEEHHHHHHHH
LTEVLGLKKEVLVKESKITEEEISTLINERLKAKKEKNYAKADEIRSLLKEKGIELIDQS
HHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCHHHHHCC
KEITTWIRV
CHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA