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The map label for this gene is hemL [H]

Identifier: 126695848

GI number: 126695848

Start: 442319

End: 443620

Strand: Reverse

Name: hemL [H]

Synonym: P9301_05101

Alternate gene names: 126695848

Gene position: 443620-442319 (Counterclockwise)

Preceding gene: 126695849

Following gene: 126695846

Centisome position: 27.02

GC content: 39.94

Gene sequence:

>1302_bases
GTGACTGACATATTAAATTACACCAAATCAGAAGAAATTTTTTCTGCTGCCCAAGAACTAATGCCTGGAGGAGTAAGCTC
TCCAGTAAGAGCCTTTAAGTCTGTAGGAGGCCAGCCAATTGTTTTTGATAGAGTCAAAGGTCCCTTCGCTTGGGATATTG
ATGGAAATAGATATATTGACTATATAGGTAGTTGGGGACCGGCTATATGTGGACATGCCCACCCTGAAGTTATAACAGCA
TTACATGAAGCAATTGAGAAAGGTACTAGCTTTGGTGCTCCATGCGTTCTAGAGAACAAACTTGCTGAAATGGTCATTGA
TGCAGTACCTTCCGTAGAAATGGTTAGATTTGTTAATAGTGGAACTGAAGCATGCATGGCAGTTTTGAGACTTATGCGAG
CATTTACTGGAAGAGATAAAGTTATTAAATTTGATGGTTGCTATCACGGTCATGCAGATATGTTTTTGGTGAAGGCAGGA
TCAGGTGTAGCCACTCTAGGTTTACCAGATTCTCCAGGTGTTCCAAGGACGACAACTGCTAACACACTTACTGCTCCCTA
CAATGACCTTGAAGCAGTAAAAAAATTATTTTCTGAAAATCCTGATGCCATTTCGGGGGTTATCCTTGAGCCTATCGTTG
GTAATGCTGGATTTATTACTCCGGAACCTGGATTCTTGGAAGGATTAAGAGAATTAACAACTGAGAATGGGTCCTTATTA
GTTTTTGACGAAGTAATGACTGGATTCAGAATAAGTTATGGAGGCGCACAAGAAAAGTTTGGTGTAACTCCTGATTTAAC
CACCCTCGGGAAAGTAATTGGTGGAGGCCTACCTGTTGGTGCATACGGAGGTAAAAAAGAAATAATGTCAATGGTGGCTC
CTGCAGGACCGGTTTACCAAGCAGGTACTTTGAGCGGTAATCCACTCGCAATGACTGCTGGGATAAAAACTCTTGAATTA
CTCAAACAAGAAGGTACATACGACAAACTTGATTCATTAACTTCTAGATTAATTGAAGGAATAATTCAATCTGCAGAAAA
TAACGGTATAGCTATTAATGGTGGAAGTGTAAGTGCTATGTTTGGTTTTTTCTTATGTGATGGGCCAGTTAGAAACTTTA
ATGAAGCTAAAACAAATGATGCCGAACTTTTTGGTAAGTTGCACAGAGAAATGCTCCGAAGAGGAATTTACTTAGCTCCA
AGTCCTTTCGAAGCCGGCTTCACATCATTAGCTCACAGCGAAGAAGAAATTGATAAAACTATCGAGGCTTTTGACGAATC
TTTCAATGAGATAAAAAAATAG

Upstream 100 bases:

>100_bases
AATATCATAATGTAGAATTTCAATCTGATTGACAAAATTTTTACTTATTTCTAATTTAGAACATGACAAGATTTTTCTCA
AAACATCATTTAGCTAAATC

Downstream 100 bases:

>100_bases
TCATTTACTCATACTCATTAAAGAAAGAAAAATAAATAAATGATTAAAACTTATACAAAGATTATTTTTAAGTAATTATC
TCCTACCACCAACTATTACT

Product: glutamate-1-semialdehyde aminotransferase

Products: NA

Alternate protein names: GSA; Glutamate-1-semialdehyde aminotransferase; GSA-AT [H]

Number of amino acids: Translated: 433; Mature: 432

Protein sequence:

>433_residues
MTDILNYTKSEEIFSAAQELMPGGVSSPVRAFKSVGGQPIVFDRVKGPFAWDIDGNRYIDYIGSWGPAICGHAHPEVITA
LHEAIEKGTSFGAPCVLENKLAEMVIDAVPSVEMVRFVNSGTEACMAVLRLMRAFTGRDKVIKFDGCYHGHADMFLVKAG
SGVATLGLPDSPGVPRTTTANTLTAPYNDLEAVKKLFSENPDAISGVILEPIVGNAGFITPEPGFLEGLRELTTENGSLL
VFDEVMTGFRISYGGAQEKFGVTPDLTTLGKVIGGGLPVGAYGGKKEIMSMVAPAGPVYQAGTLSGNPLAMTAGIKTLEL
LKQEGTYDKLDSLTSRLIEGIIQSAENNGIAINGGSVSAMFGFFLCDGPVRNFNEAKTNDAELFGKLHREMLRRGIYLAP
SPFEAGFTSLAHSEEEIDKTIEAFDESFNEIKK

Sequences:

>Translated_433_residues
MTDILNYTKSEEIFSAAQELMPGGVSSPVRAFKSVGGQPIVFDRVKGPFAWDIDGNRYIDYIGSWGPAICGHAHPEVITA
LHEAIEKGTSFGAPCVLENKLAEMVIDAVPSVEMVRFVNSGTEACMAVLRLMRAFTGRDKVIKFDGCYHGHADMFLVKAG
SGVATLGLPDSPGVPRTTTANTLTAPYNDLEAVKKLFSENPDAISGVILEPIVGNAGFITPEPGFLEGLRELTTENGSLL
VFDEVMTGFRISYGGAQEKFGVTPDLTTLGKVIGGGLPVGAYGGKKEIMSMVAPAGPVYQAGTLSGNPLAMTAGIKTLEL
LKQEGTYDKLDSLTSRLIEGIIQSAENNGIAINGGSVSAMFGFFLCDGPVRNFNEAKTNDAELFGKLHREMLRRGIYLAP
SPFEAGFTSLAHSEEEIDKTIEAFDESFNEIKK
>Mature_432_residues
TDILNYTKSEEIFSAAQELMPGGVSSPVRAFKSVGGQPIVFDRVKGPFAWDIDGNRYIDYIGSWGPAICGHAHPEVITAL
HEAIEKGTSFGAPCVLENKLAEMVIDAVPSVEMVRFVNSGTEACMAVLRLMRAFTGRDKVIKFDGCYHGHADMFLVKAGS
GVATLGLPDSPGVPRTTTANTLTAPYNDLEAVKKLFSENPDAISGVILEPIVGNAGFITPEPGFLEGLRELTTENGSLLV
FDEVMTGFRISYGGAQEKFGVTPDLTTLGKVIGGGLPVGAYGGKKEIMSMVAPAGPVYQAGTLSGNPLAMTAGIKTLELL
KQEGTYDKLDSLTSRLIEGIIQSAENNGIAINGGSVSAMFGFFLCDGPVRNFNEAKTNDAELFGKLHREMLRRGIYLAPS
PFEAGFTSLAHSEEEIDKTIEAFDESFNEIKK

Specific function: Porphyrin biosynthesis by the C5 pathway; second step. [C]

COG id: COG0001

COG function: function code H; Glutamate-1-semialdehyde aminotransferase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=405, Percent_Identity=29.6296296296296, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI24119277, Length=334, Percent_Identity=27.2455089820359, Blast_Score=105, Evalue=9e-23,
Organism=Homo sapiens, GI13994255, Length=323, Percent_Identity=26.9349845201238, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI37574042, Length=308, Percent_Identity=27.5974025974026, Blast_Score=100, Evalue=4e-21,
Organism=Homo sapiens, GI284507298, Length=250, Percent_Identity=32.4, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI226442705, Length=307, Percent_Identity=27.0358306188925, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI226442709, Length=276, Percent_Identity=27.536231884058, Blast_Score=87, Evalue=3e-17,
Organism=Escherichia coli, GI1786349, Length=425, Percent_Identity=53.6470588235294, Blast_Score=480, Evalue=1e-137,
Organism=Escherichia coli, GI1789016, Length=412, Percent_Identity=30.3398058252427, Blast_Score=163, Evalue=2e-41,
Organism=Escherichia coli, GI1788044, Length=314, Percent_Identity=35.031847133758, Blast_Score=144, Evalue=1e-35,
Organism=Escherichia coli, GI1789759, Length=307, Percent_Identity=31.5960912052117, Blast_Score=133, Evalue=2e-32,
Organism=Escherichia coli, GI145693181, Length=306, Percent_Identity=30.718954248366, Blast_Score=125, Evalue=6e-30,
Organism=Escherichia coli, GI1787560, Length=365, Percent_Identity=28.2191780821918, Blast_Score=123, Evalue=3e-29,
Organism=Escherichia coli, GI1786991, Length=320, Percent_Identity=25.625, Blast_Score=83, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI25144271, Length=296, Percent_Identity=28.7162162162162, Blast_Score=119, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI71992977, Length=330, Percent_Identity=26.969696969697, Blast_Score=104, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI25144274, Length=143, Percent_Identity=34.965034965035, Blast_Score=83, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6323470, Length=332, Percent_Identity=28.3132530120482, Blast_Score=108, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6324432, Length=350, Percent_Identity=24.8571428571429, Blast_Score=80, Evalue=5e-16,
Organism=Drosophila melanogaster, GI21357415, Length=296, Percent_Identity=26.3513513513513, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI21356575, Length=326, Percent_Identity=28.8343558282209, Blast_Score=99, Evalue=7e-21,
Organism=Drosophila melanogaster, GI161085790, Length=326, Percent_Identity=27.9141104294479, Blast_Score=99, Evalue=8e-21,
Organism=Drosophila melanogaster, GI28574759, Length=326, Percent_Identity=27.9141104294479, Blast_Score=98, Evalue=1e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004639
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =5.4.3.8 [H]

Molecular weight: Translated: 46294; Mature: 46163

Theoretical pI: Translated: 4.67; Mature: 4.67

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDILNYTKSEEIFSAAQELMPGGVSSPVRAFKSVGGQPIVFDRVKGPFAWDIDGNRYID
CCCCHHCCCHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCEEEECCCCCEEEECCCCCEEH
YIGSWGPAICGHAHPEVITALHEAIEKGTSFGAPCVLENKLAEMVIDAVPSVEMVRFVNS
HHCCCCCHHCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHC
GTEACMAVLRLMRAFTGRDKVIKFDGCYHGHADMFLVKAGSGVATLGLPDSPGVPRTTTA
CHHHHHHHHHHHHHHCCCCCEEEECCEECCCCCEEEEECCCCEEEECCCCCCCCCCCCCC
NTLTAPYNDLEAVKKLFSENPDAISGVILEPIVGNAGFITPEPGFLEGLRELTTENGSLL
CCEECCCHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCCCCEE
VFDEVMTGFRISYGGAQEKFGVTPDLTTLGKVIGGGLPVGAYGGKKEIMSMVAPAGPVYQ
EEHHHHHCEEEECCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCCCEE
AGTLSGNPLAMTAGIKTLELLKQEGTYDKLDSLTSRLIEGIIQSAENNGIAINGGSVSAM
CCCCCCCCEEEECCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCEEEECCCHHHH
FGFFLCDGPVRNFNEAKTNDAELFGKLHREMLRRGIYLAPSPFEAGFTSLAHSEEEIDKT
HHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCEEECCCCHHHHHHHHHCCHHHHHHH
IEAFDESFNEIKK
HHHHHHHHHHHCC
>Mature Secondary Structure 
TDILNYTKSEEIFSAAQELMPGGVSSPVRAFKSVGGQPIVFDRVKGPFAWDIDGNRYID
CCCHHCCCHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCEEEECCCCCEEEECCCCCEEH
YIGSWGPAICGHAHPEVITALHEAIEKGTSFGAPCVLENKLAEMVIDAVPSVEMVRFVNS
HHCCCCCHHCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHC
GTEACMAVLRLMRAFTGRDKVIKFDGCYHGHADMFLVKAGSGVATLGLPDSPGVPRTTTA
CHHHHHHHHHHHHHHCCCCCEEEECCEECCCCCEEEEECCCCEEEECCCCCCCCCCCCCC
NTLTAPYNDLEAVKKLFSENPDAISGVILEPIVGNAGFITPEPGFLEGLRELTTENGSLL
CCEECCCHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCCCCEE
VFDEVMTGFRISYGGAQEKFGVTPDLTTLGKVIGGGLPVGAYGGKKEIMSMVAPAGPVYQ
EEHHHHHCEEEECCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCCCEE
AGTLSGNPLAMTAGIKTLELLKQEGTYDKLDSLTSRLIEGIIQSAENNGIAINGGSVSAM
CCCCCCCCEEEECCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCEEEECCCHHHH
FGFFLCDGPVRNFNEAKTNDAELFGKLHREMLRRGIYLAPSPFEAGFTSLAHSEEEIDKT
HHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCEEECCCCHHHHHHHHHCCHHHHHHH
IEAFDESFNEIKK
HHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA