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The map label for this gene is aphA [H]

Identifier: 126454260

GI number: 126454260

Start: 1136172

End: 1137197

Strand: Direct

Name: aphA [H]

Synonym: BURPS1106A_1157

Alternate gene names: 126454260

Gene position: 1136172-1137197 (Clockwise)

Preceding gene: 126455263

Following gene: 126455072

Centisome position: 28.49

GC content: 69.01

Gene sequence:

>1026_bases
ATGCTGACGTACTTCCACCCCGATCAATCACTGCATCATCCGCGCACGTACTTCTCGCGCGGCCGGATGCGCATGCCGCA
GGAGGTGCCCGAGCGCGCGGCGCGGCTCGTCGCGGCGGCGTTCGCGATGGGTTTTCCGGTGCGCGAGCCGGACGATTTCG
GCATCGCGCCGATCGCGGCCGTGCACGACACGCACTACCTGCGCTTTCTCGAGACCGTGCATCGCGAATGGAAGGCGATG
CCGGAGGACTGGGGCGACGAAGCGATGTCGAATATTTTCGTGCGCGAGCCGAACGCGTTGCGCGGCGTGCTCGCACAGGC
CGCCCGTCACCTCGCGGACGGCAGTTGCCCGGTCGGCGAGCACACGTGGCGCGCGGCGTACTGGTCCGCGCAGAGCGCGC
TCGCGGCGGCGGCGGCGGTGCGCGACGGCGCGCCCGCAGCGTATGCGCTGTGCCGGCCGCCGGGCCATCATGCGCGCGTC
GACGCCGCGGGCGGCTTCTGTTATCTGAACAACGCGGCGATCGCCGCGCAGGCGCTGCGCGCGCGCCATGCGCGCGTCGC
CGTCCTCGACACCGACATGCATCACGGGCAAGGCATACAGGAAATCTTCTACGCGCGGCGCGACGTGCTGTACGTATCGA
TTCACGGCGATCCGACGAACTTCTACCCGGCCGTCGCGGGCTTCGACGACGAGCGCGGCGCGGGCGAAGGCCTCGGCTAC
AACGTGAATCTGCCGATGCCGCACGGCTCGAGCGAAGCGGCGTTCTTCGAGCGCGTCGACGATGCGCTGCGCGAGTTGCG
GCGCTTCGCGCCCGATGCGCTCGTGCTGTCGCTTGGGTTCGACATCTATCGCGACGATCCGCAATCGCAGGTGGCGGTGA
CGACGGACGGTTTCGGTCGATTGGGACACCTGATCGGCGCGCTGCGGCTGCCGACCGTCATCGTGCAGGAAGGCGGCTAT
CACATCGAGAGCCTCGAGGCGAATGCGCGGTCGTTCTTCGGCGGATTCGGCGCGCTGCGCGGTTGA

Upstream 100 bases:

>100_bases
CAAACGTCAAACGTCAAACGTCAAACGTCAAACGCGGCTCGCCCCCTACAACCGATAACGGGCGCCCCGCCGCCCACCCA
TTCGACCCGAGGACATCGAG

Downstream 100 bases:

>100_bases
GGCGGCGGCGCCTGCGCGCTCACGGGCGAGCACCCGGCGACGCGCGTTCGCGCGCGGCACGCGCCGGCGTCAAGCGTTCG
GCCGCGCACGCGAAGCGGCG

Product: acetylpolyamine aminohydrolase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 341; Mature: 341

Protein sequence:

>341_residues
MLTYFHPDQSLHHPRTYFSRGRMRMPQEVPERAARLVAAAFAMGFPVREPDDFGIAPIAAVHDTHYLRFLETVHREWKAM
PEDWGDEAMSNIFVREPNALRGVLAQAARHLADGSCPVGEHTWRAAYWSAQSALAAAAAVRDGAPAAYALCRPPGHHARV
DAAGGFCYLNNAAIAAQALRARHARVAVLDTDMHHGQGIQEIFYARRDVLYVSIHGDPTNFYPAVAGFDDERGAGEGLGY
NVNLPMPHGSSEAAFFERVDDALRELRRFAPDALVLSLGFDIYRDDPQSQVAVTTDGFGRLGHLIGALRLPTVIVQEGGY
HIESLEANARSFFGGFGALRG

Sequences:

>Translated_341_residues
MLTYFHPDQSLHHPRTYFSRGRMRMPQEVPERAARLVAAAFAMGFPVREPDDFGIAPIAAVHDTHYLRFLETVHREWKAM
PEDWGDEAMSNIFVREPNALRGVLAQAARHLADGSCPVGEHTWRAAYWSAQSALAAAAAVRDGAPAAYALCRPPGHHARV
DAAGGFCYLNNAAIAAQALRARHARVAVLDTDMHHGQGIQEIFYARRDVLYVSIHGDPTNFYPAVAGFDDERGAGEGLGY
NVNLPMPHGSSEAAFFERVDDALRELRRFAPDALVLSLGFDIYRDDPQSQVAVTTDGFGRLGHLIGALRLPTVIVQEGGY
HIESLEANARSFFGGFGALRG
>Mature_341_residues
MLTYFHPDQSLHHPRTYFSRGRMRMPQEVPERAARLVAAAFAMGFPVREPDDFGIAPIAAVHDTHYLRFLETVHREWKAM
PEDWGDEAMSNIFVREPNALRGVLAQAARHLADGSCPVGEHTWRAAYWSAQSALAAAAAVRDGAPAAYALCRPPGHHARV
DAAGGFCYLNNAAIAAQALRARHARVAVLDTDMHHGQGIQEIFYARRDVLYVSIHGDPTNFYPAVAGFDDERGAGEGLGY
NVNLPMPHGSSEAAFFERVDDALRELRRFAPDALVLSLGFDIYRDDPQSQVAVTTDGFGRLGHLIGALRLPTVIVQEGGY
HIESLEANARSFFGGFGALRG

Specific function: Acts on many types of acetylpolyamines has high affinity towards acetylputrescine, acetylcadaverine, acetylspermidine, and acetylspermine [H]

COG id: COG0123

COG function: function code BQ; Deacetylases, including yeast histone deacetylase and acetoin utilization protein

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histone deacetylase family [H]

Homologues:

Organism=Homo sapiens, GI8923769, Length=300, Percent_Identity=28.3333333333333, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI20070354, Length=215, Percent_Identity=40.4651162790698, Blast_Score=118, Evalue=8e-27,
Organism=Homo sapiens, GI262073088, Length=213, Percent_Identity=31.924882629108, Blast_Score=108, Evalue=5e-24,
Organism=Homo sapiens, GI169234807, Length=180, Percent_Identity=41.1111111111111, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI148539870, Length=180, Percent_Identity=41.1111111111111, Blast_Score=107, Evalue=1e-23,
Organism=Homo sapiens, GI153085395, Length=295, Percent_Identity=32.5423728813559, Blast_Score=107, Evalue=1e-23,
Organism=Homo sapiens, GI17158039, Length=234, Percent_Identity=34.1880341880342, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI30795204, Length=220, Percent_Identity=35, Blast_Score=106, Evalue=3e-23,
Organism=Homo sapiens, GI30795202, Length=220, Percent_Identity=35, Blast_Score=106, Evalue=3e-23,
Organism=Homo sapiens, GI13128864, Length=197, Percent_Identity=36.5482233502538, Blast_Score=105, Evalue=8e-23,
Organism=Homo sapiens, GI13128860, Length=312, Percent_Identity=24.6794871794872, Blast_Score=102, Evalue=6e-22,
Organism=Homo sapiens, GI226529806, Length=215, Percent_Identity=38.1395348837209, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI62750349, Length=201, Percent_Identity=34.8258706467662, Blast_Score=90, Evalue=3e-18,
Organism=Homo sapiens, GI62750347, Length=201, Percent_Identity=34.8258706467662, Blast_Score=90, Evalue=3e-18,
Organism=Homo sapiens, GI13128862, Length=171, Percent_Identity=29.8245614035088, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI293336691, Length=260, Percent_Identity=27.3076923076923, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI262073092, Length=234, Percent_Identity=26.9230769230769, Blast_Score=87, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17540334, Length=200, Percent_Identity=39.5, Blast_Score=126, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI193206283, Length=200, Percent_Identity=39.5, Blast_Score=125, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI17540332, Length=200, Percent_Identity=39.5, Blast_Score=125, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI17508561, Length=311, Percent_Identity=27.0096463022508, Blast_Score=108, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI17561978, Length=240, Percent_Identity=29.5833333333333, Blast_Score=106, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI193209491, Length=223, Percent_Identity=32.2869955156951, Blast_Score=100, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17537347, Length=220, Percent_Identity=31.3636363636364, Blast_Score=100, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17534739, Length=329, Percent_Identity=25.2279635258359, Blast_Score=90, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI25154022, Length=192, Percent_Identity=28.125, Blast_Score=72, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI25154020, Length=192, Percent_Identity=28.125, Blast_Score=71, Evalue=7e-13,
Organism=Saccharomyces cerevisiae, GI6324307, Length=209, Percent_Identity=36.3636363636364, Blast_Score=127, Evalue=4e-30,
Organism=Saccharomyces cerevisiae, GI6323999, Length=241, Percent_Identity=25.7261410788382, Blast_Score=96, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6321244, Length=235, Percent_Identity=24.6808510638298, Blast_Score=86, Evalue=7e-18,
Organism=Saccharomyces cerevisiae, GI6325325, Length=149, Percent_Identity=28.1879194630872, Blast_Score=74, Evalue=3e-14,
Organism=Drosophila melanogaster, GI281360801, Length=292, Percent_Identity=34.9315068493151, Blast_Score=111, Evalue=7e-25,
Organism=Drosophila melanogaster, GI24641720, Length=292, Percent_Identity=34.9315068493151, Blast_Score=111, Evalue=9e-25,
Organism=Drosophila melanogaster, GI281360799, Length=292, Percent_Identity=34.9315068493151, Blast_Score=110, Evalue=1e-24,
Organism=Drosophila melanogaster, GI281360899, Length=244, Percent_Identity=36.4754098360656, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24642144, Length=244, Percent_Identity=36.4754098360656, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24642146, Length=244, Percent_Identity=36.4754098360656, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24642142, Length=244, Percent_Identity=36.4754098360656, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24657891, Length=313, Percent_Identity=25.8785942492013, Blast_Score=105, Evalue=6e-23,
Organism=Drosophila melanogaster, GI24644244, Length=262, Percent_Identity=27.4809160305344, Blast_Score=102, Evalue=3e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000286 [H]

Pfam domain/function: PF00850 Hist_deacetyl [H]

EC number: NA

Molecular weight: Translated: 37401; Mature: 37401

Theoretical pI: Translated: 6.56; Mature: 6.56

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTYFHPDQSLHHPRTYFSRGRMRMPQEVPERAARLVAAAFAMGFPVREPDDFGIAPIAA
CCEEECCCCCCCCCHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHH
VHDTHYLRFLETVHREWKAMPEDWGDEAMSNIFVREPNALRGVLAQAARHLADGSCPVGE
HHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHEEEECCHHHHHHHHHHHHHHCCCCCCCCC
HTWRAAYWSAQSALAAAAAVRDGAPAAYALCRPPGHHARVDAAGGFCYLNNAAIAAQALR
CHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCEEECCCCEEEECCHHHHHHHHH
ARHARVAVLDTDMHHGQGIQEIFYARRDVLYVSIHGDPTNFYPAVAGFDDERGAGEGLGY
HHCCEEEEEECCCCCCCCHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCE
NVNLPMPHGSSEAAFFERVDDALRELRRFAPDALVLSLGFDIYRDDPQSQVAVTTDGFGR
EEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEECCCHHCCCCCCCEEEEEECCHHH
LGHLIGALRLPTVIVQEGGYHIESLEANARSFFGGFGALRG
HHHHHHHHHCCEEEEECCCCEEEHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MLTYFHPDQSLHHPRTYFSRGRMRMPQEVPERAARLVAAAFAMGFPVREPDDFGIAPIAA
CCEEECCCCCCCCCHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHH
VHDTHYLRFLETVHREWKAMPEDWGDEAMSNIFVREPNALRGVLAQAARHLADGSCPVGE
HHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHEEEECCHHHHHHHHHHHHHHCCCCCCCCC
HTWRAAYWSAQSALAAAAAVRDGAPAAYALCRPPGHHARVDAAGGFCYLNNAAIAAQALR
CHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCEEECCCCEEEECCHHHHHHHHH
ARHARVAVLDTDMHHGQGIQEIFYARRDVLYVSIHGDPTNFYPAVAGFDDERGAGEGLGY
HHCCEEEEEECCCCCCCCHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCE
NVNLPMPHGSSEAAFFERVDDALRELRRFAPDALVLSLGFDIYRDDPQSQVAVTTDGFGR
EEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEECCCHHCCCCCCCEEEEEECCHHH
LGHLIGALRLPTVIVQEGGYHIESLEANARSFFGGFGALRG
HHHHHHHHHCCEEEEECCCCEEEHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8824626; 3207420 [H]