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The map label for this gene is uppS [H]

Identifier: 126696537

GI number: 126696537

Start: 1013967

End: 1014770

Strand: Direct

Name: uppS [H]

Synonym: P9301_11991

Alternate gene names: 126696537

Gene position: 1013967-1014770 (Clockwise)

Preceding gene: 126696536

Following gene: 126696538

Centisome position: 61.76

GC content: 28.98

Gene sequence:

>804_bases
ATGAGTTTAGAAAAAGTAATAGACGATAAAATTACTGACTTATTAATGAAAATAGATAAGCAAAAATTGCCCAAGCATGT
AGCAATAATTATGGACGGCAATGGGAGATGGGCGACTAGAAAAGGTTTACCCCGATCATTTGGACATAAACAGGGAGTTA
GTGTTTTAAAAAAAATTCTCAAAGCTGCAAAAAAATTAGGTTGTAAGGTAATTACTGTTTATGCTTTTTCAACAGAGAAT
TGGACAAGACCATCGAAAGAGGTCGATTTTCTCATAAATCTTTTTAGCGAAGTTTTAAAAAACGAAATTGATGAAATACA
TGAAGAATCAACAAAAATAAAATTCATTGGAGATTTAACTCCTTTCCCAAAAAATTTAAAAGAAATAATATCTAGTTCAG
AATCACTTACTAAAAACAACAATAAATTTTTATTCAATGTTTGTGTTAATTACGGAGGTAGGCAAGAAATAGTAAAAGTT
GCAAAAGAATTAGCATTAAAATCTTCTTCTGGGAAAATAAAGCCAAGTGAAATTAATGAAGAATTATTTAATTCAGAGCT
ATTAACAAGAGGAATTAAAGATCCAGAATTACTAATAAGAACAAGTGGTGAAAAAAGGATAAGTAATTTTTTATTATGGC
AATTAGCATATTCAGAAATTTATATATCTGAAGTCCTTTGGCCAGATTTCAATGAGCATGAATTTCTTAAAGCAATAATT
GATTACCAATCAAGAAATAGACGTTTCGGCGGTATAGAATCATTACCAAATGAATCTTTTGCAGATTCTCAATATATTTC
CTAA

Upstream 100 bases:

>100_bases
TTCGTCTCAAAAGACAGACTCGAGTGATAATATAATCAGTGAAATTAATAAAAAAGAGTCAGAAAAATCAGAAATTTTTA
CTAACAAAAAGGATTAACTA

Downstream 100 bases:

>100_bases
TAAAAATGGCTAATTCGAATAATCAGTTATTAAAAGAAATTAGGTACGATTGGAATAGGGAGGAGATATTGCAAATACTT
AATATGCCTCTTATTGATTT

Product: undecaprenyl pyrophosphate synthase

Products: NA

Alternate protein names: UPP synthase; Di-trans,poly-cis-decaprenylcistransferase; Undecaprenyl diphosphate synthase; UDS [H]

Number of amino acids: Translated: 267; Mature: 266

Protein sequence:

>267_residues
MSLEKVIDDKITDLLMKIDKQKLPKHVAIIMDGNGRWATRKGLPRSFGHKQGVSVLKKILKAAKKLGCKVITVYAFSTEN
WTRPSKEVDFLINLFSEVLKNEIDEIHEESTKIKFIGDLTPFPKNLKEIISSSESLTKNNNKFLFNVCVNYGGRQEIVKV
AKELALKSSSGKIKPSEINEELFNSELLTRGIKDPELLIRTSGEKRISNFLLWQLAYSEIYISEVLWPDFNEHEFLKAII
DYQSRNRRFGGIESLPNESFADSQYIS

Sequences:

>Translated_267_residues
MSLEKVIDDKITDLLMKIDKQKLPKHVAIIMDGNGRWATRKGLPRSFGHKQGVSVLKKILKAAKKLGCKVITVYAFSTEN
WTRPSKEVDFLINLFSEVLKNEIDEIHEESTKIKFIGDLTPFPKNLKEIISSSESLTKNNNKFLFNVCVNYGGRQEIVKV
AKELALKSSSGKIKPSEINEELFNSELLTRGIKDPELLIRTSGEKRISNFLLWQLAYSEIYISEVLWPDFNEHEFLKAII
DYQSRNRRFGGIESLPNESFADSQYIS
>Mature_266_residues
SLEKVIDDKITDLLMKIDKQKLPKHVAIIMDGNGRWATRKGLPRSFGHKQGVSVLKKILKAAKKLGCKVITVYAFSTENW
TRPSKEVDFLINLFSEVLKNEIDEIHEESTKIKFIGDLTPFPKNLKEIISSSESLTKNNNKFLFNVCVNYGGRQEIVKVA
KELALKSSSGKIKPSEINEELFNSELLTRGIKDPELLIRTSGEKRISNFLLWQLAYSEIYISEVLWPDFNEHEFLKAIID
YQSRNRRFGGIESLPNESFADSQYIS

Specific function: Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide [H]

COG id: COG0020

COG function: function code I; Undecaprenyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI45580738, Length=225, Percent_Identity=40, Blast_Score=173, Evalue=2e-43,
Organism=Homo sapiens, GI45580742, Length=225, Percent_Identity=40, Blast_Score=173, Evalue=2e-43,
Organism=Escherichia coli, GI1786371, Length=237, Percent_Identity=45.1476793248945, Blast_Score=237, Evalue=8e-64,
Organism=Caenorhabditis elegans, GI71993029, Length=226, Percent_Identity=37.1681415929204, Blast_Score=154, Evalue=5e-38,
Organism=Saccharomyces cerevisiae, GI6319474, Length=215, Percent_Identity=38.1395348837209, Blast_Score=130, Evalue=2e-31,
Organism=Saccharomyces cerevisiae, GI6323748, Length=220, Percent_Identity=33.1818181818182, Blast_Score=119, Evalue=6e-28,
Organism=Drosophila melanogaster, GI18857969, Length=228, Percent_Identity=36.4035087719298, Blast_Score=154, Evalue=7e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001441
- InterPro:   IPR018520 [H]

Pfam domain/function: PF01255 Prenyltransf [H]

EC number: =2.5.1.31 [H]

Molecular weight: Translated: 30560; Mature: 30428

Theoretical pI: Translated: 9.44; Mature: 9.44

Prosite motif: PS01066 UPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLEKVIDDKITDLLMKIDKQKLPKHVAIIMDGNGRWATRKGLPRSFGHKQGVSVLKKIL
CCHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCEECCCCCCHHCCHHHHHHHHHHHH
KAAKKLGCKVITVYAFSTENWTRPSKEVDFLINLFSEVLKNEIDEIHEESTKIKFIGDLT
HHHHHCCCEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCC
PFPKNLKEIISSSESLTKNNNKFLFNVCVNYGGRQEIVKVAKELALKSSSGKIKPSEINE
CCCHHHHHHHCCCHHHHCCCCCEEEEEEECCCCHHHHHHHHHHHHHCCCCCCCCHHHHHH
ELFNSELLTRGIKDPELLIRTSGEKRISNFLLWQLAYSEIYISEVLWPDFNEHEFLKAII
HHHHHHHHHCCCCCCHHEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
DYQSRNRRFGGIESLPNESFADSQYIS
HHHHCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SLEKVIDDKITDLLMKIDKQKLPKHVAIIMDGNGRWATRKGLPRSFGHKQGVSVLKKIL
CHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCEECCCCCCHHCCHHHHHHHHHHHH
KAAKKLGCKVITVYAFSTENWTRPSKEVDFLINLFSEVLKNEIDEIHEESTKIKFIGDLT
HHHHHCCCEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCC
PFPKNLKEIISSSESLTKNNNKFLFNVCVNYGGRQEIVKVAKELALKSSSGKIKPSEINE
CCCHHHHHHHCCCHHHHCCCCCEEEEEEECCCCHHHHHHHHHHHHHCCCCCCCCHHHHHH
ELFNSELLTRGIKDPELLIRTSGEKRISNFLLWQLAYSEIYISEVLWPDFNEHEFLKAII
HHHHHHHHHCCCCCCHHEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
DYQSRNRRFGGIESLPNESFADSQYIS
HHHHCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12917642 [H]