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The map label for this gene is fmt [H]

Identifier: 126454119

GI number: 126454119

Start: 151871

End: 152854

Strand: Direct

Name: fmt [H]

Synonym: BURPS1106A_0160

Alternate gene names: 126454119

Gene position: 151871-152854 (Clockwise)

Preceding gene: 126453149

Following gene: 126451862

Centisome position: 3.81

GC content: 72.76

Gene sequence:

>984_bases
ATGACACATTCACTGCGCGTCATTTTTGCCGGCACGCCGGAATTCGCGGCGGCGGCGCTCGCCGCGATCCATGAGGCCGG
TTTTCCCGTCCCGCTCGTACTGACGCAGCCGGATCGTCCCGCCGGCCGCGGGATGAAGCTGCAGGCGAGCGCCGTGAAGC
GCTATGCGCTCGAGCGCGGCATGGCCGTCGCGCAGCCGCCGTCGCTGCGCCGCGCGGGCAAGTATCCGGTCGAAGCCGTC
GCCGCGCTCGATCTGTTGCATGCGACGCCGCACGACGTGATGGTCGTCGCCGCATATGGCCTGCTTCTGCCGCAAGAAGT
GCTCGAGCTGCCGCGGCACGGCTGCATCAATATCCACGCGTCGCTGCTGCCGCGCTGGCGCGGCGCGGCGCCGATCCATC
GCGCGATCGAGGCGGGCGACGCCGAAACGGGCGTCACGCTGATGCAGATGGACGCCGGGCTCGACACGGGCGCGATGCTG
CACGAAGCGCGCGTCGCGATCGCGCCCGACGATACGACGGCGACGCTGCACGACAAGCTCGCGGCGGCCGGCGCGCGCCT
CGTCGTCGACGCGCTCGTCGAACTCGAGCGTACGGGCGCGCTTGCCGCGACGCCGCAGCCCGCCGACGGCGTGACCTATG
CCGAGAAGATCGGCAAGCACGAGGCGGCGCTCGACTGGCGCAAGCCGGCCGCCGCGCTCGCGCGGCAAGTGCGCGCGTTC
GACCCGTTCCCGGGCGGCGCGGGCACGCTCGACGGCGCGACGCTCAAGCTGTGGGCGGCCGATGCGGTGCCCGGGCGCGA
CGACGCCGCGCCCGGCACGATCGTCGATATCGGCCCGGACGGCGTCGTGATCGCCTGCGGCGAAGGCGCGCTGCGCGTGA
CGCAATTACAGAAACCGGGCGGCAAACGCCTGCCCGCGCGAGAATTTCTCGCGGGGGCGCCGCTTGCGGTCGGCCAGCGC
TTCGCGCCGGCCGACGCCGCGTGA

Upstream 100 bases:

>100_bases
CAGTATCTGTCGCCGCTCAAGCAGACCCGGATCAAGACGAAGATGAAGAAACTCGAACGCGCAATGTGATGCGCGCCGCC
GCTACCCGATTCATTCGCAC

Downstream 100 bases:

>100_bases
GTGCGTCGTTCGCCATCAGTTCATCGGAATCGCGCGCGCCGCGCAATCGGCCGAACGGCCAGGTCGCGGCGCGCCGGGCG
CGCGCGTAGAATTCTCTGAC

Product: methionyl-tRNA formyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 327; Mature: 326

Protein sequence:

>327_residues
MTHSLRVIFAGTPEFAAAALAAIHEAGFPVPLVLTQPDRPAGRGMKLQASAVKRYALERGMAVAQPPSLRRAGKYPVEAV
AALDLLHATPHDVMVVAAYGLLLPQEVLELPRHGCINIHASLLPRWRGAAPIHRAIEAGDAETGVTLMQMDAGLDTGAML
HEARVAIAPDDTTATLHDKLAAAGARLVVDALVELERTGALAATPQPADGVTYAEKIGKHEAALDWRKPAAALARQVRAF
DPFPGGAGTLDGATLKLWAADAVPGRDDAAPGTIVDIGPDGVVIACGEGALRVTQLQKPGGKRLPAREFLAGAPLAVGQR
FAPADAA

Sequences:

>Translated_327_residues
MTHSLRVIFAGTPEFAAAALAAIHEAGFPVPLVLTQPDRPAGRGMKLQASAVKRYALERGMAVAQPPSLRRAGKYPVEAV
AALDLLHATPHDVMVVAAYGLLLPQEVLELPRHGCINIHASLLPRWRGAAPIHRAIEAGDAETGVTLMQMDAGLDTGAML
HEARVAIAPDDTTATLHDKLAAAGARLVVDALVELERTGALAATPQPADGVTYAEKIGKHEAALDWRKPAAALARQVRAF
DPFPGGAGTLDGATLKLWAADAVPGRDDAAPGTIVDIGPDGVVIACGEGALRVTQLQKPGGKRLPAREFLAGAPLAVGQR
FAPADAA
>Mature_326_residues
THSLRVIFAGTPEFAAAALAAIHEAGFPVPLVLTQPDRPAGRGMKLQASAVKRYALERGMAVAQPPSLRRAGKYPVEAVA
ALDLLHATPHDVMVVAAYGLLLPQEVLELPRHGCINIHASLLPRWRGAAPIHRAIEAGDAETGVTLMQMDAGLDTGAMLH
EARVAIAPDDTTATLHDKLAAAGARLVVDALVELERTGALAATPQPADGVTYAEKIGKHEAALDWRKPAAALARQVRAFD
PFPGGAGTLDGATLKLWAADAVPGRDDAAPGTIVDIGPDGVVIACGEGALRVTQLQKPGGKRLPAREFLAGAPLAVGQRF
APADAA

Specific function: Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by:(I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-

COG id: COG0223

COG function: function code J; Methionyl-tRNA formyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fmt family [H]

Homologues:

Organism=Homo sapiens, GI238814322, Length=328, Percent_Identity=27.4390243902439, Blast_Score=112, Evalue=3e-25,
Organism=Homo sapiens, GI21614513, Length=325, Percent_Identity=28.9230769230769, Blast_Score=112, Evalue=5e-25,
Organism=Homo sapiens, GI164663775, Length=232, Percent_Identity=32.7586206896552, Blast_Score=101, Evalue=9e-22,
Organism=Escherichia coli, GI1789683, Length=310, Percent_Identity=50, Blast_Score=280, Evalue=8e-77,
Organism=Escherichia coli, GI1788589, Length=318, Percent_Identity=31.7610062893082, Blast_Score=147, Evalue=1e-36,
Organism=Caenorhabditis elegans, GI133930964, Length=327, Percent_Identity=27.5229357798165, Blast_Score=105, Evalue=2e-23,
Organism=Drosophila melanogaster, GI45550868, Length=318, Percent_Identity=30.188679245283, Blast_Score=115, Evalue=4e-26,
Organism=Drosophila melanogaster, GI28571984, Length=229, Percent_Identity=34.4978165938865, Blast_Score=108, Evalue=5e-24,
Organism=Drosophila melanogaster, GI24585660, Length=257, Percent_Identity=24.9027237354086, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: 400 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005794
- InterPro:   IPR005793
- InterPro:   IPR002376
- InterPro:   IPR011034
- InterPro:   IPR001555
- InterPro:   IPR015518 [H]

Pfam domain/function: PF02911 Formyl_trans_C; PF00551 Formyl_trans_N [H]

EC number: =2.1.2.9 [H]

Molecular weight: Translated: 33928; Mature: 33797

Theoretical pI: Translated: 6.86; Mature: 6.86

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTHSLRVIFAGTPEFAAAALAAIHEAGFPVPLVLTQPDRPAGRGMKLQASAVKRYALERG
CCCCEEEEEECCCHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCEEEHHHHHHHHHHHCC
MAVAQPPSLRRAGKYPVEAVAALDLLHATPHDVMVVAAYGLLLPQEVLELPRHGCINIHA
CCCCCCCCHHHCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHCHHHHHHCCCCCEEEEHH
SLLPRWRGAAPIHRAIEAGDAETGVTLMQMDAGLDTGAMLHEARVAIAPDDTTATLHDKL
HHCCCCCCCCHHHHHHHCCCCCCCEEEEEECCCCCCCHHHHHCEEEECCCCCCHHHHHHH
AAAGARLVVDALVELERTGALAATPQPADGVTYAEKIGKHEAALDWRKPAAALARQVRAF
HHHHHHHHHHHHHHHHHCCCEECCCCCCCCCHHHHHHCCHHHHHCCCCHHHHHHHHHHHC
DPFPGGAGTLDGATLKLWAADAVPGRDDAAPGTIVDIGPDGVVIACGEGALRVTQLQKPG
CCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCEEEECCCCEEEEECCCCEEEEEECCCC
GKRLPAREFLAGAPLAVGQRFAPADAA
CCCCCHHHHHCCCCHHHCCCCCCCCCC
>Mature Secondary Structure 
THSLRVIFAGTPEFAAAALAAIHEAGFPVPLVLTQPDRPAGRGMKLQASAVKRYALERG
CCCEEEEEECCCHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCEEEHHHHHHHHHHHCC
MAVAQPPSLRRAGKYPVEAVAALDLLHATPHDVMVVAAYGLLLPQEVLELPRHGCINIHA
CCCCCCCCHHHCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHCHHHHHHCCCCCEEEEHH
SLLPRWRGAAPIHRAIEAGDAETGVTLMQMDAGLDTGAMLHEARVAIAPDDTTATLHDKL
HHCCCCCCCCHHHHHHHCCCCCCCEEEEEECCCCCCCHHHHHCEEEECCCCCCHHHHHHH
AAAGARLVVDALVELERTGALAATPQPADGVTYAEKIGKHEAALDWRKPAAALARQVRAF
HHHHHHHHHHHHHHHHHCCCEECCCCCCCCCHHHHHHCCHHHHHCCCCHHHHHHHHHHHC
DPFPGGAGTLDGATLKLWAADAVPGRDDAAPGTIVDIGPDGVVIACGEGALRVTQLQKPG
CCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCEEEECCCCEEEEECCCCEEEEEECCCC
GKRLPAREFLAGAPLAVGQRFAPADAA
CCCCCHHHHHCCCCHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA