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The map label for this gene is menB [H]

Identifier: 126695972

GI number: 126695972

Start: 562037

End: 562894

Strand: Direct

Name: menB [H]

Synonym: P9301_06341

Alternate gene names: 126695972

Gene position: 562037-562894 (Clockwise)

Preceding gene: 126695971

Following gene: 126695973

Centisome position: 34.23

GC content: 36.01

Gene sequence:

>858_bases
ATGAAAGTATTACCTGGTAAAACAAGCTTAAATTGGACAGAATACAAATCTTATGAGGATATATTGTTTCATAAATCAGA
TGAGGGAATTGCGAGAATTGCAATTAATCGCCCTGAAAAAAGAAATGCATTTAGGCCACAAACTGTAGATGAACTCATTA
ACGCATTTAATATCGTAAGAAATGATGAAAATATTGGAGTAGTTCTTTTTACAGGTGCGGGACCTGACAAGAGAGGTATT
TATTCTTTTTGCTCTGGAGGCGATCAGAGTGTAAGAGGTGAAAATGGATATAAAAATGATGAAGGGAAGCAGAGGTTAAA
TGTACTTGAACTTCAAAGATTAATAAGAAGTTTGCCTAAAGTAGTTATTGCCTTAGTTCCTGGTTTTGCAATTGGAGGAG
GTCAGGTACTTCATTTAATTTGTGATCTTAGCATTGCCGCAGAAAATGCAATTTTTGGTCAAACAGGTCCAAGAGTTGGT
AGTTTTGATGCTGGATTTGGATCTAGTTATTTGGCAAGACTCGTTGGTCAAAGAAAAGCAAAAGAAATTTGGTTTTTATG
TAGAAAATATAATTCGAAAGAAGCATTAGAGATGGGCTTGATAAATGCAATTACAAAGATTGAAGAATTAGAAGCTGAGG
GTGTAATCTGGGCAAGAGAGATTTTACGTAATAGTCCTACTGCTATTCGTATTCTTAAGGCTTCATTCAACGCGGAGAAT
GATGGAATTGCTGGTATTCAAGAATTATCTGGATACACAACTCAATTATTTTATTCGTCTGAAGAAGCTCAAGAAGGTAG
AGATGCCTTTCTCGAGAAGCGTCCACCAGACTTTTCTGAATATAAGTGGACACCCTAG

Upstream 100 bases:

>100_bases
ATATTGATCCAGAAAATGAAATTTATGAAAAAAATGCCCTGCTAGAAAAAATAATTGGCAGTTAAATTCATTTCTTTCTA
TCTTTAAATAATTAGTATTC

Downstream 100 bases:

>100_bases
TTTATTCTTCAAAAGACCTTTTTAAATAATTATCAATGAGAATTCTTCTTGCCGCTGCTGAATGTGCTCCAATGATCAAA
GTTGGAGGTATGGGAGATGT

Product: naphthoate synthase

Products: NA

Alternate protein names: DHNA-CoA synthase [H]

Number of amino acids: Translated: 285; Mature: 285

Protein sequence:

>285_residues
MKVLPGKTSLNWTEYKSYEDILFHKSDEGIARIAINRPEKRNAFRPQTVDELINAFNIVRNDENIGVVLFTGAGPDKRGI
YSFCSGGDQSVRGENGYKNDEGKQRLNVLELQRLIRSLPKVVIALVPGFAIGGGQVLHLICDLSIAAENAIFGQTGPRVG
SFDAGFGSSYLARLVGQRKAKEIWFLCRKYNSKEALEMGLINAITKIEELEAEGVIWAREILRNSPTAIRILKASFNAEN
DGIAGIQELSGYTTQLFYSSEEAQEGRDAFLEKRPPDFSEYKWTP

Sequences:

>Translated_285_residues
MKVLPGKTSLNWTEYKSYEDILFHKSDEGIARIAINRPEKRNAFRPQTVDELINAFNIVRNDENIGVVLFTGAGPDKRGI
YSFCSGGDQSVRGENGYKNDEGKQRLNVLELQRLIRSLPKVVIALVPGFAIGGGQVLHLICDLSIAAENAIFGQTGPRVG
SFDAGFGSSYLARLVGQRKAKEIWFLCRKYNSKEALEMGLINAITKIEELEAEGVIWAREILRNSPTAIRILKASFNAEN
DGIAGIQELSGYTTQLFYSSEEAQEGRDAFLEKRPPDFSEYKWTP
>Mature_285_residues
MKVLPGKTSLNWTEYKSYEDILFHKSDEGIARIAINRPEKRNAFRPQTVDELINAFNIVRNDENIGVVLFTGAGPDKRGI
YSFCSGGDQSVRGENGYKNDEGKQRLNVLELQRLIRSLPKVVIALVPGFAIGGGQVLHLICDLSIAAENAIFGQTGPRVG
SFDAGFGSSYLARLVGQRKAKEIWFLCRKYNSKEALEMGLINAITKIEELEAEGVIWAREILRNSPTAIRILKASFNAEN
DGIAGIQELSGYTTQLFYSSEEAQEGRDAFLEKRPPDFSEYKWTP

Specific function: Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA) [H]

COG id: COG0447

COG function: function code H; Dihydroxynaphthoic acid synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family [H]

Homologues:

Organism=Homo sapiens, GI194097323, Length=281, Percent_Identity=28.8256227758007, Blast_Score=105, Evalue=7e-23,
Organism=Homo sapiens, GI31542718, Length=258, Percent_Identity=27.906976744186, Blast_Score=81, Evalue=9e-16,
Organism=Homo sapiens, GI4502327, Length=276, Percent_Identity=28.9855072463768, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI45643119, Length=219, Percent_Identity=27.8538812785388, Blast_Score=69, Evalue=6e-12,
Organism=Homo sapiens, GI260275230, Length=219, Percent_Identity=27.8538812785388, Blast_Score=69, Evalue=6e-12,
Organism=Homo sapiens, GI260274832, Length=219, Percent_Identity=27.8538812785388, Blast_Score=69, Evalue=7e-12,
Organism=Homo sapiens, GI70995211, Length=238, Percent_Identity=28.5714285714286, Blast_Score=68, Evalue=8e-12,
Organism=Homo sapiens, GI4757966, Length=228, Percent_Identity=27.1929824561404, Blast_Score=68, Evalue=8e-12,
Organism=Homo sapiens, GI51538581, Length=228, Percent_Identity=27.1929824561404, Blast_Score=68, Evalue=8e-12,
Organism=Homo sapiens, GI25453481, Length=228, Percent_Identity=27.1929824561404, Blast_Score=68, Evalue=9e-12,
Organism=Homo sapiens, GI51538573, Length=228, Percent_Identity=27.1929824561404, Blast_Score=68, Evalue=9e-12,
Organism=Homo sapiens, GI4757968, Length=215, Percent_Identity=26.9767441860465, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI49355787, Length=215, Percent_Identity=26.9767441860465, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI157694516, Length=224, Percent_Identity=26.7857142857143, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI213417737, Length=224, Percent_Identity=26.7857142857143, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI1788597, Length=271, Percent_Identity=60.5166051660517, Blast_Score=350, Evalue=6e-98,
Organism=Escherichia coli, GI87082183, Length=260, Percent_Identity=27.6923076923077, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI1787659, Length=254, Percent_Identity=28.3464566929134, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI1787660, Length=266, Percent_Identity=30.4511278195489, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI221142681, Length=265, Percent_Identity=29.4339622641509, Blast_Score=72, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI25145438, Length=266, Percent_Identity=30.4511278195489, Blast_Score=107, Evalue=7e-24,
Organism=Caenorhabditis elegans, GI17554946, Length=254, Percent_Identity=27.9527559055118, Blast_Score=102, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17540714, Length=212, Percent_Identity=28.7735849056604, Blast_Score=90, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17549921, Length=209, Percent_Identity=28.7081339712919, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17560910, Length=183, Percent_Identity=29.5081967213115, Blast_Score=70, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI17534483, Length=284, Percent_Identity=25, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24653139, Length=290, Percent_Identity=30, Blast_Score=103, Evalue=1e-22,
Organism=Drosophila melanogaster, GI20129971, Length=275, Percent_Identity=28, Blast_Score=92, Evalue=3e-19,
Organism=Drosophila melanogaster, GI24653477, Length=275, Percent_Identity=28, Blast_Score=92, Evalue=3e-19,
Organism=Drosophila melanogaster, GI24654903, Length=208, Percent_Identity=30.2884615384615, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI21357171, Length=210, Percent_Identity=30.4761904761905, Blast_Score=75, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24650670, Length=181, Percent_Identity=29.2817679558011, Blast_Score=66, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014748
- InterPro:   IPR001753
- InterPro:   IPR018376
- InterPro:   IPR010198 [H]

Pfam domain/function: PF00378 ECH [H]

EC number: =4.1.3.36 [H]

Molecular weight: Translated: 31755; Mature: 31755

Theoretical pI: Translated: 6.56; Mature: 6.56

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVLPGKTSLNWTEYKSYEDILFHKSDEGIARIAINRPEKRNAFRPQTVDELINAFNIVR
CCCCCCCCCCCHHHHCCHHHHEEECCCCCEEEEEECCCHHCCCCCCHHHHHHHHHHHHHC
NDENIGVVLFTGAGPDKRGIYSFCSGGDQSVRGENGYKNDEGKQRLNVLELQRLIRSLPK
CCCCEEEEEEECCCCCCCCHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
VVIALVPGFAIGGGQVLHLICDLSIAAENAIFGQTGPRVGSFDAGFGSSYLARLVGQRKA
HHHHHHCCCCCCCHHHHHHHHHHHHHHCCCEECCCCCCCCCCCCCCCHHHHHHHHHHHHH
KEIWFLCRKYNSKEALEMGLINAITKIEELEAEGVIWAREILRNSPTAIRILKASFNAEN
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCEEEEEEECCCCCC
DGIAGIQELSGYTTQLFYSSEEAQEGRDAFLEKRPPDFSEYKWTP
CCCCHHHHHCCCEEEEEECCHHHHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure
MKVLPGKTSLNWTEYKSYEDILFHKSDEGIARIAINRPEKRNAFRPQTVDELINAFNIVR
CCCCCCCCCCCHHHHCCHHHHEEECCCCCEEEEEECCCHHCCCCCCHHHHHHHHHHHHHC
NDENIGVVLFTGAGPDKRGIYSFCSGGDQSVRGENGYKNDEGKQRLNVLELQRLIRSLPK
CCCCEEEEEEECCCCCCCCHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
VVIALVPGFAIGGGQVLHLICDLSIAAENAIFGQTGPRVGSFDAGFGSSYLARLVGQRKA
HHHHHHCCCCCCCHHHHHHHHHHHHHHCCCEECCCCCCCCCCCCCCCHHHHHHHHHHHHH
KEIWFLCRKYNSKEALEMGLINAITKIEELEAEGVIWAREILRNSPTAIRILKASFNAEN
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCEEEEEEECCCCCC
DGIAGIQELSGYTTQLFYSSEEAQEGRDAFLEKRPPDFSEYKWTP
CCCCHHHHHCCCEEEEEECCHHHHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]