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The map label for this gene is glyA

Identifier: 126695619

GI number: 126695619

Start: 257573

End: 258844

Strand: Reverse

Name: glyA

Synonym: P9301_02811

Alternate gene names: 126695619

Gene position: 258844-257573 (Counterclockwise)

Preceding gene: 126695622

Following gene: 126695618

Centisome position: 15.77

GC content: 36.01

Gene sequence:

>1272_bases
ATGAATATCCTTCAAAATCTTAAAGAAAGTGATCCAGTAATATCAAATTTTATCAAATCTGAAAAAAATAGGCAGGAAAC
TCATCTTGAGTTAATCGCAAGCGAAAATTTCGCATCAATTGCCGTTATGGAGGCTCAAGGTTCTGTCCTTACAAATAAAT
ACGCCGAGGGATTACCCCAAAAAAGATACTACGGGGGATGTGAATTTGTTGATCAGATCGAAGAATTAGCTATTCAGAGA
GCGAAAAAATTGTTTAATGCAAATTGGGCTAATGTTCAACCCCATAGTGGAGCACAGGCAAATGCTGCTGTTTTCTTAAG
TCTACTTAAACCTGGCGACACAATCATGGGGATGGATTTATCTCATGGTGGACACTTAACTCATGGGTCTCCAGTAAATA
TGAGTGGTAAGTGGTTCAATGCAGTTCACTATGGTGTAAATAAAGAAACTAGTGAATTAAATTTTGATGAAATAAGAGAG
ATAGCACTTGAAACAAAACCAAAATTGATCATATGCGGATATTCTGCTTATCCAAGAACAATCGATTTTGAATCATTTAG
AAATATTGCAGATGAAGTTGGTGCTTTCTTAATGGCTGATATTGCACATATTGCCGGTCTTGTAGCAAGTAAACTTCACC
CAAATCCAATACCTTATTGTGATGTAGTAACTACAACTACTCATAAAACATTAAGAGGGCCTAGAGGTGGACTTATCTTA
TGTAAAGATGCAGAATTTGGAAAGAAATTTGATAAATCTGTTTTCCCAGGAACTCAGGGTGGTCCCCTCGAACATATAAT
TGCCGCAAAAGCAGTTGCATTTGGAGAAGCCTTACAGCCAGATTTCGTTAATTATTCCCAACAAGTAATTAAAAATGCAA
AAGTTCTAGCTTCAACTCTAATAAATAGAGGTATTGATATCGTGAGTGGCGGCACTGATAACCATATTGTTTTACTCGAT
TTAAGAAGTATCAATATGACTGGTAAAATTGCTGACTTGCTTGTAAGTGAAGTTAATATCACTGCAAATAAAAATACCGT
TCCATTTGACCCTGAATCACCTTTTGTAACCAGCGGACTAAGGTTGGGAACTGCTGCTTTAACTACTAGAGGCTTTAATG
AGAATGCTTTTGCTGAAGTTGGTGAAATTATTGCTGATAGATTACTTAACCCAGACGATTCACTGATTGAAAGTCAATGT
AAAGAAAGAGTATTAACCCTATGTAATCGTTTTCCTCTTTATGAAAGCAAACTTGAAGCATCAATTAAATGA

Upstream 100 bases:

>100_bases
GAGTTCGAATCTCTCCAGGCGCGTTTAAAAATCTGAAATATTCTTTTTATATTTTTCTAAAAAATATCGTCTATATTATG
GATATTACTTATCAAATTCA

Downstream 100 bases:

>100_bases
GTCCTAACTCCAAGGGAGTTGAAATTCTTTCTATTGGAACAGAGCTACTCTTAGGAAATATCATAAATACAAATGCTCAA
TGGATTTCTGAACAGTTATC

Product: serine hydroxymethyltransferase

Products: NA

Alternate protein names: SHMT; Serine methylase

Number of amino acids: Translated: 423; Mature: 423

Protein sequence:

>423_residues
MNILQNLKESDPVISNFIKSEKNRQETHLELIASENFASIAVMEAQGSVLTNKYAEGLPQKRYYGGCEFVDQIEELAIQR
AKKLFNANWANVQPHSGAQANAAVFLSLLKPGDTIMGMDLSHGGHLTHGSPVNMSGKWFNAVHYGVNKETSELNFDEIRE
IALETKPKLIICGYSAYPRTIDFESFRNIADEVGAFLMADIAHIAGLVASKLHPNPIPYCDVVTTTTHKTLRGPRGGLIL
CKDAEFGKKFDKSVFPGTQGGPLEHIIAAKAVAFGEALQPDFVNYSQQVIKNAKVLASTLINRGIDIVSGGTDNHIVLLD
LRSINMTGKIADLLVSEVNITANKNTVPFDPESPFVTSGLRLGTAALTTRGFNENAFAEVGEIIADRLLNPDDSLIESQC
KERVLTLCNRFPLYESKLEASIK

Sequences:

>Translated_423_residues
MNILQNLKESDPVISNFIKSEKNRQETHLELIASENFASIAVMEAQGSVLTNKYAEGLPQKRYYGGCEFVDQIEELAIQR
AKKLFNANWANVQPHSGAQANAAVFLSLLKPGDTIMGMDLSHGGHLTHGSPVNMSGKWFNAVHYGVNKETSELNFDEIRE
IALETKPKLIICGYSAYPRTIDFESFRNIADEVGAFLMADIAHIAGLVASKLHPNPIPYCDVVTTTTHKTLRGPRGGLIL
CKDAEFGKKFDKSVFPGTQGGPLEHIIAAKAVAFGEALQPDFVNYSQQVIKNAKVLASTLINRGIDIVSGGTDNHIVLLD
LRSINMTGKIADLLVSEVNITANKNTVPFDPESPFVTSGLRLGTAALTTRGFNENAFAEVGEIIADRLLNPDDSLIESQC
KERVLTLCNRFPLYESKLEASIK
>Mature_423_residues
MNILQNLKESDPVISNFIKSEKNRQETHLELIASENFASIAVMEAQGSVLTNKYAEGLPQKRYYGGCEFVDQIEELAIQR
AKKLFNANWANVQPHSGAQANAAVFLSLLKPGDTIMGMDLSHGGHLTHGSPVNMSGKWFNAVHYGVNKETSELNFDEIRE
IALETKPKLIICGYSAYPRTIDFESFRNIADEVGAFLMADIAHIAGLVASKLHPNPIPYCDVVTTTTHKTLRGPRGGLIL
CKDAEFGKKFDKSVFPGTQGGPLEHIIAAKAVAFGEALQPDFVNYSQQVIKNAKVLASTLINRGIDIVSGGTDNHIVLLD
LRSINMTGKIADLLVSEVNITANKNTVPFDPESPFVTSGLRLGTAALTTRGFNENAFAEVGEIIADRLLNPDDSLIESQC
KERVLTLCNRFPLYESKLEASIK

Specific function: Interconversion of serine and glycine

COG id: COG0112

COG function: function code E; Glycine/serine hydroxymethyltransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SHMT family

Homologues:

Organism=Homo sapiens, GI261862352, Length=403, Percent_Identity=47.6426799007444, Blast_Score=357, Evalue=1e-98,
Organism=Homo sapiens, GI261862350, Length=403, Percent_Identity=47.6426799007444, Blast_Score=357, Evalue=1e-98,
Organism=Homo sapiens, GI261862348, Length=403, Percent_Identity=47.6426799007444, Blast_Score=357, Evalue=1e-98,
Organism=Homo sapiens, GI19923315, Length=403, Percent_Identity=47.6426799007444, Blast_Score=357, Evalue=2e-98,
Organism=Homo sapiens, GI261862346, Length=403, Percent_Identity=47.394540942928, Blast_Score=347, Evalue=2e-95,
Organism=Homo sapiens, GI22547186, Length=405, Percent_Identity=47.1604938271605, Blast_Score=332, Evalue=3e-91,
Organism=Homo sapiens, GI22547189, Length=391, Percent_Identity=45.7800511508951, Blast_Score=305, Evalue=6e-83,
Organism=Escherichia coli, GI1788902, Length=411, Percent_Identity=55.9610705596107, Blast_Score=465, Evalue=1e-132,
Organism=Caenorhabditis elegans, GI25144732, Length=404, Percent_Identity=46.2871287128713, Blast_Score=356, Evalue=1e-98,
Organism=Caenorhabditis elegans, GI25144729, Length=404, Percent_Identity=46.2871287128713, Blast_Score=356, Evalue=2e-98,
Organism=Saccharomyces cerevisiae, GI6319739, Length=401, Percent_Identity=43.3915211970075, Blast_Score=344, Evalue=2e-95,
Organism=Saccharomyces cerevisiae, GI6323087, Length=405, Percent_Identity=42.7160493827161, Blast_Score=325, Evalue=7e-90,
Organism=Drosophila melanogaster, GI24640005, Length=396, Percent_Identity=47.4747474747475, Blast_Score=371, Evalue=1e-103,
Organism=Drosophila melanogaster, GI221329721, Length=396, Percent_Identity=47.4747474747475, Blast_Score=370, Evalue=1e-103,

Paralogues:

None

Copy number: 3180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 300 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 12,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): GLYA_PROM0 (A3PAX9)

Other databases:

- EMBL:   CP000576
- RefSeq:   YP_001090505.1
- ProteinModelPortal:   A3PAX9
- SMR:   A3PAX9
- STRING:   A3PAX9
- GeneID:   4912778
- GenomeReviews:   CP000576_GR
- KEGG:   pmg:P9301_02811
- eggNOG:   COG0112
- HOGENOM:   HBG301263
- OMA:   DICADIR
- ProtClustDB:   PRK00011
- BioCyc:   PMAR167546:P9301ORF_0284-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00051_B
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- InterPro:   IPR001085
- InterPro:   IPR019798
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- PANTHER:   PTHR11680
- PIRSF:   PIRSF000412

Pfam domain/function: PF00464 SHMT; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.1.2.1

Molecular weight: Translated: 46260; Mature: 46260

Theoretical pI: Translated: 6.14; Mature: 6.14

Prosite motif: PS00096 SHMT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNILQNLKESDPVISNFIKSEKNRQETHLELIASENFASIAVMEAQGSVLTNKYAEGLPQ
CCHHHHHHHCCHHHHHHHHHHCCHHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHCCCC
KRYYGGCEFVDQIEELAIQRAKKLFNANWANVQPHSGAQANAAVFLSLLKPGDTIMGMDL
HHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHCCCCEEEEEEE
SHGGHLTHGSPVNMSGKWFNAVHYGVNKETSELNFDEIREIALETKPKLIICGYSAYPRT
CCCCCCCCCCCCCCCCCHHHHEECCCCCCCCCCCHHHHHHHHHCCCCCEEEECCCCCCCC
IDFESFRNIADEVGAFLMADIAHIAGLVASKLHPNPIPYCDVVTTTTHKTLRGPRGGLIL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCHHHHCCCCCCEEE
CKDAEFGKKFDKSVFPGTQGGPLEHIIAAKAVAFGEALQPDFVNYSQQVIKNAKVLASTL
ECCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
INRGIDIVSGGTDNHIVLLDLRSINMTGKIADLLVSEVNITANKNTVPFDPESPFVTSGL
HHCCCEEEECCCCCEEEEEEECCCCCCHHHHHHHHHHHEEEECCCCCCCCCCCCCHHCCC
RLGTAALTTRGFNENAFAEVGEIIADRLLNPDDSLIESQCKERVLTLCNRFPLYESKLEA
HHCHHHHHCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHH
SIK
CCC
>Mature Secondary Structure
MNILQNLKESDPVISNFIKSEKNRQETHLELIASENFASIAVMEAQGSVLTNKYAEGLPQ
CCHHHHHHHCCHHHHHHHHHHCCHHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHCCCC
KRYYGGCEFVDQIEELAIQRAKKLFNANWANVQPHSGAQANAAVFLSLLKPGDTIMGMDL
HHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHCCCCEEEEEEE
SHGGHLTHGSPVNMSGKWFNAVHYGVNKETSELNFDEIREIALETKPKLIICGYSAYPRT
CCCCCCCCCCCCCCCCCHHHHEECCCCCCCCCCCHHHHHHHHHCCCCCEEEECCCCCCCC
IDFESFRNIADEVGAFLMADIAHIAGLVASKLHPNPIPYCDVVTTTTHKTLRGPRGGLIL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCHHHHCCCCCCEEE
CKDAEFGKKFDKSVFPGTQGGPLEHIIAAKAVAFGEALQPDFVNYSQQVIKNAKVLASTL
ECCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
INRGIDIVSGGTDNHIVLLDLRSINMTGKIADLLVSEVNITANKNTVPFDPESPFVTSGL
HHCCCEEEECCCCCEEEEEEECCCCCCHHHHHHHHHHHEEEECCCCCCCCCCCCCHHCCC
RLGTAALTTRGFNENAFAEVGEIIADRLLNPDDSLIESQCKERVLTLCNRFPLYESKLEA
HHCHHHHHCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHH
SIK
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA