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The map label for this gene is fadA [H]

Identifier: 126454517

GI number: 126454517

Start: 673731

End: 674930

Strand: Direct

Name: fadA [H]

Synonym: BURPS1106A_0697

Alternate gene names: 126454517

Gene position: 673731-674930 (Clockwise)

Preceding gene: 126455250

Following gene: 126453598

Centisome position: 16.89

GC content: 67.58

Gene sequence:

>1200_bases
ATGAGCAAACAGCTGCAAGACGCATACATCGTCGCCGCAAGCCGCACGCCGATCGGCAAGGCGCCCCGCGGTGCATTCAA
GAACACCCGCCCGGACGAGTTGCTCGTCCACGCAATCAAGTCGGCCATCGCGCAAGTGCCGGAATTCGATACGAAGCTGA
TCGAAGACGCAATCGTCGGCTGTGCGATCCCCGAGGCCGAGCAAGGCCTGAACGTCGCGCGGATGGGCGCGCTGCTCGCC
GGCCTGCCGAACACGGTCGGCGGCGTGACGGTGAACCGCTTCTGCGCGTCGGGCATCACAGCGCTCGCGATGGCGGCGGA
CCGCATCCGCGTCGGCGAATCGGACGCGCTTCTCGCAGCCGGCGTCGAATCGATGAGCATGGTGCCGATGATGGGCAACA
AGCCGTCGATGTCGCCGCACATCTTCGATCGCAGCGAAGACTTCGGCATCGCTTACGGCATGGGCCTGACGGCCGAGCGC
GTCGCCGAGCAGTGGAAGGTGAGCCGCGAAGACCAGGACGCGTTCTCGGTCGAGTCGCATCGCAAGGCGATCGCCGCGCA
GCAGGCGGGCGAGTTCAAGGACGAGATCGCGCCCTATGCGATCGTCGAGCGCTTCCCGAATCTCGCGACGGGCGAAATCG
ATACGAAGACGCGCGAGATCGCGCTCGACGAAGGCCCGCGCGCGGAAACGTCGCTCGAAGGGCTCGCGAAGCTGAAGACG
GTGTTCGCGAACAAGGGCTCGGTGACGGCCGGCAACAGCTCGCAGACCTCGGACGGCTCGGGCGCGCTGCTCGTCGTGTC
GGAGAAGGTGCTCAAGCAATTCAACCTGACGCCGCTCGCGCGCTTCGTCAGCTTCGCCGTGCGCGGCGTGCCGCCGGAAA
TCATGGGCATCGGCCCGAAGGAAGCGATTCCCGCCGCGCTGAAGGCGGCGGGCCTCAAGCAGGACGACATCGACTGGATC
GAGCTGAACGAGGCGTTCGCCGCGCAGTCGCTCGCCGTGATCCGCGATCTCGGCCTCGACCCGTCGAAGATCAACCCGCT
CGGCGGCGCGATCGCGCTCGGCCACCCGCTCGGCGCGACGGGCGCGATTCGCGCGGCGACGGTCGTGCACGGCCTGCGCC
GCCGCAACCTGAAGTACGGGATGGTGACGATGTGCGTCGGCACCGGCATGGGCGCGGCGGGCATCATCGAGCGCCTCTGA

Upstream 100 bases:

>100_bases
GACCAGAGCAGGTGCTGAAGCGCTAACTCTGGTCGACCGTCCAAGGACATGGGACCAGAGTAAGCGCTAAAGCGCTAACT
CTGGTCGACAGGAGCTTGAA

Downstream 100 bases:

>100_bases
TCGGAGCGCGCGACGGATGACGACGGTGCGCGGGCGACGAGCTCGCGCACCGTTTTTTGTTGATCGAATGAAACCAGCCA
CGGAGACGGCTCAAATGGAT

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: Acetyl-CoA acyltransferase; Beta-ketothiolase [H]

Number of amino acids: Translated: 399; Mature: 398

Protein sequence:

>399_residues
MSKQLQDAYIVAASRTPIGKAPRGAFKNTRPDELLVHAIKSAIAQVPEFDTKLIEDAIVGCAIPEAEQGLNVARMGALLA
GLPNTVGGVTVNRFCASGITALAMAADRIRVGESDALLAAGVESMSMVPMMGNKPSMSPHIFDRSEDFGIAYGMGLTAER
VAEQWKVSREDQDAFSVESHRKAIAAQQAGEFKDEIAPYAIVERFPNLATGEIDTKTREIALDEGPRAETSLEGLAKLKT
VFANKGSVTAGNSSQTSDGSGALLVVSEKVLKQFNLTPLARFVSFAVRGVPPEIMGIGPKEAIPAALKAAGLKQDDIDWI
ELNEAFAAQSLAVIRDLGLDPSKINPLGGAIALGHPLGATGAIRAATVVHGLRRRNLKYGMVTMCVGTGMGAAGIIERL

Sequences:

>Translated_399_residues
MSKQLQDAYIVAASRTPIGKAPRGAFKNTRPDELLVHAIKSAIAQVPEFDTKLIEDAIVGCAIPEAEQGLNVARMGALLA
GLPNTVGGVTVNRFCASGITALAMAADRIRVGESDALLAAGVESMSMVPMMGNKPSMSPHIFDRSEDFGIAYGMGLTAER
VAEQWKVSREDQDAFSVESHRKAIAAQQAGEFKDEIAPYAIVERFPNLATGEIDTKTREIALDEGPRAETSLEGLAKLKT
VFANKGSVTAGNSSQTSDGSGALLVVSEKVLKQFNLTPLARFVSFAVRGVPPEIMGIGPKEAIPAALKAAGLKQDDIDWI
ELNEAFAAQSLAVIRDLGLDPSKINPLGGAIALGHPLGATGAIRAATVVHGLRRRNLKYGMVTMCVGTGMGAAGIIERL
>Mature_398_residues
SKQLQDAYIVAASRTPIGKAPRGAFKNTRPDELLVHAIKSAIAQVPEFDTKLIEDAIVGCAIPEAEQGLNVARMGALLAG
LPNTVGGVTVNRFCASGITALAMAADRIRVGESDALLAAGVESMSMVPMMGNKPSMSPHIFDRSEDFGIAYGMGLTAERV
AEQWKVSREDQDAFSVESHRKAIAAQQAGEFKDEIAPYAIVERFPNLATGEIDTKTREIALDEGPRAETSLEGLAKLKTV
FANKGSVTAGNSSQTSDGSGALLVVSEKVLKQFNLTPLARFVSFAVRGVPPEIMGIGPKEAIPAALKAAGLKQDDIDWIE
LNEAFAAQSLAVIRDLGLDPSKINPLGGAIALGHPLGATGAIRAATVVHGLRRRNLKYGMVTMCVGTGMGAAGIIERL

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI4501853, Length=395, Percent_Identity=43.7974683544304, Blast_Score=293, Evalue=1e-79,
Organism=Homo sapiens, GI167614485, Length=405, Percent_Identity=39.2592592592593, Blast_Score=265, Evalue=8e-71,
Organism=Homo sapiens, GI148539872, Length=405, Percent_Identity=37.7777777777778, Blast_Score=235, Evalue=5e-62,
Organism=Homo sapiens, GI4557237, Length=408, Percent_Identity=35.5392156862745, Blast_Score=213, Evalue=3e-55,
Organism=Homo sapiens, GI4504327, Length=442, Percent_Identity=31.2217194570136, Blast_Score=156, Evalue=3e-38,
Organism=Homo sapiens, GI194353979, Length=395, Percent_Identity=32.1518987341772, Blast_Score=130, Evalue=3e-30,
Organism=Escherichia coli, GI1787663, Length=412, Percent_Identity=43.4466019417476, Blast_Score=302, Evalue=2e-83,
Organism=Escherichia coli, GI48994986, Length=402, Percent_Identity=43.7810945273632, Blast_Score=285, Evalue=5e-78,
Organism=Escherichia coli, GI1788554, Length=406, Percent_Identity=39.9014778325123, Blast_Score=261, Evalue=5e-71,
Organism=Escherichia coli, GI87082165, Length=406, Percent_Identity=40.3940886699507, Blast_Score=257, Evalue=9e-70,
Organism=Escherichia coli, GI1788683, Length=421, Percent_Identity=30.8788598574822, Blast_Score=157, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI133906874, Length=401, Percent_Identity=41.645885286783, Blast_Score=270, Evalue=9e-73,
Organism=Caenorhabditis elegans, GI17535921, Length=408, Percent_Identity=36.7647058823529, Blast_Score=208, Evalue=5e-54,
Organism=Caenorhabditis elegans, GI25147385, Length=402, Percent_Identity=32.089552238806, Blast_Score=200, Evalue=1e-51,
Organism=Caenorhabditis elegans, GI17551802, Length=441, Percent_Identity=29.7052154195011, Blast_Score=154, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI17535917, Length=401, Percent_Identity=29.1770573566085, Blast_Score=144, Evalue=7e-35,
Organism=Saccharomyces cerevisiae, GI6322031, Length=407, Percent_Identity=42.014742014742, Blast_Score=288, Evalue=1e-78,
Organism=Saccharomyces cerevisiae, GI6325229, Length=407, Percent_Identity=38.0835380835381, Blast_Score=233, Evalue=4e-62,
Organism=Drosophila melanogaster, GI24655093, Length=404, Percent_Identity=37.8712871287129, Blast_Score=254, Evalue=1e-67,
Organism=Drosophila melanogaster, GI17648125, Length=408, Percent_Identity=39.7058823529412, Blast_Score=253, Evalue=1e-67,
Organism=Drosophila melanogaster, GI24640423, Length=409, Percent_Identity=33.9853300733496, Blast_Score=208, Evalue=5e-54,
Organism=Drosophila melanogaster, GI17137578, Length=442, Percent_Identity=31.9004524886878, Blast_Score=160, Evalue=2e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.16 [H]

Molecular weight: Translated: 42000; Mature: 41869

Theoretical pI: Translated: 6.38; Mature: 6.38

Prosite motif: PS00098 THIOLASE_1 ; PS00737 THIOLASE_2 ; PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKQLQDAYIVAASRTPIGKAPRGAFKNTRPDELLVHAIKSAIAQVPEFDTKLIEDAIVG
CCCCCCCEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
CAIPEAEQGLNVARMGALLAGLPNTVGGVTVNRFCASGITALAMAADRIRVGESDALLAA
CCCCCHHHCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
GVESMSMVPMMGNKPSMSPHIFDRSEDFGIAYGMGLTAERVAEQWKVSREDQDAFSVESH
CHHHHEECCCCCCCCCCCCCCCCCCCCCCEEECCCCCHHHHHHHHHCCCCCCHHHHHHHH
RKAIAAQQAGEFKDEIAPYAIVERFPNLATGEIDTKTREIALDEGPRAETSLEGLAKLKT
HHHHHHHHHHHHHHHHCHHHHHHHCCCCCCCCCCCCHHEEEECCCCCCHHHHHHHHHHHH
VFANKGSVTAGNSSQTSDGSGALLVVSEKVLKQFNLTPLARFVSFAVRGVPPEIMGIGPK
HHHCCCCEECCCCCCCCCCCCEEEEEEHHHHHHCCCCHHHHHHHHHHHCCCHHHHCCCCH
EAIPAALKAAGLKQDDIDWIELNEAFAAQSLAVIRDLGLDPSKINPLGGAIALGHPLGAT
HHHHHHHHHCCCCCCCCCEEEHHHHHHHHHHHHHHHCCCCHHHCCCCCCEEEECCCCCCC
GAIRAATVVHGLRRRNLKYGMVTMCVGTGMGAAGIIERL
HHHHHHHHHHHHHHCCCCHHHHEEHHHCCCCHHHHHHCC
>Mature Secondary Structure 
SKQLQDAYIVAASRTPIGKAPRGAFKNTRPDELLVHAIKSAIAQVPEFDTKLIEDAIVG
CCCCCCEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
CAIPEAEQGLNVARMGALLAGLPNTVGGVTVNRFCASGITALAMAADRIRVGESDALLAA
CCCCCHHHCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
GVESMSMVPMMGNKPSMSPHIFDRSEDFGIAYGMGLTAERVAEQWKVSREDQDAFSVESH
CHHHHEECCCCCCCCCCCCCCCCCCCCCCEEECCCCCHHHHHHHHHCCCCCCHHHHHHHH
RKAIAAQQAGEFKDEIAPYAIVERFPNLATGEIDTKTREIALDEGPRAETSLEGLAKLKT
HHHHHHHHHHHHHHHHCHHHHHHHCCCCCCCCCCCCHHEEEECCCCCCHHHHHHHHHHHH
VFANKGSVTAGNSSQTSDGSGALLVVSEKVLKQFNLTPLARFVSFAVRGVPPEIMGIGPK
HHHCCCCEECCCCCCCCCCCCEEEEEEHHHHHHCCCCHHHHHHHHHHHCCCHHHHCCCCH
EAIPAALKAAGLKQDDIDWIELNEAFAAQSLAVIRDLGLDPSKINPLGGAIALGHPLGAT
HHHHHHHHHCCCCCCCCCEEEHHHHHHHHHHHHHHHCCCCHHHCCCCCCEEEECCCCCCC
GAIRAATVVHGLRRRNLKYGMVTMCVGTGMGAAGIIERL
HHHHHHHHHHHHHHCCCCHHHHEEHHHCCCCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]