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The map label for this gene is fadA [H]

Identifier: 126454300

GI number: 126454300

Start: 69172

End: 70377

Strand: Direct

Name: fadA [H]

Synonym: BURPS1106A_0072

Alternate gene names: 126454300

Gene position: 69172-70377 (Clockwise)

Preceding gene: 126453086

Following gene: 126454240

Centisome position: 1.73

GC content: 70.98

Gene sequence:

>1206_bases
ATGGAAGCCTACATTTTCGACGCCGTGCGCACGCCGCGCGGCAAAGGCAAGAAGGACGGCAGCCTGCACGGCGTCACGCC
GCTCGCGCTCGCCGCAACCGCGCTGCGCGCGATTCGCGACCGCAACGGTCTCGACACGCGCGCCGTCGACGACGTCGTGC
TCGGCTGCGTCGAGCCCGTCGGCGAGCAAGGCGCGTGCATCGGCCGCATCGCGGTGCTCGCGGCCGGCTACGCGGAAACC
ACGGCCGGCGTGCAGATCAACCGCTTCTGCGCATCGGGCCTCGAGGCGTGCAACATGGCCGCCGCGCAGGTGATGTCCGG
CCAGTCGGAGATGGCGATCGGCGGCGGCGTCGAGAGCATGTCGCGCGTGCCGATGGGCTCGAGCGGCGGCGCGTGGCCCG
TCGATCCGGCGATCGCGATTCCGAGCTATTTCGTGCCGCAGGGCGTATCGGCCGACACGATCGCGACGAAGTGGGGCTAC
AGCCGTGCCGATGTCGACGCGTACGCCGCCGAGAGCCACCGCCGCGCGCACGCGGCGGCGCAGGCGGGCTGGTTCGCGCG
CTCGATCGTGCCGGTGCGCGACGCGAACGGCCTGACGATCCTCGATCACGACGAGACGATCCGCCCGCAGACGACGCCCG
AGACGCTCGCGACGCTCAAGCCTTCGTTCGCCGAACTGGGTGAGATGTACGGCTTCGACGCGGTGATCCGCCAGCGCTAT
CCGGAGCTCGAACGCATCGAGCACGTGCACCACGCGGGCAACAGCTCGGGGATCGTCGACGGCGCGTCGGCCGTGCTGAT
CGGCTCGCTCGAGGCGGGCAAGCGCGCGGGCCTCGCGCCGCGCGCGCGAATCCGCTCGTTCGCGAGCATCGGCTCGGAGC
CGTCGATCATGCTGACAGGGCCGGCCTACGCGGCGCAGAAGGCGCTCGAGCGCGCCGGCATGCGCGCGGCCGACATCGAT
CTGTACGAGCTGAACGAAGCGTTCGCGTCGGTCGTGCTGCGCTTCATGGACGCGATGGCGATTGCGCACGACCGGATCAA
CGTGAACGGCGGTGCGATCGCGATGGGCCATCCGCTCGGCGCGACGGGCGCGATGATCCTCGGCACGCTGCTCGACGAGC
TCGAGCGGCGCGGCGCGGCCACGGGCCTTGCAACGCTGTGCGTCGGCGCCGGCATGGGCACGGCGACCATCATCGAACGG
ATTTGA

Upstream 100 bases:

>100_bases
CGGGCCGTCCCGATCGGCGGCGGCCGCCGCCGTCCGTCCCGGCTGGCCGTCCAGACTGGCCGTCCCGACCGGCCATCTCC
ATCAACCGAAGGAACGATTC

Downstream 100 bases:

>100_bases
CGAGGGACCACCATGATCGATTACACGCTCGATGACGACGGCATCGCGACCTTGAGCTGGAACCTGCCGGCGCGCAGCCA
GAACGTGCTGAACGGCGAGA

Product: acetyl-CoA acetyltransferase

Products: CoA; oxoacyl-CoA [C]

Alternate protein names: NA

Number of amino acids: Translated: 401; Mature: 401

Protein sequence:

>401_residues
MEAYIFDAVRTPRGKGKKDGSLHGVTPLALAATALRAIRDRNGLDTRAVDDVVLGCVEPVGEQGACIGRIAVLAAGYAET
TAGVQINRFCASGLEACNMAAAQVMSGQSEMAIGGGVESMSRVPMGSSGGAWPVDPAIAIPSYFVPQGVSADTIATKWGY
SRADVDAYAAESHRRAHAAAQAGWFARSIVPVRDANGLTILDHDETIRPQTTPETLATLKPSFAELGEMYGFDAVIRQRY
PELERIEHVHHAGNSSGIVDGASAVLIGSLEAGKRAGLAPRARIRSFASIGSEPSIMLTGPAYAAQKALERAGMRAADID
LYELNEAFASVVLRFMDAMAIAHDRINVNGGAIAMGHPLGATGAMILGTLLDELERRGAATGLATLCVGAGMGTATIIER
I

Sequences:

>Translated_401_residues
MEAYIFDAVRTPRGKGKKDGSLHGVTPLALAATALRAIRDRNGLDTRAVDDVVLGCVEPVGEQGACIGRIAVLAAGYAET
TAGVQINRFCASGLEACNMAAAQVMSGQSEMAIGGGVESMSRVPMGSSGGAWPVDPAIAIPSYFVPQGVSADTIATKWGY
SRADVDAYAAESHRRAHAAAQAGWFARSIVPVRDANGLTILDHDETIRPQTTPETLATLKPSFAELGEMYGFDAVIRQRY
PELERIEHVHHAGNSSGIVDGASAVLIGSLEAGKRAGLAPRARIRSFASIGSEPSIMLTGPAYAAQKALERAGMRAADID
LYELNEAFASVVLRFMDAMAIAHDRINVNGGAIAMGHPLGATGAMILGTLLDELERRGAATGLATLCVGAGMGTATIIER
I
>Mature_401_residues
MEAYIFDAVRTPRGKGKKDGSLHGVTPLALAATALRAIRDRNGLDTRAVDDVVLGCVEPVGEQGACIGRIAVLAAGYAET
TAGVQINRFCASGLEACNMAAAQVMSGQSEMAIGGGVESMSRVPMGSSGGAWPVDPAIAIPSYFVPQGVSADTIATKWGY
SRADVDAYAAESHRRAHAAAQAGWFARSIVPVRDANGLTILDHDETIRPQTTPETLATLKPSFAELGEMYGFDAVIRQRY
PELERIEHVHHAGNSSGIVDGASAVLIGSLEAGKRAGLAPRARIRSFASIGSEPSIMLTGPAYAAQKALERAGMRAADID
LYELNEAFASVVLRFMDAMAIAHDRINVNGGAIAMGHPLGATGAMILGTLLDELERRGAATGLATLCVGAGMGTATIIER
I

Specific function: Subunit Of The Multifunctional Enzyme Complex Of The Fatty Acid Degradation Cycle. [C]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI4501853, Length=389, Percent_Identity=34.7043701799486, Blast_Score=205, Evalue=7e-53,
Organism=Homo sapiens, GI167614485, Length=413, Percent_Identity=33.1719128329298, Blast_Score=201, Evalue=1e-51,
Organism=Homo sapiens, GI148539872, Length=399, Percent_Identity=35.3383458646617, Blast_Score=200, Evalue=2e-51,
Organism=Homo sapiens, GI4557237, Length=415, Percent_Identity=31.3253012048193, Blast_Score=186, Evalue=4e-47,
Organism=Homo sapiens, GI4504327, Length=445, Percent_Identity=29.8876404494382, Blast_Score=155, Evalue=4e-38,
Organism=Homo sapiens, GI194353979, Length=115, Percent_Identity=40.8695652173913, Blast_Score=90, Evalue=4e-18,
Organism=Escherichia coli, GI48994986, Length=408, Percent_Identity=39.9509803921569, Blast_Score=265, Evalue=5e-72,
Organism=Escherichia coli, GI1787663, Length=422, Percent_Identity=38.6255924170616, Blast_Score=249, Evalue=2e-67,
Organism=Escherichia coli, GI87082165, Length=415, Percent_Identity=37.8313253012048, Blast_Score=236, Evalue=1e-63,
Organism=Escherichia coli, GI1788554, Length=413, Percent_Identity=37.5302663438257, Blast_Score=225, Evalue=3e-60,
Organism=Escherichia coli, GI1788683, Length=427, Percent_Identity=28.5714285714286, Blast_Score=135, Evalue=5e-33,
Organism=Caenorhabditis elegans, GI133906874, Length=412, Percent_Identity=31.0679611650485, Blast_Score=196, Evalue=3e-50,
Organism=Caenorhabditis elegans, GI25147385, Length=414, Percent_Identity=30.4347826086957, Blast_Score=180, Evalue=1e-45,
Organism=Caenorhabditis elegans, GI17535921, Length=413, Percent_Identity=29.5399515738499, Blast_Score=162, Evalue=3e-40,
Organism=Caenorhabditis elegans, GI17551802, Length=446, Percent_Identity=27.3542600896861, Blast_Score=129, Evalue=3e-30,
Organism=Caenorhabditis elegans, GI17535917, Length=411, Percent_Identity=27.4939172749392, Blast_Score=120, Evalue=1e-27,
Organism=Saccharomyces cerevisiae, GI6322031, Length=359, Percent_Identity=34.2618384401114, Blast_Score=197, Evalue=3e-51,
Organism=Saccharomyces cerevisiae, GI6325229, Length=414, Percent_Identity=29.7101449275362, Blast_Score=154, Evalue=3e-38,
Organism=Drosophila melanogaster, GI24655093, Length=414, Percent_Identity=35.024154589372, Blast_Score=221, Evalue=6e-58,
Organism=Drosophila melanogaster, GI17648125, Length=413, Percent_Identity=33.8983050847458, Blast_Score=199, Evalue=2e-51,
Organism=Drosophila melanogaster, GI24640423, Length=412, Percent_Identity=30.0970873786408, Blast_Score=168, Evalue=6e-42,
Organism=Drosophila melanogaster, GI17137578, Length=443, Percent_Identity=29.5711060948081, Blast_Score=159, Evalue=3e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: 2.3.1.16 [C]

Molecular weight: Translated: 41813; Mature: 41813

Theoretical pI: Translated: 6.05; Mature: 6.05

Prosite motif: PS00737 THIOLASE_2 ; PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEAYIFDAVRTPRGKGKKDGSLHGVTPLALAATALRAIRDRNGLDTRAVDDVVLGCVEPV
CCCEEEHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCC
GEQGACIGRIAVLAAGYAETTAGVQINRFCASGLEACNMAAAQVMSGQSEMAIGGGVESM
CCCCCHHHHHHHHHCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCHHHH
SRVPMGSSGGAWPVDPAIAIPSYFVPQGVSADTIATKWGYSRADVDAYAAESHRRAHAAA
HCCCCCCCCCCCCCCCHHHCCCHHCCCCCCCCHHHHHCCCCHHCHHHHHHHHHHHHHHHH
QAGWFARSIVPVRDANGLTILDHDETIRPQTTPETLATLKPSFAELGEMYGFDAVIRQRY
HHHHHHHHEEEEECCCCCEEECCCCCCCCCCCHHHHHHCCCCHHHHHHHHCHHHHHHHHC
PELERIEHVHHAGNSSGIVDGASAVLIGSLEAGKRAGLAPRARIRSFASIGSEPSIMLTG
CHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHCCCCCCEEEEC
PAYAAQKALERAGMRAADIDLYELNEAFASVVLRFMDAMAIAHDRINVNGGAIAMGHPLG
CHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCEECCCCEEEECCCCC
ATGAMILGTLLDELERRGAATGLATLCVGAGMGTATIIERI
CHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHCC
>Mature Secondary Structure
MEAYIFDAVRTPRGKGKKDGSLHGVTPLALAATALRAIRDRNGLDTRAVDDVVLGCVEPV
CCCEEEHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCC
GEQGACIGRIAVLAAGYAETTAGVQINRFCASGLEACNMAAAQVMSGQSEMAIGGGVESM
CCCCCHHHHHHHHHCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCHHHH
SRVPMGSSGGAWPVDPAIAIPSYFVPQGVSADTIATKWGYSRADVDAYAAESHRRAHAAA
HCCCCCCCCCCCCCCCHHHCCCHHCCCCCCCCHHHHHCCCCHHCHHHHHHHHHHHHHHHH
QAGWFARSIVPVRDANGLTILDHDETIRPQTTPETLATLKPSFAELGEMYGFDAVIRQRY
HHHHHHHHEEEEECCCCCEEECCCCCCCCCCCHHHHHHCCCCHHHHHHHHCHHHHHHHHC
PELERIEHVHHAGNSSGIVDGASAVLIGSLEAGKRAGLAPRARIRSFASIGSEPSIMLTG
CHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHCCCCCCEEEEC
PAYAAQKALERAGMRAADIDLYELNEAFASVVLRFMDAMAIAHDRINVNGGAIAMGHPLG
CHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCEECCCCEEEECCCCC
ATGAMILGTLLDELERRGAATGLATLCVGAGMGTATIIERI
CHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Acyl-CoA; acetyl-CoA [C]

Specific reaction: Acyl-CoA + acetyl-CoA = CoA + oxoacyl-CoA [C]

General reaction: Acyl group transfer; Claisen condensation [C]

Inhibitor: Tris (hydroxy methyl) aminomethane [C]

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230 [H]