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The map label for this gene is fadJ [H]

Identifier: 126454240

GI number: 126454240

Start: 70390

End: 72513

Strand: Direct

Name: fadJ [H]

Synonym: BURPS1106A_0073

Alternate gene names: 126454240

Gene position: 70390-72513 (Clockwise)

Preceding gene: 126454300

Following gene: 126455425

Centisome position: 1.76

GC content: 70.86

Gene sequence:

>2124_bases
ATGATCGATTACACGCTCGATGACGACGGCATCGCGACCTTGAGCTGGAACCTGCCGGCGCGCAGCCAGAACGTGCTGAA
CGGCGAGAGCTGCGAGGCGTTCTTCGCGGCGGCGGCGCGCGCGTTGCAGGATGCGGCGGTGAAGGGAATGCTCGTCACGT
CGGCGAAGCCCGACTTCATCGCGGGCGGCGACCTCGAATGGCTGCAGGCGAGCGACAGCGCCGAGACGCTCTTCGCGCGC
ACGTGCGAGCTGCATCGCGCGCTGCGCGCGCTCGAAACAGGCGGCAAGCCGGTGGCGATCGCGATGCCGGGCTCGGCGCT
CGGCGGTGGGCTGGAGATCGCGCTCGCGGGCCACTATCGTGTCGCGGCCGACAATCCGAAGGCGCGCTTCGGCCTGCCCG
AAGTGACGCTCGGCCTGCTGCCGGGCGGCGGCGGCACGCAGCGCCTGCCGCGTCTCGTCGGCGTCCAGGCGTCGCTGCCG
CTGTTGCTCGAAGGCAAGCGGCTGAAGGCGGCCGACGCGCTGGCCGCGGGCATCCTGCATGCGGTCGTGCCGGCGGGCGA
GGAGATCGCGGCCGCGCGCGCGTGGCTGCTCGACGCGAGCCGCCGCACCGCGACGCAGCCGTGGGACGCGAAGGGCTTCC
GGATTCCGGGCGGCGCGCTCACGCATCCGTCCGTCCAGCAGGTGTTCATGGCGGCGAACGCGCTCGCGCGGCAGAAGACG
TATGGCAACTACCCGGCCGTCGCGAGCATCCTGTCGTGCGTGTACGAAGGGCTGCTGACCGATCTCGACACGGGCTTGAA
GACCGAGGCGCGCTATTTCGTGAAGGCGGTGCTGTCGCCGGAAGCGAAGGCGATGATCCGCACGCTGTTCTTCGGGATGA
ACGAAGCGAACAAGCTCGCCGCGCGGCCGGCCGGCGTGCCGACGCAGCGCTACCGGAAGGTCGGCGTGCTCGGCGCGGGG
ATGATGGGCGCGGGCATCGCGTACGTGAGCGCGAAGGCGGGGCTCGACGTCGTGCTGATCGATACCGGCGAAGAGGCGGC
CGCGCGCGGCAAGGACTATTCGCGCAAGCTCGTCGACAAGCAGGTGCAGCGCGGCCGGCTCGCGCGGGAAAAGGCCGATG
CATTGCTCGCGAAGATCGTGCCGACGACCGATTTCGCGCGGCTCGACGGCGCGCAGCTCGTGATCGAGGCGGTGTTCGAG
GATCGCGCGATCAAGGCCGACGTCACGCGCCGGAGCGAAGCGGTGCTCGCGCCCGACGCGCTTTTCGCGTCGAACACGTC
GACGCTGCCGATCACGGGGCTCGCGCAGGCGAGCGCGCGGCCGGCGAACTTCATCGGCCTGCATTTCTTCTCGCCGGTGG
ACAAGATGCCGCTCGTCGAGGTGATCGTCGGCCGCGACACGAGCGAGGCGACGCTCGCGCGCGCGCTCGACTACGTGAAG
ACGATCGGCATGACGCCGATCGTGGTCAACGATTCGCGGGGCTTCTACACGAGCCGCGTGTTTTCGACGTACGTGCTCGA
AGGGCTCGCGATGCTCGCCGAGGGCGTCGCGCCCGCGCTGATCGAGAACGCCGGATTGCTCGCCGGCATGCCGGTGGGCC
CGCTCGCGCTGACCGACGAGGTGTCGAGCGAGCTGATCCACAAGATCACCAGGCAGACGCGCGCCGATCTCGGCGACGCG
TACGTCGCGCGCCCCGGCGAGGACGTGGCCGCGCGCATGGTCGAACTCGGCCGGCTCGGCCGCAAGGCGGGGCTCGGCTA
TTACGACTATCCGGCGAGCGGCGGCAAGAAGGCGCTGTGGCCGGGGCTCGCGCAGGAGTTTCCGCTCGCGGCCGAGCAGC
CCGACGTGGCGGCGCTGATCGAGCGGCTCGTGACGGTGCAGGCGGTCGAGACCGCGCGCTGCCTCGAAGAGCGCGTGCTG
ACGACGGCGCGCGATGCGGACGTCGGCGCGATTCTCGGCTGGGGTTTCCCGGCGTTCCGCGGCGGGCCCGCGTCGTACAT
TCACGGCGTCGGGGTGGACGCGTTCGTCGCGACGTGCGATCGTCTTGCCGCGCGGCACGGCGCGCGTTTCGCCGCGCCGG
CGTTGCTGCGCGAGATGGCGGCGCAGGGGCGAAGCTTCTATTGA

Upstream 100 bases:

>100_bases
GCTCGAGCGGCGCGGCGCGGCCACGGGCCTTGCAACGCTGTGCGTCGGCGCCGGCATGGGCACGGCGACCATCATCGAAC
GGATTTGACGAGGGACCACC

Downstream 100 bases:

>100_bases
GCGCCGGTGCGTCGACGCGCGCGGCGAGTGCGGCGCGGCGCGCGTCGGGCCGCGCGCGTAGACGCGTGGCGTGTCTTGCG
TCGCATCGCGACGCGTCGAG

Product: putative 3-hydroxyacyl-CoA dehydrogenase

Products: NA

Alternate protein names: Enoyl-CoA hydratase/3-hydroxybutyryl-CoA epimerase; 3-hydroxyacyl-CoA dehydrogenase [H]

Number of amino acids: Translated: 707; Mature: 707

Protein sequence:

>707_residues
MIDYTLDDDGIATLSWNLPARSQNVLNGESCEAFFAAAARALQDAAVKGMLVTSAKPDFIAGGDLEWLQASDSAETLFAR
TCELHRALRALETGGKPVAIAMPGSALGGGLEIALAGHYRVAADNPKARFGLPEVTLGLLPGGGGTQRLPRLVGVQASLP
LLLEGKRLKAADALAAGILHAVVPAGEEIAAARAWLLDASRRTATQPWDAKGFRIPGGALTHPSVQQVFMAANALARQKT
YGNYPAVASILSCVYEGLLTDLDTGLKTEARYFVKAVLSPEAKAMIRTLFFGMNEANKLAARPAGVPTQRYRKVGVLGAG
MMGAGIAYVSAKAGLDVVLIDTGEEAAARGKDYSRKLVDKQVQRGRLAREKADALLAKIVPTTDFARLDGAQLVIEAVFE
DRAIKADVTRRSEAVLAPDALFASNTSTLPITGLAQASARPANFIGLHFFSPVDKMPLVEVIVGRDTSEATLARALDYVK
TIGMTPIVVNDSRGFYTSRVFSTYVLEGLAMLAEGVAPALIENAGLLAGMPVGPLALTDEVSSELIHKITRQTRADLGDA
YVARPGEDVAARMVELGRLGRKAGLGYYDYPASGGKKALWPGLAQEFPLAAEQPDVAALIERLVTVQAVETARCLEERVL
TTARDADVGAILGWGFPAFRGGPASYIHGVGVDAFVATCDRLAARHGARFAAPALLREMAAQGRSFY

Sequences:

>Translated_707_residues
MIDYTLDDDGIATLSWNLPARSQNVLNGESCEAFFAAAARALQDAAVKGMLVTSAKPDFIAGGDLEWLQASDSAETLFAR
TCELHRALRALETGGKPVAIAMPGSALGGGLEIALAGHYRVAADNPKARFGLPEVTLGLLPGGGGTQRLPRLVGVQASLP
LLLEGKRLKAADALAAGILHAVVPAGEEIAAARAWLLDASRRTATQPWDAKGFRIPGGALTHPSVQQVFMAANALARQKT
YGNYPAVASILSCVYEGLLTDLDTGLKTEARYFVKAVLSPEAKAMIRTLFFGMNEANKLAARPAGVPTQRYRKVGVLGAG
MMGAGIAYVSAKAGLDVVLIDTGEEAAARGKDYSRKLVDKQVQRGRLAREKADALLAKIVPTTDFARLDGAQLVIEAVFE
DRAIKADVTRRSEAVLAPDALFASNTSTLPITGLAQASARPANFIGLHFFSPVDKMPLVEVIVGRDTSEATLARALDYVK
TIGMTPIVVNDSRGFYTSRVFSTYVLEGLAMLAEGVAPALIENAGLLAGMPVGPLALTDEVSSELIHKITRQTRADLGDA
YVARPGEDVAARMVELGRLGRKAGLGYYDYPASGGKKALWPGLAQEFPLAAEQPDVAALIERLVTVQAVETARCLEERVL
TTARDADVGAILGWGFPAFRGGPASYIHGVGVDAFVATCDRLAARHGARFAAPALLREMAAQGRSFY
>Mature_707_residues
MIDYTLDDDGIATLSWNLPARSQNVLNGESCEAFFAAAARALQDAAVKGMLVTSAKPDFIAGGDLEWLQASDSAETLFAR
TCELHRALRALETGGKPVAIAMPGSALGGGLEIALAGHYRVAADNPKARFGLPEVTLGLLPGGGGTQRLPRLVGVQASLP
LLLEGKRLKAADALAAGILHAVVPAGEEIAAARAWLLDASRRTATQPWDAKGFRIPGGALTHPSVQQVFMAANALARQKT
YGNYPAVASILSCVYEGLLTDLDTGLKTEARYFVKAVLSPEAKAMIRTLFFGMNEANKLAARPAGVPTQRYRKVGVLGAG
MMGAGIAYVSAKAGLDVVLIDTGEEAAARGKDYSRKLVDKQVQRGRLAREKADALLAKIVPTTDFARLDGAQLVIEAVFE
DRAIKADVTRRSEAVLAPDALFASNTSTLPITGLAQASARPANFIGLHFFSPVDKMPLVEVIVGRDTSEATLARALDYVK
TIGMTPIVVNDSRGFYTSRVFSTYVLEGLAMLAEGVAPALIENAGLLAGMPVGPLALTDEVSSELIHKITRQTRADLGDA
YVARPGEDVAARMVELGRLGRKAGLGYYDYPASGGKKALWPGLAQEFPLAAEQPDVAALIERLVTVQAVETARCLEERVL
TTARDADVGAILGWGFPAFRGGPASYIHGVGVDAFVATCDRLAARHGARFAAPALLREMAAQGRSFY

Specific function: Catalyzes the formation of an hydroxyacyl-CoA by addition of water on enoyl-CoA. Also exhibits 3-hydroxyacyl-CoA epimerase and 3-hydroxyacyl-CoA dehydrogenase activities [H]

COG id: COG1250

COG function: function code I; 3-hydroxyacyl-CoA dehydrogenase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: In the central section; belongs to the 3-hydroxyacyl- CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI20127408, Length=736, Percent_Identity=34.1032608695652, Blast_Score=366, Evalue=1e-101,
Organism=Homo sapiens, GI68989263, Length=697, Percent_Identity=29.9856527977045, Blast_Score=246, Evalue=8e-65,
Organism=Homo sapiens, GI261878539, Length=631, Percent_Identity=30.2694136291601, Blast_Score=228, Evalue=2e-59,
Organism=Homo sapiens, GI296179429, Length=287, Percent_Identity=34.1463414634146, Blast_Score=147, Evalue=5e-35,
Organism=Homo sapiens, GI296179427, Length=304, Percent_Identity=31.5789473684211, Blast_Score=141, Evalue=2e-33,
Organism=Homo sapiens, GI194097323, Length=145, Percent_Identity=35.1724137931034, Blast_Score=81, Evalue=3e-15,
Organism=Homo sapiens, GI213417737, Length=199, Percent_Identity=29.1457286432161, Blast_Score=70, Evalue=8e-12,
Organism=Homo sapiens, GI157694516, Length=199, Percent_Identity=29.1457286432161, Blast_Score=70, Evalue=9e-12,
Organism=Escherichia coli, GI1788682, Length=715, Percent_Identity=38.6013986013986, Blast_Score=398, Evalue=1e-112,
Organism=Escherichia coli, GI1790281, Length=721, Percent_Identity=32.0388349514563, Blast_Score=289, Evalue=5e-79,
Organism=Escherichia coli, GI1787661, Length=283, Percent_Identity=34.982332155477, Blast_Score=149, Evalue=6e-37,
Organism=Escherichia coli, GI1787659, Length=172, Percent_Identity=37.7906976744186, Blast_Score=90, Evalue=4e-19,
Organism=Escherichia coli, GI221142681, Length=145, Percent_Identity=37.2413793103448, Blast_Score=74, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17558304, Length=728, Percent_Identity=35.3021978021978, Blast_Score=377, Evalue=1e-104,
Organism=Caenorhabditis elegans, GI17508951, Length=727, Percent_Identity=34.8005502063274, Blast_Score=358, Evalue=6e-99,
Organism=Caenorhabditis elegans, GI17508953, Length=727, Percent_Identity=34.8005502063274, Blast_Score=357, Evalue=8e-99,
Organism=Caenorhabditis elegans, GI25144276, Length=601, Percent_Identity=35.6073211314476, Blast_Score=309, Evalue=3e-84,
Organism=Caenorhabditis elegans, GI71985923, Length=403, Percent_Identity=27.0471464019851, Blast_Score=163, Evalue=3e-40,
Organism=Caenorhabditis elegans, GI71985930, Length=368, Percent_Identity=25, Blast_Score=147, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI17549919, Length=298, Percent_Identity=33.5570469798658, Blast_Score=137, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI17553560, Length=296, Percent_Identity=30.7432432432432, Blast_Score=127, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI17563036, Length=293, Percent_Identity=31.3993174061433, Blast_Score=119, Evalue=6e-27,
Organism=Caenorhabditis elegans, GI17540714, Length=181, Percent_Identity=35.3591160220994, Blast_Score=84, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17554946, Length=195, Percent_Identity=30.2564102564103, Blast_Score=79, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI25145438, Length=221, Percent_Identity=29.8642533936652, Blast_Score=77, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17560910, Length=174, Percent_Identity=28.1609195402299, Blast_Score=69, Evalue=9e-12,
Organism=Drosophila melanogaster, GI24583077, Length=730, Percent_Identity=34.7945205479452, Blast_Score=333, Evalue=2e-91,
Organism=Drosophila melanogaster, GI24583079, Length=730, Percent_Identity=34.7945205479452, Blast_Score=333, Evalue=2e-91,
Organism=Drosophila melanogaster, GI19921000, Length=730, Percent_Identity=34.7945205479452, Blast_Score=333, Evalue=2e-91,
Organism=Drosophila melanogaster, GI20129971, Length=185, Percent_Identity=30.8108108108108, Blast_Score=82, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24653477, Length=185, Percent_Identity=30.8108108108108, Blast_Score=82, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24653139, Length=185, Percent_Identity=35.1351351351351, Blast_Score=79, Evalue=9e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006180
- InterPro:   IPR006176
- InterPro:   IPR006108
- InterPro:   IPR008927
- InterPro:   IPR001753
- InterPro:   IPR013328
- InterPro:   IPR018376
- InterPro:   IPR012802
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00725 3HCDH; PF02737 3HCDH_N; PF00378 ECH [H]

EC number: =4.2.1.17; =5.1.2.3; =1.1.1.35 [H]

Molecular weight: Translated: 74689; Mature: 74689

Theoretical pI: Translated: 7.90; Mature: 7.90

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIDYTLDDDGIATLSWNLPARSQNVLNGESCEAFFAAAARALQDAAVKGMLVTSAKPDFI
CCCEEECCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCEEEECCCCCCE
AGGDLEWLQASDSAETLFARTCELHRALRALETGGKPVAIAMPGSALGGGLEIALAGHYR
ECCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCEEEEEECCEE
VAADNPKARFGLPEVTLGLLPGGGGTQRLPRLVGVQASLPLLLEGKRLKAADALAAGILH
EECCCCCCCCCCCCEEEEEECCCCCHHHHHHHHCCCCCCCEEECCCCHHHHHHHHHHHHH
AVVPAGEEIAAARAWLLDASRRTATQPWDAKGFRIPGGALTHPSVQQVFMAANALARQKT
HHCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCEECCCCCCCCHHHHHHHHHHHHHHHHHC
YGNYPAVASILSCVYEGLLTDLDTGLKTEARYFVKAVLSPEAKAMIRTLFFGMNEANKLA
CCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCHHHHHHHHHHHCCCCHHHHH
ARPAGVPTQRYRKVGVLGAGMMGAGIAYVSAKAGLDVVLIDTGEEAAARGKDYSRKLVDK
CCCCCCCHHHHHHHHHCCCCHHHCCHHEEECCCCCEEEEEECCCHHHHCCCHHHHHHHHH
QVQRGRLAREKADALLAKIVPTTDFARLDGAQLVIEAVFEDRAIKADVTRRSEAVLAPDA
HHHHHHHHHHHHHHHHHHHCCCCCHHHCCCHHHHHHHHHHCCCHHHHHHHCCCCEECCCH
LFASNTSTLPITGLAQASARPANFIGLHFFSPVDKMPLVEVIVGRDTSEATLARALDYVK
HCCCCCCCCCEECCHHCCCCCCCEEEEEECCCCCCCCHHHHEECCCCHHHHHHHHHHHHH
TIGMTPIVVNDSRGFYTSRVFSTYVLEGLAMLAEGVAPALIENAGLLAGMPVGPLALTDE
HCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCEECCCCCCCHHHHH
VSSELIHKITRQTRADLGDAYVARPGEDVAARMVELGRLGRKAGLGYYDYPASGGKKALW
HHHHHHHHHHHHHHHHCCCHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
PGLAQEFPLAAEQPDVAALIERLVTVQAVETARCLEERVLTTARDADVGAILGWGFPAFR
CCHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCC
GGPASYIHGVGVDAFVATCDRLAARHGARFAAPALLREMAAQGRSFY
CCCHHHHHHCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MIDYTLDDDGIATLSWNLPARSQNVLNGESCEAFFAAAARALQDAAVKGMLVTSAKPDFI
CCCEEECCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCEEEECCCCCCE
AGGDLEWLQASDSAETLFARTCELHRALRALETGGKPVAIAMPGSALGGGLEIALAGHYR
ECCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCEEEEEECCEE
VAADNPKARFGLPEVTLGLLPGGGGTQRLPRLVGVQASLPLLLEGKRLKAADALAAGILH
EECCCCCCCCCCCCEEEEEECCCCCHHHHHHHHCCCCCCCEEECCCCHHHHHHHHHHHHH
AVVPAGEEIAAARAWLLDASRRTATQPWDAKGFRIPGGALTHPSVQQVFMAANALARQKT
HHCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCEECCCCCCCCHHHHHHHHHHHHHHHHHC
YGNYPAVASILSCVYEGLLTDLDTGLKTEARYFVKAVLSPEAKAMIRTLFFGMNEANKLA
CCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCHHHHHHHHHHHCCCCHHHHH
ARPAGVPTQRYRKVGVLGAGMMGAGIAYVSAKAGLDVVLIDTGEEAAARGKDYSRKLVDK
CCCCCCCHHHHHHHHHCCCCHHHCCHHEEECCCCCEEEEEECCCHHHHCCCHHHHHHHHH
QVQRGRLAREKADALLAKIVPTTDFARLDGAQLVIEAVFEDRAIKADVTRRSEAVLAPDA
HHHHHHHHHHHHHHHHHHHCCCCCHHHCCCHHHHHHHHHHCCCHHHHHHHCCCCEECCCH
LFASNTSTLPITGLAQASARPANFIGLHFFSPVDKMPLVEVIVGRDTSEATLARALDYVK
HCCCCCCCCCEECCHHCCCCCCCEEEEEECCCCCCCCHHHHEECCCCHHHHHHHHHHHHH
TIGMTPIVVNDSRGFYTSRVFSTYVLEGLAMLAEGVAPALIENAGLLAGMPVGPLALTDE
HCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCEECCCCCCCHHHHH
VSSELIHKITRQTRADLGDAYVARPGEDVAARMVELGRLGRKAGLGYYDYPASGGKKALW
HHHHHHHHHHHHHHHHCCCHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
PGLAQEFPLAAEQPDVAALIERLVTVQAVETARCLEERVLTTARDADVGAILGWGFPAFR
CCHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCC
GGPASYIHGVGVDAFVATCDRLAARHGARFAAPALLREMAAQGRSFY
CCCHHHHHHCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA