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The map label for this gene is yciC [H]

Identifier: 126696473

GI number: 126696473

Start: 954188

End: 955537

Strand: Direct

Name: yciC [H]

Synonym: P9301_11351

Alternate gene names: 126696473

Gene position: 954188-955537 (Clockwise)

Preceding gene: 126696472

Following gene: 126696474

Centisome position: 58.12

GC content: 37.33

Gene sequence:

>1350_bases
ATGAGCATCAAAGATAAAGTTCCCGTAACCATCCTCACTGGATTCTTAGGTTCAGGAAAGACTACTTTGCTTAATAGAAT
ACTAAGTGAAGAGCACGGGAAAAGAATAGCCGTAATTGAGAATGAATACGGTGAAGTAGGTATAGATCAAGGTCTCGTAA
TTAATGCCGATGAAGAAGTGTTTGAGATGTCAAACGGGTGCATTTGTTGTACTGTTCGCGGTGATCTAATAAGAGTCCTT
GGCAACCTTATGAAAAGAAGAGATAAGTTTGACTATGTTTTAGTAGAGACGACAGGATTAGCAGATCCAGGGCCAGTTGC
TCAGACATTTTTCATGGATGAAGAAATTAGTTCTGAATTTACTCTCGATGGAATTGTGACTTTAGTTGATGCTGCACATA
TTGATCAACAGTTAGGCAGGAGTGATGAAAGTTCAGAACAAGTCGCATTTGCAGATGTTCTTGTCCTTAATAAAACTGAT
TTAGTATCTGATGATGCACTAGATACTCTTGAATCGAGATTGAGAGATATGAACAGAATGACCCGAATTATTAGAGCCGA
GAATGCCAAAGTACCAATTGAAACAGTCTTAAATTTAAGTGCATTTGATCTTGATCAAATCCTTAAACGCAGGCCAACAT
TCCTTGAACCAGAATATCCTTTTGAATGGACAGGTGTTTACGATCTTGATGCAGGTAAATATGAATTAATGCTAGAAGAA
GGACCCGATCCAGAAATGTCCTTAGTAGCCCTCGCTAACCAAGGAGAGAGTGAAGAAGAACTTAAAGATGGTTCTGAATC
CTCCGTGAGACTTTATGCAGAAAAAGCTAATAGTTTAGTTCCTGGAAATACCATCCCATATGGAGAACATATAAATCTCA
AATTGGAGGATAAAGGAAATAAATCTTTCATCCTGAACATAGAAAAACCAACAAAAATAGGTTTGTTTACACAGCACACC
GCTGAAGAATTCAATATGAAAGTCATTAAAAGTGACGAAAATAAAGAGATTCCATTAAATACTGAAAGATTCTGGCAAGC
AGAGCACGAACATGATGATGAAGTAGGCTCAATTGCTATAGAGCGTTTTGGAGATGTTGACCCAGAAAAACTAAATACTT
GGATGGGAAGACTTCTATCAGAAAAAGGAGTGGATATATTCAGAACTAAAGGTTTCATAAGTTACTCAGGTAACCCAAGG
AGAATAGTTTTCCAGGGAGTTCACATGTTATTTACTGCACAACCTGATAAAGAATGGGGTAACGAACCTCGTAGAAATCA
ACTTGTTTTTATCGGTAGAAATTTAAATGAGAAAGAGATGCAAGAAGGCTTTGATAAATGCCTGATATAG

Upstream 100 bases:

>100_bases
AATGGTACAAACTTTCAGATTAAATTTTTCTAATAAAAACGGTTTTCATTTCTTATTATTACTATTATTAAACTATTATT
TATTTAGTAAAAATCAATAA

Downstream 100 bases:

>100_bases
AACCATTTAGCCCAAGAGGCATGTTCCATGAAGGATGGACTGCTGAAGTTAGCGATTATGCCATAGCATGTGGTTGGGCT
CTTAAAGGGAAACAATTTAT

Product: cobalamin synthesis protein/P47K

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 449; Mature: 448

Protein sequence:

>449_residues
MSIKDKVPVTILTGFLGSGKTTLLNRILSEEHGKRIAVIENEYGEVGIDQGLVINADEEVFEMSNGCICCTVRGDLIRVL
GNLMKRRDKFDYVLVETTGLADPGPVAQTFFMDEEISSEFTLDGIVTLVDAAHIDQQLGRSDESSEQVAFADVLVLNKTD
LVSDDALDTLESRLRDMNRMTRIIRAENAKVPIETVLNLSAFDLDQILKRRPTFLEPEYPFEWTGVYDLDAGKYELMLEE
GPDPEMSLVALANQGESEEELKDGSESSVRLYAEKANSLVPGNTIPYGEHINLKLEDKGNKSFILNIEKPTKIGLFTQHT
AEEFNMKVIKSDENKEIPLNTERFWQAEHEHDDEVGSIAIERFGDVDPEKLNTWMGRLLSEKGVDIFRTKGFISYSGNPR
RIVFQGVHMLFTAQPDKEWGNEPRRNQLVFIGRNLNEKEMQEGFDKCLI

Sequences:

>Translated_449_residues
MSIKDKVPVTILTGFLGSGKTTLLNRILSEEHGKRIAVIENEYGEVGIDQGLVINADEEVFEMSNGCICCTVRGDLIRVL
GNLMKRRDKFDYVLVETTGLADPGPVAQTFFMDEEISSEFTLDGIVTLVDAAHIDQQLGRSDESSEQVAFADVLVLNKTD
LVSDDALDTLESRLRDMNRMTRIIRAENAKVPIETVLNLSAFDLDQILKRRPTFLEPEYPFEWTGVYDLDAGKYELMLEE
GPDPEMSLVALANQGESEEELKDGSESSVRLYAEKANSLVPGNTIPYGEHINLKLEDKGNKSFILNIEKPTKIGLFTQHT
AEEFNMKVIKSDENKEIPLNTERFWQAEHEHDDEVGSIAIERFGDVDPEKLNTWMGRLLSEKGVDIFRTKGFISYSGNPR
RIVFQGVHMLFTAQPDKEWGNEPRRNQLVFIGRNLNEKEMQEGFDKCLI
>Mature_448_residues
SIKDKVPVTILTGFLGSGKTTLLNRILSEEHGKRIAVIENEYGEVGIDQGLVINADEEVFEMSNGCICCTVRGDLIRVLG
NLMKRRDKFDYVLVETTGLADPGPVAQTFFMDEEISSEFTLDGIVTLVDAAHIDQQLGRSDESSEQVAFADVLVLNKTDL
VSDDALDTLESRLRDMNRMTRIIRAENAKVPIETVLNLSAFDLDQILKRRPTFLEPEYPFEWTGVYDLDAGKYELMLEEG
PDPEMSLVALANQGESEEELKDGSESSVRLYAEKANSLVPGNTIPYGEHINLKLEDKGNKSFILNIEKPTKIGLFTQHTA
EEFNMKVIKSDENKEIPLNTERFWQAEHEHDDEVGSIAIERFGDVDPEKLNTWMGRLLSEKGVDIFRTKGFISYSGNPRR
IVFQGVHMLFTAQPDKEWGNEPRRNQLVFIGRNLNEKEMQEGFDKCLI

Specific function: May bind GTP. Might act as metal chaperone (Potential). Contributes to optimal growth under starvation for zinc [H]

COG id: COG0523

COG function: function code R; Putative GTPases (G3E family)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 cobW C-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI33469141, Length=209, Percent_Identity=45.4545454545455, Blast_Score=196, Evalue=5e-50,
Organism=Homo sapiens, GI126722884, Length=209, Percent_Identity=45.4545454545455, Blast_Score=195, Evalue=7e-50,
Organism=Homo sapiens, GI146231952, Length=209, Percent_Identity=45.4545454545455, Blast_Score=191, Evalue=1e-48,
Organism=Homo sapiens, GI148727351, Length=209, Percent_Identity=44.9760765550239, Blast_Score=190, Evalue=2e-48,
Organism=Homo sapiens, GI223941779, Length=197, Percent_Identity=44.6700507614213, Blast_Score=182, Evalue=6e-46,
Organism=Homo sapiens, GI223941776, Length=198, Percent_Identity=43.9393939393939, Blast_Score=176, Evalue=5e-44,
Organism=Homo sapiens, GI119120938, Length=133, Percent_Identity=51.1278195488722, Blast_Score=145, Evalue=5e-35,
Organism=Escherichia coli, GI87082430, Length=215, Percent_Identity=39.0697674418605, Blast_Score=158, Evalue=8e-40,
Organism=Escherichia coli, GI1788499, Length=183, Percent_Identity=30.6010928961749, Blast_Score=86, Evalue=4e-18,
Organism=Saccharomyces cerevisiae, GI6324356, Length=225, Percent_Identity=33.3333333333333, Blast_Score=142, Evalue=1e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003495
- InterPro:   IPR011629 [H]

Pfam domain/function: PF02492 cobW; PF07683 CobW_C [H]

EC number: NA

Molecular weight: Translated: 50720; Mature: 50589

Theoretical pI: Translated: 4.38; Mature: 4.38

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIKDKVPVTILTGFLGSGKTTLLNRILSEEHGKRIAVIENEYGEVGIDQGLVINADEEV
CCCCCCCCEEEEEECCCCCHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCEEECCCHHH
FEMSNGCICCTVRGDLIRVLGNLMKRRDKFDYVLVETTGLADPGPVAQTFFMDEEISSEF
HHCCCCEEEEEECHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCHHHEEECHHHCCCE
TLDGIVTLVDAAHIDQQLGRSDESSEQVAFADVLVLNKTDLVSDDALDTLESRLRDMNRM
EHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHH
TRIIRAENAKVPIETVLNLSAFDLDQILKRRPTFLEPEYPFEWTGVYDLDAGKYELMLEE
HHHHHHCCCCCCHHHHHCCCCCCHHHHHHCCCCCCCCCCCEEECEEEECCCCCEEEEEEC
GPDPEMSLVALANQGESEEELKDGSESSVRLYAEKANSLVPGNTIPYGEHINLKLEDKGN
CCCCCEEEEEEECCCCCHHHHHCCCCCCEEEEEECCCCCCCCCCCCCCCEEEEEEECCCC
KSFILNIEKPTKIGLFTQHTAEEFNMKVIKSDENKEIPLNTERFWQAEHEHDDEVGSIAI
CEEEEEECCCCEEEEEECCCHHHCCEEEEECCCCCCCCCCHHHHHCCCCCCCCHHHHHHH
ERFGDVDPEKLNTWMGRLLSEKGVDIFRTKGFISYSGNPRRIVFQGVHMLFTAQPDKEWG
HHHCCCCHHHHHHHHHHHHHHCCCEEEEECCEEEECCCCCEEEEECEEEEEEECCCHHHC
NEPRRNQLVFIGRNLNEKEMQEGFDKCLI
CCCCCCEEEEEECCCCHHHHHHHHHHHCC
>Mature Secondary Structure 
SIKDKVPVTILTGFLGSGKTTLLNRILSEEHGKRIAVIENEYGEVGIDQGLVINADEEV
CCCCCCCEEEEEECCCCCHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCEEECCCHHH
FEMSNGCICCTVRGDLIRVLGNLMKRRDKFDYVLVETTGLADPGPVAQTFFMDEEISSEF
HHCCCCEEEEEECHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCHHHEEECHHHCCCE
TLDGIVTLVDAAHIDQQLGRSDESSEQVAFADVLVLNKTDLVSDDALDTLESRLRDMNRM
EHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHH
TRIIRAENAKVPIETVLNLSAFDLDQILKRRPTFLEPEYPFEWTGVYDLDAGKYELMLEE
HHHHHHCCCCCCHHHHHCCCCCCHHHHHHCCCCCCCCCCCEEECEEEECCCCCEEEEEEC
GPDPEMSLVALANQGESEEELKDGSESSVRLYAEKANSLVPGNTIPYGEHINLKLEDKGN
CCCCCEEEEEEECCCCCHHHHHCCCCCCEEEEEECCCCCCCCCCCCCCCEEEEEEECCCC
KSFILNIEKPTKIGLFTQHTAEEFNMKVIKSDENKEIPLNTERFWQAEHEHDDEVGSIAI
CEEEEEECCCCEEEEEECCCHHHCCEEEEECCCCCCCCCCHHHHHCCCCCCCCHHHHHHH
ERFGDVDPEKLNTWMGRLLSEKGVDIFRTKGFISYSGNPRRIVFQGVHMLFTAQPDKEWG
HHHCCCCHHHHHHHHHHHHHHCCCEEEEECCEEEECCCCCEEEEECEEEEEEECCCHHHC
NEPRRNQLVFIGRNLNEKEMQEGFDKCLI
CCCCCCEEEEEECCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969502; 9384377; 9811636 [H]