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The map label for this gene is ispA [C]

Identifier: 126696514

GI number: 126696514

Start: 989058

End: 989957

Strand: Direct

Name: ispA [C]

Synonym: P9301_11761

Alternate gene names: 126696514

Gene position: 989058-989957 (Clockwise)

Preceding gene: 126696513

Following gene: 126696515

Centisome position: 60.24

GC content: 38.33

Gene sequence:

>900_bases
ATGACTAAAGTAATAAATAGCTATGATTTTGAAAAATATCTTAAACAAACAAAAAAGGTTATAGAAGAAGCACTTGATTT
TTCCTTGGGCCCTGAGAATCCAGAAATATTAAGAGAATCAATGAGATATTCCCTTTTGGCTGGAGGAAAAAGGATACGTC
CAATTTTATGTTTAGCATCTTGCTCACTGGCTGGAGGGGAGCCCTCTCTTGCTGTTCCTACTGCAGTAGCGATAGAAATG
ATTCATACAATGTCCTTGATACATGATGATCTTCCCGCGATGGATAATGATGACTTAAGGAGAGGAAGACCAACGAATCA
TAAAGTATATGGGGATGCAGTAGCTATTCTTGCAGGCGATGCTTTATTAACTAGGGCCTTTGAAATGGTCTCTTTAAGAA
GCCCTGGAGTAGATCCAAATAGATTATTAAATGTAATTGGCGAATTATCCTTAGTCGCAGGCGCACCAGGCCTAGTCGGG
GGACAAGTTGTTGATTTAGAATGCGAAGGCAAAGAAGTCGACCTTGATACTCTCGAATATATTCATCTTCATAAGACTGG
GGCTTTATTGAAGGCTTGTGTAAGAACAGGCGCGATGATCGCAGGCGCTAACGAAAAACTTTTACAAGCTCTTACAACAT
ATGCAGAGGGAATTGGTTTGGCCTTCCAAATAATTGATGATATTCTTGATTTAACTTCAAGTAGTGAAAAGCTTGGTAAA
ACTGCTGGTAAAGATCTTTTAGCCGACAAAACTACTTACCCTAAATTACTTGGTATGGAGGAGTCAAAGAAAAGAGCATT
TGATTTAGTTGAAAAAGCAAAAAAAGCAATTGAACCTTGGGGGGCAGATGCAAATCATTTAATATCATTAGCCGACTTTA
TTACAAACAGAGATAGATAA

Upstream 100 bases:

>100_bases
TACTATTTTTAGCTGGCAAAAACAATTTGGTTTATCATCAAATCTTAATGATCTTTTGCCATAAACTCCAAGATGAAAAA
TTTTTTACTAAAAGGATAAA

Downstream 100 bases:

>100_bases
ATAGTTTTAGTTCATGGCTGAGTTTTTTACCTTTTTTAATAATTCAGTTCTTTTCTGGAGCTTATTATCATGTTTACTAG
CTCAATTTTTTAAAATTGTA

Product: polyprenyl synthetase

Products: NA

Alternate protein names: FPP synthase; (2E,6E)-farnesyl diphosphate synthase; Geranyltranstransferase [H]

Number of amino acids: Translated: 299; Mature: 298

Protein sequence:

>299_residues
MTKVINSYDFEKYLKQTKKVIEEALDFSLGPENPEILRESMRYSLLAGGKRIRPILCLASCSLAGGEPSLAVPTAVAIEM
IHTMSLIHDDLPAMDNDDLRRGRPTNHKVYGDAVAILAGDALLTRAFEMVSLRSPGVDPNRLLNVIGELSLVAGAPGLVG
GQVVDLECEGKEVDLDTLEYIHLHKTGALLKACVRTGAMIAGANEKLLQALTTYAEGIGLAFQIIDDILDLTSSSEKLGK
TAGKDLLADKTTYPKLLGMEESKKRAFDLVEKAKKAIEPWGADANHLISLADFITNRDR

Sequences:

>Translated_299_residues
MTKVINSYDFEKYLKQTKKVIEEALDFSLGPENPEILRESMRYSLLAGGKRIRPILCLASCSLAGGEPSLAVPTAVAIEM
IHTMSLIHDDLPAMDNDDLRRGRPTNHKVYGDAVAILAGDALLTRAFEMVSLRSPGVDPNRLLNVIGELSLVAGAPGLVG
GQVVDLECEGKEVDLDTLEYIHLHKTGALLKACVRTGAMIAGANEKLLQALTTYAEGIGLAFQIIDDILDLTSSSEKLGK
TAGKDLLADKTTYPKLLGMEESKKRAFDLVEKAKKAIEPWGADANHLISLADFITNRDR
>Mature_298_residues
TKVINSYDFEKYLKQTKKVIEEALDFSLGPENPEILRESMRYSLLAGGKRIRPILCLASCSLAGGEPSLAVPTAVAIEMI
HTMSLIHDDLPAMDNDDLRRGRPTNHKVYGDAVAILAGDALLTRAFEMVSLRSPGVDPNRLLNVIGELSLVAGAPGLVGG
QVVDLECEGKEVDLDTLEYIHLHKTGALLKACVRTGAMIAGANEKLLQALTTYAEGIGLAFQIIDDILDLTSSSEKLGKT
AGKDLLADKTTYPKLLGMEESKKRAFDLVEKAKKAIEPWGADANHLISLADFITNRDR

Specific function: Unknown

COG id: COG0142

COG function: function code H; Geranylgeranyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FPP/GGPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI50659086, Length=237, Percent_Identity=27.8481012658228, Blast_Score=87, Evalue=2e-17,
Organism=Escherichia coli, GI1786623, Length=302, Percent_Identity=45.364238410596, Blast_Score=204, Evalue=8e-54,
Organism=Escherichia coli, GI1789578, Length=233, Percent_Identity=32.618025751073, Blast_Score=119, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI17505681, Length=190, Percent_Identity=31.0526315789474, Blast_Score=82, Evalue=4e-16,
Organism=Saccharomyces cerevisiae, GI6319475, Length=231, Percent_Identity=29.8701298701299, Blast_Score=96, Evalue=7e-21,
Organism=Drosophila melanogaster, GI24651612, Length=221, Percent_Identity=30.316742081448, Blast_Score=91, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000092
- InterPro:   IPR017446
- InterPro:   IPR008949 [H]

Pfam domain/function: PF00348 polyprenyl_synt [H]

EC number: =2.5.1.10 [H]

Molecular weight: Translated: 32414; Mature: 32283

Theoretical pI: Translated: 5.25; Mature: 5.25

Prosite motif: PS00723 POLYPRENYL_SYNTHET_1 ; PS00444 POLYPRENYL_SYNTHET_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKVINSYDFEKYLKQTKKVIEEALDFSLGPENPEILRESMRYSLLAGGKRIRPILCLAS
CCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHH
CSLAGGEPSLAVPTAVAIEMIHTMSLIHDDLPAMDNDDLRRGRPTNHKVYGDAVAILAGD
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCCCCCEEHHCCHHHHHHH
ALLTRAFEMVSLRSPGVDPNRLLNVIGELSLVAGAPGLVGGQVVDLECEGKEVDLDTLEY
HHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCCCHHHHHH
IHLHKTGALLKACVRTGAMIAGANEKLLQALTTYAEGIGLAFQIIDDILDLTSSSEKLGK
HHHHHHHHHHHHHHHHCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
TAGKDLLADKTTYPKLLGMEESKKRAFDLVEKAKKAIEPWGADANHLISLADFITNRDR
HHCHHHHCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TKVINSYDFEKYLKQTKKVIEEALDFSLGPENPEILRESMRYSLLAGGKRIRPILCLAS
CCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHH
CSLAGGEPSLAVPTAVAIEMIHTMSLIHDDLPAMDNDDLRRGRPTNHKVYGDAVAILAGD
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCCCCCEEHHCCHHHHHHH
ALLTRAFEMVSLRSPGVDPNRLLNVIGELSLVAGAPGLVGGQVVDLECEGKEVDLDTLEY
HHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCCCHHHHHH
IHLHKTGALLKACVRTGAMIAGANEKLLQALTTYAEGIGLAFQIIDDILDLTSSSEKLGK
HHHHHHHHHHHHHHHHCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
TAGKDLLADKTTYPKLLGMEESKKRAFDLVEKAKKAIEPWGADANHLISLADFITNRDR
HHCHHHHCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8486607; 7918490 [H]