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The map label for this gene is gyaR [H]

Identifier: 126454705

GI number: 126454705

Start: 2824644

End: 2825702

Strand: Reverse

Name: gyaR [H]

Synonym: BURPS1106A_2870

Alternate gene names: 126454705

Gene position: 2825702-2824644 (Counterclockwise)

Preceding gene: 126453505

Following gene: 126455148

Centisome position: 70.85

GC content: 71.29

Gene sequence:

>1059_bases
ATGACGGCCGCACGGGCGATGCGCGGCGCGATGCGCGCGCGCCGCCCGCGCGGCGCAACGGAGACGGCAATGCAGAAAAT
CCTGGTCGCGCGCCCGATCTTTCCGGACGTGATCGAGCGGCTCAAGCAGTATTTCGACGTCGACTGGAACGACGGCGACG
CGCTCGCCCCCGATGCGCTGAAGGCGCGCCTCGCGGACAAGGACGGCGCGCTGACGGCGGGCGACATGATCGACGCGTCG
GTGCTCGCGGCCGCGCCGCGGCTGCGCGTCGTGTCGAACATGGCGGTCGGCTACAACAACTTCGACATCGGCGCGTTCGA
CGCCGCGCACGTGCTCGGCACCAACACGCCCGACGTGCTGACCGAGACGACGGCCGATTTCGGCTGGGCGCTGATGATGG
CGGCCGCGCGGCGGATCACCGAATCCGAGCACTGGCTGCGCGCGGGGCAATGGCGCAAGTGGTCGTACGACAGCTTTCTC
GGCGCGGACATTCACGGCGCGACGCTCGGCGTGCTCGGCATGGGCCGCATCGGCCAGGCGCTCGCGCGCCGCGCGCGCGG
CTTCGGCATGCGCGTGATCTATCACAACCGCTCGCGCGTCGCGCCCGAGATCGAGGCCGAGCTCAACGCCGAATACGTGC
CGAAGGCGGCGCTGCTCGTGCAAGCCGATCACGTCGTGCTCGTGCTGCCGTACTCGGCGCAAAGTCATCACACGATCGGC
GCGGCCGAGCTCGCGCTGATGAAGCCGAGCGCGACGCTCACGAACATCGCGCGCGGCGGGATCGTCGACGACGCGGCGCT
CGCCGACGCGCTGCGCGAGAAGCGGATCGCGGCGGCGGGCCTCGACGTGTTCGAAGGCGAGCCGAGCGTGCATCCGGCGC
TGCTCGACGTGCCGAACGTCGTGCTGACGCCGCACATCGCGAGCGCGAGCGAAGGCACGCGCCGCGCGATGGCGAATCTC
GCGGCGGACAACCTGATCGCGGCGCTCGGCGCGGGCCCGCGCGCGGGCCGCCCGCCGAATCCGATCAATCCCGGCGTGCT
GGGGAAGGCTCGCATATGA

Upstream 100 bases:

>100_bases
GGATGCCGAGCTTCTTCGCGTACCTCGGCTGGGCGCTCGCGATTCTCGTGCCGGTGTTCCTGCTGACGACGTGGGTGTTC
TTCAGCGCTCAGGCGGCGCA

Downstream 100 bases:

>100_bases
CCGAAACCTTGTTGCTGGCCGCGATCGTCGCGCTCGCGGTGGCGCTCGTCGTCGCGCTCGTCATGCTGTTGCGCGGCGGC
CCGCGCGGCGGTGGCCTCGA

Product: D-isomer specific 2-hydroxyacid dehydrogenase family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 352; Mature: 351

Protein sequence:

>352_residues
MTAARAMRGAMRARRPRGATETAMQKILVARPIFPDVIERLKQYFDVDWNDGDALAPDALKARLADKDGALTAGDMIDAS
VLAAAPRLRVVSNMAVGYNNFDIGAFDAAHVLGTNTPDVLTETTADFGWALMMAAARRITESEHWLRAGQWRKWSYDSFL
GADIHGATLGVLGMGRIGQALARRARGFGMRVIYHNRSRVAPEIEAELNAEYVPKAALLVQADHVVLVLPYSAQSHHTIG
AAELALMKPSATLTNIARGGIVDDAALADALREKRIAAAGLDVFEGEPSVHPALLDVPNVVLTPHIASASEGTRRAMANL
AADNLIAALGAGPRAGRPPNPINPGVLGKARI

Sequences:

>Translated_352_residues
MTAARAMRGAMRARRPRGATETAMQKILVARPIFPDVIERLKQYFDVDWNDGDALAPDALKARLADKDGALTAGDMIDAS
VLAAAPRLRVVSNMAVGYNNFDIGAFDAAHVLGTNTPDVLTETTADFGWALMMAAARRITESEHWLRAGQWRKWSYDSFL
GADIHGATLGVLGMGRIGQALARRARGFGMRVIYHNRSRVAPEIEAELNAEYVPKAALLVQADHVVLVLPYSAQSHHTIG
AAELALMKPSATLTNIARGGIVDDAALADALREKRIAAAGLDVFEGEPSVHPALLDVPNVVLTPHIASASEGTRRAMANL
AADNLIAALGAGPRAGRPPNPINPGVLGKARI
>Mature_351_residues
TAARAMRGAMRARRPRGATETAMQKILVARPIFPDVIERLKQYFDVDWNDGDALAPDALKARLADKDGALTAGDMIDASV
LAAAPRLRVVSNMAVGYNNFDIGAFDAAHVLGTNTPDVLTETTADFGWALMMAAARRITESEHWLRAGQWRKWSYDSFLG
ADIHGATLGVLGMGRIGQALARRARGFGMRVIYHNRSRVAPEIEAELNAEYVPKAALLVQADHVVLVLPYSAQSHHTIGA
AELALMKPSATLTNIARGGIVDDAALADALREKRIAAAGLDVFEGEPSVHPALLDVPNVVLTPHIASASEGTRRAMANLA
ADNLIAALGAGPRAGRPPNPINPGVLGKARI

Specific function: Unknown

COG id: COG1052

COG function: function code CHR; Lactate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GyaR subfamily [H]

Homologues:

Organism=Homo sapiens, GI6912396, Length=290, Percent_Identity=34.8275862068965, Blast_Score=166, Evalue=2e-41,
Organism=Homo sapiens, GI23308577, Length=302, Percent_Identity=30.1324503311258, Blast_Score=144, Evalue=1e-34,
Organism=Homo sapiens, GI145580578, Length=250, Percent_Identity=37.6, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI4557499, Length=250, Percent_Identity=37.6, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI145580575, Length=250, Percent_Identity=37.6, Blast_Score=125, Evalue=5e-29,
Organism=Homo sapiens, GI61743967, Length=268, Percent_Identity=35.0746268656716, Blast_Score=124, Evalue=2e-28,
Organism=Homo sapiens, GI4557497, Length=268, Percent_Identity=35.0746268656716, Blast_Score=124, Evalue=2e-28,
Organism=Escherichia coli, GI87082289, Length=325, Percent_Identity=41.5384615384615, Blast_Score=231, Evalue=8e-62,
Organism=Escherichia coli, GI1789279, Length=313, Percent_Identity=29.3929712460064, Blast_Score=111, Evalue=8e-26,
Organism=Escherichia coli, GI1787645, Length=251, Percent_Identity=29.0836653386454, Blast_Score=99, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI17532191, Length=305, Percent_Identity=30.8196721311475, Blast_Score=147, Evalue=6e-36,
Organism=Caenorhabditis elegans, GI25147481, Length=254, Percent_Identity=25.9842519685039, Blast_Score=81, Evalue=8e-16,
Organism=Saccharomyces cerevisiae, GI6324055, Length=246, Percent_Identity=34.9593495934959, Blast_Score=152, Evalue=7e-38,
Organism=Saccharomyces cerevisiae, GI6320925, Length=279, Percent_Identity=26.5232974910394, Blast_Score=99, Evalue=7e-22,
Organism=Saccharomyces cerevisiae, GI6322116, Length=327, Percent_Identity=25.0764525993884, Blast_Score=98, Evalue=3e-21,
Organism=Saccharomyces cerevisiae, GI6321253, Length=168, Percent_Identity=31.547619047619, Blast_Score=75, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6325144, Length=144, Percent_Identity=31.9444444444444, Blast_Score=75, Evalue=2e-14,
Organism=Drosophila melanogaster, GI45551003, Length=331, Percent_Identity=35.0453172205438, Blast_Score=175, Evalue=5e-44,
Organism=Drosophila melanogaster, GI28574284, Length=313, Percent_Identity=36.1022364217252, Blast_Score=173, Evalue=2e-43,
Organism=Drosophila melanogaster, GI45552429, Length=313, Percent_Identity=36.1022364217252, Blast_Score=173, Evalue=2e-43,
Organism=Drosophila melanogaster, GI24585514, Length=313, Percent_Identity=36.1022364217252, Blast_Score=173, Evalue=2e-43,
Organism=Drosophila melanogaster, GI28574282, Length=313, Percent_Identity=36.1022364217252, Blast_Score=173, Evalue=2e-43,
Organism=Drosophila melanogaster, GI28574286, Length=262, Percent_Identity=38.1679389312977, Blast_Score=171, Evalue=6e-43,
Organism=Drosophila melanogaster, GI28571528, Length=313, Percent_Identity=35.4632587859425, Blast_Score=165, Evalue=4e-41,
Organism=Drosophila melanogaster, GI24585516, Length=260, Percent_Identity=33.8461538461538, Blast_Score=146, Evalue=2e-35,
Organism=Drosophila melanogaster, GI19921140, Length=319, Percent_Identity=30.4075235109718, Blast_Score=130, Evalue=2e-30,
Organism=Drosophila melanogaster, GI24646446, Length=248, Percent_Identity=35.0806451612903, Blast_Score=125, Evalue=5e-29,
Organism=Drosophila melanogaster, GI24646448, Length=248, Percent_Identity=35.0806451612903, Blast_Score=125, Evalue=5e-29,
Organism=Drosophila melanogaster, GI24646452, Length=248, Percent_Identity=35.0806451612903, Blast_Score=125, Evalue=5e-29,
Organism=Drosophila melanogaster, GI24646450, Length=248, Percent_Identity=35.0806451612903, Blast_Score=125, Evalue=5e-29,
Organism=Drosophila melanogaster, GI62472511, Length=248, Percent_Identity=34.6774193548387, Blast_Score=124, Evalue=9e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.26 [H]

Molecular weight: Translated: 37506; Mature: 37375

Theoretical pI: Translated: 9.33; Mature: 9.33

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAARAMRGAMRARRPRGATETAMQKILVARPIFPDVIERLKQYFDVDWNDGDALAPDAL
CCHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCHHHH
KARLADKDGALTAGDMIDASVLAAAPRLRVVSNMAVGYNNFDIGAFDAAHVLGTNTPDVL
HHHHCCCCCCEEECHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCCCHHHHHCCCCCHHH
TETTADFGWALMMAAARRITESEHWLRAGQWRKWSYDSFLGADIHGATLGVLGMGRIGQA
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHCCHHHHHH
LARRARGFGMRVIYHNRSRVAPEIEAELNAEYVPKAALLVQADHVVLVLPYSAQSHHTIG
HHHHHHCCCEEEEEECCCCCCCHHHHHCCCCCCCCEEEEEECCCEEEEEECCCCCCCCCC
AAELALMKPSATLTNIARGGIVDDAALADALREKRIAAAGLDVFEGEPSVHPALLDVPNV
HHHEEEECCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCHHCCCCCCCCCHHHCCCCE
VLTPHIASASEGTRRAMANLAADNLIAALGAGPRAGRPPNPINPGVLGKARI
EECCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TAARAMRGAMRARRPRGATETAMQKILVARPIFPDVIERLKQYFDVDWNDGDALAPDAL
CHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCHHHH
KARLADKDGALTAGDMIDASVLAAAPRLRVVSNMAVGYNNFDIGAFDAAHVLGTNTPDVL
HHHHCCCCCCEEECHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCCCHHHHHCCCCCHHH
TETTADFGWALMMAAARRITESEHWLRAGQWRKWSYDSFLGADIHGATLGVLGMGRIGQA
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHCCHHHHHH
LARRARGFGMRVIYHNRSRVAPEIEAELNAEYVPKAALLVQADHVVLVLPYSAQSHHTIG
HHHHHHCCCEEEEEECCCCCCCHHHHHCCCCCCCCEEEEEECCCEEEEEECCCCCCCCCC
AAELALMKPSATLTNIARGGIVDDAALADALREKRIAAAGLDVFEGEPSVHPALLDVPNV
HHHEEEECCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCHHCCCCCCCCCHHHCCCCE
VLTPHIASASEGTRRAMANLAADNLIAALGAGPRAGRPPNPINPGVLGKARI
EECCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA