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The map label for this gene is srpG [H]

Identifier: 126695764

GI number: 126695764

Start: 371813

End: 372799

Strand: Reverse

Name: srpG [H]

Synonym: P9301_04261

Alternate gene names: 126695764

Gene position: 372799-371813 (Counterclockwise)

Preceding gene: 126695765

Following gene: 126695758

Centisome position: 22.71

GC content: 39.31

Gene sequence:

>987_bases
ATGGCAAAAATTTATGAGGACAACAGTTTTGCTATTGGAAACACTCCATTAGTAAAATTAAAATCAGTTACTAAAAACGC
GAAAGCTACAGTACTTGCAAAAATTGAAGGTAGAAACCCCGCTTATAGTGTCAAATGTAGGATCGGCGCAAACATGATCT
GGGATGCCGAGAAAAGTGGGAAACTTACAAAAGACAAAACTATTGTTGAGCCAACTTCTGGAAATACAGGCATAGCTCTA
GCTTTTACTGCTTCAGCAAGAGGTTATAAACTAATCCTTACAATGCCAGAATCCATGTCAATTGAAAGAAGAAGGGTTAT
GGCAGTGTTGGGTGCTGAAATTGTTTTAACAGAGGCATCTAAAGGTATGCCTGGAGCAATAGCTAAGGCTAAAGAAATTG
CAGAAAGTAATCCTTCTCAATATTTCATGCCAGGTCAATTTGATAATCCAGCAAACCCTGAAATTCATTTCAAAACTACT
GGGCCAGAAATCTGGGATGATTGCGATGGTGAAATTGATGTCCTAGTTGCAGGGGTTGGAACTGGCGGCACAATTACAGG
AGTTTCAAGATACATTAAGCAAGAGAAGGGTAAGAATATTACTTCTGTAGCAGTAGAACCATCACACAGTCCTGTTATTA
CACAGACAATGAATGGAGAAGAGGTTAAATCCGGACCACATAAAATCCAAGGAATTGGAGCAGGATTTATTCCTAAGAAC
CTTGACTTATCAATTGTTGATAAGGTCGAACAAGTAACAAATGACGAATCAATTGAGATGGCTCTTAGGTTAGCTAAAGA
GGAGGGTCTATTAGTAGGAATATCTTGTGGGGCTGCCGCTGCTGCCGCTGTTAGATTAGCTGAACAAGATGAATATGCGG
GGAAGACAATTGTAGTTGTTCTACCTGATTTAGCAGAGAGGTATTTATCATCAATTATGTTTACTGAAGTTCCAAGCGGA
ATCATTCAAGAACCAGTCAAAGCCTAA

Upstream 100 bases:

>100_bases
ACTAAATAATTTCTAAATTCCTAGTATTTACCGTATAGAAACTTATATACTCTTTTTCTGAATAATAGTTAGTATTAAAA
TATATTTTCTCAATATATAA

Downstream 100 bases:

>100_bases
ATCTATTTTTTCTCCAGTAGTGAATCTGGTGAAATATACATCGCATCGCCATAAGAGAAGAATCTAAATTTTTCTTTTAT
GGCTTTTTTATACAGATCTA

Product: O-acetylserine (thiol)-lyase A

Products: NA

Alternate protein names: CSase; O-acetylserine (thiol)-lyase; OAS-TL; O-acetylserine sulfhydrylase [H]

Number of amino acids: Translated: 328; Mature: 327

Protein sequence:

>328_residues
MAKIYEDNSFAIGNTPLVKLKSVTKNAKATVLAKIEGRNPAYSVKCRIGANMIWDAEKSGKLTKDKTIVEPTSGNTGIAL
AFTASARGYKLILTMPESMSIERRRVMAVLGAEIVLTEASKGMPGAIAKAKEIAESNPSQYFMPGQFDNPANPEIHFKTT
GPEIWDDCDGEIDVLVAGVGTGGTITGVSRYIKQEKGKNITSVAVEPSHSPVITQTMNGEEVKSGPHKIQGIGAGFIPKN
LDLSIVDKVEQVTNDESIEMALRLAKEEGLLVGISCGAAAAAAVRLAEQDEYAGKTIVVVLPDLAERYLSSIMFTEVPSG
IIQEPVKA

Sequences:

>Translated_328_residues
MAKIYEDNSFAIGNTPLVKLKSVTKNAKATVLAKIEGRNPAYSVKCRIGANMIWDAEKSGKLTKDKTIVEPTSGNTGIAL
AFTASARGYKLILTMPESMSIERRRVMAVLGAEIVLTEASKGMPGAIAKAKEIAESNPSQYFMPGQFDNPANPEIHFKTT
GPEIWDDCDGEIDVLVAGVGTGGTITGVSRYIKQEKGKNITSVAVEPSHSPVITQTMNGEEVKSGPHKIQGIGAGFIPKN
LDLSIVDKVEQVTNDESIEMALRLAKEEGLLVGISCGAAAAAAVRLAEQDEYAGKTIVVVLPDLAERYLSSIMFTEVPSG
IIQEPVKA
>Mature_327_residues
AKIYEDNSFAIGNTPLVKLKSVTKNAKATVLAKIEGRNPAYSVKCRIGANMIWDAEKSGKLTKDKTIVEPTSGNTGIALA
FTASARGYKLILTMPESMSIERRRVMAVLGAEIVLTEASKGMPGAIAKAKEIAESNPSQYFMPGQFDNPANPEIHFKTTG
PEIWDDCDGEIDVLVAGVGTGGTITGVSRYIKQEKGKNITSVAVEPSHSPVITQTMNGEEVKSGPHKIQGIGAGFIPKNL
DLSIVDKVEQVTNDESIEMALRLAKEEGLLVGISCGAAAAAAVRLAEQDEYAGKTIVVVLPDLAERYLSSIMFTEVPSGI
IQEPVKA

Specific function: Cysteine biosynthesis. [C]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=316, Percent_Identity=39.873417721519, Blast_Score=207, Evalue=1e-53,
Organism=Homo sapiens, GI295821200, Length=316, Percent_Identity=39.873417721519, Blast_Score=207, Evalue=1e-53,
Organism=Homo sapiens, GI4557415, Length=316, Percent_Identity=39.873417721519, Blast_Score=207, Evalue=1e-53,
Organism=Escherichia coli, GI1788754, Length=318, Percent_Identity=64.1509433962264, Blast_Score=399, Evalue=1e-112,
Organism=Escherichia coli, GI2367138, Length=305, Percent_Identity=39.672131147541, Blast_Score=205, Evalue=4e-54,
Organism=Caenorhabditis elegans, GI17535051, Length=307, Percent_Identity=49.5114006514658, Blast_Score=285, Evalue=3e-77,
Organism=Caenorhabditis elegans, GI115535073, Length=315, Percent_Identity=51.4285714285714, Blast_Score=274, Evalue=5e-74,
Organism=Caenorhabditis elegans, GI17562970, Length=319, Percent_Identity=44.2006269592476, Blast_Score=273, Evalue=6e-74,
Organism=Caenorhabditis elegans, GI32566674, Length=307, Percent_Identity=45.6026058631922, Blast_Score=269, Evalue=1e-72,
Organism=Caenorhabditis elegans, GI17561720, Length=322, Percent_Identity=45.3416149068323, Blast_Score=249, Evalue=1e-66,
Organism=Caenorhabditis elegans, GI32566672, Length=229, Percent_Identity=42.3580786026201, Blast_Score=197, Evalue=9e-51,
Organism=Caenorhabditis elegans, GI17534315, Length=316, Percent_Identity=40.1898734177215, Blast_Score=155, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI25147552, Length=312, Percent_Identity=37.5, Blast_Score=146, Evalue=1e-35,
Organism=Caenorhabditis elegans, GI17561716, Length=137, Percent_Identity=40.8759124087591, Blast_Score=95, Evalue=5e-20,
Organism=Saccharomyces cerevisiae, GI6321594, Length=318, Percent_Identity=36.1635220125786, Blast_Score=179, Evalue=8e-46,
Organism=Saccharomyces cerevisiae, GI6321449, Length=323, Percent_Identity=33.1269349845201, Blast_Score=139, Evalue=5e-34,
Organism=Drosophila melanogaster, GI24643623, Length=308, Percent_Identity=37.987012987013, Blast_Score=163, Evalue=1e-40,
Organism=Drosophila melanogaster, GI20129101, Length=308, Percent_Identity=37.987012987013, Blast_Score=163, Evalue=1e-40,

Paralogues:

None

Copy number: 2820 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001216
- InterPro:   IPR005856
- InterPro:   IPR005859
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =2.5.1.47 [H]

Molecular weight: Translated: 34936; Mature: 34804

Theoretical pI: Translated: 5.52; Mature: 5.52

Prosite motif: PS00901 CYS_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKIYEDNSFAIGNTPLVKLKSVTKNAKATVLAKIEGRNPAYSVKCRIGANMIWDAEKSG
CCEEEECCCEEECCCCEEEEECCCCCCCEEEEEEEECCCCCEEEEEEECCCEEECCCCCC
KLTKDKTIVEPTSGNTGIALAFTASARGYKLILTMPESMSIERRRVMAVLGAEIVLTEAS
CCCCCCEEEECCCCCCCEEEEEEECCCCEEEEEECCCCCCHHHHHHHHHHCCEEEEEECC
KGMPGAIAKAKEIAESNPSQYFMPGQFDNPANPEIHFKTTGPEIWDDCDGEIDVLVAGVG
CCCCCHHHHHHHHHHCCCCCEECCCCCCCCCCCEEEEEECCCCCCCCCCCCEEEEEEECC
TGGTITGVSRYIKQEKGKNITSVAVEPSHSPVITQTMNGEEVKSGPHKIQGIGAGFIPKN
CCCHHHHHHHHHHHHHCCCEEEEEECCCCCCEEEEECCCCHHHCCCCEEEECCCCCCCCC
LDLSIVDKVEQVTNDESIEMALRLAKEEGLLVGISCGAAAAAAVRLAEQDEYAGKTIVVV
CCHHHHHHHHHHCCCHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHCCCCCCCCEEEEE
LPDLAERYLSSIMFTEVPSGIIQEPVKA
CCHHHHHHHHHHHHHHCCCHHHHHCCCC
>Mature Secondary Structure 
AKIYEDNSFAIGNTPLVKLKSVTKNAKATVLAKIEGRNPAYSVKCRIGANMIWDAEKSG
CEEEECCCEEECCCCEEEEECCCCCCCEEEEEEEECCCCCEEEEEEECCCEEECCCCCC
KLTKDKTIVEPTSGNTGIALAFTASARGYKLILTMPESMSIERRRVMAVLGAEIVLTEAS
CCCCCCEEEECCCCCCCEEEEEEECCCCEEEEEECCCCCCHHHHHHHHHHCCEEEEEECC
KGMPGAIAKAKEIAESNPSQYFMPGQFDNPANPEIHFKTTGPEIWDDCDGEIDVLVAGVG
CCCCCHHHHHHHHHHCCCCCEECCCCCCCCCCCEEEEEECCCCCCCCCCCCEEEEEEECC
TGGTITGVSRYIKQEKGKNITSVAVEPSHSPVITQTMNGEEVKSGPHKIQGIGAGFIPKN
CCCHHHHHHHHHHHHHCCCEEEEEECCCCCCEEEEECCCCHHHCCCCEEEECCCCCCCCC
LDLSIVDKVEQVTNDESIEMALRLAKEEGLLVGISCGAAAAAAVRLAEQDEYAGKTIVVV
CCHHHHHHHHHHCCCHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHCCCCCCCCEEEEE
LPDLAERYLSSIMFTEVPSGIIQEPVKA
CCHHHHHHHHHHHHHHCCCHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7603442 [H]