Click here to switch to the map view.

The map label for this gene is hsrA [H]

Identifier: 126454631

GI number: 126454631

Start: 1960757

End: 1962160

Strand: Reverse

Name: hsrA [H]

Synonym: BURPS1106A_1998

Alternate gene names: 126454631

Gene position: 1962160-1960757 (Counterclockwise)

Preceding gene: 126453478

Following gene: 126452444

Centisome position: 49.2

GC content: 74.79

Gene sequence:

>1404_bases
ATGCGCGCCGGCGACTTTCGCGTGACCGCGGCCGTCGTCGCGAGCGCGCTCTTCATGCAGAACCTCGACAGCACGGTCGT
CGCGACCGCGCTGCCGAGCATGGCGCGCGAGCTTGGCGTAAACGTCGTGTTCCTGAGCAGCGCGATCACGTCGTACCTCG
TCGCGCTGACGGTGTTCATTCCGGTGAGCGGCTGGATCGCGGAGCACTTCGGCGCGAAGCGCGTGTTCATCGCCGCGATC
GCGATCTTCACGGCGGCGTCCGTGATGTGCGCGGCGGCGAACGGGCTCGCGACGCTGGTCGCCGCGCGCATCCTGCAGGG
CGCGGGCGGCGCGCTGATGGTGCCCGTCGGCCGCCTGATCCTCTATCGCGGCGTGTCGCGCCACGAGATGCTCGCGGCGA
CCACCTGGCTCACGATGCCCGCGCTCGTCGGCCCGCTGCTCGGGCCGCCGCTCGGCGGCTTTTTGACCGATGCGCTGTCG
TGGCGCGCGGTGTTCTGGATCAACGTGCCGGTCGGCGTCGCGGGCGCGGCGCTCGCCGCGCGCCTCGTCCCCGCGTCGGC
CGGCGAGCGTCGCGCGCCCGCCGACGCGCGCGGCATGCTGCTCGTCGGCGCGGCACTCGCCGCGCTGATGCTCGGCGTCG
AGACCGCGGGCCGCGACGTGCTGCCGGCGGGGGCGCCCGCCCTGTGCCTCGGCGCGGGCGTCGCGCTCGGCGGGCTCGCG
ATCCGCCATTGCCGGCGCGTCGCGCATCCGGCCGTCGATCTGTCGCTGCTCGGCATTCCGACCTTTCACGCGGCGACGAT
CGCGGGCAGCCTGTTCCGCGCGGGGGCCGGCGCGCTGCCGTTTCTCGTGCCGCTCACGCTGCAGGTCGGCTTCGGCGCGA
GCGCGTCGAGAAGCGGCGCCATCACGCTCGCGAGCGCGCTCGGCTCGCTCGTGATGCGGCCGATGACGCATGCGGCGCTG
CATCGCGCGCCGATGCGCACGGTGCTGATCGCGGGCAGCGTGTCGTTCGCGGCCGTGCTCGCCGCGTGCGCGACGCTATC
GCCCGCGTGGCCGGATGCGGCCGTCTTCGCGCTGCTGCTCGTCGGCGGGCTGTCGCGCTCGCTCAGCTTCGCGTCGCTCG
GCGCGCTCGTATTCTCGGACGTGCCGAGCGAGCGCCTGTCGGCCGCGACGTCGTTCCAGGGAACCGCGCAGCAGTTGATG
CGGGCGGTGGGCGTCGCCGTCGCGGCGGGCGCGCTGCATCTGGCGATGCTGATCGGCGGGCGCGGCCAGGCGAGCCGGAC
GGATTTCGCCTGCGCGTTCGCGGCGATCGCGCTCGTCGTGCTCGCGTCGGTGCCGATGTTCGCCGCGCTGCCGGCCGACG
CCGGCGAAGGGCTCGCGGGGCCGGCGCGCCGGCCGAGGCCATGA

Upstream 100 bases:

>100_bases
GCGGCCGCCGCGCGCGAGCGCGCGTCGTGAACGCCGCGCCGCGCTGCCCGCCGCCGCCCCGCCGGGTTCGGCGGGGCGGC
GCCATGCGGGGCGAACCCTG

Downstream 100 bases:

>100_bases
TGCGGATCGCGTGACGATGCGGGGCGTGCGCGCGGCGTATCGAGCATGCCGACGCGGCCGGGCGGCGGCCGGATAGCCGG
GGCAAGTCGGCAAGTCGGCA

Product: major facilitator family transporter

Products: Proton [Cytoplasm]; drug [Periplasm] [C]

Alternate protein names: High-copy suppressor of rspA [H]

Number of amino acids: Translated: 467; Mature: 467

Protein sequence:

>467_residues
MRAGDFRVTAAVVASALFMQNLDSTVVATALPSMARELGVNVVFLSSAITSYLVALTVFIPVSGWIAEHFGAKRVFIAAI
AIFTAASVMCAAANGLATLVAARILQGAGGALMVPVGRLILYRGVSRHEMLAATTWLTMPALVGPLLGPPLGGFLTDALS
WRAVFWINVPVGVAGAALAARLVPASAGERRAPADARGMLLVGAALAALMLGVETAGRDVLPAGAPALCLGAGVALGGLA
IRHCRRVAHPAVDLSLLGIPTFHAATIAGSLFRAGAGALPFLVPLTLQVGFGASASRSGAITLASALGSLVMRPMTHAAL
HRAPMRTVLIAGSVSFAAVLAACATLSPAWPDAAVFALLLVGGLSRSLSFASLGALVFSDVPSERLSAATSFQGTAQQLM
RAVGVAVAAGALHLAMLIGGRGQASRTDFACAFAAIALVVLASVPMFAALPADAGEGLAGPARRPRP

Sequences:

>Translated_467_residues
MRAGDFRVTAAVVASALFMQNLDSTVVATALPSMARELGVNVVFLSSAITSYLVALTVFIPVSGWIAEHFGAKRVFIAAI
AIFTAASVMCAAANGLATLVAARILQGAGGALMVPVGRLILYRGVSRHEMLAATTWLTMPALVGPLLGPPLGGFLTDALS
WRAVFWINVPVGVAGAALAARLVPASAGERRAPADARGMLLVGAALAALMLGVETAGRDVLPAGAPALCLGAGVALGGLA
IRHCRRVAHPAVDLSLLGIPTFHAATIAGSLFRAGAGALPFLVPLTLQVGFGASASRSGAITLASALGSLVMRPMTHAAL
HRAPMRTVLIAGSVSFAAVLAACATLSPAWPDAAVFALLLVGGLSRSLSFASLGALVFSDVPSERLSAATSFQGTAQQLM
RAVGVAVAAGALHLAMLIGGRGQASRTDFACAFAAIALVVLASVPMFAALPADAGEGLAGPARRPRP
>Mature_467_residues
MRAGDFRVTAAVVASALFMQNLDSTVVATALPSMARELGVNVVFLSSAITSYLVALTVFIPVSGWIAEHFGAKRVFIAAI
AIFTAASVMCAAANGLATLVAARILQGAGGALMVPVGRLILYRGVSRHEMLAATTWLTMPALVGPLLGPPLGGFLTDALS
WRAVFWINVPVGVAGAALAARLVPASAGERRAPADARGMLLVGAALAALMLGVETAGRDVLPAGAPALCLGAGVALGGLA
IRHCRRVAHPAVDLSLLGIPTFHAATIAGSLFRAGAGALPFLVPLTLQVGFGASASRSGAITLASALGSLVMRPMTHAAL
HRAPMRTVLIAGSVSFAAVLAACATLSPAWPDAAVFALLLVGGLSRSLSFASLGALVFSDVPSERLSAATSFQGTAQQLM
RAVGVAVAAGALHLAMLIGGRGQASRTDFACAFAAIALVVLASVPMFAALPADAGEGLAGPARRPRP

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. EmrB family [H]

Homologues:

Organism=Escherichia coli, GI1790195, Length=456, Percent_Identity=35.0877192982456, Blast_Score=273, Evalue=2e-74,
Organism=Escherichia coli, GI1788392, Length=465, Percent_Identity=35.0537634408602, Blast_Score=209, Evalue=3e-55,
Organism=Escherichia coli, GI1789042, Length=406, Percent_Identity=26.3546798029557, Blast_Score=124, Evalue=1e-29,
Organism=Escherichia coli, GI1788710, Length=417, Percent_Identity=25.4196642685851, Blast_Score=106, Evalue=3e-24,
Organism=Escherichia coli, GI87081983, Length=419, Percent_Identity=26.0143198090692, Blast_Score=88, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6325455, Length=128, Percent_Identity=32.8125, Blast_Score=65, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004638
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR001411 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 46992; Mature: 46992

Theoretical pI: Translated: 11.81; Mature: 11.81

Prosite motif: PS00626 RCC1_2 ; PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRAGDFRVTAAVVASALFMQNLDSTVVATALPSMARELGVNVVFLSSAITSYLVALTVFI
CCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHH
PVSGWIAEHFGAKRVFIAAIAIFTAASVMCAAANGLATLVAARILQGAGGALMVPVGRLI
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHH
LYRGVSRHEMLAATTWLTMPALVGPLLGPPLGGFLTDALSWRAVFWINVPVGVAGAALAA
HHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCEEEEEEECCHHHHHHHHHH
RLVPASAGERRAPADARGMLLVGAALAALMLGVETAGRDVLPAGAPALCLGAGVALGGLA
HHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHH
IRHCRRVAHPAVDLSLLGIPTFHAATIAGSLFRAGAGALPFLVPLTLQVGFGASASRSGA
HHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHCCCCCCHHHHHHHEEECCCCCCCCCCH
ITLASALGSLVMRPMTHAALHRAPMRTVLIAGSVSFAAVLAACATLSPAWPDAAVFALLL
HHHHHHHHHHHHHHHHHHHHHHCCHHEEEEECCHHHHHHHHHHHHCCCCCCHHHHHHHHH
VGGLSRSLSFASLGALVFSDVPSERLSAATSFQGTAQQLMRAVGVAVAAGALHLAMLIGG
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC
RGQASRTDFACAFAAIALVVLASVPMFAALPADAGEGLAGPARRPRP
CCCCCCHHHHHHHHHHHHHHHHHCCHHHCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MRAGDFRVTAAVVASALFMQNLDSTVVATALPSMARELGVNVVFLSSAITSYLVALTVFI
CCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHH
PVSGWIAEHFGAKRVFIAAIAIFTAASVMCAAANGLATLVAARILQGAGGALMVPVGRLI
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHH
LYRGVSRHEMLAATTWLTMPALVGPLLGPPLGGFLTDALSWRAVFWINVPVGVAGAALAA
HHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCEEEEEEECCHHHHHHHHHH
RLVPASAGERRAPADARGMLLVGAALAALMLGVETAGRDVLPAGAPALCLGAGVALGGLA
HHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHH
IRHCRRVAHPAVDLSLLGIPTFHAATIAGSLFRAGAGALPFLVPLTLQVGFGASASRSGA
HHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHCCCCCCHHHHHHHEEECCCCCCCCCCH
ITLASALGSLVMRPMTHAALHRAPMRTVLIAGSVSFAAVLAACATLSPAWPDAAVFALLL
HHHHHHHHHHHHHHHHHHHHHHCCHHEEEEECCHHHHHHHHHHHHCCCCCCHHHHHHHHH
VGGLSRSLSFASLGALVFSDVPSERLSAATSFQGTAQQLMRAVGVAVAAGALHLAMLIGG
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC
RGQASRTDFACAFAAIALVVLASVPMFAALPADAGEGLAGPARRPRP
CCCCCCHHHHHHHHHHHHHHHHHCCHHHCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; drug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + drug [Cytoplasm] = Proton [Cytoplasm] + drug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7686882; 9278503 [H]