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The map label for this gene is folD

Identifier: 126696513

GI number: 126696513

Start: 988125

End: 989021

Strand: Direct

Name: folD

Synonym: P9301_11751

Alternate gene names: 126696513

Gene position: 988125-989021 (Clockwise)

Preceding gene: 126696511

Following gene: 126696514

Centisome position: 60.18

GC content: 32.33

Gene sequence:

>897_bases
ATGTCATTAAAATTAGACGGTAAAAAATTATCCCTTGAAATTGAGGAGAGATTAAATGAATATATTTCTAGTAATAAAGA
AATTGCAAAAAGAGCTCCTGGTTTAGCTGTGATAAGAATAGGTGAAGACCCAGCAAGTGGTGTTTACGTTAATAATAAGG
AAAAAGCATGTTCAAGGGTAGGAATAAAAAGCTTCATATTTCATCTAAAAGATAATATAGAGCAAAAAGAAGTTGAACAA
TTAATAAACAAACTAAACTTAGACAAGAATATAGATGGAATGTTGCTACAACTTCCCATCCCAAAGAAGTTTGATGAGCA
AAAACTAATCAGCCATATTAATCCAAGCAAAGATGTAGATGGATTAAATGAGATAAACATCGGGAAATTAGTGAAAAATG
AGCCTGCGATGAGATCATGTACACCAGCAGGAATTATTAATTTATTAAGATCCCAAAATATTAAAATTGAAGGCAAGAAA
ATTGTTGTTGTAGGAAGAAGTTTGCTTGTTGGGAAACCCCTATCGCTTATGTTGTTGAATCTAAATGGCACGGTAACAAT
GACTCATTCAAAAACATTAAATTTGAATAAAGTCTGTAGAGAAGCCGACATACTAATTGCGGCTGCAGGAAAACCCAATC
TCATAGATTCTAGTTTTGTGAAAGAAGGAGCAATAATAATTGATGTTGGAATACATAGATTAAAAAGTTCCAATAAAAAT
CAAACCAGATTATGTGGCGATGTATTATTAGAAGATGTCATTTCTAAAGTATTTGCATACACACCTGTACCAGGAGGCGT
TGGACCAATGACCGTAACAATGTTACTTGTGAATACTATTTTTAGCTGGCAAAAACAATTTGGTTTATCATCAAATCTTA
ATGATCTTTTGCCATAA

Upstream 100 bases:

>100_bases
TTTAAAGTAGATGTGATGTTTTGCACAGAATATGATTAAATCTATTTGAATAATTTAAAATTATAGGCATCCTAGATGTA
AAAAGGAGATCTTTTCATAA

Downstream 100 bases:

>100_bases
ACTCCAAGATGAAAAATTTTTTACTAAAAGGATAAAATGACTAAAGTAATAAATAGCTATGATTTTGAAAAATATCTTAA
ACAAACAAAAAAGGTTATAG

Product: bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase

Products: NA

Alternate protein names: Methylenetetrahydrofolate dehydrogenase; Methenyltetrahydrofolate cyclohydrolase

Number of amino acids: Translated: 298; Mature: 297

Protein sequence:

>298_residues
MSLKLDGKKLSLEIEERLNEYISSNKEIAKRAPGLAVIRIGEDPASGVYVNNKEKACSRVGIKSFIFHLKDNIEQKEVEQ
LINKLNLDKNIDGMLLQLPIPKKFDEQKLISHINPSKDVDGLNEINIGKLVKNEPAMRSCTPAGIINLLRSQNIKIEGKK
IVVVGRSLLVGKPLSLMLLNLNGTVTMTHSKTLNLNKVCREADILIAAAGKPNLIDSSFVKEGAIIIDVGIHRLKSSNKN
QTRLCGDVLLEDVISKVFAYTPVPGGVGPMTVTMLLVNTIFSWQKQFGLSSNLNDLLP

Sequences:

>Translated_298_residues
MSLKLDGKKLSLEIEERLNEYISSNKEIAKRAPGLAVIRIGEDPASGVYVNNKEKACSRVGIKSFIFHLKDNIEQKEVEQ
LINKLNLDKNIDGMLLQLPIPKKFDEQKLISHINPSKDVDGLNEINIGKLVKNEPAMRSCTPAGIINLLRSQNIKIEGKK
IVVVGRSLLVGKPLSLMLLNLNGTVTMTHSKTLNLNKVCREADILIAAAGKPNLIDSSFVKEGAIIIDVGIHRLKSSNKN
QTRLCGDVLLEDVISKVFAYTPVPGGVGPMTVTMLLVNTIFSWQKQFGLSSNLNDLLP
>Mature_297_residues
SLKLDGKKLSLEIEERLNEYISSNKEIAKRAPGLAVIRIGEDPASGVYVNNKEKACSRVGIKSFIFHLKDNIEQKEVEQL
INKLNLDKNIDGMLLQLPIPKKFDEQKLISHINPSKDVDGLNEINIGKLVKNEPAMRSCTPAGIINLLRSQNIKIEGKKI
VVVGRSLLVGKPLSLMLLNLNGTVTMTHSKTLNLNKVCREADILIAAAGKPNLIDSSFVKEGAIIIDVGIHRLKSSNKNQ
TRLCGDVLLEDVISKVFAYTPVPGGVGPMTVTMLLVNTIFSWQKQFGLSSNLNDLLP

Specific function: Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate

COG id: COG0190

COG function: function code H; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family

Homologues:

Organism=Homo sapiens, GI94721354, Length=296, Percent_Identity=41.554054054054, Blast_Score=206, Evalue=3e-53,
Organism=Homo sapiens, GI222418558, Length=292, Percent_Identity=39.3835616438356, Blast_Score=199, Evalue=3e-51,
Organism=Homo sapiens, GI222136639, Length=287, Percent_Identity=38.3275261324042, Blast_Score=197, Evalue=1e-50,
Organism=Homo sapiens, GI36796743, Length=199, Percent_Identity=28.643216080402, Blast_Score=74, Evalue=1e-13,
Organism=Escherichia coli, GI1786741, Length=276, Percent_Identity=43.4782608695652, Blast_Score=239, Evalue=2e-64,
Organism=Caenorhabditis elegans, GI17568735, Length=268, Percent_Identity=39.5522388059701, Blast_Score=177, Evalue=5e-45,
Organism=Saccharomyces cerevisiae, GI6319558, Length=298, Percent_Identity=40.2684563758389, Blast_Score=213, Evalue=3e-56,
Organism=Saccharomyces cerevisiae, GI6321643, Length=299, Percent_Identity=38.7959866220736, Blast_Score=209, Evalue=4e-55,
Organism=Saccharomyces cerevisiae, GI6322933, Length=320, Percent_Identity=25.3125, Blast_Score=81, Evalue=2e-16,
Organism=Drosophila melanogaster, GI17136818, Length=297, Percent_Identity=40.7407407407407, Blast_Score=215, Evalue=3e-56,
Organism=Drosophila melanogaster, GI17136816, Length=297, Percent_Identity=40.7407407407407, Blast_Score=214, Evalue=4e-56,
Organism=Drosophila melanogaster, GI62472483, Length=283, Percent_Identity=37.1024734982332, Blast_Score=191, Evalue=6e-49,
Organism=Drosophila melanogaster, GI45551871, Length=283, Percent_Identity=37.1024734982332, Blast_Score=191, Evalue=6e-49,
Organism=Drosophila melanogaster, GI24645718, Length=283, Percent_Identity=37.1024734982332, Blast_Score=190, Evalue=8e-49,
Organism=Drosophila melanogaster, GI17137370, Length=283, Percent_Identity=37.1024734982332, Blast_Score=190, Evalue=8e-49,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FOLD_PROM0 (A3PDH3)

Other databases:

- EMBL:   CP000576
- RefSeq:   YP_001091399.1
- ProteinModelPortal:   A3PDH3
- SMR:   A3PDH3
- STRING:   A3PDH3
- GeneID:   4911923
- GenomeReviews:   CP000576_GR
- KEGG:   pmg:P9301_11751
- eggNOG:   COG0190
- HOGENOM:   HBG328751
- OMA:   DVVYETA
- ProtClustDB:   PRK14186
- BioCyc:   PMAR167546:P9301ORF_1196-MONOMER
- GO:   GO:0005488
- HAMAP:   MF_01576
- InterPro:   IPR016040
- InterPro:   IPR000672
- InterPro:   IPR020630
- InterPro:   IPR020867
- InterPro:   IPR020631
- Gene3D:   G3DSA:3.40.50.720
- PRINTS:   PR00085

Pfam domain/function: PF00763 THF_DHG_CYH; PF02882 THF_DHG_CYH_C

EC number: =1.5.1.5; =3.5.4.9

Molecular weight: Translated: 32768; Mature: 32637

Theoretical pI: Translated: 9.86; Mature: 9.86

Prosite motif: PS00766 THF_DHG_CYH_1; PS00767 THF_DHG_CYH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLKLDGKKLSLEIEERLNEYISSNKEIAKRAPGLAVIRIGEDPASGVYVNNKEKACSRV
CCEECCCCEEEEEHHHHHHHHHHCCHHHHHHCCCEEEEEECCCCCCCEEECCHHHHHHHH
GIKSFIFHLKDNIEQKEVEQLINKLNLDKNIDGMLLQLPIPKKFDEQKLISHINPSKDVD
HHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCHHHHHHHCCCCCCCC
GLNEINIGKLVKNEPAMRSCTPAGIINLLRSQNIKIEGKKIVVVGRSLLVGKPLSLMLLN
CCCCCCHHHHHCCCCCHHCCCHHHHHHHHHCCCEEECCCEEEEEECHHHHCCCCEEEEEE
LNGTVTMTHSKTLNLNKVCREADILIAAAGKPNLIDSSFVKEGAIIIDVGIHRLKSSNKN
CCCEEEEEECCCCCHHHHHHHCCEEEEECCCCCCCCHHHHHCCCEEEEECHHHHHCCCCC
QTRLCGDVLLEDVISKVFAYTPVPGGVGPMTVTMLLVNTIFSWQKQFGLSSNLNDLLP
HHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHCC
>Mature Secondary Structure 
SLKLDGKKLSLEIEERLNEYISSNKEIAKRAPGLAVIRIGEDPASGVYVNNKEKACSRV
CEECCCCEEEEEHHHHHHHHHHCCHHHHHHCCCEEEEEECCCCCCCEEECCHHHHHHHH
GIKSFIFHLKDNIEQKEVEQLINKLNLDKNIDGMLLQLPIPKKFDEQKLISHINPSKDVD
HHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCHHHHHHHCCCCCCCC
GLNEINIGKLVKNEPAMRSCTPAGIINLLRSQNIKIEGKKIVVVGRSLLVGKPLSLMLLN
CCCCCCHHHHHCCCCCHHCCCHHHHHHHHHCCCEEECCCEEEEEECHHHHCCCCEEEEEE
LNGTVTMTHSKTLNLNKVCREADILIAAAGKPNLIDSSFVKEGAIIIDVGIHRLKSSNKN
CCCEEEEEECCCCCHHHHHHHCCEEEEECCCCCCCCHHHHHCCCEEEEECHHHHHCCCCC
QTRLCGDVLLEDVISKVFAYTPVPGGVGPMTVTMLLVNTIFSWQKQFGLSSNLNDLLP
HHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA